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Purification and evaluating in vitro activity of a fibrinolytic protease produced by a mangrove isolate Bacillus subtilis AIBL_AMSB2_M7E32
One of the main causes of heart-related problems globally is intravascular thrombosis. Microbial fibrinolytic proteases play a very crucial role in the management of thrombosis. Plasminogen activators and plasmin-like proteins, which are fibrinolytic enzymes of microbial origin, hydrolyze thrombin with great efficacy and without causing noticeable side effects. These fibrinolytic enzymes can also be manufactured efficiently and economically in huge quantities within a short period. However, the search for novel fibrinolytic enzymes demands difficult purification procedures, as well as physicochemical and structural-functional properties that provide information about their mode of action. In this study, the strain named Bacillus subtilis AIBL_AMSB2_M7E32, isolated from the Coringa mangrove soils, was shown to produce a fibrinolytic enzyme. The enzyme was purified by a four-step purification process that resulted in a 43.33-fold purification with a specific activity of 6368.20 (U/mg). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the purified enzyme was a protein of about 28 kDa and showed fibrinolytic activity on a zymogram. In vitro assay on blood clots revealed that the purified enzyme could lyse the blood effectively by a percentage of 72.96 0.16a%, indicating that the enzyme could be used as a fibrinolytic agent. Furthermore, an observation for enzyme stability and its in vivo activity studies would be necessary for its application in the market. 2024 Bhavana Sompalli and Alok Malaviya. -
Purple Blue emission in MoO3:Ce3+ nanorods: Investigation on the structural and photoluminescence properties
MoO3:Ce3+ nanophosphors were synthesized with different doping concentrations of cerium by hydrothermal method. Structural, optical, and photoluminescence properties were explored. Raman spectroscopy and X-ray diffraction studies were carried out to examine the crystal structure, vibrational modes and symmetry. XRD and Raman spectroscopy assures the orthorhombic phase of MoO3 for the pure and doped samples. Nanorod like morphology was obtained for pure and doped samples. XPS analysis confirms the presence of Ce3+. While analyzing UVVis absorption spectra, the change in optical bandgap was observed with doping concentration in agreement with size effect. The refractive index of the prepared nanorods was evaluated. For MoO3:Ce3+nanorods excited at 250 nm, purple-blue emission comprising of transitions between 2D ? 2F7/2 along with 2D ? 2F5/2 levels of Ce3+ in MoO3 lattice were obtained. The concentration quenching mechanism was observed in MoO3:Ce3+ nanophosphors. Purple-blue emission from different samples were quantified using CIE chromaticity diagram. This work marks MoO3:Ce3+ nanorods as a suitable candidate for display and fluorescence imaging application. 2023 Elsevier Masson SAS -
Purpose-driven leadership and organizational success: a case of higher educational institutions
Purpose: This paper aims to examine the relationships between organizational purpose, leadership practices and sustainable outcomes for universities in emerging economies. We propose that a strong sense of purpose is a fundamental and defining feature in the leadership practices of these institutions, which ultimately contributes to their success. Design/methodology/approach: The authors present a research model that defines the relationships between a sense of purpose, leadership practices, student success outcomes, alumni involvement outcomes and societal reputation outcomes. Over 200 higher education administrators in India participated in the study. Findings: The institutions' sense of purpose directly relates to their leadership engagement practices and their student success outcomes. Student success outcomes are a crucial linkage between leadership engagement practices and alumni involvement outcomes to achieve their societal reputation. Practical implications: As competitiveness intensifies, educational institutions under resource constraints must differentiate their organizational practices. This paper demonstrates how their core purpose and leadership actions result in achieving effective outcomes and overall sustainable societal reputation. Originality/value: There is a significant difference between having an organizational purpose and enacting that purpose through their leadership practices. These results highlight the cascading effect from the institution's fundamental sense of purpose to their leadership practices and the positive outcomes of student success, alumni involvement and societal reputation. 2021, Emerald Publishing Limited. -
Pyrazole Derivative Containing Naphthalene Moiety: Cytotoxocity (Breast and Cervical Cancer), Antibacterial and Antifungal Studies Using Experimental and Theoretical Tools
In the present study, the title compound is named 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(6-methoxynaphthalen-1-yl)methyl)-5-methyl-2-phenyl-1,2-dihydropyrazol-3-one was synthesized, and its antibacterial, antifungal, cytotoxic activity was studied by both experimental and in silico methods. The molecular structure was optimized using DFT/B3LYP method with cc-pVDZ as a besis set, and frontier molecular orbital (FMO) studies was used to explain the physiochemical properties of that molecule by the energy of interacting orbitals. NBO describes the intra delocalization of electrons in the molecule, which support the stability of that molecule. Noncovalent interaction (NCI) explains the nonbond interactions present in the molecule. Drug-likeness property of 405 C have been checked by absorption, distribution, metabolism and excretion (ADME) assay, result shown all the drug-likeness properties in red color region, so we have confirmed this molecule as a drug. 405 C undergoes antibiotic activity against P. aeruginosa organism, antifungal activity against B. cinerea and cytotoxicity activity against MCF-7 and HeLa cell when compared to standard drugs. 2022 Taylor & Francis Group, LLC. -
QSPR ANALYSIS OF CERTAIN ANTI-HIV DRUGS
A broad spectrum of advanced medications appears yearly following the accelerated evolution of the chemical and pharmaceutical industry. In this paper, various degree-based and neighborhood degree sum-based topological indices of some anti-HIV drugs are explored applying the M-polynomial and NM-polynomial formulations. Moreover, QSPR analysis is carried out for the topological indices with regard to the physico-chemical properties of the anti-HIV drugs. The activity of nucleoside and non-nucleoside reverse transcriptase inhibitors is implemented as in drug configuration to manifest the significance of topological indices in the medicinal world. The procured outcomes affirm that topological indices being stud- ied reflect effective correlation in accordance to physical and chemical properties of the anti-HIV drugs and consequently can assist in development of advanced and promising pharmaceutical for HIV medication. 2022, RAMANUJAN SOCIETY OF MATHEMATICS AND MATHEMATICAL SCIENCES. All rights reserved. -
QSPR analysis of certain degree and eccentricity based topological indices and butane derivatives
Butane derivatives are chemical compounds formally derived from Butane C4H10 by replacement of one or more hydrogen atoms with other atoms or functional groups. In this paper, we do the QSPR analysis of few Butane derivatives with respect to some selected degree based topological indices and one eccentricity based topological index. In QSPR studies, topological indices are extensively used in determining specific bioactivity of chemical compounds. Our study showcases some important results on the correlation between Heavy atomic count, Complexity, Density, Surface tension and Index of refraction of Butane derivatives with the selected topological indices which further helps in characterizing the predicting power of these topological indices. RAS?YAN. All rights reserved. -
QSPR Analysis of Polycyclic Aromatic Hydrocarbons
Topological indices serve as a crucial component in chemical graph theory linked with some molecular structure. The First and Second Zagreb Indices are one among the earliest and extensively explored molecular descriptors. The study on equitable zagreb indices have been initiated earlier by Akram Alqesmah, Anwar Alwardi and R. Rangarajan based on the equitable degree of the vertices. In this paper, we introduce the first and second equitable and non-equitable zagreb polynomials and compute the exact values of the respective equitable and non-equitable zagreb indices for polycyclic aromatic hydrocarbons. We have also utilised certain formulations for the determination of the corresponding relative equitable and non-equitable zagreb indices of the chemical graph. Further, QSPR analysis is carried out for the topological indices with regard to the physico-chemical properties of the polycyclic hydrocarbon molecules. 2022, Books and Journals Private Ltd.. All rights reserved. -
QSPR Analysis On Octane Isomers Using Degree-Based Topological Indices?
Octane isomers are structures with the chemical formula C8H18. Despite having the same formula, they have variations in the way their atoms are arranged, leading to differences in their chemical and physical properties. In this paper, we conduct a QSPR analysis on various isomers of octane, focusing on specific degree-based topological indices. In QSPR studies, these measures, known as topological indices, are helpful in understanding and quantifying the biological effects of chemical compounds. We specifically look at how certain properties of octane, such as complexity, acentric factor, standard enthalpy of vaporization, entropy, and enthalpy of vaporization, are connected to these topological indices. Our research provides valuable insights into how these indices can predict the behavior of octane isomers, contributing to a better overall understanding of their properties. 2024, Tsing Hua University. All rights reserved. -
Quadratic convection on the radiative flow of ternary nanofluid Gr-Ag-TiO2-H2O subjected to velocity slip and temperature jump
This paper deals with the analysis of the flow and heat transfer performance of ternary nanofluid flowing past a stretching sheet under the influence of quadratic convection. The ternary nanofluid is formed by suspending three dierent nanoparticles, namely, titanium dioxide (TiO2), silver (Ag) and graphene (Gr) in the base fluid water (H2O). Thus, the ternary nanofluid obtained is Gr-Ag-TiO2/H2O where the hybrid nanofluid Ag-TiO2/H2O forms the base fluid for the resulting ternary nanofluid. The addition of TiO2 nanoparticles enhances the photocatalytic nature of the base fluid and makes it useful in various applications concerning the medicinal field. The presence of Gr helps in intensifying the thermal conductivity of water while the suspension of silver nanoparticles ensures chemical stability. Meanwhile, the thermophysical properties of the ternary nanofluid are mathematically defined and the system of equations that describe the flow of a ternary nanofluid past a stretching sheet is framed using dierential equations. The outcomes of this study are interpreted through graphs for velocity and temperature profiles of the ternary nanofluid. It was mainly observed that the thermal conductance of ternary nanofluid was higher than the monophase and hybrid nanofluid. Also, the presence of quadratic convection had a prominent impact on the ternary nanofluid flow. The Nusselt number was found to be greater for spherical nanoparticles and it was found to be least for blade-shaped nanoparticles. 2024 World Scientific. All rights reserved. -
Quadratic convective flow of radiated nano-Jeffrey liquid subject to multiple convective conditions and Cattaneo-Christov double diffusion
A nonlinear flow of Jeffrey liquid with Cattaneo-Christov heat flux is investigated in the presence of nanoparticles. The features of thermophoretic and Brownian movement are retained. The effects of nonlinear radiation, magnetohydrodynamic (MHD), and convective conditions are accounted. The conversion of governing equations into ordinary differential equations is prepared via stretching transformations. The consequent equations are solved using the Runge-Kutta-Fehlberg (RKF) method. Impacts of physical constraints on the liquid velocity, the temperature, and the nanoparticle volume fraction are analyzed through graphical illustrations. It is established that the velocity of the liquid and its associated boundary layer width increase with the mixed convection parameter and the Deborah number. 2018, Shanghai University and Springer-Verlag GmbH Germany, part of Springer Nature. -
Quadratic convective transport of Cu-Al2O3 hybrid nanoliquid with Hall current, variable suction, and exponential heat source
The time-dependent slip flow and heat transport of the Cu-Al2O3 hybrid nanofluid through a vertical permeable plate with Hall current and variable suction is investigated. An exponential heat source and quadratic convection effects are considered. The dimensionless governing equations are solved analytically using the regular perturbation method. The graph of variation of the different flow fields with respect to the distance from the plate is drawn for the analysis. It is established that the exponential heat source aspect increased the temperature profile while the quadratic convection aspect decreased the temperature profile. The applied magnetic field and nonlinear convection aspects reduce the axial velocity field. The quadratic convection and exponential space-dependent heat source phenomena are favorable to friction factors. Furthermore, the global heat transfer is increased in the presence of an exponential space dependent heat source and hybrid nanoparticles. 2021 John Wiley & Sons, Ltd. -
Quadratic convective transport of dusty Casson and dusty Carreau fluids past a stretched surface with nonlinear thermal radiation, convective condition and non-uniform heat source/sink
Here, the nonlinear convective transport of non-Newtonian fluids embedded with dust particles over a stretched surface is investigated. The silent features of non-Newtonian fluid are considered by Casson and Carreau fluid models. The heat transfer mechanism involves the influences of a magnetic dipole, nonlinear radiative heat and non-uniform heat source/sink. The convective condition is also retained at the boundary. The non-linear partial differential equations that model the transport phenomenon was transformed, non-dimensionalized and parameterized. The subsequent boundary value problems were computed numerically for distinct pertinent parameters using RungeKutta based shooting techniques. The present results are validated with the existing literature by direct comparison. The heat transfer rate in Casson/Carreau fluid phase is significantly higher than that of dust phase. 2019 Elsevier B.V. -
Quality assurance in big data analytics: An IoT perspective
Emergence of IoT as one of the key data contributors in a big data application has presented new data quality challenges and has necessitated for an IoT inclusive data validation ecosystem. Standardized data quality approaches and frameworks are available for data obtained for a variety of sources like data warehouses, webblogs, social media, etc. in a big data application. Since IoT data differs significantly from other data, challenges in ensuring the quality of this data are also different and thus a specially designed IoT data testing layer paves its way in. In this paper, we present a detailed review of existing data quality assurance practices used in big data applications. We highlight the requirement for IoT data quality assurance in the existing framework and propose an additional data testing layer for IoT. The data quality aspects and possible implementation models for quality assurance contained in the proposed layer can be used to construct a concrete set of guidelines for IoT data quality assurance. 2019 Telecommunications Society and Academic Mind. -
Quality enhanced framework through integration of blockchain with supply chain management
Recently, there has been significant growth in the consumption of the most widely diversified Internet of Things (IoT) technological knowledge, and devices, which has resulted in an impact on not only electrical items and the agricultural and food industries (Agri-Food) supply chain networks. This has sparked intense curiosity about the development of information sharing that is reliable, traceable, and transparent, and also increased significant research and advancement efforts. Existing IoT-based trace & authenticity methods for agri-food distribution networks are constructed on top of centralized architectures, which creates the potential for significant issues such as data security, manipulation, and standard points of weakness. A creative and scraping methodological approach to implementing decentralized trust-free networks is represented by blockchain technologies, the decentralized blockchain technologies that underpin cryptocurrencies. The fault tolerance, data integrity, visibility, and complete tracing of saved transactional data, along with cohesive digital information of property resources and independent transactions implementations, are in fact features built into this digitalization. This study introduces Agri-BlockIoT, a completely decentralized blockchain-based traceable platform for managing a global agro-food distribution network that can seamlessly connect IoT systems that produce and consume digital information all along the distribution chain. We implemented a use caseto achieve transparency and traceability. Lastly, we analyzed and contrasted the implementations' capability in terms of delay, CPU, or network utilization. 2022 The Authors -
Quality of Drinking Water and Sanitation in India
Wide disparity exists in access to drinking water across social groups in rural and urban India. This article shows that the economically weaker sections or the lower quintile class does not have access to water within the premises both in rural and urban areas. This indicates that low income or wealth would mean poor access to basic amenities for households. Similarly, access to toilets and incidence of open defaecation reflect social disparities. The regression results show that an increase in the household income increases the predicted probability of maintaining an exclusive latrine. Further, compared to the General Category, the Scheduled Castes and Other Backward Classes have a lower probability of constructing an exclusive latrine facility, in the rural and urban areas. 2021 Institute for Human Development. -
Quality of life of children and adolescents living with HIV in India: a systematic review and meta-analysis
Children and adolescents living with HIV (CALHIV) encounters compromised health and well-being especially in developing countries. Understanding the health-related quality of life (HRQOL) of CALHIV living in India is vital in planning and developing comprehensive care approach. A systematic review and meta-analysis were conducted to explore and examine the HRQOL of CALHIV in India. Five electronic databases were searched, retrieving 2,729 citations with a final eight studies that met the inclusion criteria. Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. The included studies predominantly evaluated quality of life using the Paediatric Quality of Life Inventory, with a mean self-reported HRQOL score of 77.62 (95% CI 72.9182.34, I 2 = 93%). HRQOL of CALHIV observed to be better than other chronically ill children. However, CALHIV demonstrated lower HRQOL than the matched general population. Younger age children and boys reported better HRQOL. Poor socio-economic status, immunological status and advanced clinical stages noted to be adversely affecting HRQOL. HRQOL of children reared in institutional care reported to better or in par with family reared children. The review highlights the sparse evidence investigating the HRQOL of children with HIV in India, and the need for further well-designed studies in this population. A population-specific holistic-care approach recommended to be benefiting the well-being of CALHIV. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Quality of work life and work motivation among garment sector executive employees /
The International journal Of Indian Psychology, Vol.3, Issue 1, pp.111-119, ISSN No: 2349-3429. -
Quality of work life, emotional and physical well-being of police personnel in India
The job profile of police officers places exceptional demands on them leading to risks to life, personal discomfort and stress. This article aims to examine how the physical and emotional well-being of police personnel is affected by their perceived quality of work life (QWL). The study looked at the questionnaire responses of 234 police personnel. Emotional well-being is measured as the absence of depression, emotional hyperactivity, difficulty relaxing, irritability and anxiety, whereas physical well-being is measured as the presence of diabetes, thyroid problems, insomnia and obesity. The study assessed police perceptions of QWL as provided by the government. The study findings are segregated for QWL on the basis of dominant ill-being and dominant well-being. Factors such as career and development, working environment, safety, work load, compensation and fear of punishment should be carefully analysed and improved. Some 71.8% of the respondents suffered from two or more emotional ailments; 70% suffered from two or more physical ailments. Findings suggest that QWL dimensions that fall within dominant ill-being need to be addressed immediately by policy makers and management to improve police well-being. The Author(s) 2021. -
Quantifying the role of nanocarbon fillers on dielectric properties of poly(vinylidene fluoride) matrix
Development of polymers with excellent dielectric properties is a challenge for advanced electronic devices. Impregnating conducting fillers like carbon nanoparticles can enhance the dielectric constant, retaining low loss due to its compatibility and favorable polarization within the polymer matrix. The multifunctional characteristics of coal-derived nanocarbon can improve permittivity and facilitate large-scale production at a lower cost. The incorporation of coal-based nanocarbon in the polymer matrix and its dielectric response is seldom investigated. In this work, different ratios (10:90, 50:50, 90:10 by weight) of nanocarbon/PVDF composite are prepared via a simple solution casting technique. The dielectric measurements show that nanofillers addition significantly augments the dielectric constant value, which is ?3 times (50:50 composite) higher than pure PVDF. The uniform distribution of 50% filler within the polymer matrix impeded the seepage of charge at the interface and enhanced the permittivity via polarization of accumulated charges. The composite also exhibited balanced dielectric loss that is essential for energy storage applications. The Author(s) 2022.