Bioactive compounds from Cordyceps and their therapeutic potential

Title

Bioactive compounds from Cordyceps and their therapeutic potential

Creator

Krishna K.V.; Ulhas R.S.; Malaviya A.

Description

The Clavicipitaceae familys largest and most diverse genus is Cordyceps. They are most abundant and diverse in humid temperate and tropical forests and have a wide distribution in: Europe, North America, and East and Southeast Asian countries, particularly: Bhutan, China, Japan, Nepal, Korea, Thailand, Vietnam, Tibet, and the Himalayan region of India, and Sikkim. It is a well-known parasitic fungus that feeds on insects and other arthropods belonging to 10 different orders. Over 200 bioactive metabolites, that include: nucleotides and nucleosides, polysaccharides, proteins, polypeptides, amino acids, sterols, and fatty acids, among others have been extracted from Cordyceps spp. demonstrating the phytochemical richness of this genus. These components have been associated with a variety of pharmacological effects, including: anti-microbial, anti-apoptotic, anti-cancer, anti-inflammatory, antioxidant, and immunomodulatory activities. In this paper, the bioactivity of various classes of metabolites produced by Cordyceps spp., and their therapeutic properties have been reviewed in an attempt to update the existing literature. Furthermore, one of its nucleoside and a key bioactive compound, cordycepin has been critically elaborated with regard to its biosynthesis pathway and the recently proposed protector-protmechanism as well as various biological and pharmacological effects, such as: suppression of purine and nucleic acid biosynthesis, induction of apoptosis, and cell cycle regulation with their mechanism of action. This review provides current knowledge on the bioactive potential of Cordyceps spp. 2023 Informa UK Limited, trading as Taylor & Francis Group.

Source

Critical Reviews in Biotechnology, Vol-44, No. 5, pp. 753-773.

Date

2024-01-01

Publisher

Taylor and Francis Ltd.

Subject

Bioactive compounds; C. militaris; Cordycepin; Cordyceps sinesis; Himalayan viagra; Keeda Jadi

Coverage

Krishna K.V., Applied and Industrial Biotechnology Laboratory, Christ (Deemed-to-be University), Karnataka, Bangalore, India; Ulhas R.S., Institute of Biochemistry and Biophysics, Faculty of Life Sciences, University of Jena (Friedrich-Schiller-Universit Jena), Jena, Germany; Malaviya A., Applied and Industrial Biotechnology Laboratory, Christ (Deemed-to-be University), Karnataka, Bangalore, India, Division of Life Sciences, Gyeongsang National University, Gyeongsangnam-do, South Korea, QuaLife Biotech Pvt Ltd, Bangalore, India

Rights

Restricted Access

Relation

ISSN: 7388551; PubMed ID: 37518188; CODEN: CRBTE

Format

Online

Language

English

Type

Review

Identifier

https://doi.org/10.1080/07388551.2023.2231139

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175117662&doi=10.1080%2f07388551.2023.2231139&partnerID=40&md5=d09f776a98d9858272a9a97385e751e1