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Production Of Boeravinone B And Related Bioactive Molecules From Cell Cultures Of Punarnava, Boerhavia Diffusa Linn.
Boerhavia diffusa L., commonly referred to as punarnava, belongs to the Nyctaginaceae family. It contains a variety of phytochemicals that contribute to the plant's pharmacological activities. Among these compounds, Boeravinone-B, a significant secondary metabolite synthesized within the plant, has been reported to possess various pharmacological properties, including antioxidant, anti-inflammatory, cardio-protective, antimicrobial, and anti-cancer activities. Given its potential, there is a growing need to produce Boeravinone-B through biotechnological approaches such as plant tissue cultures. However, limited studies have been conducted on its production via tissue culture. Therefore, our objective was to produce Boeravinone-B using callus and cell suspension cultures. To induce callus, different auxins (2,4-D, NAA, IAA, IBA, and picloram) and cytokinins (kinetin, BAP, TDZ, and 2-iP) alone and in combination to maximize biomass and Boeravinone-B production was employed. Results showed that semi-solid medium supplemented with 5.0 mg/L 2,4-D produced the highest biomass and Boeravinone-B production from leaf explants. Subsequently, we established cell suspension cultures and observed that a combination of 2.0 mg/L picloram and 5.0 mg/L NAA yielded the highest production of Boeravinone-B. We further optimized cultural conditions such as inoculum density, carbon sources, sucrose concentration, MS medium strength, pH, ammonium and nitrate ratio, and various concentrations of macronutrients to enhance Boeravinone-B production. Additionally, we explored elicitation strategies using both biotic and abiotic components to determine their effects on Boeravinone-B production. Elicitation involved the use of polysaccharides (chitosan), fungi (yeast extract, Aspergillus niger and Cordyceps militaris) bacteria (Escherichia coli and Bacillus subtilis), and algal members (Valonia utricularis and Spirulina platensis). Likewise, signalling molecules (salicylic acid, sodium nitroprusside, and ethephon), polyamines (putrescine, spermine, and spermidine), and heavy metal salts (lead acetate, cadmium chloride, and lanthanum chloride) to stimulate Boeravinone-B production. Significant variations were observed among the elicitors in their ability to promote Boeravinone-B production, with the order of effectiveness being spermidine > Spirulina platensis > salicylic acid > spermine > sodium nitroprusside > Aspergillus niger > Valonia utricularis > Cordyceps militaris > yeast extract > putrescine. By employing these elicitation strategies alongside advancements in molecular aspects and large-scale production in bioreactors, we can ensure a sustainable supply of Boeravinone-B and its associated metabolites. -
Addressing harassment against men through the lens of gender equality in India: A critical analysis /
Harassment refers to harassment derives from the English verb harass plus the suffixment. The verb harass, in turn, is a loan word from the French, which was already attested in meaning torment, annoyance, bother, trouble.1 It refers to when an individual continually performs undesirable behaviour against a victim. This may include offensive language, rude and cruel remarks, but it must continue over time in order then it is considered as harassment. Harassment has many types like sexual harassment, mental harassment; workplace harassment, domestic harassment and many more it cover wide range of offence Harassment. Harassment against men is a serious issue that needs to be addressed in India, just as harassment against women does. It is important to approach this issue through the lens of gender equality, as both men and women should have the right to live free from harassment and violence. To start with, it is important to acknowledge that men can be victims of harassment and violence, and that this issue is not limited to women alone. -
Social security concerns of students pursuing higher education during Russia-Ukraine conflict: Legal analysis /
A stateless migrant is not considered a citizen or national of any country under the operation of its laws. Such a person has no recognized nationality or legal status and is therefore not entitled to the protection and benefits of any state. Stateless migrants may face significant difficulties in exercising their basic human rights, including the right to education, work, and access to healthcare, among others. There are many different concepts regarding migrants and stateless migrants. This research will emphasize upon the concept of stateless migrant and the Indian students those are pursuing higher education from Ukraine and that is disturbed because of the uncertain conflict happened in Ukraine. Migrant is defined as a person who leaves their country of origin to live in another country, while a stateless migrant is someone who does not have a recognized nationality. Both concepts are important to understand when considering the rights of individuals. However, this research will also encounter often challenges in ensuring that these rights should be respected and protected by the authorities. -
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Responsible Service of Alcohol: An Evaluation of Policies and Practices of Five Star Hotels in Karnataka
Networking and socializing has been a human practice since ancient times and alcohol has been the social lubricant ??yesterday, today and also tomorrow. While we cannot trace its origin to a particular culture or civilization, its role and impact has been recorded in ancient texts and literature across cultures. A person can get drunk for a few rupees or spend a few lakhs for the same. It is consumed across social classes- by a daily wage worker to a business tycoon. The only thing differentiating the two being the price he has paid for the drink and the glass he is having it from. Even though the price and glass differs the effect it has on a person is more or less the same. This research and study is based on the belief that alcohol in itself is not the major cause of all the issues and troubles it is blamed for, but it is the nature and manner in which it is treated, consumed and served. This study is based on the latter aspect, ????the service of alcohol???. As mentioned in the previous paragraph, alcohol is a social lubricant and bars and restaurants have always been a popular place for socializing. The people who deal with the sale and service of alcoholic beverages along with the management and owners have a moral responsibility to ensure that alcohol is both served and consumed responsibly. This practice of Responsible Beverage Service or Responsible Service of Alcohol might look simple and easy on paper but to practice it, is a different story! It involves the support and approval of all the stakeholders. The owner and management on their part have to compromise on the earnings from the extra sale alcohol. The server has the additional responsibility of checking that his customers are not getting intoxicated and that he is following all the rules and regulations associated with alcohol service and above all the consumers too have to support and accept responsible service practices by the establishment. This study has looked into the practice of Responsible Beverage Service followed in the bars and restaurants in five star hotels, in the state of Karnataka. The initial study involved a review on early research and study on Responsible Beverage Service, Its impact on controlling alcohol abuse and intoxication, Responsible Beverage Service practices and various other dimensions and issues associated with Responsible Service of Alcohol. VII This research has focused on both the consumer as well as the server???s perspective on Responsible Beverage Service. The primary data for the study was collected from both consumers and hotels through a structured questionnaire, followed by data analysis using the appropriate tool. The findings give an insight and understanding into the acceptance of responsible beverage service in the state. What works and what needs to be improved? The practices which has the most impact in controlling alcohol abuse and answers to other questions associated with the study. -
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Developing a democratic constitutional framework through a people driven constitution making process for zimbabwe
Zimbabweans are currently grappling with the question of how to produce a national peopledriven democratic constitution as a permanent solution to the country s myriad problems of poor governance, violent bloody electoral political conflicts, sham elections, governmental illegitimacy, corruption, economic collapse, unemployment, social disintegration, and international isolation. The purpose of the study was to explore a people-driven democratic newlineconstitution-making process that the people of Zimbabwe want. The study was largely newlinebased on phenomenology research philosophy supported by mixed methods of data collection, analysis, and interpretation. The researcher s mental model conceptual newlineframework consisting of operational definitions of terms in chapter 1 was used to guide the exploratory study and to measure data in qualitative analysis. Descriptive statistics of frequencies and percentages were used to measure data in quantitative analysis. The research population comprising the people of Zimbabwe was segmented into two classes of research units: individuals segment; and institutions segment. The institutions segment was further subdivided into six subsidiary segments. Using a non probability purposive sampling method, 1120 individuals and 67 institutions were selected to inform the study. Institutions were interviewed and observed while individuals completed a questionnaire. The phenomenological inductive study discovered major findings of contextual meanings of newlinephenomena associated with a people-driven democratic constitution-making process for newlineZimbabwe such as the people, the constitution, constitution-making, and people-driven. One of the major notable findings revealed by the study is that institutions or organizations are not people, and as such, they cannot make, author or write a constitution. The people think and originate ideas as individuals not as groups, institutions or organizations. Another newlinenotable major finding is that a constitution is made up of ideas not papers. -
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An evaluation of workplace HIV and AIDS programme development in zimbabwe stock exchange listed companies based in harare zimbabwe
The study explores the state of workplace HIV and AIDS interventions in Zimbabwe with specific reference to programming interventions in Zimbabwe Stock Exchange newlinelisted Companies in the Harare Metropolitan Province. The scientific knowledge domain-location of the study involves Strategic Human Resource management, Human Resource Management, Business (Corporate) planning and Labour administration (integrated occupation health and safety, employee welfare and newlinewellness) and Policy development and implementation. The key consideration is that newlinethe company has an enlightened self-interest to facilitate workplace HIV and AIDS because it leads to employee welfare, wellness and longevity which translate to increased productivity in the context of in Zimbabwe Stock Exchange-listed Companies. In this background, Zimbabwe Workplace HIV and AIDS programmes are generally considered to be fragile, fragmented, under-developed, weak and unsustainable in both design and management by a wide range of stakeholders despite close to two decades of implementation since promulgation and establishment. The study tries to identify key determinants of workplace HIV and AIDS program development in Harare, assesses the current state of workplace HIV and AIDS newlineprogramme development in Harare, tries to establish the significance of senior newlinemanagement commitment on workplace HIV programme development, ascertains the newlinerelationship between having a Comprehensive Staff Welfare Program (CSWP) and workplace HIV and AIDS program development and evaluates the extent to which companies comply with workplace HIV program development standards. The study was conducted using mixed methods and data was collected using a survey questionnaire and focus group discussions. Based on the study it was found that the general state of the Workplace HIV and AIDS Programme Development is in a state newlineof serious underdevelopment. -
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Purchase intention of deconstructed end-of-lifecycle Fashion products in an outline and offline retail environment
Obsolete or slow-moving inventory is one of the major influencers for the bottom line of any business today. Surplus stock- be it from overbuys, returns, defects or simply merchandise hitting the end of their lifecycle- need to be accounted, accommodated and dealt with in a manner that can least affect the planned margins. For the fashion business, such merchandise poses greater challenges. The business is ground by seasonal preferences, fast-changing trends, short lead-times and shorter shelf-lives. With rising costs of traditional retail businesses, the associated costs of carrying such inventory are something that the retailer can easily do without. At the retailers’ end, such merchandise is often subjected to traditional liquidation methods such as Markdowns, carry forwards, or selling at lowered prices to discount stores or factory outlets. From a manufacturer’s perspective, overruns from production are either sold at discounted costs to the retailer or are diverted to other sources of sales. In either case, such decisions do affect the margins of the business, and retailers often account for these “necessary evils” while planning their pricing strategy.