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Online Education and English Language Learning Among Tribal Students of Kerala
Kerala, a South Indian state has tribal population in all her districts. About 1.5% of the total population of the state constitute tribal population. They depend upon natural environment and resources for their survival. Children from the same community usually depend on government funded schools for their education. Education for this deprived section during COVID 19 Pandemic was a massive exclusion and an uphill task. Digital divide and medium of communication (Standard Malayalam) were some of the critical concerns to knowledge acquisition among tribal children. This paper primarily focuses on the challenges of online education among tribal students with a clear emphasis on the English language acquisition. This study was conducted in four most tribal populated districts of the State, namely, Wayanad, Malappuram, Palakkad, and Idukki. This is a qualitative explorative study that explores the experiences of the tribal students' English language learning challenges from the teachers' perspective in these districts. The Electrochemical Society -
Spoofing Face Detection Using Novel Edge-Net Autoencoder for Security
Recent security applications in mobile technologies and computer systems use face recognition for high-end security. Despite numerous security tech-niques, face recognition is considered a high-security control. Developers fuse and carry out face identification as an access authority into these applications. Still, face identification authentication is sensitive to attacks with a 2-D photo image or captured video to access the system as an authorized user. In the existing spoofing detection algorithm, there was some loss in the recreation of images. This research proposes an unobtrusive technique to detect face spoofing attacks that apply a single frame of the sequenced set of frames to overcome the above-said problems. This research offers a novel Edge-Net autoencoder to select convoluted and dominant features of the input diffused structure. First, this pro-posedmethodistestedwiththeCross-ethnicityFaceAnti-spoofing (CASIA), Fetal alcohol spectrum disorders (FASD) dataset. This database has three models of attacks: distorted photographs in printed form, photographs with removed eyes portion, and video attacks. The images are taken with three different quality cameras: low, average, and high-quality real and spoofed images. An extensive experimental study was performed with CASIA-FASD, 3 Diagnostic Machine Aid-Digital (DMAD) dataset that proved higher results when compared to existing algorithms. 2023, Tech Science Press. All rights reserved. -
The computational model of nanofluid considering heat transfer and entropy generation across a curved and flat surface
The entropy generation analysis for the nanofluid flowing over a stretching/shrinking curved region is performed in the existence of the cross-diffusion effect. The surface is also subjected to second-order velocity slip under the effect of mixed convection. The Joule heating that contributes significantly to the heat transfer properties of nanofluid is incorporated along with the heat source/sink. Furthermore, the flow is assumed to be governed by an exterior magnetic field that aids in gaining control over the flow speed. With these frameworks, the mathematical model that describes the flow with such characteristics and assumptions is framed using partial differential equations (PDEs). The bvp4c solver is used to numerically solve the system of non-linear ordinary differential equations (ODEs) that are created from these equations. The solutions of obtained through this technique are verified with the available articles and the comparison is tabulated. Meanwhile, the interpretation of the results of this study is delivered through graphs. The findings showed that the Bejan number was decreased by increasing Brinkman number values whereas it enhanced the entropy generation. Also, as the curvature parameter goes higher, the speed of the nanofluid flow diminishes. Furthermore, the increase in the Soret and Dufour effects have enhanced the thermal conduction and the mass transfer of the nanofluid. 2023, The Author(s). -
A comparative study of the impact of thermal indices on Indian coral ecosystem
Coral reefs have been the diversified ecosystem in the planet. Advantages are opportunities in tourism, coastal protection and fisheries production. Corals, as key ingredient is sourced got drug manufacturing. Its distribution is evident in locations of where sea water temperature ranges between 16C to 30C. Their presence is >0.2% of ocean area and supports >25% of marine species. India has five reef formations. Globally, last two decades have seen an increase in reporting reef deterioration. The reason significantly attributed to be climate change, apart other challenges such as pollution, sedimentation, oil spillage, etc. Such events lead to widespread mortality of corals. Mortality during bleaching events are inevitable and varied; depends on intensity of such events. The primary reason is due to significant rise in average sea surface temperature (SST). Recovery takes time after such events, and it becomes worse with recurring events. The reefs of Indian seas have reported events of severe bleaching during 1998, 2010 and 2016. IPCC reviews show mass bleaching will be prominent in future due to elevated SST. This work tries to compare the HS values of a few regions. The data collected is from 2001 to 2017. A few significant observations are drawn which could further help us to extend the work to take help from Artificial Intelligence to make predictions for the future. This study uses the indices derived out of SST to look at relative risk faced by Indian reefs. The need for comprehensive and localized actions will be discussed. 2021 Author(s). -
Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability
Data variations, library changes, and poorly tuned hyperparameters can cause failures in data-driven modelling. In such scenarios, model drift, a gradual shift in model performance, can lead to inaccurate predictions. Monitoring and mitigating drift are vital to maintain model effectiveness. USFDA and ICH regulate pharmaceutical variation with scientific risk-based approaches. In this study, the hyperparameter optimization for the Artificial Neural Network Multilayer Perceptron (ANN-MLP) was investigated using open-source data. The design of experiments (DoE) approach in combination with target drift prediction and statistical process control (SPC) was employed to achieve this objective. First, pre-screening and optimization DoEs were conducted on lab-scale data, serving as internal validation data, to identify the design space and control space. The regression performance metrics were carefully monitored to ensure the right set of hyperparameters was selected, optimizing the modelling time and storage requirements. Before extending the analysis to external validation data, a drift analysis on the target variable was performed. This aimed to determine if the external data fell within the studied range or required retraining of the model. Although a drift was observed, the external data remained well within the range of the internal validation data. Subsequently, trend analysis and process monitoring for the mean absolute error of the active content were conducted. The combined use of DoE, drift analysis, and SPC enabled trend analysis, ensuring that both current and external validation data met acceptance criteria. Out-of-specification and process control limits were determined, providing valuable insights into the models performance and overall reliability. This comprehensive approach allowed for robust hyperparameter optimization and effective management of model lifecycle, crucial in achieving accurate and dependable predictions in various real-world applications. Graphical Abstract: [Figure not available: see fulltext.]. 2023, The Author(s). -
Machine LearningEnabled NIR Spectroscopy. Part 2: Workflow for Selecting a Subset of Samples from Publicly Accessible Data
Abstract: An increasingly large dataset of pharmaceuticsdisciplines is frequently challenging to comprehend. Since machine learning needs high-quality data sets, the open-source dataset can be a place to start. This work presents a systematic method to choose representative subsamples from the existing research, along with an extensive set of quality measures and a visualization strategy. The preceding article (Muthudoss et al. in AAPS PharmSciTech 23, 2022) describes a workflow for leveraging near infrared (NIR) spectroscopy to obtain reliable and robustdata on pharmaceutical samples. This study describes the systematic and structured procedure for selecting subsamples from the historical data. We offer a wide range of in-depth quality measures, diagnostic tools, and visualization techniques. A real-world, well-researched NIR dataset was employed to demonstrate this approach. This open-source tablet dataset (http://www.models.life.ku.dk/Tablets) consists of different doses in milligrams, different shapes, and sizes of dosage forms, slots in tablets, three different manufacturing scales (lab, pilot, production), coating differences (coated vs uncoated), etc. This sample is appropriate; that is, the model was developed on one scale (in this research, the lab scale), and it can be great to investigate how well the top models are transferable when tested on new data like pilot-scale or production (full) scale. A literature review indicated that the PLS regression models outperform artificial neural network-multilayer perceptron (ANN-MLP). This work demonstrates the selection of appropriate hyperparameters and their impact on ANN-MLP model performance. The hyperparameter tuning approaches and performance with available references are discussed for the data under investigation. Model extension from lab-scale to pilot-scale/production scale is demonstrated. Highlights: We present a comprehensive quality metrics and visualization strategy in selecting subsamples from the existing studies A comprehensive assessment and workflow are demonstrated using historical real-world near-infrared (NIR) data sets Selection of appropriate hyperparameters and their impact on artificial neural network-multilayer perceptron (ANN-MLP) model performance The choice of hyperparameter tuning approaches and performance with available references are discussed for the data under investigation Model extension from lab-scale to pilot-scale successfully demonstrated Graphical Abstract: [Figure not available: see fulltext.]. 2023, The Author(s). -
DDoS Intrusions Detection in Low Power SD-IoT Devices Leveraging Effective Machine Learning
Security and privacy are significant concerns in software-defined networking (SDN)-applied Internet of Things (IoT) environments, due to the proliferation of connected devices and the potential for cyberattacks. Hence, robust security mechanisms need to be developed, including authentication, encryption, and distributed denial of service (DDoS) attack detection, tailored to the constraints of low-power IoT devices. Selecting a suitable tiny machine learning (TinyML) algorithm for low-power IoT devices for DDoS attack detection involves considering various factors such as computational complexity, robustness in dealing with heterogeneous data, accuracy, and the specific constraints of the target IoT device. In this paper, we present a two-fold approach for the optimal TinyML algorithm selection leveraging the hybrid analytical network process (HANP). First, we make a comparative analysis (qualitative) of the machine learning algorithm in the context of suitability for TinyML in the domain of SD-IoT devices and generate the weights of suitability for TinyML applications in SD-IoT. Then we evaluate the performance of the machine learning algorithms and validate the results of the model to demonstrate the effectiveness of the proposed method. Finally, we see the effect of dimensionality reduction with respect to features and how it affects the precision, recall, accuracy, and F1 score. The results demonstrate the effectiveness of the scheme. 1975-2011 IEEE. -
Wireless Network Security Using Load Balanced Mobile Sink Technique
Real-time applications based on Wireless Sensor Network (WSN) technologies are quickly increasing due to intelligent surroundings. Among the most significant resources in the WSN are battery power and security. Clustering stra-tegies improve the power factor and secure the WSN environment. It takes more electricity to forward data in a WSN. Though numerous clustering methods have been developed to provide energy consumption, there is indeed a risk of unequal load balancing, resulting in a decrease in the networks lifetime due to network inequalities and less security. These possibilities arise due to the cluster heads limited life span. These cluster heads (CH) are in charge of all activities and control intra-cluster and inter-cluster interactions. The proposed method uses Lifetime centric load balancing mechanisms (LCLBM) and Cluster-based energy optimization using a mobile sink algorithm (CEOMS). LCLBM emphasizes the selection of CH, system architectures, and optimal distribution of CH. In addition, the LCLBM was added with an assistant cluster head (ACH) for load balancing. Power consumption, communications latency, the frequency of failing nodes, high security, and one-way delay are essential variables to consider while evaluating LCLBM. CEOMS will choose a cluster leader based on the influence of the fol-lowing parameters on the energy balance of WSNs. According to simulated find-ings, the suggested LCLBM-CEOMS method increases cluster head selection self-adaptability, improves the networks lifetime, decreases data latency, and bal-ances network capacity. 2023, Tech Science Press. All rights reserved. -
A PV-Powered Single Phase Seven-Level Invertera's Photocurrent and Injected Power
The PV inverter in this study is linked to the grid and its performance analysis is evaluated using a PI controller. It is a single phase multi-level PV inverter. The major objective of this research is to increase efficiency and eliminate harmonics caused by DC link voltage fluctuations created by Maximum Power Point Tracking (MPPT) during foggy situations. PV inverters generate and inject actual power into the main grid. This study uses a transformer-less photovoltaic inverter to cut down on losses, cost, and size. A transformer-less multilayer inverter is described in this paper. There is no high-frequency leakage current since that inverter can distribute both actual and reactive electricity. MATLAB/Simulink software was used to analyze and assess the effects of various PV-based seven-level techniques on the devicea's Maximum Power Point Tracking (MPPT) performance. The Authors, published by EDP Sciences, 2024. -
Next-Generation Connectivity in A Heterogenous Railway World
Global System for Mobile communication - Railway (GSM-R) is widely used for operational communications between train and signaler. However, there is a need to define a successor that addresses: obsolescence, radio spectrum demand and the enabling of a range of emerging digital applications such as radio-based signaling and Automatic Train Control (ATC). Therefore, the International Union of Railways (UIC) started the initiative to develop the Future Railway Mobile Communication System (FRMCS). This article describes an Adaptable Communication System (ACS) that is being developed jointly by industry and railway operators as a possible successor covering all types of railways and all aspects of the FRMCS. A pragmatic approach is suggested that considers diverse railway settings and makes use of various radio access technologies. Countries, geographical regions and infrastructure managers differ concerning available radio technologies, but use of a suitable ACS could pave the way towards innovation in the railway sector. For this adaptive concept we discuss several network models and enhancements including satellite communications (SatCom), Software-Defined Networking (SDN) integration and antenna systems that support multiple bearers in one. For SatCom a software defined radio (SDR) prototype using random access is presented that is able to fulfill the requirements of ETCS. We found that SDN can be used for dynamically changing the access technology for critical and non-critical railway use cases. Furthermore, we present an antenna prototype that can be used for 5G, GSM, WLAN and LTE in parallel which saves limited mounting surface on the train. 1979-2012 IEEE. -
Optimization-Based Cash Management Model for Microfinance Applications Using GSA and PSO
Banks and businesses use cash as a means for exchange in finance on a regular basis to please customers. Making decisions about cash management can be challenging because banks must keep significant sums of cash in order to sustain high levels of client satisfaction. In this paper, linear PSO and GSA models are given for estimating the daily cash demand of a bank by taking into account the variables Year of Reference (RY), Years Month (My), Months Day (Dm), Days Week (Dw), Payday Effect Salary (Se), and Holiday Effect (He). Using PSO and GSA in MATLAB, the algorithms for estimating both the model coefficients for short term are implemented from the real data of a specific bank branch. The proposed system's overall cost is minimized using a fitness function. It was discovered that the results are in good accord with the observed data and that the PSO-based cash management model outperformed other models with superior accuracy. The models are then used for future cash management for validation. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
Customized SEIR Mathematical Model to Predict the trends of Vaccination for Spread of COVID-19
The uncertainty in life plans, restrictions on physical classrooms, loss of jobs, large number of infections and deaths due to COVID-19 are some significant causes of concern for the public as well as Governments all over the globe. Moreover, the exponential increase in the number of infected people in a short time is responsible for the collapse of the health industry during the pandemic caused by COVID-19. The health experts recommended that the quick and early diagnosis followed by treatment of patients in isolation is a way to minimize its spread and save lives. The objective of this research is to propose a customized SEIR model to predict the trends of vaccination in the USA. The experimental results prove that the Moderna vaccine reports the efficacy of 93%, which is higher than the Pfizer and Johnson and Johnson vaccines. 2022 ACM. -
Integrated hybrid membrane system for enhanced water treatment and desalination for environmental preservation
Technology advancements in desalination, water treatment, and energy efficiency are crucial to preserving our planet. It is critical to find solutions for the future that save natural resources and lessen environmental damage because the freshwater shortage is getting worse, and energy demand is increasing. They face various obstacles, even though their breakthroughs are extremely important. Lot of energy can be utilized for the traditional desalination techniques, as it negatively impacts the environment. Then, the process of the existing Water Treatment (WT) are expensive and ineffective. An Integrated Hybrid Membrane System for Enhanced WT (IHMS-EWT) is a unique technique for WT and desalination was suggested in this study. The integration of many membrane procedures like nanofiltration, reverse and forward osmosis, and membrane distillation, and these will helps in facilitating the best WT and desalination methods. Due to the incorporating Renewable Energy (RE), the IHMS-EWT also demonstrates the (SWMS) Sustainable Water Management System, as it enhances the EE and thereby reducing the environmental impact. The great potential in the wide range of applications was offered by the IHMS-EWT technique. Providing the decentralized WT solutions in the remote areas, this unique approach has the ability to reduce the fresh water scarcity in the coastal areas based on the demands of the municipal, industrial and agricultural demands. The environmental sustainability throughout the lenghthy operations was ensured by the support of IHMS-EWT. It also helps in providing resilience in the crisis situations. The cost-effective evaluations, operating parameter optimization, and performance prediction of the method was enabled by employing the computational modelling. Through simulatimg different contexts, the effective configurations and operational techniques are focussed on the study for enhancing the IHMS-EWT technology.The model shift in the SWM, the IHMS-EWT technique addresses the main problems and brings one step for more secure environment. Comparing to other existing methods, Improving the water purification by 98.2 %, 94.2 % efficiency rate, the EC prediction rate of 96.2 %, the cost-effectiveness rate by 82.4 % and the performance rate by 96.7 % by the suggested IHMS-EWT model and it was demonstrated by the outcomes of the experiment. 2024 The Authors -
End-to-End Encryption in Resource-Constrained IoT Device
Internet of Things (IoT) technologies will interconnect with a wide range of network devices, regardless of their local network and resource capacities. Ensuring the security, communication, and privacy protection of end-users is a major concern in IoT development. Secure communication is a significant requirement for various applications, especially when communication devices have limited resources. The emergence of IoT also necessitates the use of low-power devices that interconnect with each other for essential processing. These devices are expected to handle large amounts of monitoring and control data while having limited capabilities and resources. The algorithm used for secure encryption should protect vulnerable devices. Conventional encryption methods such as RSA or AES are computationally expensive and require large amounts of memory, which can adversely affect device performance. Simplistic encryption techniques are easily compromised. To address these challenges, an effective and secure lightweight cryptographic process is proposed for computer devices. This process utilizes a symmetrical encryption key block, incorporating a custom proxy network (SP) and a modified Feistel architecture. Security analysis and performance evaluation results demonstrate that the proposed protocol is secure and energy-efficient. The symmetric key encryption scheme is based on sequences in the Feistel cipher, with multiple rounds and sub-keys generated using principles derived from genetic algorithms. This proposed algorithm minimizes processing cycles while providing sufficient security. 2013 IEEE. -
Novel HGDBO: A Hybrid Genetic and Dung Beetle Optimization Algorithm for Microarray Gene Selection and Efficient Cancer Classification; [Nuevo HGDBO: Un Algoritmo Hrido de Optimizaci Genica y de Escarabajos Peloteros para la Selecci de Genes en Microrrays y la Clasificaci Eficiente del Ccer]
Introduction: ovarian cancer ranked as the seventh most common cancer and the eighth leading cause of cancer-related mortality among women globally. Early detection was crucial for improving survival rates, emphasizing the need for better screening techniques and increased awareness. Microarray gene data, containing numerous genes across multiple samples, presented both opportunities and challenges in understanding gene functions and disease pathways. This research focused on reducing feature selection time in large gene expression datasets by applying a hybrid bio-inspired method, HGDBO. The goal was to enhance classification accuracy by optimizing gene subsets for improved gene expression analysis. Method: the study introduced a novel hybrid feature selection method called HGDBO, which combined the Dung Beetle Optimization (DBO) algorithm with the Genetic Algorithm (GA) to improve microarray data analysis. The HGDBO method leveraged the exploratory strengths of DBO and the exploitative capabilities of GA to identify relevant genes for disease classification. Experiments conducted on multiple microarray datasets showed that the hybrid approach offered superior classification performance, stability, and computational efficiency compared to traditional methods. Ovarian cancer classification was performed using Nae Bayes (NB) and Random Forest (RF) algorithms. Results and Discussion: the Random Forest model outperformed the Nae Bayes model across all metrics, achieving higher accuracy (0,96 vs. 0,91), precision (0,95 vs. 0,91), recall (0,97 vs. 0,90), F1 score (0,95 vs. 0,91), and specificity (0,97 vs. 0,86). Conclusions: these results demonstrated the effectiveness of the HGDBO method and the Random Forest classifier in improving the analysis and classification of ovarian cancer using microarray gene data. 2024; Los autores. -
A comprehensive review on energy management strategy of microgrids
Renewable energy resources are a one-stop solution for major issues that include drastic climate change, environmental pollution, and the depletion of fossil fuels. Renewable energy resources, their allied storage devices, load supplied, non-renewable sources, along with the electrical and control devices involved, form the entity called microgrids. Energy management systems are essential in microgrids with more than one energy resource and storage system for optimal power sharing between each component in the microgrid for efficient, reliable and economic operation. A critical review on energy management for hybrid systems of different configurations, the diverse techniques used, forecasting methods, control strategies, uncertainty consideration, tariffs set for financial benefits, etc. are reviewed in this paper. The novelty of reformer based fuel cells, which generates hydrogen on demand, thereby eliminating the requirement of hydrogen storage and lowest carbon footprint is discussed for the first time in this paper. The topics requiring extended research and the existing gap in literature in the field of energy management studies are presented in the authors perspective, which will be helpful for researchers working in the same specialization. Papers are segregated based on multiple aspects such as the configuration, in particular, grid-tied, islanded, multi microgrids, the control strategies adopted besides the identification of limitations/factors not considered in each work. Moreover, at the end of each section, the literature gap related to each category of segregated group is identified and presented. 2023 The Author(s) -
Energy management of hybrid microgrids A comparative study with hydroplus and methanol based fuel cells
Energy management is essential for the efficient operation of microgrids with reduced energy costs and minimized emissions. Energy management of PV/battery/fuel cell/diesel generator-based microgrid to minimize the operations cost considering battery degradation and emissions for a fully functional microgrid existing in the campus of Sultan Qaboos University, Oman, is presented in this work. A microgrid with a state-of-the-art hydroplus fuel cell without the necessity for hydrogen storage is presented in this study with experimentally obtained parameters. Also, a comparison of operations cost with microgrids using two different technologies of PEM fuel cells, one with hydroplus fuel cell and the second with the methanol fuel cell which requires provision for hydrogen storage is performed with three different cases; the scheduled, grid-tied, and islanded with different scenarios under grid-tied mode. The analysis proved that using a hydroplus fuel cell instead of a methanol fuel cell with hydrogen storage reduces the cost of the daily operation by 6.9% in the scheduled mode and 18.2% in the islanded mode. In the grid-tied mode three different grid limits, 20 kW, 15 kW, and 10 kW are considered. The analysis showed no reduction, 1.3% and 5.9% reduction in the operations cost respectively. The results obtained are highly promising to be applied in microgrids where conventional fuel cells are currently employed. The new technology of fuel cells introduced in this study, possesses the advantages of near zero emissions and reduced operations costs besides avoiding the perilousness of hydrogen storage. 2024 Hydrogen Energy Publications LLC -
Development of Biocompatible Barium peroxide/Pluronic F127/L-ornithine Composite for Enriched Antimicrobial, Antioxidant and Anticancer Potential: An in vitro Study
Osteosarcoma (MG-63) is a type of bone cancer affects mostly adolescents and young adults. Disease-causing microorganisms like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans pose serious illness in humans. There is a need to develop multifunctional composite to combat cancer and other most common disease caused by disease causing microorganisms. In this context, BaO2 and pluronic F127, L-Ornithine coated BaO2 (BaO2-PF127-LO) composite have been prepared and characterized by XRD, FTIR, UV-Vis, SEM, HRTEM, EDAX, and XPS analytical techniques. BaO2 and BaO2-PF127-LO were orthorhombic crystalline structure and the crystallite size was found as 32nm for BaO2 and 26nm for modified BaO2 PL studies revealed the green emission observed at 506nm for BaO2-PF127-LO composite which is absent in the case of bare BaO2. Antimicrobial activity of BaO2 and BaO2-PF127-LO was investigated. MTT assay was performed to determine the anticancer potential while the DPPH free radical scavenging assay was carried out to determine the antioxidant potential. The experiment study revealed that the BaO2-PF127-LO exhibited enhanced antimicrobial, antioxidant, and anticancer activity and low toxicity when compared to pristine BaO2. The experimental results revealed that the BaO2-PF127-LO composite holds promising potential for biomedical applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Optimized green synthesis of ZnO nanoparticles: evaluation of structural, morphological, vibrational and optical properties
In this study, leaf extracts of Aloe vera (AV), Azadirachta indica (AI), and Amaranthus dubius (AD) were used to synthesize zinc oxide nanoparticles utilizing a simple green synthesis process. The structural, optical, band energy, size, surface area, and shape of as-prepared nanoparticles were studied using analytical techniques. The hexagonal phase was revealed by XRD studies for all three samples: AV-ZnO, AI-ZnO, and AD-ZnO, with crystallite sizes of 35.8nm, 30.83nm, and 33.1nm, respectively. The UVVisible spectra of AV-ZnO, AI-ZnO, and AD-ZnO exhibit the characteristic absorption in the range of 200 to 450nm, and the band gap energy was found to be 3.10eV, 3.12eV, and 3.07eV, respectively. FESEM and TEM studies revealed that the ZnO NPs are rod-shaped with a roughly spherical appearance. EDAX analysis confirmed the presence of zinc and oxygen and indicates that the formed product is a pure phase of ZnO NPs. Increased antibacterial activity was noted for AV-ZnO, AI-ZnO, and AD-ZnO against gram-negative (Klebsiella pneumonia, Shigella dysenteriae), gram positive (Staphylococcus aureus, and Bacillus) bacterial strain. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Structural modification of electrophilic group substituted phenyldiazenyl derivatives for antitubercular application
In the present work, four electrophilic group substitute phenyldiazenyl derivatives were synthesized using an electrophilic substitution reaction. The physicochemical analysis was carried out using FT-IR, 1H NMR, and HR-MS data. The photophysical studies were carried out using theoretical methods. Density functional theory was employed to illustrate the electronic and optical characteristics of the synthesized compounds. The HOMO-LUMO energies were theoretically computed in different solvents using Gaussian 09W software and results are compared with the experimental values. The molecule PT4 shows highest bandgap of 4.497eV. Further, the global chemical reactivity descriptors were used to determined nature of chemical reactivity. The anti-tubercular activity was evaluated using invitro and molecular docking techniques and results reveal that barbituric acid coupled with phenyldiazenyl displayed excellent anti-tubercular activity compared with the standard Gentamycin. 2024 Indian Chemical Society