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                <text>Thangavelu, Indumathi; Tadepalli, Srinivas</text>
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                <text>Biocompatible NiTiO3Dopamine nanocomposites for combating drug-resistant pathogens through membrane disruption and oxidative stress</text>
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                <text>Journal of Drug Delivery Science and Technology;Volume;114;Issue;;Article No.;107553;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia</text>
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                <text>The rising threat of multidrug-resistant pathogens poses a challenge to public health. Highlighting the urgent need for novel antimicrobial agents, this study reports the synthesis of NiTiO3 nanoparticles and dopamine-functionalized NiTiO3 nanocomposites. Structural and elemental confirmation was obtained through XPS studies, which confirmed the presence of Ni2+ and Ti4+ in the nanocomposite, along with C 1s and O 1s peaks corresponding to dopamine coating. Photoluminescence spectra revealed that the NiTiO3dopamine nanocomposite exhibits notable green emission bands at 510, 518, and 527nm which arises from deep-level recombination associated with complex oxygen-related defects like oxygen vacancies. The NiTiO3-dopamine exhibited enhanced antimicrobial activity against S. aureus, B. subtilis, K. pneumoniae, S. dysenteriae, and C. albicans, compared to NiTiO3 alone. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays further revealed that NiTiO3dopamine achieved MIC at 600?g/mL and MBC at 1000?g/mL for K. pneumoniae, outperforming pure NiTiO3. ROS assays confirmed oxidative stress-mediated antimicrobial action, with ROS levels significantly quenched in the presence of histidine. SEM images of bacterial morphology showed extensive membrane disruption in NiTiO3dopamine treated cells. Furthermore, zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO3dopamine nanocomposite, with normal development observed up to 72h post fertilization.  2025 Published by Elsevier B.V.</text>
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                <text>Naunyn-Schmiedeberg's Archives of Pharmacology;Volume;398;Issue;12;pp.17895-17906</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to Be University), Karnataka, Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; A. AlGhamdi A., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India</text>
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                <text>Societies continue to face the urgent challenge of developing effective, safe, and stable nanoparticles with promising biomedical applications. Herein, the present study synthesis chitosan and L-Histidine dually coated titanium dioxide (TiCSLH) nanocomposite (NC) by chemical co-precipitation method. The antimicrobial performance of TiO? nanoparticles is closely linked to their physicochemical properties, such as reduced particle size, increased bandgap, and the presence of oxygen vacancies, all of which collectively enhance reactive oxygen species (ROS) generation and inhibit microbial growth. Structural analyses using XRD and TEM confirmed that TiCSLH nanoparticles possess an anatase phase and a spherical morphology. Compared to TiO?, TiCSLH nanoparticles demonstrated significantly enhanced antimicrobial activity against MRSA, E. coli, K. pneumoniae, P. aeruginosa and C. albicans strains, as evidenced by larger zones of inhibition from 2324mm. This enhanced efficacy is attributed to their smaller particle size (~ 26  3nm), wider bandgap (3.34eV), and prominent oxygen vacancy-related emissions at 518 and 531nm, which facilitate increased ROS production, resulting in cellular membrane disruption and microbial death. Furthermore, compared to TiO2, TiCSLH exhibited notable anticancer potential against breast cancer cells, with an IC?? of 10?g/mL, while maintaining excellent biocompatibility, as evidenced by its non-toxic response toward L929 fibroblast cells, which showed 83.5% cell viability. Collectively, these findings underscore the potential of TiCSLH nanoparticles for diverse biomedical applications.  The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.</text>
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                <text>Breast cancer cell; Chitosan; L-Histidine; MRSA; TiO&lt;sub&gt;2&lt;/sub&gt;</text>
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                <text>Thangavelu, Indumathi; Tadepalli, Srinivas; Boopathi, Thalakulam Shanmugam</text>
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                <text>Biocompatible Pluronic F127-coated nickel titanate nanoparticles: toward effective antimicrobial and antioxidant therapies</text>
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                <text>Polymer International;</text>
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                <text>&lt;a href="https://doi.org/10.1002/pi.70095" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1002/pi.70095&lt;/a&gt; &lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.scopus.com/pages/publications/105031490121?origin=resultslist" target="_blank" rel="noreferrer noopener"&gt;https://www.scopus.com/pages/publications/105031490121?origin=resultslist&lt;/a&gt;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, India</text>
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                <text>Multidrug-resistant bacterial infections are a major global health concern. Nickel titanate (NiTiO?) nanoparticles offer potential antimicrobial applications, but their biocompatibility is limited. This study explores the surface modification of NiTiO? with Pluronic F127 (PF127) to enhance biological performance. NiTiO? nanoparticles were synthesized and coated with PF127. Characterization was performed using XRD, FTIR, HRTEM, BET and DLS. Antibacterial activity was assessed via pathogenic bacteria assays and colony-forming unit quantification. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and zebrafish embryos evaluated in vivo toxicity. XRD confirmed hexagonal NiTiO?, and FTIR/HRTEM verified PF127 incorporation. BET analysis indicated a surface area of 28.66 m2 g?1 and mesoporous structure (2.59 nm pore diameter). DLS showed particle size reduction from 219.3 nm (NiTiO?) to 135.9 nm (NiTiO?PF127), confirming improved dispersion. NiTiO?PF127 exhibited enhanced antibacterial activity, with colony-forming unit counts decreasing in a concentration-dependent manner. The DPPH assay showed 53.7% radical scavenging at 20 ?g mL?1. Zebrafish embryo studies revealed higher viability and lower developmental toxicity for PF127-coated nanoparticles compared to uncoated NiTiO?. PF127 modification of NiTiO? improves dispersion, antibacterial and antioxidant activity, and biocompatibility. These results highlight NiTiO?PF127 nanocomposite as a promising candidate for biomedical and antimicrobial applications.  2026 Society of Chemical Industry.  2026 Society of Chemical Industry.</text>
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                <text>antibacterial activity; biocompatibility; nanocomposite; NiTiO? nanoparticles; Pluronic F127; zebrafish embryo model</text>
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                <text>ISSN: 9598103;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India</text>
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                <text>The alarming rise in multidrug-resistant bacterial infections has necessitated the development of novel and biocompatible antimicrobial agents. In this study, NiFe2O3 nanoparticles were prepared using co-precipitation method. The NiFe2O3 nanoparticles were functionalized with carboxymethyl cellulose to enhance their stability, dispersibility, and biological activity. The characterization results revealed that the CMC-modified NiFe2O3 nanoparticles exhibited an enhanced physicochemical property when compared to bare NiFe2O3. The hydrodynamic diameter of the CMC-modified NiFe2O3 nanoparticles were found to be 202.3 nm. The crystallite size of the nanoparticles was found to be 28.2 nm for NiFe2O3 and 24.3 nm for CMC-NiFe2O3. Fourier-transform infrared spectra revealed the effective functionalization of CMC through typical O[sbnd]H, C[sbnd]H, and C[sbnd]O[sbnd]C vibrations. The HRTEM results revealed the homogenous particle morphology with negligible aggregation. BET analysis indicated a high surface area of 85.75 m2/g and a pore volume of 1.789 cm3/g, showing a mesoporous structure. The optical studies demonstrated a narrowed band gap from 3.22 eV to 3.12 eV, and lower PL intensity, implying better charge separation and higher surface defects. Antibacterial activity, assessed by agar well diffusion method, indicated drastically bigger zones of inhibition for CMC-NiFe2O3 over bare NiFe2O3, against Shigella dysenteriae and Proteus vulgaris. The antioxidant activity of CMC-NiFe2O3 was determined through DPPH assay which demonstrated dose-dependent radical scavenging activity. The zebrafish embryo toxicity testing revealed dose-dependent developmental anomalies, with high doses (3 mg/mL) triggering pericardial edema, tail malformation, and reduced pigmentation.  2025 Elsevier B.V.</text>
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                <text>Thangavelu, Indumathi; Tadepalli, Srinivas; Gadallah, Abdelrahman G.</text>
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                <text>Journal of Inorganic and Organometallic Polymers and Materials;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Gadallah A.G., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia</text>
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                <text>In this study, Calcium carbonate (CaCO?) nanoparticles and calcium carbonatesodium alginate (CaCO?SA) nanocomposite were successfully synthesized via a controlled precipitation method and evaluated for multifunctional biomedical applications. Structural and surface analyses confirmed the formation of a calcite phase with effective surface functionalization using SA. The nanocomposite exhibited reduced crystallite size (~ 29nm vs. ~38nm for CaCO?), improved dispersion, and enhanced defect density, as evidenced by XRD, DLS, PL, and TEM analyses. PL studies revealed multiple defect-related emission bands (370534nm), indicating the presence of active surface states. The CaCO?SA nanocomposite demonstrated significantly enhanced antimicrobial activity compared to CaCO?, with zone of inhibition values reaching ~ 20mm (S. aureus), ~ 21mm (S. pneumoniae), ~ 20mm (E. coli), and ~ 18mm (C. albicans), comparable to standard drugs. CFU analysis confirmed a concentration-dependent reduction in bacterial viability, while MIC and MBC values were reduced to 500g mL? and 750g mL?, respectively, indicating improved bacteriostatic and bactericidal efficiency. In anticancer studies, the nanocomposite exhibited enhanced cytotoxicity against MG-63 osteosarcoma cells, reducing cell viability to ~ 30% at higher concentrations, while maintaining high biocompatibility of &amp;gt; 80% viability toward L929 fibroblast cells. Overall, this work highlights the potential of surface engineered CaCO? based nanomaterials as promising candidates for combined antimicrobial and anticancer applications, providing a foundation for future in-depth biological investigations and translational studies.  The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026.</text>
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                <text>ISSN: 15741443;</text>
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                <text>Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S.</text>
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                <text>Green synthesis of biocompatible L-Histidine-Modified NiFe2O4 Nanoparticles: A multifaceted approach toward cancer and bacterial therapy</text>
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                <text>Journal of Molecular Structure;Volume;1352;Issue;;Article No.;144396;</text>
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                <text>&lt;a href="https://doi.org/10.1016/j.molstruc.2025.144396" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1016/j.molstruc.2025.144396&lt;/a&gt; &lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.scopus.com/pages/publications/105019076957?origin=resultslist" target="_blank" rel="noreferrer noopener"&gt;https://www.scopus.com/pages/publications/105019076957?origin=resultslist&lt;/a&gt;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India</text>
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                <text>Cancer and infections caused by microbes remain serious global health threats, with multidrug resistance and toxicity associated with treatment constraining the efficacy of traditional therapies. In the present research, biocompatible L-histidine-functionalized nickel ferrite nanoparticles (NiFe2O4-LH) were green synthesized using of Clitoria ternatea flower extract and systematically evaluated for their therapeutic effects. Characterization established their spinel cubic structure, reduced crystallite size (14.4 nm), and enhanced stability when compared to bare NiFe2O4 (21.6 nm). UVvisible spectra revealed a blue shift with expanded band gap from 3.16 eV (NiFe2O4) to 3.92 eV (NiFe2O4-LH). The PL spectra revealed that the NiFe2O4-LH exhibited green emission at 516, 526 nm suggesting increased oxygen vacancies facilitating ROS production. The NiFe2O4-LH NPs demonstrated excellent antibacterial activity when compared to pure NiFe2O4. SEM analysis confirmed extensive bacterial membrane breakdown when exposed to NiFe2O4-LH. Cytotoxicity to MDA-MB-231 breast cancer cells showed a significant dose-dependent response with an IC50 of 12.41 ?g/mL. Biocompatibility assessments with zebrafish embryos supported negligible development toxicity, wherein NiFe?O?-LH-treated groups preserved normal morphology until 72 hpf compared to the bare NiFe2O4.  2025 Elsevier B.V.</text>
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                <text>Antibacterial activity; Anticancer activity; Biocompatibility; L-histidine functionalization; MDA-MB-231; NiFe&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt;; Zebrafish embryo</text>
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                <text>Thangavelu, Indumathi; Tadepalli, Srinivas; Kasibatla, Murthy S.</text>
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                <text>Biofunctional NiTiO3D-carvone nanocomposite: Synthesis, characterization, antibacterial, antioxidant, and zebrafish biocompatibility evaluation</text>
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                <text>Journal of Molecular Structure;Volume;1354;Issue;;Article No.;144872;</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India</text>
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                <text>The growing threat of microbial resistance and oxidative stress-related disorders highly demands the development of multifunctional nanoparticles with enhanced bioactivity and biocompatibility. In response to this demand, D-carvone functionalized nickel titanate (NiTiO?-D-carvone) was synthesized. XRD confirmed the formation of a crystalline rhombohedral NiTiO3 phase, while HRTEM revealed reduced agglomeration and uniform distribution upon D-carvone modification. The average crystallite size of the composite was 27 nm. DLS analysis showed a decreased hydrodynamic diameter (D?? = 112.50 nm) for the functionalized nanocomposite compared to bare NiTiO3 (225.70 nm). XPS spectra confirmed the presence of Ni? and Ti?? oxidation states, along with C=O and CO groups from D-carvone. The NiTiO3D-carvone nanocomposite exhibited a surface area of 2.658 m/g and showed strong UV absorption at 326 nm. PL studies revealed that the nanocomposite exhibited green emission at 524 nm, attributed to oxygen vacancy-related defect states which is favorable for enhanced ROS generation. Antibacterial studies demonstrated enhanced inhibition zones against K. pneumoniae (16 mm), S. dysenteriae (17 mm), Escherichia coli (18 mm) P. aeruginosa (12 mm) and P. vulgaris (17 mm) compared to bare NiTiO?. CFU assays revealed a concentration-dependent reduction in viable colonies, with the highest activity at 10 mg/mL. The antioxidant efficiency reached 61.4 % DPPH inhibition at 20 g/mL, closely comparable to Vitamin C (64.7 %). Zebrafish embryo assays confirmed excellent biocompatibility of the NiTiO?D-carvone system, with normal morphology and survival up to 96 hpf. The experimental results suggest that surface modification with D-carvone significantly enhances the biological activity and safety of NiTiO3 nanoparticles.  2025</text>
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                <text>Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Tadepalli S., Department of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11432, Saudi Arabia; Kasibatla M.S., Department of Chemistry, Applied Science Cluster, University of Petroleum and Energy Studies, Uttarakhand, Dehradun, 248007, India</text>
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                <text>This study investigated the environmentally friendly synthesis, structural characterization, and biomedical potential of nickel titanate (NiTiO?) nanoparticles (NPs) prepared using Tagetes erecta (marigold) flower extract, with particular emphasis on their tartaric acid-coated, functionalized derivative (NiTiO?-T NPs). Structural analyses via FTIR spectroscopy revealed functional groups characteristic of the tartaric acid coating on NiTiO?-T NPs, while XRD confirmed the crystalline hexagonal phase for both NiTiO? and NiTiO?-T NPs. FESEM images demonstrated that both types of NPs exhibited uniform, spherical morphologies. Biomedical evaluations highlighted the enhanced efficacy of NiTiO?-T NPs, which achieved 85.2 % DPPH radical scavenging at 100 ?g/mL, significantly outperforming uncoated NiTiO? NPs (72.4 %). Antimicrobial testing against various pathogens showed that NiTiO?-T NPs generated larger inhibition zones compared to their counterparts, effectively targeting Gram-positive bacteria (S. aureus, B. subtilis), Gram-negative bacteria (E. coli, P. aeruginosa), and fungi (C. albicans). Further analysis revealed notably lower minimum inhibitory concentrations (MICs: 1000 ?g/mL) and minimum bactericidal concentrations (MBCs: 1500 ?g/mL) for NiTiO?-T NPs, confirming their potent bactericidal action. These findings position tartaric acid-functionalized NiTiO?-T NPs as promising candidates for dual-functional therapeutic applications.  2025</text>
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                <text>International Journal of Research in Finance and Marketing, Vol.5, Issue 1, pp.14-22, ISSN No: 2231-5985.</text>
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