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Influence of ChatGPT in professional communication moderating role of perceived innovativeness
Purpose: ChatGPT, a cutting-edge language model, stands as an unparalleled, unmatched conversational ally, showcasing novel versatility and intelligence in its responses. This research delves into the incorporation of ChatGPT, a powerful generative AI tool, into professional communication. This study utilizes the information system success model (ISSM) to examine the role of ChatGPTs in strengthening information quality (IQ), system quality (SQ) and service quality (SEQ) for improving customer usage intention (UI) and satisfaction (SAT). The study also investigates the moderating impact of perceived innovativeness between these relationships. Design/methodology/approach: The research collected data from a sample of 400 customers through an online survey and validated the hypothesized relationships using structural equation modelling (SEM). Process Macros 4.1 in SPSS 22.0 is used to test the moderating role of perceived innovation between IQ, SQ and SEQ and UI and SAT. Findings: The results of SEM analysis indicate that IQ, SQ and SEQ all positively support UI to use ChatGPT for professional communication with SAT. The result also establishes that perceived innovativeness positively moderates the relationship between IQ, SQ and SEQ and UI and SAT. Originality/value: This research study offers novel contributions to the literature and body of knowledge by establishing the moderating role of perceived innovativeness in strengthening the relationship between IQ, SQ and SEQ and UI and SAT. Further, this study also proposes a 2*2 matrix to segment the UI and SAT of ChatGPT users in professional communication with varying degrees of perceived innovativeness. 2024, Emerald Publishing Limited. -
Routing TQM through HR strategies to achieve organizational effectiveness: themediating role of HR outcomes in India
Purpose: The present research focuses on improving the awareness related to soft total quality management (TQM) practices by looking from the viewpoint of strategic human resources (HR). In addition, it is intended to reflect on the resulting soft TQM-HR outcomes and determine the mediating effect between soft TQM-HR strategies and organizational effectiveness (OE). Design/methodology/approach: An exploratory research methodology with an online survey technique was adopted for the study. Three hundred and three managerial-level personnel from nine large Indian manufacturing organizations participated in the research. A theoretical model is projected and verified using correlation and mediation analysis. Findings: The results show that commitment, reduced turnover intentions and satisfaction levels of employees mediate the relationship between resources, development and retention strategies and OE. However, the retention strategy has the strongest association with the OE of the three strategies. Also, of the three HR outcomes, satisfaction was strongly associated with OE. The analysis proved that the proposed model is an acceptable fit. Practical implications: Implementing HR-related TQM strategies will likely impact OE since it elicits positive HR outcomes such as commitment, reduced turnover intention and satisfaction. Recognizing human resources as a unique strategic asset will help HR managers devise adequate resourcing, development and retention strategies instrumental in executing TQM. Originality/value: The present micro study is unique in scrutinizing the influence of soft TQM-HR practices on organizational effectiveness by analysing the mediating effects of commitment, reduced turnover intention and satisfaction in Indian large-scale manufacturing organizations. The study is unique since no literature deciphers the linkages between HR strategies and organizational effectiveness in the Indian manufacturing sector. 2023, Emerald Publishing Limited. -
Bounds on Sombor index of graph operations
Operations in graph theory have a significant influence in the theoretical and application aspect of the domain. Topological indices serve as a crucial component in chemical graph theory linked with some molecular structure. Recently, Gutman initiated the study on the Sombor index. In this paper, the computation of some bounds for Sombor index of graph operation notably join, cartesian product, corona product, lexicographic product, tensor product and strong product is carried out. The computation has been utilized to determine the upper bounds of the index for the specified graph operations for some standard graphs like the path and cycle graphs. 2025 World Scientific Publishing Company. -
Embedding behavioral biases into robo-advisory platforms-case of UAE investors
Purpose: This study aims to identify individuals' biases while making investment decisions and explore how these biases can be incorporated into a robo-advisory platform to help mitigate these biases. This paper identifies eight investment-related behavioral biases: mental accounting, gamblers fallacy, hindsight, regret aversion, disposition, trend-chasing, loss aversion and herding. Design/methodology/approach: This study uses primary data from 263 respondents across various age groups, of which approximately 50 were wealth management professionals in the UAE. A random sampling method from probability sampling is employed to gather the primary data. The identified biases serve as dependent variables; the age and income of individuals serve as the independent variables. Findings: Age and income are significantly related to mental accounting, herding, gambler fallacy and loss aversion. Existing studies on behavioral finance demonstrate that individuals who make investment decisions are susceptible to cognitive fallacies, leading to nonrational investment decisions. Practical implications: By studying these biases affecting individuals of varying ages and income levels, wealth management professionals can tailor their financial robo-advisory services to address these biases and help clients build wealth with consistent investment. Originality/value: This study uses survey-based sampling in the context of the UAE; hence, the data and analysis represent originality. 2024, Emerald Publishing Limited. -
Lung cancer prediction with advanced graph neural networks
This research aims to enhance lung cancer prediction using advanced machine learning techniques. The major finding is that integrating graph convolutional networks (GCNs) with graph attention networks (GATs) significantly improves predictive accuracy. The problem addressed is the need for early and accurate detection of lung cancer, leveraging a dataset from Kaggle's "Lung Cancer Prediction Dataset," which includes 309 instances and 16 attributes. The proposed A-GCN with GAT model is meticulously engineered with multiple layers and hidden units, optimized through hyperparameter adjustments, early stopping mechanisms, and Adam optimization techniques. Experimental results demonstrate the model's superior performance, achieving an accuracy of 0.9454, precision of 0.9213, recall of 0.9743, and an F1 score of 0.9482. These findings highlight the model's efficacy in capturing intricate patterns within patient data, facilitating early interventions and personalized treatment plans. This research underscores the potential of graph-based methodologies in medical research, particularly for lung cancer prediction, ultimately aiming to improve patient outcomes and survival rates through proactive healthcare interventions. 2025 Institute of Advanced Engineering and Science. All rights reserved. -
Rheostatic effect of a magnetic field on the onset of chaotic and periodic motions in a five-dimensional magnetoconvective Lorenz system
This paper deals with a weakly nonlinear study of two-dimensional RayleighBard magnetoconvection using a simplified five-dimensional Lorenz model. The governing equations of the system are nondimensionalized and formulated in terms of the stream function and the scalar magnetic potential. A five-modal Fourier truncation scheme is employed and the resulting equations are scaled to obtain a five-dimensional autonomous dynamical system. The Hopf-Rayleigh number, signifying Hopf bifurcation, is numerically evaluated from the analysis of weakly nonlinear stability. Chaotic and periodic motions are depicted by plotting bifurcation diagrams, largest Lyapunov exponent (LLE) diagrams and three-dimensional projections of the phase-space. For a fixed set of parameter values, increasing the strength of the applied magnetic field is found to increase the Hopf-Rayleigh number, thereby delaying the destabilization of the system's equilibrium points. It is shown that while low magnetic field strengths favor the onset of chaotic motion directly from the steady state, stronger magnetic field strengths favor the onset of periodic convection from the steady state prior to the appearance of chaotic motion. We observe here that the applied magnetic field regulates the onset of chaotic and periodic motions in the system and therefore, has a rheostatic control over chaotic and periodic behaviors. 2025 Elsevier Ltd -
Beyond the basics: mapping the inflation response to fiscal deficit in India with smooth transition autoregressive model
Purpose: Indias historical fiscal performance has featured elevated deficit levels. Driven by the imperative need for fiscal stimulus measures in response to the crisis, efforts toward fiscal consolidation from 2003 to 2008 were reversed in 20082009 due to the financial crisis. These stimulus actions are believed to have wielded a notable influence on inflation dynamics. Presumably, a high inflation rate hinders growth and inflicts severe welfare costs. Accordingly, the principal objective of this paper is to scrutinise the threshold effects of fiscal deficit on inflation within the context of the Indian economy. Design/methodology/approach: We employed the Smooth Transition Autoregressive (STAR) Model, a robust tool for capturing non-linear relationships, to discern the specific threshold level of fiscal deficit. Our analysis encompasses annual data spanning from 1971 to 2020. Additionally, we have leveraged the Toda-Yamamoto causality test to establish the existence and direction of a causal connection between fiscal deficit and inflation in the Indian economy. Findings: Our analysis pinpointed a critical threshold level of 3.40% for fiscal deficit, a value beyond which inflation dynamics in India undergo a marked transition, signifying the presence of significant non-linear effects. Moreover, the results derived from the Toda-Yamamoto causality test offer substantiating evidence of a causal relationship originating from the fiscal deficit and leading to inflation within the Indian economic framework. Research limitations/implications: The findings of our study carry significant implications, particularly for the formulation and execution of both fiscal and monetary policies. Understanding the threshold effects of fiscal deficit on inflation in India provides policymakers with valuable insights into achieving a harmonious balance between these two critical economic variables. Originality/value: To the best of our knowledge, this study is the first of its kind to empirically investigate threshold effects of fiscal deficit on inflation in India from a non-linear perspective using the Smooth Transition Autoregression (STAR) model. 2024, Emerald Publishing Limited. -
Surface modified CaO nanoparticles with CMC/D-carvone for enhanced anticancer, antimicrobial and antioxidant activities
The rising prevalence of antimicrobial resistance and the continued challenge to cancer therapy are in desperate need of developing innovative therapeutic strategies. In this regard, the present research work focuses on the development of CaO NPs and CaO-CMC-Dcar nanocomposites for enhanced antimicrobial and anti-cancer activities. CaO nanoparticles were synthesized by facile one pot chemical approach and eventually functionalized with CMC and D-carvone biomolecules. XRD analysis revealed that the crystallite size for CaO and CaO-CMC-Dcar nanoparticles was found to be 21.18 nm and 17.02 nm respectively. The band gap values obtained for CaO and CaO-CMC-Dcar nanoparticles were 4.44 eV, and 4.25 eV respectively. The CaO-CMC-Dcar nanoparticles show absorption maxima at 292 nm, slightly red-shifted from bare CaO nanoparticles. HRTEM and SEM analysis revealed that the prepared samples were roughly spherical and agglomerated in nature. Antimicrobial activity was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and Candida albicans. The zone of inhibition (ZOI) for CaO-CMC-Dcar nanoparticles against MRSA and C. albicans was 20.1 0.3 mm and 21.1 0.2 mm, respectively, significantly higher than that of pure CaO nanoparticles (14.1 0.2 mm and 13.2 0.1 mm) and comparable to standard anti-bacterial streptomycin and antifungal fluconazole discs. Anticancer activity was assessed via MTT assay against MOLT-4 blood cancer cells, where the IC50 values for CaO and CaO-CMC-Dcar nanoparticles were 22.6 ?g/mL and 21.54 ?g/mL, respectively. Additionally, CaO-CMC-Dcar nanoparticles exhibited enhanced antioxidant activity (80 %) compared to CaO (70 %) at 20 ?g/mL, with performance comparable to that of Vitamin C. Experimental results revealed that the CaO-CMC-Dcar nanoparticles exhibited superior biological activity compared to pure CaO nanoparticles. 2025 Indian Chemical Society -
A method for identification of restarted radio sources from large radiosurveys
Active galaxies hosting radio jets can exhibit distinct active phases marked by two sets of radio lobes. Typically, these episodic radio sources have been identified through morphological observations. In addition, spectral characteristics-based methods are also employed wherever multi-frequency deep radio observations are available. However, these methods are inefficient in detecting restarted radio sources that do not exhibit a clear morphology. To address this, a method of using the spectral curvature (SPC=?150MHz1400MHz-?74MHz150MHz) to identify restarted radio sources is presented. This is based on the fact that restarted radio sources with significant remnant emission are expected to have concave spectra in contrast to the convex or straight spectra observed in most radio sources. We use available wide area radio surveys in the range of frequencies from 74MHz to 1.4GHz to search for episodic radio sources and to shortlist 9,405 sources based on the criteria of SPC?0.5. The candidates thus identified can be followed up for detailed morphological and spectral index studies. This method will find application in the automated identification of episodic radio sources in large radio sky surveys from telescopes like LOFAR and SKA. Indian Academy of Sciences 2025. -
Unfolding the aggression and locus of control paradigm in sportspersons and non-sportspersons
The present study investigated Aggression and Locus of Control on Combat Sports Persons, Non-Combat Sports Persons, and Non-Sports Persons. In this study, a sample of 240 individuals (80 Combat sports, 80 Non-Combat Sports & 80 Non-Sportspersons) was used through purposive sampling. The tools administered were the Buss and Perry Aggression Questionnaire by Arnold H. Buss and Mark Perry and Rotters Locus of Control Scale by Julian Rotter respectively. The objective of the study was to investigate Aggression and Locus of Control in males and females from Combat, Non-Combat, and Non-Sports persons. This research also aims to explore the relationship between Aggression and Locus of Control. Mean, t-test, F-value (ANOVA), and correlation have been computed over SPSS-16. Results suggest that males from Combat have higher Aggression than people from non-sports and non-combat sports. There is also a significant difference between non-sports persons and sports people over the Locus of Control, sports persons showed internal locus of control compared to non-sports persons who were higher on external locus of control. The result also indicates a significant relationship between the anger dimension of the Aggression and Locus of Control. 2025 ARD Asociaci Espala. -
Electrical transport and magnetoresistance studies on the magnetic moment compensated Mn2V1-xCoxZ (Z=Ga, Al; x=0, 0.25, 0.5, 0.75, 1) Heusler alloys
We report the electrical resistivity and magnetoresistance properties of arc-melted Mn2V1-xCoxZ (Z=Ga, Al; x =0, 0.25, 0.5, 0.75, 1) alloys, which possess compensated ferrimagnetic behaviour with high TC when x=0.5. Apart from metallicity, the alloys in the Ga series with x= 0, 0.75, 1 composition showed a positive to negative crossover in the magnetoresistance versus temperature curves. This crossover was absent for Mn2V0.75Co0.25Ga and the fully compensated ferrimagnet Mn2V0.5Co0.5Ga. In contrast to this, Co-substituted Mn2VAl exhibits distinctly different resistive behaviour. While the alloys Mn2VAl and Mn2CoAl exhibit metallic and semiconducting behaviour respectively, the intermediate compositions show a gradual metallic to semiconducting transition as the Co concentration increases. The compensated ferrimagnet Mn2V0.5Co0.5Al showed a mixed transport behaviour of metallic and semiconducting nature with a resistivity minimum at 140 K. In contrast to this mixed response of the arc-melted bulk sample, the Mn2V0.5Co0.5Al melt-spun ribbon shows a clear semiconducting nature throughout the temperature range, indicating that the sample preparation methods could highly influence the electrical properties of the investigated compensated ferrimagnets. 2024 Elsevier B.V. -
An exploration of 'pull' and 'push' motivational factors among transgender entrepreneurs
To date, studies have focused on the men and women entrepreneurs and the gender difference in motivations among cisgender entrepreneurs. The study aims to determine whether a transgender individual entrepreneur is motivated through a push motivational factor or a pull motivational factor. This study employs a qualitative approach uses face-to-face interviews and a semi-structured interview with a sample size of 16 transgender entrepreneurs in India. It was found that the participants in this study were motivated by both push and pull factors. The motivational factors, which add to the knowledge of already existing push and pull factors, were to forego begging and commercial sex work, to break stereotypes, to create a business opportunity for other transgender individuals, to earn respect from society, to prove entrepreneurship is non-binary, to be a role model for other transgender individuals and to the society. In contrast, the push motivational factors were the limited opportunities, support received from society, the hijra guru, media, government support, family, friends, landlords, NGOs and another push motivational factor was the exhibitions conducted exclusively for the transgender individual entrepreneurs. 2025 Inderscience Enterprises Ltd. -
Polypyrrole functionalized MoS2 for sensitive and simultaneous determination of heavy metal ions in water
Assessing heavy metal ion (HMI) contamination to sustain drinking water hygiene is a challenge. Conventional approaches are appealing for the detection of HMIs but electrochemical approaches can resolve the limitations of these approaches, such as tedious sample preparation, high cost, time consuming and the need for trained professionals. Here, an electrochemical approach is developed using a nano-sphered polypyrrole (PPy) functionalized with MoS2 (PPy/MoS2) by square wave anodic stripping voltammetry for the detection of HMIs. The developed sensor can detect Pb2+ with a limit of detection of 0.03 nM and a sensitivity of 36.42 ?A nM?1. Additionally, the PPy/MoS2 sensor was employed for the simultaneous detection of HMIs of Cd2+, Pb2+, Cu2+ and Hg2+. The reproducibility, stability and anti-interference studies confirm that the sensor can be used to monitor HMI contamination of water. 2025 The Royal Society of Chemistry. -
Influence of alkali treatment on physiochemical and morphological properties of palmyra fibers
As a part of sustainable development in construction, natural fibers are used as reinforcement in cement composites. The degradation of these natural fibers in matrix has led to growing interest among researchers to enhance the fiber properties by adopting suitable treatment techniques. This research focuses on examining the influence of alkali treatment on various aspects, including the physical, chemical, crystallinity, mechanical and surface characteristics of palmyra fibers. Herein, the palmyra fibers were immersed in alkaline solution for different duration (30 minutes, 60 minutes and 120 minutes) to arrive at optimum treatment period. The investigation utilizes XRD, FTIR, SEM and EDS analysis to gain insights into these properties. The findings indicated that the treatment effectively removed excess amorphous components like extractives, hemicellulose and lignin leading to the increase in crystallinity index and surface roughness. The crystallinity index increased by 11 %, 13 % and 23 % for 30 minutes, 60 minutes and 120 minutes treatment respectively. The water absorption of palmyra fibers reduced by 13 %, 14 % and 14 % for 30 minutes, 60 minutes and 120 minutes treatment duration respectively. Additionally, SEM-EDS exhibited best results for 60 min treatment of fibers, with 38 % increase in Oxygen to Carbon ratio of cellulose compared to untreated fibers. Among the different treatment duration, the 60 minutes treatment duration of fibers in 0.5 M sodium hydroxide solution has exhibited considerable enhancement in properties. These enhancements in palmyra fiber properties post-alkali treatment suggests their potential utility in the reinforcement of composites using alkali treated palmyra fibers. 2024 The Authors -
Environmental value development among preadolescents: a content analysis of reflective responses
Addressing the environmentally detrimental values prevalent in society in the context of rapid climate change is the need of the hour. Combining empathy with cognitive skills such as reflective thinking effectively creates new values among people. The present study attempts to reveal the pattern of environmental value development among 33 preadolescents by reflecting upon the empathy-generating story experiences and the related contents. The study is part of a more extensive quasi-experimental study, and it specifically performs a content analysis on the participants responses in their workbooks. Biospheric nature-related values are the most highly developed, and social justice is the least developed value, implying the need to focus more on the value of social justice. Stories are aids, and reflective thinking and empathetic elicitation are effective techniques for passing environmental values. Empathy generation instead of negative emotions from self-concern and emotion regulation through reflective thinking may be helpful to promote well-being in the context of climate change. Reflective thinking helps environmental value development by enhancing comprehension, emotion regulation, and self-awareness of values, implying a shift from telling the moral of a story to exploring the same through reflective thinking. 2025 Informa UK Limited, trading as Taylor & Francis Group. -
A First Report of Docosahexaenoic Acid-Clocked Polymer Enveloped Gold Nanoparticles: A Way to Precision Breast Cancer and Triple Negative Breast Cancer Therapy and Its Apoptosis Induction
Functionalized gold nanoparticles (GNPs) are extensively utilized in various disciplines due to their excellent bioactivity, biocompatibility, and extended drug half-life, influenced by the ligands and size that are changed on surfaces. In this study, we successfully fabricated GNPs coated with ligands containing docosahexaenoic acid (DHA) and polyethylene glycol (PEG) clocked by a carboxyl group. These nanoparticles are referred to as MPA@GNPs-PEG-DHA. The cytotoxicity results demonstrate that MPA@GNPs-PEG-DHA exhibits superior cell selectivity, explicitly inhibiting the proliferation of breast cancerous cells than noncancerous cell lines. Apoptosis is involved in the reduction of cell proliferation by MPA@GNPs-PEG-DHA, as demonstrated clearly through many assays measuring apoptotic index, including AO/EB staining, DAPI, annexin V-FITC staining, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) measurement. The efficacy of MPA@GNPs-PEG-DHA in inducing apoptosis was demonstrated by its inhibition of mitochondrial dysfunction by ROS. MPA@GNPs-PEG-DHA has the potential to improve the induction of apoptosis in breast cancerous cells. 2024 Wiley Periodicals LLC. -
Cross Correlation Between Plasmaspheric Hiss Waves and Enhanced Radiation Levels at Aviation Altitudes
Enhanced radiation in the Earth's atmosphere can pose serious hazards to pilots, aircraft passengers, and commercial space travelers. Recent results have shown, statistically, that there is a strong correlation between dose rates observed by Automated Radiation Measurements for Aerospace Safety (ARMAS) instruments at aviation altitudes (>9km) and plasmaspheric hiss wave power measured by NASA's Van Allen Probes within the inner magnetosphere. Plasmaspheric hiss waves play a very important role in removing energetic electrons from the Earth's radiation belts by precipitating them into the upper atmosphere. These relativistic electrons generally drift eastwards along closed magnetic drift shells. In this study, we use magnetic conjunction events between ARMAS and the Van Allen Probes to analyze the causality between plasmaspheric hiss waves and enhanced radiation observed at aviation altitude. We specifically study how the size of the conjunction window and a shift in L and MLT of the conjunction window affect the correlation between dose rates and plasmaspheric hiss wave power. This is to determine if the observed enhanced radiation at aviation altitude is indeed caused by the plasmaspheric hiss waves in the inner magnetosphere. The results show that the enhanced radiation levels are only correlated with plasmaspheric hiss waves within conjunction windows of ?1 (Formula presented.) L (Formula presented.) 1 and 0 (Formula presented.) MLT (Formula presented.) 2. The correlation between dose rate and hiss wave power increases slightly if ARMAS is shifted approximately 1hr in MLT to the east of the Van Allen Probes, consistent with the drift trajectory of the electrons precipitating into the atmosphere. 2025. The Author(s). -
A Methodological Framework for Descriptive Phenomenological Research
Background: Descriptive phenomenological research is crucial in nursing for understanding individuals experiences, perceptions, and relationships, which are essential for person-centered healthcare. However, a common critique is that researchers often use phenomenological methods without fully comprehending their historical and philosophical foundations. Existing literature highlights discrepancies in the application of phenomenological principles by nurse researchers, particularly in their presentation of philosophical underpinnings and methodological details. Aim: This article aims to provide a comprehensive methodological framework for descriptive phenomenological research in nursing, addressing both theoretical and practical aspects to guide novice researchers. Data Sources: This framework synthesizes existing scholarship on descriptive phenomenology. Discussion: Starting from Husserl, this article provides a detailed overview of the history, foundations, and philosophical assumptions of the methodology. It also includes key terms and a comprehensive detailing of all aspects of the research process. Conclusion: This framework enriches existing scholarship by offering a streamlined, step-by-step methodological guide for researchers embarking on descriptive phenomenological studies. It emphasizes the importance of establishing minimum, yet critical criteria for publishing research employing this methodology. Implications for Research: Future nurse researchers are encouraged to enhance methodological transparency in their descriptive phenomenological studies to facilitate rigorous evaluation of method effectiveness and study quality. This framework aims to alleviate potential apprehensions and provide clarity and structure to novice researchers in the field. The Author(s) 2024. -
Appraisal of prolyl 4-hydroxylase alpha subunit gene polymorphisms in Spondyloepimetaphyseal dysplasia of Handigodu type (SEMDHG)
Background: The Handigodu variant of Spondyloepimetaphyseal Dysplasia (SEMDHG) is a severe, progressive osteoarthritic disorder characterized by chronic pain and joint degeneration. Clinically, the disorder presents in three distinct phenotypic forms, each exhibiting varying degrees of stature reduction and disease severity. Urine analysis of affected individuals reveals an elevated peptide-bound proline to 4-hydroxyproline ratio relative to controls, suggesting disruptions in collagen metabolism. Given the critical role of prolyl 4-hydroxylase enzymes in stabilizing collagen structure, this study undertook a comprehensive sequence analysis of all three isoforms of prolyl 4-hydroxylase in both affected and unaffected individuals to elucidate potential molecular underpinnings of the disorder. Method: The entire exonic regions and 2000 base pairs upstream of the translation start sites of the P4HA1, P4HA2, and P4HA3 genes were sequenced in a cohort of 300 individuals, comprising 166 affected and 134 unaffected individuals. Results: Sequence analysis of the ? (I), ? (II), and ? (III) subunit genes identified three novel SNPs and a 39-bp deletion variant, in addition to ten previously reported SNPs catalogued in dbSNP. The SNP rs28384495 in P4HA1, the 39-bp deletion variant, and a novel mutation (SNP3) in P4HA3 exhibited significantly different allele frequencies between patients and controls. Genotype association analysis revealed that SNPs in P4HA1 and P4HA3 were associated with Type 2 and Type 3 HD under various genetic models. Notably, all Type 2 HD patients were heterozygous for the 39-bp deletion, whereas all Type 3 HD patients were homozygous for the variant. Haplotype analysis corroborated the findings of the genotype association analysis. Conclusion: This study is the first to account an association between the P4H gene and disease. Further research is needed to evaluate the functional implications of the identified mutations. 2024 -
Serendipitous detection of an intense X-ray flare in the weak-line T Tauri star KM Ori with SRG/eROSITA
Weak-line T Tauri stars (WTTS) exhibit X-ray flares, likely resulting from magnetic reconnection that heats the stellar plasma to very high temperatures. These flares are difficult to identify through targeted observations. Here, we report the serendipitous detection of the brightest X-ray flaring state of the WTTS KM Ori in the eROSITA DR1 survey. Observations from SRG/eROSITA, Chandra X-ray Observatory, and XMM-Newton are analysed to assess the X-ray properties of KM Ori, thereby establishing its flaring state at the eROSITA epoch. The long-term (1999-2020) X-ray light curve generated for the Chandra observations confirmed that eROSITA captured the source at its highest X-ray flaring state recorded to date. Multi-instrument observations support the X-ray flaring state of the source, with time-averaged X-ray luminosity reaching at the eROSITA epoch, marking it the brightest and possibly the longest flare observed so far. Such intense X-ray flares have been detected only in a few WTTS. The X-ray spectral analysis unveils the presence of multiple thermal plasma components at all epochs. The notably high luminosity , energy (erg), and the elevated emission measures of the thermal components in the eROSITA epoch indicate a superflare/megaflare state of KM Ori. Additionally, the H line equivalent width of from our optical spectral analysis, combined with the lack of infrared excess in the spectral energy distribution, were used to re-confirm the WTTS (thin disc/disc-less) classification of the source. The long-duration flare of KM Ori observed by eROSITA indicates the possibility of a slow-rise top-flat flare. The detection demonstrates the potential of eROSITA to uncover such rare, transient events, thereby providing new insights into the X-ray activity of WTTS. The Author(s), 2025. Published by Cambridge University Press on behalf of Astronomical Society of Australia.