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Imidazopyridine chalcones as potent anticancer agents: Synthesis, single-crystal X-ray, docking, DFT and SAR studies
New imidazopyridinechalcone analogs were synthesized through the ClaisenSchmidt condensation reaction. The newly synthesized imidazopyridine-chalcones (S1S12) were characterized using spectroscopic and elemental analysis. The structures of compounds S2 and S5 were confirmed by X-ray crystallography. The global chemical reactivity descriptor parameter was calculated using theoretically (DFT-B3LYP-3-211, G) estimated highest occupied molecular orbital and lowest unoccupied molecular orbital values and the results are discussed. Compounds S1S12 were screened on A-549 (lung carcinoma epithelial cells) and MDA-MB-231 (M.D. Anderson-Metastatic Breast 231) cancer cell lines. Compounds S6 and S12 displayed exceptional antiproliferative activity against lung A-549 cancer cells with IC50 values of 4.22 and 6.89 M, respectively, compared to the standard drug doxorubicin (IC50 = 3.79 ?M). In the case of the MDA-MB-231 cell line, S1 and S6 exhibited exceptionally superior antiproliferative activity with IC50 of 5.22 and 6.50 ?M, respectively, compared to doxorubicin (IC50 = 5.48 ?M). S1 was found to be more active than doxorubicin. Compounds S1S12 were tested for their cytotoxicity on human embryonic kidney 293 cells, which confirmed the nontoxic nature of the active compounds. Further molecular docking studies verified that compounds S1S12 have a higher docking score and interacted well with the target protein. The most active compound S1 interacted well with the target protein carbonic anhydrase II in complex with pyrimidine-based inhibitor, and S6 with human Topo II? ATPase/AMP-PNP. The results suggest that imidazopyridine-chalcone analogs may serve as new leads as anticancer agents. 2023 Deutsche Pharmazeutische Gesellschaft. -
Imidazopyridine Hydrazine Conjugates as Potent Anti-TB Agents with their Docking, SAR, and DFT Studies
Novel imidazopyridines hydrazine conjugates were designed and synthesized for their anti-tubercular (anti-TB) activity. A cytotoxicity assay was conducted with Vero cells to determine the safety profile of the most effective compounds. It was found that compound (IA3) (MIC=0.78 ?M) and (IA8) (MIC=1.12 ?M) were nearly 3.7 and 2.5 times more active than pyrazinamide. Based on Density functional theory (DFT), these molecules exhibited better charge transfer between molecular orbital's, which made them suitable for biological applications. Molecular docking on Mycobacterium tuberculosis InhA bound to NITD-916 (PDB: 4R9S) revealed that compounds possessed greater binding affinity towards proteins. In addition, the most active anti-TB compounds (IA3) and (IA8) exhibited high levels of interaction with the target protein and exceptional safety profile, suggesting they may prove to be effective leads for new drugs. 2024 Wiley-VCH GmbH. -
Immersive Technologies: Navigating the Impacts, Challenges, and Opportunities
Immersive technology is going to govern the next generation in terms of education, health, military, tourism, and much more. Through its comprehensive exploration, didactic approach, and insightful analyses, this book provides an invaluable resource for understanding and harnessing the power of immersive technology. Immersive Technologies: Navigating the Impacts, Challenges, and Opportunities serves as a guiding compass through the immersive technology landscape and takes a multifaceted approach, addressing both the technical and human aspects. The book dissects the underlying methods and technologies that power immersive experiences, offering readers a clear understanding of how VR, AR, and MR function. The latest advancements, from cutting-edge hardware developments to revolutionary software applications are discussed in detail. The book also delves into the potential societal impacts and takes the reader on a journey from education to healthcare, entertainment to remote collaboration, so the reader can gain insights into the myriad of ways immersive technology is already shaping industries and human interaction. The ultimate benefit readers will derive from this book is a holistic grasp of the immersive technology landscape and they will be armed with knowledge about the challenges and opportunities presented by VR, AR, and MR. They will be well-equipped to navigate the future. This is a must-read for anyone interested in how this technology has the potential to reshape our world. Academicians will be enriched with the applications and practical perspectives. 2025 Sagaya Aurelia. -
Immobilized proline-based electro-organocatalyst for the synthesis of bis-?-diketone via Knoevenagel condensation reaction
In the quest for more sustainable chemical processes, we devised a technique using electro-organocatalysis to synthesize bis-?-diketone compounds via Knoevenagel condensation of benzaldehyde and dimedone. Our approach involves a modified electrode fabricated via anchoring L-proline onto a carbon fiber paper electrode supported by poly-3,4-diaminobenzoic acid (PDABA), which enhances efficiency in addition to the simple catalyst separation from the reaction mixture in heterogeneous catalysis. The electrochemical and surface topographical studies for the fabricated electrode were carried out, revealing high efficiency in comparison to the bare carbon fiber paper electrode. This electrochemical reaction operates under mild conditions utilizing lithium perchlorate and acetonitrile, yielding high amounts of the desired product. This study showcases a promising pathway for producing valuable organic compounds in an environmentally friendly manner, marking a significant stride forward in sustainable synthesis practices. 2024 Elsevier Ltd -
Immortality and beyond: review of the film Seo Bok
[No abstract available] -
Impact of 3D printed components and ventilators on COVID-19
The disease caused by a virus known as the novel Coronavirus, also known as "COVID-19" by the public, was classified as a major epidemic by the World Health Organisation in 2019. Each country across the globe is affected by COVID-19. While writing this, over 150 million people were affected by the fast-spreading deadly pandemic, and over 3.5 million deaths due to COVID-19 were reported worldwide as per WHO's official COVID-19 dash panel-https://covid19.who.int/Economy and social life of no territory on earth was left unaffected by the COVID-19. Now vaccines are ready, it may take a reasonable amount of time to complete the vaccination process. One major challenge was the need for more support equipment like Beds, Oxygen Cylinders, and Ventilators. Improvisation in the mass production of many critical components, especially those supporting 3D printing technology, has shown some well-managed results in handling the shortage of many critical components. This chapter examines and describes how 3D printing technologies were used during the dangerous pandemic. It aims to describe many 3D-printed devices like face masks, face shields, various valves, etc. It also makes an effort to point out the dominant drawbacks of additive manufacturing technology in this area and examines the options for a future pandemic. 2023 Bentham Science Publishers. All rights reserved. -
Impact of Abuse on Mental Health and Happiness Among Students: Mediating Role of Family Environment
Background: Child abuse and neglect is an issue of concern for public health professionals. The impact of abuse may lead to poor physical and mental health conditions. Family environment may impact coping and recovery among victims of abuse. The association between child abuse, mental health, happiness, and family environment is complex. The study examines the association and pathways between child abuse exposure, mental health and happiness, while exploring the potentially mediating effect of the family environment. Methods: Data were collected from 571 high school students from Kerala, India, by using various tools, including a semi-structured questionnaire, Depression and Anxiety Youth Scale, and happiness scale. A mediation analysis using structural equation modeling (SEM) was carried out to test the objectives of the study. Results: The analysis shows that mental health, happiness, and family environment are correlated with abuse experience. The mediation analysis further shows that the indirect effect of abuse on mental health via the family environment was significant (? = 0.013, 95% CI [0.002, 0.033]). The indirect effect of abuse on happiness via the family environment was significant (? = 0.019, 95% CI [0.044, 0.003]). Furthermore, the total effect of abuse on mental health (? = 0.266, 95% CI [0.164, 0.354]) and abuse on happiness (? = 0.152, 95% CI [0.259, 0.050]) was significant. Conclusion: The study reveals that abuse experiences impact happiness and mental health outcomes among students. The family environment mediates the relationship between child abuse and mental health, and between child abuse and happiness. 2023 The Author(s). -
Impact of Aggressive and Conservative Working Capital Management Policy on Firms Profitability
The International Journal's Research Journal of Social Science & Management, Vol-4 (1), pp. 105-110. ISSN-2251-1571 -
Impact of AI in Financial Technology- A Comprehensive Study and Analysis
Presently across the world, financial institutions strive tremendously hard to make financial services smarter to benefit from the advantages of digitization. To enhance client services, financial technology (Fintech) uses a variety of modern breakthrough technologies, including Artificial Intelligence (AI), 5G/6G, Blockchain, Metaverse, IoT, and others, in the financial sector. Many important financial services and procedures, including loans, authentication, fraud detection, quality control, creditworthiness, and several more, would be streamlined and improved by the adoption of technology. However, a need exists for the development of innovative financial products as well as the corresponding technological ecosystem. To launch Information and Communication Technology (ICT) alternatives, various major tech companies have placed their emphasis on Fintech. In this paper, we first explore the latest opportunities in Fintech. Furthermore, we also attempt to present a foundation of the Fintech accelerators, such as IoT, 5G, Digital twins, and Metaverse. Additionally, we also outline recommendations for future research directions in Fintech while looking forwards to potential difficulties. 2023 IEEE. -
Impact of AI Technology Disruption on Turnover Intention of Employees in Digital Marketing
The rapid integration of AI technology into the digital marketing sector has prompted a need to understand its effects on employee perspectives and behaviors. This study investigates how AI adoption influences job insecurity, turnover intention, and job mobility among digital marketing professionals. Addressing concerns about AI rendering roles obsolete is crucial for fostering a supportive work environment. Turnover intention, influenced by AI adoption and potential job dissatisfaction, offers insights into employees' commitment to the industry. Job mobility, influenced by growth prospects and alignment with AI-driven workplaces, sheds light on career aspirations. Our study involving 303 employees of digital marketing industry in India reveals that AI disruption significantly impacts turnover intention, with job insecurity mediating this effect. Additionally, mistreatment by superiors increases turnover intention. Overall, this research underscores the profound impact of AI technology on employees' attitudes, behaviors, and career decisions in digital marketing, providing valuable insights into their perceptions and engagement 2024 IEEE. -
Impact of air pollution in health and socio-economic aspects: Review on future approach
Air contamination is mainly induced by human activity and environmental pollution. Consumption of Air pollution in fewer amounts leads to a significant range of harmful effects on public safety. Nevertheless, with the accelerated pace of economic growth and modernization and the high quantity of electricity need results in huge amounts of pollutants and waste creates significant air pollution. The latest research has shown that because humans only use a tiny part of their day to drive, their constant air quality intake is primarily attributed to the commuting microenvironment. The nature of life on this planet is dependent on clean air. This article presents the literature to include a review of the effect on different facets of human existence of air emissions. The effect is narrowly classified into health and climate change. The study shows that air contamination has a broad variety of consequences, from infectious illnesses and life-threatening disorders and the breakdown of particular organ systems and psychological health. There is no question that this problem has to be addressed with the utmost focus. Such results should be used to prompt further work and to deliver clean air initiatives to officials. 2020 Elsevier Ltd. All rights reserved. -
Impact of Artificial Intelligence on Business Strategy and Decision-Making
Market analysis as knowledge-enhancement function, its use in internal politics, its abuse, and its ability to generate market understanding were recognised as the four key performance variables in market analysis. Profitability and bottom line may be increased, inefficiencies in corporate processes can be reduced, and other hidden insights can be uncovered by analyzing financial accounting transactions. The research focuses on the business strategy in decision-making using artificial intelligence. Reviewing existing research and providing recommendations. In this study, firstly collect the dataset finance data from Kaggle for the better-trained model. After that perform the pre-processing data for outlier removal. The implementation work is complete on the Python programming language. The results showed that the proposed KNN, the Decision tree model, achieved high accuracy. Businesses and organisations working in the field of artificial intelligence (AI) might greatly benefit from this research in terms of narrowing down the profiles that are certain to avoid in the future. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
IMPACT OF ARTIFICIAL INTELLIGENCE ON E-BANKING AND FINANCIAL TECHNOLOGY DEVELOPMENT
Artificial intelligence has a significant impact on financial technologies. Machine learning is an important field of artificial intelligence. Machine learning is a subset of artificial intelligence. According to client knowledge gathered by machine learning, data structures may be more easily comprehended and changed. Machine learning, although still being employed in the IT business, has its own set of benefits. They are used by computer program to explain or solve a typical issue because they are a set of well-written instructions. Data inputs for factual research may be prepared by computers using master learning algorithms that can deliver results within a certain range. Computers are used to model test data, and frameworks are used to make automated decisions based on input data. Banks and financial institutions may benefit from the use of machine learning. This article discusses applications of machine learning in banking and finance sector. The Electrochemical Society -
Impact of Artificial Intelligence on the Social Media Marketing Strategies
The use of social media is increasing as the use of smartphones is increasing, various applications on smartphones are now becoming good platform for market. As the use of smartphones is increasing the use of different artificial intelligence (AI) technologies making the phones smarter. The social media is now one of the most globally crowded platforms with millions of users. Most of the businesses are now turning their marketing strategies by highlighting the digital marketing from various platforms. Thus, the focus of study is to find the increasing impact of AI on the social media related marketing strategies. Different studies highlight the different impacts of social media and marketing using different AI tools and platforms which makes customer to find the best product as per their choice. So, social media marketing has become simpler and more adaptable thanks to the development of artificial intelligence. 2024 IEEE. -
Impact of bioconvection on the free stream flow of a pseudoplastic nanofluid past a rotating cone
In the current work, the repercussions of Brownian motion and thermophoresis on the three-dimensional free stream flow of tangent hyperbolic (pseudoplastic) nanofluid past a rotating cone are explored. The tangent hyperbolic model expresses the characteristics of a shear-thinning nanofluid. Furthermore, oxytactic microorganisms were used as mixers to actively stabilize the nanoparticles. The movement of these microorganisms within the nanofluid gives rise to a major phenomenon termed bioconvection. The flow of nanofluid past a rotating cone finds applications in the field of nuclear reactors, biomedical applications, solar power collectors, steam generators, and so on. The mathematical model is designed using Buongiorno's model that describes the two major slip mechanisms experienced by the nanoparticles moving within a fluid namely thermophoretic force and Brownian motion. The model thus formed is nondimensionalized using the apt similarity transformation. The resulting system is solved by the (Formula presented.) technique by adapting the shooting method. The velocity, temperature, concentration, and motile density profiles are graphically interpreted for different flow parameters involved in the study. It was observed that thermophoresis reduces concentration and enhances the temperature whereas Brownian motion enhanced both temperature and concentration profiles. Also, the increase in the mixed convection parameter effectively decreased the temperature of the nanofluid. 2022 Wiley Periodicals LLC. -
Impact of blended education system on outcome-based learning and sector skills development
An effective education system transforms the teaching and learning process into innovative idea generation and independent working ability. A blended education system is the representation of effective education that connects the teachers, students, and educational institutions for content development, delivery of effective teaching methods, and choice-based learning. The motive for initiating the research work was to address the demand for outcome-based learning in society that can fulfill the sector-wise human resource requirements and sector skill development. A blended education system helps to design effective courses and degrees with the capacity of choosing subjects, lectures, and teachers either in online or offline mode of education. The system may also assist in preparing the learning pattern like classroom-based learning, internship-based learning, or learning through project works. The researchers identified the dependent and independent variables with the help of expert opinion. The questionnaire was designed with all relevant questions based on the variables and refined through a pilot study. The research outcomes are described by understanding the nature of quantitative data using statistical tools like frequency distribution, t-test, and ANOVA test with the connectivity of qualitative data and the reality of social issues. 2023 IEEE. -
Impact of Blockchain Technology in the Healthcare Systems
The healthcare industry is one of the most important industries in the world which is in dire need of a restructuring process because of its poor and outdated techniques of data management. Healthcare system has adopted a centralized environment and deals with a lot of intermediaries which makes it prone to issues of single point of failure, lack of traceability of transactions, and privacy issues such as data leakage. Blockchain is a relatively new technology which is able to tackle the obsolete methods and practices existing in the healthcare industry. In this chapter, we analyzed the applications of blockchains in the healthcare industry which can solve the issues prevalent in the healthcare industry. The aim of this chapter is to reveal the potential benefits that comes from using blockchain technology in the healthcare industry and identify the various challenges that this technology has. 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. -
Impact of boundary conditions on Rayleigh-Bard convection: stability, heat transfer and chaos
The paper compares the results of Rayleigh-Bard convection problem for rigid-rigid-isothermal, rigid-free-isothermal and free-free isothermal boundaries. A minimal Fourier-Galerkin expansion yields the generalized-Lorenz-model whose scaled version is reduced to the Stuart-Landau-model using the multiscale-method. Nusselt number is estimated for both steady and unsteady regimes. Regular, chaotic, and periodic natures of the solution are studied using the Hopf-Rayleigh-number and by means of a bifurcation diagram. The linear and weakly-nonlinear-analyses reveal that the onset of regular and chaotic motions in the case of rigid-free-isothermal boundaries happens later than that of free-free isothermal boundaries but earlier than rigid-rigid-isothermal boundaries. It is shown that the scaled-Lorenz-model possesses all the features of the classical-Lorenz-model. Beyond the value of the Hopf-Rayleigh-number, we observe chaotic-motion between two consecutive spells of periodic motion. It is found that one can also have a window of periodicity for all three boundaries. 2024 Informa UK Limited, trading as Taylor & Francis Group. -
Impact of Brexit on bond yields and volatility spillover across France, Germany, UK, USA, and India's debt markets
Britain's decision to exit the EU lead to disruptions in global markets. This study investigates the change in the return and volatility spillover pattern due to the repercussions of the Brexit vote between the US, France, the UK, Germany, and India's 10-year government bond yields by applying the VAR and GARCH-BEKK models. The findings demonstrate a substantial rise in the return spillover to India and USA 10-year government bond yields following the Brexit vote compared to the pre-Brexit vote era. In addition, the results showed evidence of unidirectional volatility spillover from India to France, bidirectional volatility spillover between the USA and India, and unidirectional volatility spillover from the UK to India 10-year government bond market post-Brexit vote. However, there was no interconnection between these markets before the Brexit vote. Therefore, the Brexit vote did affect and significantly increased the linkage between the US, France, the UK, and India's 10-year government bond market. The increase in correlation in India-US, India-UK, and India-France's 10-year government bond markets will help predict and have an important implication for hedgers, decision-makers, and portfolio managers if similar political events occur in the future. Sangeetha G. Nagarakatte, Natchimuthu Natchimuthu, 2022. -
Impact of catchment, direct to consumer advertisement on consumer buying intention: Retailer and consumer aligned perspective from Indian pharmaceuticals industry /
Internaional Journal of Management Studies, Vol.6, Issue 1, Part 5, ISSN No: 2249-0302.