Browse Items (9795 total)
Sort by:
-
Recent advances in the development, design and mechanism of negative electrodes for asymmetric supercapacitor applications
Continuous technical advancements in a variety of industries, such as portable electronics, transportation, green energy, are frequently hampered by the inadequacy of energy-storage technologies. Asymmetric supercapacitors can expand their operating voltage window past the thermodynamic breakdown voltage of electrolytes by utilizing two distinct electrode materials, providing a workaround for the symmetric supercapacitors energy storage constraints. This evaluation offers a thorough understanding of this area. To comprehend the extensive research done in this field, we first examine the fundamental energy-storage mechanisms and performance evaluation standards for asymmetric supercapacitors. The most recent developments in the design and manufacture of electrode materials as well as the general structure of asymmetric supercapacitors. We have also discussed a number of significant scientific issues and offer our opinions on how to improve the electrochemical properties of future asymmetric energy storage devices. First, methods for designing high-performance electrode materials for supercapacitors must be developed; next, controllably built supercapacitor types must be attained (such as symmetric capacitors including double-layer and pseudocapacitors, asymmetric capacitors, and Li-ion capacitors). This review is timely because of the rapid expansion of research in this area. It summarizes recent developments in the study and creation of high-performance electrode materials with high supercapacitors. A number of crucial topics for enhancing the energy density of supercapacitors are examined, along with some reciprocal correlations between the main impacting parameters. Difficulties and prospects in this fascinating field are also covered. This offers a fundamental understanding of supercapacitors and serves as a crucial design rule for enhanced next-generation supercapacitors that will be used in both industrial and consumer applications. In this context, we extensively reviewed the classification of supercapacitor, EDLC (activated carbon, carbon aerogel, carbon nanotube), Pseudocapacitors, conducting polymers, metal oxides, hybrid materials, composite hybrids, rechargeable batteries, asymmetric devices and its design, aqueous solid state, fiber based asymmetric device, graphene based asymmetric device, terminologies used during the electrode selection, positive and negative electrodes in asymmetric device, material used for fabrication of negative electrodes, electrochemical performance of various devices which are fabricated by different electrode materials. Performance of material for various asymmetric device applications, conclusions outlook, recent developments in asymmetric devices. The current review may offer a thorough understanding and future prospects for developing negative electrodes to enhance asymmetric supercapacitor performance. 2023 Taylor & Francis Group, LLC. -
Extrinsic pseudocapacitance: Tapering the borderline between pseudocapacitive and battery type electrode materials for energy storage applications
Extrinsic pseudocapacitance, which can also be referred to as induced pseudocapacitance, is, at present, one of the most widely explored fields in energy storage. Extrinsic pseudocapacitive mechanism can be imparted to an otherwise diffusion-controlled faradaic energy storage material by external methods like size engineering, compositional modification, doping, anion intercalation, and morphological modifications. As a significant mechanism that plays a borderline role between battery-type and pseudocapacitive nature of energy storage, extrinsic pseudocapacitance tends to narrow down the boundary between these conventionally diverse systems, which in turn would contribute a lot to the development of hybrid energy storage technologies. For effective utilization in upcoming energy storage technologies, a critical analysis on the effect of this mechanism on reported devices shall turn into a valid account. This review gives a detailed insight into extrinsic pseudocapacitance, its significance, and recently reported materials, methods, and devices. The future outlook and challenges in transforming extrinsic pseudocapacitive mechanisms into a promising strategy for next-generation energy storage devices are also discussed. 2023 Elsevier Ltd -
A Comprehensive Review on the Antimicrobial and Photocatalytic Properties of Green Synthesized Silver Nanoparticles
With the advancement of technology, there is a growing demand for new nanoparticles that are viable, eco-friendly, non-toxic, and non-hazardous, as well as having unique chemical and physical properties. Silver nanoparticles are currently promising for antibacterial, antimicrobial, and photocatalytic applications. Because of their toxicity, nanosilver particles are now widely used in various applications, including cosmetics, clothing, sunscreen, medicinal, sensing, antibacterial, antimicrobial, and photocatalytic. The importance of plant extracts in the synthesis of AgNPs is emphasized. The various mechanisms and characterization techniques used in the study of silver nanoparticles will also be covered. This review also discusses the role of green synthesized AgNPs in antimicrobial and photocatalytic applications, which adds to our understanding of improving health, and the environment and preventing contagious diseases. 2022 by the authors. -
Biopolymers as promising vehicles for drug delivery to the brain
The brain is a privileged organ, tightly guarded by a network of endothelial cells, pericytes, and glial cells called the blood brain barrier. This barrier facilitates tight regulation of the transport of molecules, ions, and cells from the blood to the brain. While this feature ensures protection to the brain, it also presents a challenge for drug delivery for brain diseases. It is, therefore, crucial to identify molecules and/or vehicles that carry drugs, cross the blood brain barrier, and reach targets within the central nervous system. Biopolymers are large polymeric molecules obtained from biological sources. In comparison with synthetic polymers, biopolymers are structurally more complex and their 3D architecture makes them biologically active. Researchers are therefore investigating biopolymers as safe and efficient carriers of brain-targeted therapeutic agents. In this article, we bring together various approaches toward achieving this objective with a note on the prospects for biopolymer-based neurotherapeutic/neurorestorative/neuroprotective interventions. Finally, as a representative paradigm, we discuss the potential use of nanocarrier biopolymers in targeting protein aggregation diseases. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Greener Assembly of Nano Catalysts and Sustainable Applications of Magnetically Retrievable and Plasmonic Nano Catalysts
Since ages, catalysts have played a pivotal role in accelerating the production and lowering the cost of a plethora of industrially important commodities. The latest in the scenario are nanocatalysts, which offer a wide array of advantages ranging from improved reaction rates to higher rates of recyclability. However, factors such as stability and support systems must be fine-tuned to achieve maximum efficiency. In accordance with the principle of sustainability, green synthesis methods have propelled the development of a range of nanocatalysts that can be applied in various domains, such as the food industry and biofuel production. Simultaneously, heterogeneous catalysis is gaining more attention globally, primarily due to the ease of recoverability of the nanocatalysts and in this context, magnetically retrievable nanocatalysts are indeed a boon for the green synthesis and sustainable production. Nanocomposites combining plasmonic and catalytic components with noble metal nanoparticles (Au and Ag) and doped semiconductor nanostructures have gained interest in recent years owing to their utility in multiple sectors by virtue of their ability to convert sunlight to chemical energy. The current review describes some methods for the synthesis of such nanocatalysts and their applications in diverse domains. Graphical Abstract: (Figure presented.) The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. -
Bioactive compounds from Cordyceps and their therapeutic potential
The Clavicipitaceae familys largest and most diverse genus is Cordyceps. They are most abundant and diverse in humid temperate and tropical forests and have a wide distribution in: Europe, North America, and East and Southeast Asian countries, particularly: Bhutan, China, Japan, Nepal, Korea, Thailand, Vietnam, Tibet, and the Himalayan region of India, and Sikkim. It is a well-known parasitic fungus that feeds on insects and other arthropods belonging to 10 different orders. Over 200 bioactive metabolites, that include: nucleotides and nucleosides, polysaccharides, proteins, polypeptides, amino acids, sterols, and fatty acids, among others have been extracted from Cordyceps spp. demonstrating the phytochemical richness of this genus. These components have been associated with a variety of pharmacological effects, including: anti-microbial, anti-apoptotic, anti-cancer, anti-inflammatory, antioxidant, and immunomodulatory activities. In this paper, the bioactivity of various classes of metabolites produced by Cordyceps spp., and their therapeutic properties have been reviewed in an attempt to update the existing literature. Furthermore, one of its nucleoside and a key bioactive compound, cordycepin has been critically elaborated with regard to its biosynthesis pathway and the recently proposed protector-protmechanism as well as various biological and pharmacological effects, such as: suppression of purine and nucleic acid biosynthesis, induction of apoptosis, and cell cycle regulation with their mechanism of action. This review provides current knowledge on the bioactive potential of Cordyceps spp. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Anthocyanin Production from Plant Cell and Organ Cultures In Vitro
Anthocyanins are water-soluble pigments found in plants. They exist in various colors, including red, purple, and blue, and are utilized as natural colorants in the food and cosmetics industries. The pharmaceutical industry uses anthocyanins as therapeutic compounds because they have several medicinal qualities, including anti-obesity, anti-cancer, antidiabetic, neuroprotective, and cardioprotective effects. Anthocyanins are conventionally procured from colored fruits and vegetables and are utilized in the food, pharmaceutical, and cosmetic industries. However, the composition and concentration of anthocyanins from natural sources vary quantitively and qualitatively; therefore, plant cell and organ cultures have been explored for many decades to understand the production of these valuable compounds. A great deal of research has been carried out on plant cell cultures using varied methods, such as the selection of suitable cell lines, medium optimization, optimization culture conditions, precursor feeding, and elicitation for the production of anthocyanin pigments. In addition, metabolic engineering technologies have been applied for the hyperaccumulation of these compounds in varied plants, including tobacco and arabidopsis. In this review, we describe various strategies applied in plant cell and organ cultures for the production of anthocyanins. 2023 by the authors. -
Bioreactor configurations for adventitious root culture: recent advances toward the commercial production of specialized metabolites
In vitro plant cell and organ cultures are appealing alternatives to traditional methods of producing valuable specialized metabolites for use as: pharmaceuticals, food additives, cosmetics, perfumes, and agricultural chemicals. Cell cultures have been adopted for the production of specialized metabolites in certain plants. However, in certain other systems, adventitious roots are superior to cell suspension cultures as they are organized structures that accumulate high levels of specialized metabolites. The cultivation of adventitious roots has been investigated in various bioreactor systems, including: mechanically agitated, pneumatically agitated, and modified bioreactors. The main relevance and importance of this work are to develop a long-lasting industrial biotechnological technology as well as to improve the synthesis of these metabolites from the plant in vitro systems. These challenges are exacerbated by: the peculiarities of plant cell metabolism, the complexity of specialized metabolite pathways, the proper selection of bioreactor systems, and bioprocess optimization. This reviews major objective is to analyze several bioreactor types for the development of adventitious roots, as well as the advantages and disadvantages of each type of bioreactor, and to describe the strategies used to increase the synthesis of specialized metabolites. This review also emphasizes current advancements in the field, and successful instances of scaled-up cultures and the generation of specialized metabolites for commercial purposes are also covered. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Origin, ecotoxicity, and analytical methods for microplastic detection in aquatic systems
Over the decades, interaction of microplastics with other pollutants in a dynamic environmental set up was observed to increase their toxic effects. This scenario is worse in aquatic environments due to the entry of huge loads of microplastic components into the waterbodies through direct plastic dumping and those delivered from effluents originating from various treatment plants. Although extensive research was done to understand the issue associated with microplastic contamination of various aquatic environments, a huge research gap still exists in areas like their ecotoxicology, fate, distribution, and detection methods in aquatic environments. Moreover, the combined deleterious effect of microplastics in association with other environmental pollutants is not widely studied and requires more research focus. The major scope of this review is to present a comprehensive outlook on the recent studies carried out to understand the types, origin, distribution, transport, fate, and toxicity of microplastics in aquatic environments, both fresh water and marine. The review summarizes the ecotoxicological effects of microplastic contaminants in aquatic environment like the oxidative damage, neurotoxicity and decreased reproductive potential. An in-depth discussion regarding the ability of the microplastics in combination with other pollutants to serve as potentially hazardous agents in aquatic environment is also elaborated in the review. Further a summary on various microplastic detection methods, challenges associated with microplastic detection and management is carefully reviewed and compiled in this work. The need for proper awareness programs to general public highlighting the toxicity of microplastics and strict regulations regarding their continuous assessment and management in waterbodies are essential factors in controlling their adverse effect on aquatic environment. 2023 Elsevier B.V. -
Review on the fish collagen-based scaffolds in wound healing and tissue engineering
Collagen from marine organisms is an emerging source in tissue engineering, an alternative to bovine and porcine collagen. Despite the positive results on wound healing from fish collagen scaffolds, the comprehension and advancements in its properties are limited. Given this context, this study aimed to carry out a systematic review to examine the effects of collagen scaffolds on different models of experimental skin wounds, the advantages and its limitations. The search was conducted according to the orientations of Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) and the MeSH (Medical Subject Healings) terms used were Fish Collagen AND Wound Healing AND Scaffold. 36 articles in total were sorted out from the databases of Google Scholar and PubMed. After the analysis, the current review covers 10 articles from the beginning of 2017 to March 2023. The results are mainly focused on the different methods of collagen extraction, preparation of scaffolds and its treatment on the animal model along with its effects. To infer, this current review states that, despite the positive effects of collagen on tissue repair and regeneration, no product is available for medical purposes. Thus, this review also demonstrates the huge potential for collagen in tissue engineering. 2024 Visagaa Publishing House. -
Production of biomass and bioactive compounds from cell and organ cultures of ginseng, He-shou-wu, purple coneflower, and St. John's wort for the use in cosmetic industry
Plants and their products have been utilized as raw materials in the preparation of cosmetics for millennia. Currently, research is being done to find new plant materials that may be used as ingredients in cosmetic preparations, including body sprays, shampoos, conditioners, hair dyes/sprays, and other cosmetics. The plants that are used in the preparation of cosmetic products are usually procured from nature, however, the quality and quantity of bioactive ingredients present in the biomass vary based on the species, environment, and geographical locations from where the material has been procured. In addition, procurement of plant material from natural resources may lead to a shortage of material and even endanger the status of rare plants in the natural environment. Therefore, there is increased interest in the use of plant cell, tissue, and organ cultures (PCTOC) for the production of raw materials and bioactive specialized metabolites. There is also scope for increasing the accumulation of biomass and bioactive compounds in PCTOC by adopting various strategies such as optimization of culture medium, culture environment, elicitation, and other bioprocess methods. Furthermore, PCTOC-produced raw materials are free from contaminants, pesticides, and heavy metals and an important benefit of producing biomass in vitro is that it is easily accepted by regulatory authorities and consumers. In the current review, we describe the bioactive compounds of ginseng, purple coneflower, He-shou-wu, and St. John's wort which have cosmetological importance. Additionally, we elucidate the PCTOC method adopted for the production of biomass and bioactive compounds in these plants. 2023 SAAB -
Prevalence of Cardiovascular Diseases in South Asians: Scrutinizing Traditional Risk Factors and Newly Recognized Risk Factors Sarcopenia and Osteopenia/Osteoporosis
One of the primary reasons for complications and death worldwide are cardiovascular diseases (CVDs), with a death toll of approximately 18 million per year. CVDs include cardiomyopathy, hypertension, ischemic heart disease, coronary heart disease, myocardial infarction, heart attack, hearth failure, etc. Over 80% of the CVD mortality is recorded from lower and middle-income countries. Records from the past decade have highlighted the increase of CVDs among the South Asian populations, and the prime purpose of the review is to jot down the reasons for the steep spike in CVDs. Studies analyzing the causative factors for the increase of CVDs in South Asians are still to be verified. Apart from known predisposing and lifestyle factors, other emerging risk factors associated with CVDs, namely the musculoskeletal diseases sarcopenia and osteopenia, should be tracked to tackle research gaps in upcoming analyses. This requires loads of scientific efforts. With proper monitoring, the raising alarm that the CVD burden generates can be reduced. This review discusses the already established signs and recognizes important clues to the emerging etiology of CVDs in the Asian population and prevention measures to keep it at bay. 2023 Elsevier Inc. -
Excited state intramolecular proton transfer dual emission Schiff bases for metal detection and cell imaging
Fluorescent probes incorporating the excited-state intramolecular proton transfer (ESIPT) phenomenon have emerged as versatile tools in scientific research. These probes exhibit dual emission, resulting from the unique transfer of a proton within the molecule upon excitation. This property makes ESIPT-based Schiff bases highly attractive for metal detection, cell imaging, and sensing biologically important molecules. In metal detection, the spectral changes of ESIPT-based Schiff bases upon interaction with metal ions enable the development of sensitive and selective sensors. For cell imaging, their photophysical properties make them ideal for labeling cellular components and facilitating multicolor imaging. In sensing biomolecules, ESIPT-based Schiff bases offer selective detection of interactions and enzymatic activities. Integration of these probes holds great promise for applications in environmental monitoring, biomedical research, and healthcare. This review focuses on the photoluminescent properties and application of ESIPT dual emission Schiff bases for sensing of metal ions, biologically relevant molecules and cell imaging. 2023 Taylor & Francis Group, LLC. -
Carbon Dot-Based Fluorescence Resonance Energy Transfer (FRET) Systems for Biomedical, Sensing, and Imaging Applications
Carbon dots (CDs) emerge as a potential group of photo-luminescent nano-materials due to their excellent optical, electrical, and chemical properties, as well as their competence in a wide range of environmental applications. CDs have unique and appealing properties such as excellent stability, low toxicity, water solubility, and derivability. When coupled with CDs, fluorescence resonance energy transfer (FRET) results in the development of highly sensitive ratiometric fluorescence sensor probes with potential applications in bio-imaging, metal sensing, membrane dynamics, and environmental sensing. In this review, the progress and recent developments in CDs based FRET systems utilized for various environmental applications are conferred. An in-depth description is provided regarding the numerous donor/acceptor systems which when integrated with CDs generate efficient FRET systems. The review enables researchers to identify and develop specific systems which can be utilized to generate a FRET pair with potential physicochemical properties that aid the development of the same for various applications. 2023 Wiley-VCH GmbH. -
Production of specialized metabolites in plant cell and organo-cultures: the role of gamma radiation in eliciting secondary metabolism
Purpose: To provide an updated summary of recent advances in the application of gamma irradiation to elicit secondary metabolism and for induction of mutations in plant cell and organ cultures for the production of industrially important specialized metabolites (SMs). Conclusions: Research on the application of gamma radiation with plants has contributed a lot to microbial decontamination of seeds, and the promotion of physiological processes such as seed germination, seedling vigor, plant growth, and development. Various studies have demonstrated the influence of gamma rays on the morphology, physiology, and biochemistry of plants. Recent research efforts have also shown that low-dose gamma (5100 Gy) irradiation can be utilized as an expedient solution to alleviate the deleterious effect of abiotic stresses and to obtain better yields of plants. Inducing mutagenesis using gamma irradiation has also evolved as a better option for inducing genetic variability in crops, vegetables, medicinal and ornamentals for their genetic improvement. Plant SMs are gaining increasing importance as pharmaceutical, therapeutic, cosmetic, and agricultural products. Plant cell, tissue, and organ cultures represent an attractive alternative to conventional methods of procuring useful SMs. Among the varied approaches the elicitor-induced in vitro culture techniques are considered an efficient tool for studying and improving the production of SMs. This review focuses on the utilization of low-dose gamma irradiation in the production of high-value SMs such as phenolics, terpenoids, and alkaloids. Furthermore, we present varied successful examples of gamma-ray-induced mutations in the production of SMs. Copyright 2024 Taylor & Francis Group LLC. -
A Prompt Study on Recent Advances in the Development Of Colorimetric and Fluorescent Chemosensors for Nanomolar Detection of Biologically Important Analytes
Fluorescent and colorimetric chemosensors for selective detection of various biologically important analytes have been widely applied in different areas such as biology, physiology, pharmacology, and environmental sciences. The research area based on fluorescent chemosensors has been in existence for about 150years with the development of large number of fluorescent chemosensors for selective detection of cations as metal ions, anions, reactive species, neutral molecules and different gases etc. Despite the progress made in this field, several problems and challenges still exist. The most important part of sensing is limit of detection (LOD) which is the lowest concentration that can be measured (detected) with statistical significance by means of a given analytical procedure. Although there are so many reports available for detection of millimolar to micromolar range but the development of chemosensors for the detection of analytes in nanomolar range is still a challenging task. Therefore, in our current review we have focused the history and a general overview of the development in the research of fluorescent sensors for selective detection of various analytes at nanomolar level only. The basic principles involved in the design of chemosensors for specific analytes, binding mode, photophysical properties and various directions are also covered here. Summary of physiochemical properties, mechanistic view and type of different chemosensors has been demonstrated concisely in the tabular forms. Graphical Abstract: In our current review we have focused the history and a general overview of the development in the research of fluorescent sensors for selective detection of various analytes at nanomolar level only. [Figure not available: see fulltext.] 2024, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Exploring the Relationship between Environmental Cognition, Pro-Environmental Behavior, and Mental Health among Adolescents: A Narrative Review
Introduction: Adolescents cognition, behavior, and attitudes are essential for environmental conservation; hence, the physical environment is inevitable in their mental health. The environment can influence adolescents sense of support, freedom, and the stimulation they seek in life. Environmental factors such as pollution, weather, lifestyle changes, and working conditions significantly influence adolescents' mental health. Knowing and learning about environmental cognition and its influence on adolescents is vital. Objective: To understand the relationship between environmental cognition, pro-environmental behavior, and mental health among adolescents with the help of a narrative approach. Methods: The present article employed a narrative review. Research articles were taken from four databases, PubMed, Research Gate, Web of Science, and Science Direct, using the PRISMA procedure from 2000 to 2023. The data was collected from various databases and narrowed down for the results. Results: This study proves a strong relationship between environmental cognition, pro-environmental behavior, and adolescents' mental health. Twenty-six selected research studies out of 45 initial studies state that solid environmental cognition may lead to enhanced pro-environmental behavior, which is crucial to adolescents mental health and well-being. Furthermore, pro-environmental cognition wholly mediated the relationship between environmental behavior and mental well-being. Conclusion: Implications of this study concentrate on developing focused interventions, creating urban planning policies, and developing adolescent-friendly community designs, which are solid pillars for promoting mental health. Adolescents must be motivated to protect the environment to become pioneers of pro-environmental behavior. The Author(s). 2024 Open Access. -
Artificial intelligence for diabetic retinopathy detection: A systematic review
The incidence of diabetic retinopathy (DR) has increased at a rapid pace in recent years all over the world. Diabetic eye illness is identified as one of the most common reasons for vision loss among people. To properly manage DR, there has been immense research and exploration of state-of-the-art methods using artificial intelligence (AI) enabled models. Specifically, AI-empowered models combine multiple machine learning (ML) and deep learning (DL) based algorithms to improve the performance of the developed system architectures that are commercially utilized for the detection of DR disease. However, these models still exhibit several limitations, such as computational complexity, low accuracy in DR stage detection due to class imbalance, more time consumption, and high maintenance cost. To overcome these limits, a more advanced model is required to accurately predict the DR stage in the initial stages. For example, the identification of DR disease in the initial stage helps the ophthalmologist to make an accurate and safe diagnosis, and thereby, eyesight-related issues may be treated more effectively. This study conducted a systematic literature review (SLR) to provide a detailed discussion of the background of diabetic retinopathy, its major causes, challenges faced by ophthalmologists in DR detection, and possible solutions for identifying DR in the initial stage. Also, the SLR provides an in-depth analysis of the existing state-of-the-art techniques and system models used in DR diagnosis based on AI, ML, and recently developed DL-based approaches. Furthermore, this present survey would be helpful for the research community to receive information on the recent approaches used for DR identification along with their significant challenges and limitations. 2024 The Authors -
Dolastatins and their analogues present a compelling landscape of potential natural and synthetic anticancer drug candidates
Human cancer remains a leading cause of global mortality. Traditional treatment methods, while effective are often associated with substantial side effects, high technical requirements, and considerable expenses. Recently, anticancer peptides, such as dolastatin-type peptides naturally found in marine mollusc Dolabella auricularia, have gained attention due to their enhanced characteristics and specific targeting of cancer cells with minimal toxicity to normal cells. This review aims to provide a comprehensive summary of the anticancer activities of natural dolastatins and synthetic analogues over the past 35 years, focusing on their utilization in advancing cancer treatment strategies. This updated review encompasses a detailed analysis of numerous studies demonstrating the cytotoxic effects of dolastatins and their synthetic analogues on various human tumour cell lines. The analysis includes investigations into their ability to activate apoptosis pathways, inhibit cell cycle progression, and indirectly limit inflammation and angiogenesis in tumours. Both natural dolastatins and synthetic analogues have demonstrated significant anticancer properties through a variety of mechanisms in vitro and in vivo pharmacological studies. Some have even advanced to clinical trials, either alone or in combination with other agents, and have shown promising outcomes. The biological activities of dolastatins and their synthetic analogues offer a promising path in the development of more effective and sustainable anticancer drugs. Their specific action on cancer cells and relative non-toxicity to normal cells highlight their potential as superior cancer therapeutic agents. The current study provides a platform for the most recent preclinical and clinical research on dolastatins and their analogues. Further research into these marine peptides may contribute to the development of sustainable and efficient treatment models for cancer, filling a significant gap in the current cancer therapeutic portfolio. 2023 The Authors -
Experience of psychic restructuring among refugees in the context of life in refuge
Changes in the inner voice, thoughts, and feelings due to the recurrent experiences in social and cultural reality are defined as psychic restructuring (PR). Any collective trauma can drastically change a persons psyche in multiple ways. The first argument of the study is that PR happens in individuals as a result of exile, which has manifold reasons. The second argument is that first-generation older adults crave for their homeland more intensely because of their subtle memories of the left behind. The third argument is that there are metaphorical representations of exilic experiences in the art forms that would depict their inexplicable quest for PR. Finally, it suggests the possibility of constructive PR in refugees with the aid of clinically driven and standardized art-based therapies (ABT). These arguments have multicollinearity in the context of PR, which still needs to be studied. The study tries to bridge the gap or lacuna in this research arena. 2023 The Association for Psychoanalytic Psychotherapy in the Public Sector.