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Citric-Acid-Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3-e]pyrimidin- and Pyrano[2, 3-d]pyrazol-amines in Water via One-Pot Multicomponent Approaches
An efficient entry into the preparation of elusive, novel pyrano[2, 3-e]pyrimidin-amines and pyrano[2, 3-d]pyrazol-amines has been accomplished using citric acid as a green catalyst in aqueous medium at 25 C. The strategy successively tolerates a variety of functional groups and interestingly, it is eco-compatible, environment-friendly, propitious and the products are obtained in excellent yields without chromatographic purification. The current methodology unfolds the benefits of citric acid as an effective, expeditious, economical, green catalyst and thus adheres to the principles of green chemistry. Ecstatically, the reaction was scaled to the gram level ascertaining the wide applicability of the protocol in academia and industry. The green metrics (E-factor: 0.0497, Mass intensity: 1.1022, PMI: 1.0497 and Emw: 0.0497) for the reaction was also envisaged and the pathway was found to acquaint excellent green chemistry metrics. 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim -
Citrus for wellness: Exploring the bioactive properties of Citrus medica fruit peel with emphasis on its anticancer, antioxidant, antimicrobial and anthelmintic properties
Citrus medica (Citron) is an underutilised plant consisting of various bioactive elements with numerous medicinal benefits. The present study aimed to evaluate the bioactive properties, including anthelmintic, antimicrobial, antioxidant and anticancer activities, of chloroform extract obtained from the of fruit peel of C. medica. The different types of phytochemicals present in the chloroform extract were analysed using GC-MS. The major components detected included n-hexadecanoic acid, octadecanoic acid, t-tetradecenal, 1-nonadecene etc. Anthelmintic study was conducted using Eisenia fetida as a test organism, revealing a significant anthelmintic effect in the C. medica fruit peel extract compared to the standard drug. Antimicrobial properties were assessed against five test bacterial and fungal strains. Antibacterial tests showed zones of inhibition ranging from 8 to 11 mm, while no prominent zones of inhibition were observed in antifungal tests. The DPPH assay demonstrated significant antioxidant properties of Citron fruit peel extract compared to the standard ascorbic acid. The Chloroform extract of citron fruit peel exhibited significant cytotoxic properties against FaDu (human hypopharyngeal tumour) cell line. The present study indicates the potential of the chloroform extract of C. medica fruit peel to be employed as an anthelmintic, antibacterial, antioxidant and anticancer agent. Hence, it emphasises the prominence that can be given to the dietary consumption of citrus fruit peel in various forms, such as dried peel, powder etc. The Author(s). -
Citrus Medica-derived Fluorescent Carbon Dots for the Imaging of Vigna Radiate Root Cells
Bio-imaging is a crucial tool for researchers in the fields of cell biology and developmental biomedical sector. Among the various available imaging techniques, fluorescence based imaging stands out due to its high sensitivity and specificity. However, traditional fluorescent materials used in biological imaging often suffer from issues such as photostability and biocompatibility. Moreover, plant tissues contain compounds that cause autofluorescence and light scattering, which can hinder fluorescence microscopy effectiveness. This study explores the development of fluorescent carbon dots (Cm-CDs) synthesized from Citrus medica fruit extract for the fluorescence imaging of Vigna radiata root cells. The successful synthesis of CDs with an average size of 6.7nm is confirmed by Transmission Electron Microscopy (TEM). The X-ray diffraction (XRD) analysis and raman spectroscopy indicated that the obtained CDs are amorphous in nature. The presence of various functional groups on the surface of CDs were identified by Fourier transform infrared (FTIR) spectra. The optical characteristics of Cm-CDs were studied by UV-Visible spectroscopy and photoluminescence spectroscopy. Cm-CDs demonstrated strong excitation-dependent fluorescence, good solubility, and effective penetration in to the Vigna radiata root cells with multicolor luminescence, and addressed autofluorescence issues. Additionally, a comparative analysis determined the optimal concentration for high-resolution, multi-color root cell imaging, with Cm-CD2 (2.5mg/ml) exhibiting the highest photoluminescence (PL) intensity. These findings highlight the potential of Cm-CDs in enhancing direct endocytosis and overcoming autofluorescence in plant cell imaging, offering promising advancements for cell biology research. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Citrus Medica-derived Fluorescent Carbon Dots for the Imaging of Vigna Radiate Root Cells
Bio-imaging is a crucial tool for researchers in the fields of cell biology and developmental biomedical sector. Among the various available imaging techniques, fluorescence based imaging stands out due to its high sensitivity and specificity. However, traditional fluorescent materials used in biological imaging often suffer from issues such as photostability and biocompatibility. Moreover, plant tissues contain compounds that cause autofluorescence and light scattering, which can hinder fluorescence microscopy effectiveness. This study explores the development of fluorescent carbon dots (Cm-CDs) synthesized from Citrus medica fruit extract for the fluorescence imaging of Vigna radiata root cells. The successful synthesis of CDs with an average size of 6.7nm is confirmed by Transmission Electron Microscopy (TEM). The X-ray diffraction (XRD) analysis and raman spectroscopy indicated that the obtained CDs are amorphous in nature. The presence of various functional groups on the surface of CDs were identified by Fourier transform infrared (FTIR) spectra. The optical characteristics of Cm-CDs were studied by UV-Visible spectroscopy and photoluminescence spectroscopy. Cm-CDs demonstrated strong excitation-dependent fluorescence, good solubility, and effective penetration in to the Vigna radiata root cells with multicolor luminescence, and addressed autofluorescence issues. Additionally, a comparative analysis determined the optimal concentration for high-resolution, multi-color root cell imaging, with Cm-CD2 (2.5mg/ml) exhibiting the highest photoluminescence (PL) intensity. These findings highlight the potential of Cm-CDs in enhancing direct endocytosis and overcoming autofluorescence in plant cell imaging, offering promising advancements for cell biology research. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Clan Culture in Organizational Leadership and Strategic Emphases: Expectations Among School Teachers in India
Understanding the current and preferred organizational culture among school teachers in India is a primary requirement, particularly when the National Educational Policy (NEP) is being implemented. Measuring the competing values using the Organizational Culture Assessment Instrument (OCAI) provides information about the dominant characteristics of the organizational culture and the school teachers' preferences. We surveyed school teachers and received 273 responses. Research revealed that clan culture is the overall current and preferred organizational culture type. Many of the results are not a surprise. However, we found that organizational leadership is currently in the hierarchy culture and strategic emphasis is on adhocracy, whereas teachers prefer a clan culture on these dimensions. Teachers expect school leaders to be the ones who facilitate the path to achieve, provide mentoring, and are instrumental in team building. They prefer a culture that provides for the development of human capital, promotes high trust and transparency among teachers, and offers an opportunity to participate in decision-making. This study is unique as it measures schools' organizational culture that has not been done earlier in the Indian context. The results suggest implications on the leadership practices and the strategic emphasis that need to change, in order to facilitate the implementation of the National Education Policy (NEP). 2022. All Rights Reserved. -
CLASS onboard Chandrayaan-2: Five years around the Moon
Chandrayaan-2 Large Area soft X-ray Spectrometer (CLASS) is a remote X-ray Fluorescence experiment to map the lunar surface elemental abundances. With its large effective area and low energy threshold, CLASS generates the highest spatial resolution maps of all major rock-forming elements on the Moon, such as Mg, Al, Si, Ca, Ti, and Fe. Five years of operation in lunar orbit has resulted in global coverage. With several lunar missions planned for this decade for in situ exploration and sample returns, the 155 km geochemical maps from CLASS will serve as an important dataset. This article highlights the scientific results of CLASS in the last five years and discusses its potential applications. Indian Academy of Sciences 2025. -
Classic Models, Modern Threats: A Study on Adversarial Attack and Defense for Traditional ML Models
Adversarial attacks are a serious threat to machine learning models, both for conventional architectures, like neural networks, and for more sophisticated frameworks, like Vision Transformers (ViTs). Although a lot of work has been done to defend state-of-the-art deep learning models against attacks like Fast Gradient Sign Method (FGSM), Projected Gradient Descent (PGD), and Gaussian noise perturbations, classical machine learning models like logistic regression, support vector machines (SVMs), and decision trees are relatively less explored despite their extensive use in situations where low computational complexity and high interpretability are needed. This work presents a rigorous evaluation of the adversarial vulnerability of binary and other classical models on the MNIST dataset and explores the effectiveness of various defense mechanisms, including adversarial training, input pre-processing (Gaussian smoothing), and defensive distillation. Experiments demonstrate that adversarial training is the most effective defense that improves model robustness with classification accuracies of up to 96% in all attack scenarios. In contrast, defensive distillation and input preprocessing make modest gains, with accuracy levels ranging from 61 to 81% based on the nature of the attack. Through adversarial threat analysis of typical machine learning models, this work points out their inherent susceptibility to adversarial perturbations and introduces robust defense techniques. These results identify the necessity for robust security and reaffirm the practical viability of typical models in the scenario of resource-constrained environments, contributing towards a more complete picture of adversarial defenses for the entire spectrum of machine learning architectures. The Author(s), under exclusive license to Springer Nature Switzerland AG 2026. -
Classification Algorithms Used in the Study of EEG-Based Epileptic Seizure Detection
Epilepsy is a neurological illness that has become more frequent around the world. Nearly 80% of epileptic seizure sufferers live in low- and middle-income nations. In persons with encephalopathy, the risk of dying prematurely is three times higher than in the general population. Three-quarters of people with brain illnesses in low-income countries do not receive the treatment they require. Recurrent seizures are a symptom of epilepsy, characterized by strange bursts of excess energy in mind. Experts agree that most people diagnosed with epilepsy may be managed successfully, provided the episodes are discovered early on. As a result, machine learning plays an essential role in seizure detection and diagnosis. Support Vector Machine(SVM), Extreme Gradient Boosting(Xgboost), Decision Tree Classifier, Linear Discriminant Analysis(LDA), Perceptron, Naive Bayes Classifier, k-Nearest Neighbor(k-NN), and Logistic Regression are eight of the most widely used machine learning classification algorithms used to classify EEG based mostly Epileptic Seizures. Almost all classifiers, according to the study, give an efficient process. Despite this, the results show that SVM is the most effective method for detecting epileptic seizures, with a 96.84% accuracy rate. For diagnosing Epileptic Seizures using EEG signals, the perceptron model has a lower accuracy of 76.21% percent. 2021 IEEE. -
Classification and analysis of Alzheimer's Disease using Deep Learning methods on MRI and PET
Alzheimer's disease (AD) falls in the category of neurodegenerative illness in which an individual loses his or her power to remember things and behaviors. It affects memory in younger patients and as it progresses causes diffuse cortical functions. However, a major issue with the diagnosis and treatment of AD symptoms is that it has complex pathogenesis because of which there is no clinical intervention for its treatment. There is no disease-modifying treatment to cure AD symptoms that increases co-morbidities among the patients. The present research identified this gap and focuses on using Deep Learning methods on MRI and PET data so that there is early diagnosis of AD by healthcare experts and they could propose a better treatment process for reducing AD symptoms. The present research identified that by using deep learning-based approaches particularly ResNet50 architecture, there is the execution of quantitative assessment of brain MRI and PET to acquire insights about the internal abnormalities through self-learning features. It will help in initiating proper treatment and avoiding damage to the brain further. 2022 IEEE. -
Classification and characterization using HCT/HFOSC spectra of carbon stars selected from the HES survey
We present results from the analysis of 88 carbon stars selected from Hamburg/ESO (HES) survey using low-resolution spectra (R ?1330 & 2190). The spectra were obtained with the Himalayan Faint Object Spectrograph Camera (HFOSC) attached to the 2-m Himalayan Chandra Telescope (HCT). Using well-defined spectral criteria based on the strength of carbon molecular bands, the stars are classified into different groups. In our sample, we have identified 53 CH stars, four C-R stars, and two C-N type stars. Twenty-nine stars could not be classified due to the absence of prominent C2 molecular bands in their spectra. We could derive the atmospheric parameters for 36 stars. The surface temperature was determined using photometric calibrations and synthesis of the H-alpha line profile. The surface gravity log g estimates are obtained using parallax estimates from the Gaia DR3 database whenever possible. Microturbulent velocity (?) was derived using calibration equation of log g & ? . We could determine metallicity for 48 objects from near-infrared Ca II triplet features using calibration equations. The derived metallicity ranges from ?0.43 ? [Fe/H] ? ?3.49. Nineteen objects were found to be metal-poor ([Fe/H] ? ?1), 14 very metal-poor ([Fe/H] ? ?2), and five extremely metal-poor ([Fe/H] ? ?3.0) stars. Eleven objects were found to have a metallicity in the range ?0.43 ? [Fe/H] ? ?0.97. We could derive the carbon abundance for 25 objects using the spectrum synthesis calculation of the C2 band around 5165 The most metal-poor objects found will make important targets for follow-up detailed chemical composition studies based on high-resolution spectroscopy, and are likely to provide insight into the Galactic chemical evolution. 2024, The Author(s), under exclusive licence to Springer Nature B.V. -
Classification and correlational analysis on lower spine parameters using data mining techniques
The application of data mining in the field of medical science is slowly gaining popularity. This is due to the fact that enormous statistical inferences from data related to the human body and medicine was a possible with high accuracy rates which was a tedious task in the past. This had led to discoveries and breakthroughs which has saved thousands of lives. Lower back pain is one of the most common issues faced by majority of the population throughout the world. The early detection and treatment of LBP can avoid life threatening issues in the body. Objective: This study aims to create a classification model which can be used to detect an unhealthy spine using the lumbar and sacral parameters. Correlational analysis was performed between different attributes to find distinguishing factors between healthy and unhealthy spine. Method: Classification methods were used such as decision tree and SVM. Correlational analysis was performed using pearson method between each attribute. Results: After creating the model using the different classification methods it was found that Ctree produced the highest accuracy with 92.80% on average. It was also found that there were 6 attribute pairs that had high correlation coefficient to distinguish unhealthy and healthy spine observations. BEIESP. -
Classification Framework for Fraud Detection Using Hidden Markov Model
Machine learning is described as a computer program that learns from experience E with regard to some task T and some performance measure P, if its performance on T improves with E as measured by P. Suppose we have a credit card fraud detection which watches which transactions we mark as fraud or not, and on the basis, it knows how to filter better fraudulent transactions then, E is watching your transactions is fraud or not, T is classifying your transactions as fraud or not, P is number of transactions correctly differentiated as spam or not spam. Machine learning has two types: supervised learning and unsupervised learning. Supervised learning is the type of machine learning where machine is provided with input mapped with its output, and these inputs and outputs are used to make a machine learn a particular function from the trained dataset. There are two branches of supervised learning, i.e., classification and regression. In unsupervised learning, we do not supervise model instead we allow machine to work on its own to discover information. Clustering is type of unsupervised learning. 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. -
Classification of a New-Born Infant's Jaundice Symptoms Using a Binary Spring Search Algorithm with Machine Learning
A yellowing of the skin and eyes, called jaundice, is the consequence of an abnormally high bilirubin concentration in the blood. All across the world, both newborns and adults are afflicted by this illness. Jaundice is common in new-borns because their undeveloped livers have an imbalanced metabolic rate. Kernicterus is caused by a delay in detecting jaundice in a newborn, which can lead to other complications. The degree to which a newborn is affected by jaundice depends in large part on the mitotic count. Nonetheless, a promising tool is early diagnosis using AI-based applications. It is straightforward to implement, does not require any special skills, and comes at a minimal cost. The demand for AI in healthcare has led to the realisation that it may have practical applications in the medical industry. Using a deep learning algorithm, we created a method to categorise jaundice cases. In this study, we suggest using the binary spring search procedure (BSSA) to identify features and the XGBoost classifier to grade histopathology images automatically for mitotic activity. This investigation employs real-time and benchmark datasets, in addition to targeted methods, for identifying jaundice in infants. Evidence suggests that feature quality can have a negative effect on classification accuracy. Furthermore, a bottleneck in classification performance may emerge from compressing the classification approach for unique key attributes. Therefore, it is necessary to discover relevant features to use in classifier training. This can be achieved by integrating a feature selection strategy with a classification classical. Important findings from this study included the use of image processing methods in predicting neonatal hyperbilirubinemia. Image processing involves converting photos from analogue to digital form in order to edit them. Medical image processing aims to acquire data that can be used in the detection, diagnosis, monitoring, and treatment of disease. Newburn jaundice detection accuracy can be verified using image datasets. As opposed to more traditional methods, it produces more precise, timely, and cost-effective outcomes. Common performance metrics such as accuracy, sensitivity, and specificity were also predictive. 2023 Lavoisier. All rights reserved. -
Classification of adaptive back propagation neural network along with fuzzy logic in chronic kidney disease
A steady deterioration in kidney function over months or years is known as chronic kidney disease (CKD). Through a range of techniques, such as pharmacological intervention in moderate cases and hemodialysis and renal transport in severe cases, early identification of CKD is crucial and has a substantial influence on reducing the patient's health development. The outcomes show the patient's kidneys' present state. It is suggested to develop a system for detecting chronic renal disease using machine learning. Finding the best feature sets typically involves using metaheuristic algorithms since feature selection is an NP-hard issue with amorphous polynomials. Semi-crystalline tabu search (TS) is frequently used for both local and global searches. In this study, we employ a brand-new hybrid TS with stochastic diffusion search (SDX)-based feature selection. The adaptive backpropagation neural network (ABPNN-ANFIS) is then classified using fuzzy logic. Fuzzy logic may be used to combine the ABPNN findings. Consequently, these techniques can aid experts in determining the stage of chronic renal disease. The Adaptive Neuron Clearing Inference System (ABPNN-ANFIS) was utilised to develop adaptive inverse neural networks using the MATLAB programme. The outcomes demonstrate that the suggested ABPNN-ANFIS is 98 % accurate in terms of efficiency. 2024 -
Classification of Breast Invasive Ductal Carcinomas Using Histopathological Images Based on Deep Learning Techniques
Women suffer from cancer, which is the main reason for death for females around the world. With the use of artificial intelligence, it is possible to predict and detect all types of cancers in the near future. It is not just women who can heal, and most breast cancers are caused by the most vulnerable type of breast. Eighty percent of all diagnoses of carcinoma are invasive ductal carcinomas (IDCs). In this paper, deep learning techniques are extended to support visible semantic evaluation of tumor areas, using convolutional neural networks (CNNs).A CNN is skilled ended a large number of photo covers (tissue areas) after Whole Slide Images (WSI) to study ranked part-based total image. About 600 normal image patches and 200 breast invasive ductal carcinomas are selected for the experiment. It was intended to amount classifier correctness in the detection of IDC tissue areas in Whole Slide Images. We achieved excellent measurable outcomes for an automated finding of IDC areas with our technique. The results are evaluated based on performance measures and compared with a different number of neurons, and the results are highlighted. 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. -
Classification of countries based on development indices by using K-means and grey relational analysis
Clustering countries based on their development profile is important, as it helps in the efficient allocation and use of resources for institutions like the World Bank, IMF and many others. However, measuring the status of development in each country is challenging, as development encompasses several facets such as economic, social, environmental and institutional aspects. These dimensions should be captured and aggregated appropriately before attempting to classify countries based on development. In this context, this paper attempts to measure various dimensions of development through four indices namely, Economic Index (EI), Social Index (SI), Sustainability Index (SUI) and Institutional Index (II) for the period between 1996 through 2015 for 102 countries. And then we categorize the countries based on these development indices using the grey relational analysis and K-means clustering method. Our study classifies countries into four clusters with twelve countries in the first cluster, fifty in second, twenty-seven and thirteen countries in third and fourth clusters respectively. Having taken each of the dimensions of development independently, our results show that no cluster has performed poorly in all four aspects. 2021, The Author(s), under exclusive licence to Springer Nature B.V. -
Classification of Disaster Tweets using Machine Learning and Deep Learning Techniques
Social networks provide a plethora of information for gathering extra data on people's behavior, trends, opinions, and feelings during human-affecting occurrences, such as natural catastrophes. Twitter is an inevitable communication medium during calamities. People mainly depend on Twitter to announce real-time emergencies. However, it is rarely straightforward if someone is declaring a tragedy. Sentiment analysis of disaster tweets aid in situational awareness and realizing the disaster dynamics. In our paper, we perform a sentimental analysis of disaster tweets using techniques based on machine learning and deep learning. The tweets are pre-processed before being converted into a structured form using Natural Language Processing (NLP) methods. Supervised learning techniques such as the Support Vector Machine and the Naive Bayes Classifier algorithm are used to develop the Classifier, which categorizes tweets into distinct catastrophes and selects the most appropriate algorithm. The chosen algorithm is further enriched with an emoticon detection algorithm for explicit elucidation. Our research would help disaster relief organizations and news agencies to conclude about the state of affairs and do the needful. 2022 IEEE. -
Classification of Diseased Leaves in Plants Using Convolutional Neural Networks
The article focuses on the classification of diseased leaves using a machine learning algorithm. The main focus in agriculture is controlling pests and weeds, for which farmers spray chemical pesticides to get a good yield. The issue here is over-usage and under-usage of pesticides, which might harm the end consumer. To achieve the goal of reducing pesticide use and detecting pests in the crop early, the machine learning algorithm is deployed on the leaf image. The image data of the leaf of the cauliflower plant is collected for 40days. The data was collected from the day the plant was seeded in a pot until the day it was ready to be planted in the soil. From this data, the pest attack on the plants is tracked without the application of pesticides. To achieve this, the CNN algorithm is used on the collected image data. The outcome of the study would be to classify the diseased leaves based on the pest attack and know the right time to spray the pesticides to reduce the damage to the plant. This also reduces the use of pesticides and costs to the farmer. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
Classification of epileptic seizures using wavelet packet log energy and norm entropies with recurrent Elman neural network classifier
Electroencephalogram shortly termed as EEG is considered as the fundamental segment for the assessment of the neural activities in the brain. In cognitive neuroscience domain, EEG-based assessment method is found to be superior due to its non-invasive ability to detect deep brain structure while exhibiting superior spatial resolutions. Especially for studying the neurodynamic behavior of epileptic seizures, EEG recordings reflect the neuronal activity of the brain and thus provide required clinical diagnostic information for the neurologist. This specific proposed study makes use of wavelet packet based log and norm entropies with a recurrent Elman neural network (REN) for the automated detection of epileptic seizures. Three conditions, normal, pre-ictal and epileptic EEG recordings were considered for the proposed study. An adaptive Weiner filter was initially applied to remove the power line noise of 50Hz from raw EEG recordings. Raw EEGs were segmented into 1s patterns to ensure stationarity of the signal. Then wavelet packet using Haar wavelet with a five level decomposition was introduced and two entropies, log and norm were estimated and were applied to REN classifier to perform binary classification. The non-linear Wilcoxon statistical test was applied to observe the variation in the features under these conditions. The effect of log energy entropy (without wavelets) was also studied. It was found from the simulation results that the wavelet packet log entropy with REN classifier yielded a classification accuracy of 99.70% for normal-pre-ictal, 99.70% for normal-epileptic and 99.85% for pre-ictal-epileptic. 2016, Springer Science+Business Media Dordrecht. -
Classification of fibroid using novel fully connected CNN with back propagation classifier (NFCCNNBP)
In this phase, we utilize features extracted from a prior stage to classify uterine fibroids. We employ a predefined dataset with feature values as our training set for a novel classifier called the "Novel Fully Connected CNN with Back Propagation Classifier."This classifier learns from the training set. We then put this method to the test with new images not included in the training dataset. Its primary objective is to assess the extent of infection across the entire uterine surface. Through the adoption of a Convolutional Neural Network (CNN) combined with Back Propagation (BP), we have achieved an impressive accuracy rate of 98.3% for predictions. When we compare this accuracy to existing classifiers like Fuzzy Logic, Naive Bayes, and SVM, our proposed model, NFCCNNBP, outperforms them significantly. 2024 Author(s).