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A comprehensive investigation of ethyl 2-(3-methoxybenzyl) acrylate substituted pyrazolone analogue: Synthesis, computational and biological studies
In this study, we successfully synthesized ethyl 2-(3-methoxybenzyl) acrylate-substituted pyrazolones derivative (EMH) through the reaction of Baylis-Hillman acetate with pyrazolones. We conducted comprehensive screenings to evaluate its invitro antifungal, antibacterial, and antioxidant properties. The molecule demonstrated notable in vitro antifungal and antibacterial activities attributed to the presence of anisole, enhancing absorption rates through increased lipid solubility and improving pharmacological effects. Structure-activity relationship (SAR) studies supported these findings. Additionally, insilico studies delved into the molecular interactions of the synthesized molecule with DNA Gyrase, Lanosterol 14 alpha demethylase, and KEAP1-NRF2 proteins, revealing strong binding interactions at specific sites. Furthermore, we employed ab-initio techniques to theoretically estimate the photophysical properties of the compounds. Ground state optimization, dipole moment, and HOMO-LUMO energy levels were calculated using the DFT-B3LYP-6-31G(d) basis set. The theoretical HOMO-LUMO values indicated high electronegativity and electrophilicity index. NBO analysis confirmed the presence of intermolecular ONH hydrogen bonds resulting from the interaction of the lone pair of oxygen with the anti-bonding orbital. Overall, our results suggest that anisole-substituted pyrazolones derivatives exhibit promising applications in both photophysical and biological domains. 2024 -
A comprehensive investigation of the effect of mineral additives to bituminous concrete
Research efforts to employ sustainable materials for road construction have been on the rise in recent years. In particular, the use of polymers as additives in asphalt mix has been actively explored by several researchers. Bituminous pavementsnormally constructed in India, have increasing number of premature failures, due to increase in traffic density and noteworthy variations in road temperatures. The modified binders have proven to improve numerous properties of bituminous surfaces such as temperature susceptibility, fatigue life, creep, resistance to permanent deformation and rutting. The present study has focussed on the experimental investigations conducted to evaluate the influence of mineral additives, such as wollostonite and Rice Husk Ash (RHA) on Indirect Tensile Strength (ITS) and Tensile Strength Ratio (TSR) of bituminous concrete (BC)maintaining uniformity of aggregate properties.The results establish that the bituminous concrete blends modified using rice husk ash at 20% and wollostonite at 8%, with hydrated lime are most suitable for practical applications. 2021 Elsevier Ltd. All rights reserved. -
A comprehensive investigation on machine learning techniques for diagnosis of down syndrome
Down Syndrome is a chromosomal disease which causes many physical and cognitive disabilities. Down Syndrome patients are more vulnerable than any other patient. Medical experts started knowing it now with keen awareness. In recent years it has become a field of interest for many researchers, medical experts and social organisation. For the researchers it is an area of interest where very little work is done and a lot to be explored. Machine Learning consists of different processing levels like pre-processing, segmentation, feature selection and classification. Each level contains a vast set of techniques like filters, segmentation algorithms and classifiers. Machine Learning is one of the most popular algorithm, which is used to automate the decision making process with higher rate of accuracy in less time with least error rate. Machine Learning proved its significance with highest rate of accuracy in decision making and problem solving in almost all the fields but automated decision making in medical science is still a challenge. This paper reviews the different works done in the field of Down Syndrome using Machine Learning applied on different medical images, and the techniques like pre-processing, segmentation, feature selection and classification. The aim of this research work is to analyse and identify the Machine Learning methodologies that works efficiently to detect Down Sundrome. 2017 IEEE. -
A comprehensive literature review on financial inclusion /
Asian Journal Of Research In Banking And Financial, Vol.7, Issue 8, pp.119-133, ISSN: 2249-7323. -
A comprehensive LR model for predicting banks stock performance in Indian stock market
The study focusses on developing a Logistic Regression model to distinguish between Good and Poor Performance of Bank-stocks which are traded in Indian stock market with regard to the financial ratios. The study- sample comprises of financialratios of 40 nationalised and private banks, for a period of six years. The study ascertains and scrutinizes eleven financial ratios that can categorize the Banksbroadly into two categories as good or poor, up to the accuracy level of 78 percent, based on their rate of return. First, the study predicts the performance of banks by using financial ratios and tries to build the goodness of fit by using Logistic Regression approach. The study also emphasizes that this model can enrich an investors ability to forecast the price of various stocks. However, the paper confers the real-world implications of Logistic Regression model to envisage the performance of Banks in the stock market. The study reveals that the model could be useful to potential investors, fund managers, and investment companies to improve their strategies and to select the out-performing Bank-stocks. Serials Publications Pvt. Ltd. -
A Comprehensive Meta-Analysis on Animal Identification Using Machine Learning and Deep Learning
Artificial Intelligence (AI)-based models have shown promising results in the identification of animals breeds. The surge in the development of new models has opened up new avenues for computer vision. The growing need to achieve cent percent accuracy in the prediction, identification and classification of data/images has motivated researchers to develop innovative strategies seamlessly. The results of various AI models are analyzed in terms of their classification accuracy. EfficientNet-B0 provided an accuracy of 95% in cat breed identification. InceptionV3 deep learning model reached the maximum accuracy of 96.75%, 96.57%, and 100% on dog, goat, and pig breed identification, respectively. ResNet attained an accuracy of 85.77% on snake species identification. This article provides an in-depth analysis of animal classification/species identification models. The inferences drawn out of this literature review would help the researchers in the selection of an ideal AI model to develop an automated animal classification model. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025. -
A Comprehensive Methodical Strategy for Forecasting Anticipated Time of Delivery in OnlineFood Delivery Organizations
Determining the cost of shipping has long been a cornerstone of urban logistics, but today's effective outcomes need acceptable precision. Around the globe, internet-based meal ordering and distribution services have surpassed public expectations; for example, in India, platform-to-consumer distributions and delivery of food and drinks reached an astounding amount of more than 290 million transactions in 2023. Businesses are required to provide customers with precise details on the time it will take for their food to be delivered, starting from the moment the purchase is placed until it reaches the customer's door. Customers won't place orders if the result measure is greater than the actual delivery date, but a greater number of consumers are going to contact the customer service line if the period of waiting falls shorter than their actual shipment period. This study's primary goals are to identify critical variables that affect the availability of nutritious food inspiring leaders as well as to provide an approach for making accurate predictions. Analyzing and contrasting the primary effects and challenges of distribution and shipping in the nation's many different sectors. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
A Comprehensive Model for Forecasting the Nifty50 Index Using MAchine and Deep Learning Methodologgy with Reference to National Stock Exchange
The volatility and uncertainty make stock and stock price index predictions challenging. Many financial professionals and academics are interested in stock price/index prediction studies. This study presents computational ML and DL intelligence techniques for estimating the NIFTY50 index closing value on the Indian NSE using Fundamental Analysis and Technical Analysis. To forecast the NIFTY50 index, we first employed Fundamental Analysis and max voting, bagging, boosting, and stacking ensemble learning techniques. An embedded feature selection algorithm is utilized to determine the model's best fundamental indicators, and a grid search is performed to tweak hyperparameters for each base regressor. Our results demonstrate that the bagging and stacking regressor model 2 beat all other models, with the lowest RMSE of 0.0084 and 0.0085, respectively, indicating an improved fit of ensemble regressors. Subsequently, TA research was done to exhibit the influence of deep learning on the NIFTY50. This method employs a data augmentation mechanism and three GRU model variations. It is examined using two datasets, TA1 and TA2, which include technical indicators from the NIFTY50 index. The GRU model enhanced the NIFTY50 index prediction using the TA1 technical indicator dataset. Finally, the study examines a hybrid model to estimate equity market trends, combining PCA with ML methods such as ANN, SVM, NB, and RF. The proposed approach uses the trend deterministic data preparation layer to convert the continuous data to a discrete form denoted by +1 or -1. The empirical findings of this hybrid model demonstrate that the RF model with the first three principal components obtains precision of 0.9969, F1-score 0.9968 and AUC score of 1. Overall, the suggested research design outperforms baseline models in our experiments and shows promising results using fundamental and technical analysis indicators. Thus, this study provides an ideal tool for stock market prediction and financial decision-makers. -
A comprehensive molecular docking-based study to identify potential drug-candidates against the novel and emerging severe fever with thrombocytopenia syndrome virus (SFTSV) by targeting the nucleoprotein
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging haemorrhagic fever that is caused by an RNA virus called Severe fever with Thrombocytopenia Syndrome virus (SFTSV). The disease has spread globally with a case fatality rate of 30%. The nucleoprotein (N) of the virus has a pivotal role in replication and transcription of RNA inside the host. Considering that no specific treatment regime is suggested for the disease, N protein may be regarded as the potential candidate drug target. In the present study, in silico molecular docking was performed with 130 compounds (60 natural compounds and 70 repurposed synthetic drugs) against the N protein. Based on the binding affinity (kcal mol?1), we selected Cryptoleurine (?10.323kcalmol?1) and Ivermectin (?10.327kcalmol?1) as the top-ranked ligands from the natural compounds and repurposed synthetic drugs groups respectively, and pharmacophore analysis of these compounds along with other high performing ligands revealed that two aromatic and one acceptor groups could strongly interact with the target protein. Finally, molecular dynamic simulations of Cryptoleurine and Ivermectin showed stable interactions with the N protein of SFTSV. To conclude, Cryptoleurine and Ivermectin can be considered as a potential therapeutic agent against the infectious SFTS virus. Graphical abstract: (Figure presented.) The Author(s) under exclusive licence to Archana Sharma Foundation of Calcutta 2024. -
A comprehensive molecular docking-based study to identify potential drug-candidates against the novel and emerging severe fever with thrombocytopenia syndrome virus (SFTSV) by targeting the nucleoprotein
Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging haemorrhagic fever that is caused by an RNA virus called Severe fever with Thrombocytopenia Syndrome virus (SFTSV). The disease has spread globally with a case fatality rate of 30%. The nucleoprotein (N) of the virus has a pivotal role in replication and transcription of RNA inside the host. Considering that no specific treatment regime is suggested for the disease, N protein may be regarded as the potential candidate drug target. In the present study, in silico molecular docking was performed with 130 compounds (60 natural compounds and 70 repurposed synthetic drugs) against the N protein. Based on the binding affinity (kcal mol?1), we selected Cryptoleurine (?10.323kcalmol?1) and Ivermectin (?10.327kcalmol?1) as the top-ranked ligands from the natural compounds and repurposed synthetic drugs groups respectively, and pharmacophore analysis of these compounds along with other high performing ligands revealed that two aromatic and one acceptor groups could strongly interact with the target protein. Finally, molecular dynamic simulations of Cryptoleurine and Ivermectin showed stable interactions with the N protein of SFTSV. To conclude, Cryptoleurine and Ivermectin can be considered as a potential therapeutic agent against the infectious SFTS virus. The Author(s) under exclusive licence to Archana Sharma Foundation of Calcutta 2024. -
A comprehensive novel model for network speech anomaly detection system using deep learning approach
Network Intrusion Detection System (NIDS) is the key technology for information security, and it plays significant role for classifying various attacks in the networks accurately. An NIDS gains an understanding of normal and anomalous behavior by examining the network traffic and can identify unknown and new attacks. Analyzing and Identifying unfamiliar attacks are one of the big challenges in Network IDS research. A huge response has been given to deep learning over the past several years and novelty in deep learning techniques are also improved regularly. Deep learning based Network Intrusion Detection approach is highly essential for improved performance. Nowadays, Machine learning algorithms made a revolution in the area of human computer interaction and achieved significant advancement in imitating human brain exactly. Convolutional Neural Network (CNN) is a powerful learning algorithm in deep learning model for improving the machine learning ability in order to achieve high attack classification accuracy and low false alarm rate. In this article, an overview of deep learning methodologies for commonly used NIDS such as Auto Encoder (AE), Deep Belief Network (DBN), Deep Neural Network (DNN), Restricted Boltzmann Machine (RBN). Moreover, the article introduces the most recent work on network anomaly detection using deep learning techniques for better understanding to choose appropriate method while implementing NIDS through widespread literature analysis. The experimental results designate that the accuracy, false alarm rate, and timeliness of the proposed CNN-NIDS model are superior than the traditional algorithms. 2020, Springer Science+Business Media, LLC, part of Springer Nature. -
A comprehensive record of fishes and crustaceans in a poorly known tropical estuary-Kavvayi from the west coast of India
A comprehensive study conducted from 2019 to 2021 in the Kavvayi estuarine wetland along Indias southwest coast documented its fish and crustacean diversity, providing valuable insights for conservation. Monthly surveys across 19 sampling stations recorded 151 species, including 79 demersal fish, 55 pelagic fish, and 17 crustaceans from 63 families. According to IUCN criteria, 98 species are classified as Least concern, 32 as Not evaluated, 14 as 'Data Deficient',four as Vulnerable, two as Near threatened, and one as Critically endangered. Marine migrant species dominate the estuary, while freshwater species are rare. The Eupercaria order contributes significantly to finfish diversity, representing 12.58%. Families such as Carangidae (14 species), Portunidae (8), and Clupeidae (7) exhibit notable species richness. Prominent species like Ambassis gymnocephalus, Mugil cephalus, Planiliza macrolepisStolephorus indicus, Etroplus suratensis, Pseudetroplus maculatus, Sillago sihama, Caranx ignobilis, and Gerres filamentosus are consistently present throughout the year, highlighting the estuarys reliability as a habitat. This dataset not only offers a crucial inventory of Kavvayis biodiversity but also emphasizes its conservation potential. The scarcity of information on the fish and crustacean diversity underscores the importance of the dataset provided in this paper, as it will significantly contribute to the assessment for designating Kavvayi estuary as a wetland of international importance. This dataset enhances local, regional, and global fish community data for estuarine fisheries. It also addresses the challenges faced by the fishing community, emphasizing the need for conservation strategies to ensure the long-term health of the estuarine ecosystem. The Author(s), under exclusive licence to Senckenberg Gesellschaft f Naturforschung 2025. -
A Comprehensive Research on Deep Learning Based Routing Optimization Algorithms in Software Defined Networks
Discovering an optimal routing in Software Defined Networks (SDNs) is challenging due to several factors like scalability issues, interoperability, reliability, poor configuration of controllers and security measures. The compromised SDN controller attacks at the control plane layer, packet losses in the topology and end-to-end delay are the most security risk factors in SDNs. To overcome this, in most of the existing researches, Deep Reinforcement Learning (DRL) algorithm with various optimization techniques was implemented for optimal routing in SDN by providing link weights to balance the end-to-end delay and packet losses. DRL used Deterministic Policy Gradient (DPG) method which acts as an actor-critic reinforcement learning agent that searches for an optimal policy to minimize the expected cumulative long-term reward. However, discovering an optimal routing with efficient security measures is still a major challenge in SDNs. This research proposes a detailed review of routing optimization algorithms in SDN using Deep Learning (DL) methods which supports the researchers in accomplishing a better solution for future research. 2023 IEEE. -
A Comprehensive Review of Advanced Analytics for Predicting HRQoL in Cancer Survivors Using a Synergistic Approach
This systematic review explores the role applied and emerging methods including AI, Explainable AI and Quantum machine learning techniques in the prediction of Health-Related Quality of Life (HRQoL) of cancer survivors. It also gives possible benefits and limitation of using the advanced analytics to predict the HRQoL. In all, 141 research papers implemented in the last fifteen years with focus between the years 2008 to 2023 are analyzed. For the convenience, this literature review is divided into four primary categories - (i) Artificial intelligence, (ii) Explainable artificial intelligence, (iii) Quantum machine learning, and (iv) Synergistic integration. The third way the present systematic review paper differs from other papers in the domain is that the paper offers a direction of future research. Furthermore, the hypothetical illustration is provided in order to compare outcomes of the synergistic approach with the existing data. Consequently, this analysis provides beneficial insights for further research and development of the synergistic approach in both research and clinical practice. The assessment shows that there is a continued need for research focusing on improving the quality of life of those that survived cancer. 2025 IEEE. -
A comprehensive review of AI based intrusion detection system
In today's digital world, the tremendous amount of data poses a significant challenge to cyber security. The complexity of cyber-attacks makes it difficult to develop efficient tools to detect them. Signature-based intrusion detection has been the common method used for detecting attacks and providing security. However, with the emergence of Artificial Intelligence (AI), particularly Machine Learning, Deep Learning and ensemble learning, promising results have been shown in detecting attacks more efficiently. This review discusses how AI-based mechanisms are being used to detect attacks effectively based on relevant research. To provide a broader view, the study presents taxonomy of the existing literature on Machine Learning (ML), Deep learning (DL), and ensemble learning. The analysis includes 72 research papers and considers factors such as the algorithm and performance metrics used for detection. The study reveals that AI-based intrusion detection methods improve accuracy, but researchers have primarily focused on improving performance for detecting attacks rather than individual attack classification. The main objective of the study is to provide an overview of different AI-based mechanisms in intrusion detection and offer deeper insights for future researchers to better understand the challenges of multi-classification of attacks. 2023 -
A Comprehensive Review of IoT, Intelligent Systems, and Computing Applications in Enhancing Renewable Energy Sources
This chapter provides a thorough examination of the application of the Internet of Things (IoT), intelligent systems, and advanced computing in enhancing the effectiveness and sustainability of renewable energy sources such as wind, ocean, hydro, and solar energies. This study explores the incorporation of real-time monitoring, predictive maintenance, and energy forecasting facilitated by the Internet of Things (IoT) and intelligent systems. The integration of artificial intelligence (AI)-based analytics and cloud computing methodologies significantly improves the process of decision-making, grid management, and optimization of energy storage. This analysis highlights the significant impact of recent technological breakthroughs and case studies on the transformation of renewable energy generation and management, ultimately contributing to the development of a sustainable and intelligent energy landscape. 2026 River Publishers. -
A Comprehensive Review of Linear Regression, Random Forest, XGBoost, and SVR: Integrating Machine Learning and Actuarial Science for Health Insurance Pricing
Actuarial science and data science are being studied as a fusion using Industry 4.0 technologies such as the Internet of Things, artificial intelligence, big data, and machine learning (ML) algorithms. When analyzing earlier components of actuarial science, it could have been more accurate and quick, but when later stages of AI and ML were integrated, the algorithms weren't up to the standard, and actuaries experienced some accuracy concerns. The company requires actuaries to be precise with analysis to acquire reliable results. As a result of the large amount of data these companies collect, a choice made manually may turn out to be incorrect. We will, therefore, examine alternative models in this article as part of the decision-making process. Once we have chosen the best path of action, we will use our actuarial expertise to evaluate the risk associated with specific charges features. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
A comprehensive review of microplastic pollution in freshwater and marine environments
Water popularly termed the The Elixir of Life is now polluted beyond control in several regions. Microplastics, the tiny contaminants have found their way into all walks of life. They have also been found to be present in human blood, multiple organs, and even breast milk. There is an abundance of microplastics in the air we breathe, the food we eat, and the water we drink. Curbing them has to start with a ban of all forms of primary microplastics, and single use plastics with preference being given to biodegradable alternatives. India in particular banned single use plastics in 2022, which put an end to several commonly used plastic items being replaced with biodegradables. Paint is one of the largest contributors to microplastics, followed by textile industry, cosmetic, pharmaceutical industry, packaging industry are all top contributors to microplastics. The wastewater treatment plants aren't designed to filter microplastics from the source and this results in microplastics polluting all water resources. Though several novel techniques for microplastic segregation exist such as sieving, filtration, density separation, visual sorting, alkali digestion exist, they aren't fully employed as the initial process of microplastic segregation from waste is still in question. 2024 The Author(s) -
A Comprehensive Review of Small Building Detection in Collapsed Images: Advancements and Applications of Machine Learning Algorithms
Accurately identifying small buildings in images of collapses is essential for disaster assessment and urban planning. In the context of collapsed images, this study provides an extensive overview of the methods and approaches used for small building detection. The investigation covers developments in machine learning algorithms, their uses, and the consequences for urban development and disaster management. This work attempts to give a brief grasp of the difficulties, approaches, and potential paths in the field of small building detection from collapsed imaging through a thorough investigation of the body of existing literature. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
A comprehensive review of the Indian retail industry growth /
International Journal of Social And Allied Research, Vol.7, Issue 2, pp.49-53, ISSN No: 2319-3611.