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Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges
Malignant growth is expected to surpass other significant causes of death as one of the top reasons for dismalness and mortality worldwide. According to a World Health Organization (WHO) study, this illness causes approximately between 9 and 10 million instances of deaths annually. Chemotherapy, radiation, and surgery are the three main methods of treating cancer. These methods seek to completely eradicate all cancer cells while having the fewest possible unintended impacts on healthy cell types. Owing to the lack of target selectivity, the majority of medications have substantial side effects. On the other hand, nanomaterials have transformed the identification, diagnosis, and management of cancer. Nanostructures with biomimetic properties have been grown as of late, fully intent on observing and treating the sickness. These nanostructures are expected to be consumed by growth in areas with profound disease. Furthermore, because of their extraordinary physicochemical properties, which incorporate nanoscale aspects, a more prominent surface region, explicit geometrical features, and the ability to embody different substances within or on their outside surfaces, nanostructures are remarkable nano-vehicles for conveying restorative specialists to their designated regions. This review discusses recent developments in nanostructured materials such as graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid nanoparticles, magnetic nanoparticles, and nano-omics in the diagnosis and management of cancer. 2025 by the authors. -
Psychological adjustment, choice of game genre and living arrangements among adolescents with and without IGD
In India, the prevalence of internet gaming disorders ranges from 8 to 9%. Adolescents are more likely to become addicted to online games. This study compares teenage gamers with and without Internet Gaming Disorder (IGD) in terms of game genre, psychosocial adjustment, and living conditions with a sample of 80 in each group. The results demonstrate that adolescents with this disorder had significantly higher scores for depression, anxiety, and psychosocial deterioration than adolescents without gaming disorder. Even though the prevalence of males is high, both genders do not significantly differ from one another in psychological adjustment. Another finding is that adolescents with gaming disorders play multiplayer online role-play games and Battle Royal games more frequently than average players. The prevalence of this disorder is also influenced by living conditions; teenagers who stay in hostels or pay guest rooms are more likely to develop a gaming addiction. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Properties of alkali-activated concrete (AAC) incorporating demolished building waste (DBW) as aggregates
This study was undertaken to evaluate the potential of demolished building waste (DBW) as aggregates in alkali-activated concrete (AAC). A recent road-widening activity led to the demolition of commercial buildings along National Highway 275, Bangalore-Bantwal, India. DBW was collected from these sites and processed manually at the laboratory facility of CHRIST (Deemed to be University). Processing of DBW was done to obtain both waste coarse and fine aggregates from demolished concrete and brick waste units, respectively. AAC was synthesized by fly ash, ground granulated blast furnace slag, sodium hydroxide, sodium silicate, along with waste aggregate replacement rates of 0, 25, 50, and 75% by weight of natural aggregates. Fresh and hardened properties of developed concrete mixtures were experimentally determined. Results of the study indicate that 28-day compressive strength of 30.4 and 21 MPa was obtained for AAC with 25 and 50% DBW aggregates, which was 8.6 and 36.9% lower than control mix, respectively. Further, there was an increase in the water absorption and a reduction to acid resistance for all the AAC mixes with DBW aggregates. Based on the results obtained, it was observed that AAC with 25 and 50% DBW aggregates find great potential in civil engineering applications. 2021 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. -
An hybrid technique for optimized clustering of EHR using binary particle swarm and constrained optimization for better performance in prediction of cardiovascular diseases
The significant adoption of Electronic Health Records (EHR) in healthcare has furnished large new quantities of information for statistical machine gaining knowledge of researchers in their efforts to version and expects affected person health popularity, doubtlessly permitting novel advances in treatment. Unsupervised system learning is the project of studying styles in facts where no labels are present. In comparison to loads of optimization problems, an most beneficial clustering end result does not exist. One-of-a-kind algorithms with special parameters produce special clusters, and none can be proved to be the quality answer given that numerous good walls of the records might be found. In the previous work, a novel Two-fold clustering technique which uses the Long Short Term Memory (LSTM) technique (TFC: LSTM) for the prediction of Cardiovascular Disease (CVD) was proposed. The proposed model was fond to be experimentally efficient; however when applied to large EHR data, the model suffered from optimization issues on the number of clusters formed and time complexity. In order to overcome the drawbacks, this paper proposes a hybrid method of optimization using the Binary Particle Swarm (BPS) and Constrained Optimization (CO) for optimizing the number of clusters produced and to increase the efficiency in terms of decreasing the time complexity. 2022 The Authors -
CRISPR-Cas9 genome editing of crops: Food and nutritional security
The United Nations established the goal of achieving global food security by 2030 as one of its top sustainable development goals in 2015. The current agricultural harvest is insufficient to accomplish the zero-hunger objective and feed the world's growing population. It would require more extensive and consistent crop production. Gene-editing technologies have recently emerged as viable alternatives to permit precise modifications in genomes with increased efficiency and yield higher agricultural productivity. Due to their simplicity, adaptability, and reproducibility across a diverse variety of species, genetic engineering techniques like CRISPR-Cas9 have become quite prominent. CRISPR-Cas9 gene-editing technology can improve crop yields, quality, stress resistance, food safety, nutritional security, and shelf-life, reduce antibiotic resistance, and hasten plant domestication. Cutting-edge techniques like genome editing (GE) allow for the precise introduction or mutation of specified genes into plant genomes. The advent of programmable nucleases like CRISPR-Cas9 has improved gene editing and potentially improved food production and nutritional security. Knock-out, knock-in, gene activation, gene repression, nuclear rearrangements, base editing, molecular breeding, and epigenome engineering are just a few ways that CRISPR systems can target and change genes. For novel applications in plant genetic engineering, CRISPR-Cas systems can be repurposed for GE toward de-novo speciation; mitochondrial and plastid genome engineering toward enhancing photosynthesis, submergence, and drought tolerance. The versatility of CRISPR-associated systems broadens the scope of crop development applications that they can be used for, especially in improving food and nutritional security, which is the focus of this chapter. 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. -
Architecture of visible-light induced Z-scheme MoS2/g-C3N4/ZnO ternary photocatalysts for malachite green dye degradation
The synthesis of bilayer heterojunctions has received considerable attention recently. Fabrication of novel bilayer composites is of significant interest to improve their photocatalytic efficiency. In this study, molybdenum disulfide (MoS2), a layered dichalcogenide material exhibiting unique properties, in combination with graphitic carbon nitride (g-C3N4), a carbon-based layered material, was fabricated with small amounts of zinc oxide (ZnO). Three composites, MoS2/g-C3N4, MoS2/ZnO, and MoS2/g-C3N4/ZnO were prepared via a simple exfoliation method and characterized by various physicochemical methods. The Z-scheme charge transfer mechanism in the prepared ternary composite improves efficiency by inhibiting the recombination rate of electron-hole pairs. It has shown excellent performance in degrading a major water contaminant, malachite green (MG) dye, under visible light irradiation. 2022 Elsevier Inc. -
The catalytic reduction of 4-nitrophenol using MoS2/ZnO nanocomposite
Nanocomposite MoS2/ZnO was prepared by an exfoliation process and characterized. A flower-like morphology was obtained for the hybrid where uniformly spread ZnO is stacked over thin layers of MoS2. A tight interface between the two components coupled with the energy band bending at the junction has resulted in a high activity of the composite towards the reduction of 4-nitrophenol. A complete reduction to 4-aminophenol from 4-nitrophenol took place within 15 min under the optimized conditions. The catalyst has a recyclability of six times without any perceptible decrease in the catalytic activity. 2022 The Author(s) -
Artificial intelligence talent acquisition in HEIs recruitments
Purpose: The current research study aims to examine the application feasibility and impact of artificial intelligence (AI) among higher educational institutions (HEIs) in talent acquisitions (TA). Design/methodology/approach: A systematic sampling method was adopted to collect the responses from the 385 staff working across the various levels of management in HEIs in metropolitan cities in India. JAMOVI & SmartPLS 4 were applied to validate the hypothesis by performing the simple percentage analysis and structural equation modelling. The demographic and construct variables considered were adoption, actual usage, perceived usefulness, perceived ease of use and talent management. Findings: The key indicators of perceived usefulness are productivity, perceived ease of use, adaptability, candidate experience with the adoption of AI, frequency in decision-making in its actual usage and career path of development in the HEIs. These are the most influential items impacting the application of AI in TA. Originality/value: AI has the potential to revolutionize TA in HEIs in the form of enhanced efficiency, improved candidate experience, more objective hiring decisions, talent analytics and risk automation. However, they facilitate resume screening, candidate sourcing, applicant tracking, interviewing and predictive analytics for attrition. 2024, Emerald Publishing Limited. -
Does the nifty sectoral indices shake hands with nifty? : A time series analysis /
International Journal Of Applied Business And Economic Research, Vol.15, Issue 10, pp.251-262, ISSN: 9727-7302. -
Structural investigation of Cr2CTx/NiFe2O4 MXene composite as a bifunctional electrocatalyst for water splitting
The electrocatalytic water splitting offers great potential as an environmentally friendly and sustainable method to produce hydrogen and oxygen, the former serving as a renewable alternative to traditional fossil fuels. MXene, a novel two-dimensional (2D) layered class of materials, has gained enormous attention as an electrocatalyst for water splitting. This versatile material can be tailored to enhance its electroactive surface sites and stability toward electrocatalytic performance. Herein, we have designed a 2D hybrid material, Cr2CTx/NiFe2O4, via an in-situ hydrothermal approach. NiFe2O4 spheres decorated on layered-Cr2CTx are subjected to analysis using XRD, FTIR, TGA, XPS, FESEM, HRTEM-SAED, and optical profilometry. The synthesized hybrid MXene material shows outstanding activity for overall water splitting compared to Cr2CTx and NiFe2O4. Cr2CTx/NiFe2O4 exhibits an overpotential of 144 mV and 159 mV at a current density of 10 mA cm?2 for hydrogen evolution and oxygen evolution reactions, respectively, and achieves a cell potential of 1.69 V for overall water splitting. This study reveals valuable insights on bi-functional 2D hybrid MXene materials for electrocatalytic water splitting. 2024 Elsevier B.V. -
Rock abrading in South India /
Encyclopedia of Global Archaeology, pp.1-10 -
A top-down approach for studying the in-silico effect of the novel phytocompound tribulusamide B on the inhibition of Nipah virus transmission through targeting fusion glycoprotein and matrix protein
The proteins of Nipah virus ascribe to its lifecycle and are crucial to infections caused by the virus. In the absence of approved therapeutics, these proteins can be considered as drug targets. This study examined the potential of fifty-three (53) natural compounds to inhibit Nipah virus fusion glycoprotein (NiV F) and matrix protein (NiV M) in silico. The molecular docking experiment, supported by the principal component analysis (PCA), showed that out of all the phytochemicals considered, Tribulusamide B had the highest inhibitory potential against the target proteins NiV F and NiV M (-9.21 and ?8.66 kcal mol?1, respectively), when compared to the control drug, Ribavirin (-7.01 and ?6.52 kcal mol?1, respectively). Furthermore, it was found that Tribulusamide B pharmacophores, namely, hydrogen donors, acceptors, aromatic and hydrophobic groups, contributed towards the effective residual interactions with the target proteins. The molecular dynamic simulation further validated the results of the docking studies and concluded that Tribulusamide B formed a stable complex with the target proteins. The data obtained from MM-PBSA study further explained that the phytochemical could strongly bind with NiV F (-31.26 kJ mol?1) and NiV M (-40.26 kJ mol?1) proteins in comparison with the control drug Ribavirin (-13.12 and ?13.94 kJ mol?1, respectively). Finally, the results indicated that Tribulusamide B, a common inhibitor effective against multiple proteins, can be considered a potential therapeutic entity in treating the Nipah virus infection. 2024 Elsevier Ltd -
Evaluation of therapeutic potentials of selected phytochemicals against Nipah virus, a multi-dimensional in silico study
The current study attempted to evaluate the potential of fifty-three (53) natural compounds as Nipah virus attachment glycoprotein (NiV G) inhibitors through in silico molecular docking study. Pharmacophore alignment of the four(4) selected compounds (Naringin, Mulberrofuran B, Rutin and Quercetin 3-galactoside) through Principal Component Analysis (PCA) revealed that common pharmacophores, namely four H bond acceptors, one H bond donor and two aromatic groups were responsible for the residual interaction with the target protein. Out of these four compounds, Naringin was found to have the highest inhibitory potential ( 9.19kcalmol?1) against the target protein NiV G, when compared to the control drug, Ribavirin ( 6.95kcalmol?1). The molecular dynamic simulation revealed that Naringin could make a stable complex with the target protein in the near-native physiological condition. Finally, MM-PBSA (Molecular Mechanics-PoissonBoltzmann Solvent-Accessible Surface Area) analysis in agreement with our molecular docking result, showed that Naringin ( 218.664kJmol?1) could strongly bind with the target protein NiV G than the control drug Ribavirin ( 83.812kJmol?1). 2023, King Abdulaziz City for Science and Technology. -
Advances in Crime Identification: A Machine Learning Perspective
Crime profoundly impacts individuals, communities, and families. Technological advancements have provided perpetrators with new opportunities for criminal activities. The primary objective of the police department is to resolve crimes, ensuring justice for the victims. Additionally, preventing such incidents is crucial for creating a safer world. The landscape of criminal justice has undergone a significant shift with the integration of machine learning techniques, unlocking unparalleled potential for accuracy and efficiency. This study thoroughly examines the concept of various applications of machine learning in crime detection, prediction, and prevention. We examine the evolution of these technologies, from early developments to state- of-the-art methodologies, conducting a thorough analysis of their strengths, limitations, and ethical considerations. Moreover, the paper sheds light on crimes discussed in academic circles, serving as a repository for scholars and researchers. This facilitates informed discussions and guides future research endeavours. 2024 IEEE. -
Performance inquisition of web services using soap UI and JMeter
Web Service is a managed code through which the user can expose the existing functionality over the network. Web Service allows multiple applications to communicate with each other. The communication involves passing the data or interaction of two services for a specified action. There are commercial and open source tools available for testing web services. This paper describes about two popular open source tools to test the performance of the web services in terms of response time. The performance is tested based on the time acquired by each service. The comparison study will help in understanding the usage of web service testing tools and adoption of these tools for testing purpose. 2017 IEEE. -
Future of knowledge management in investment banking: Role of personal intelligent assistants
Purpose: The studys objective focuses on investigating the involvement of Personal Intelligent Assistants (PIAs) in the Knowledge Management Process (KMP) in Investment Banking Companies leading to Industrial Revolution 5.0 leading to effective Organizational Knowledge Management. Design/Methodology: A Self-administered Survey Questionnaire was circulated to 695 employees of Investment Banking Companies operating in Bangalore, Mumbai, Delhi, Hyderabad, Chennai, and Pune using the Cluster Sampling method. The Covariance-based Structural Equation Modelling (CB-SEM) and Gradient Boosting Regression technique of Machine Learning were used to validate the hypothesis through JASP V.18 Software. Knowledge Creation, Knowledge Sharing, Knowledge Retrieval, Knowledge Application, and Organizational Knowledge Management are the crucial constructs considered in the study. Findings: The results revealed that Knowledge Application is the most influencing factor in effective organizational Knowledge management among the Investment Banks followed by Knowledge Sharing. It also emphasizes that they have a weak Knowledge retrieval process and minimal efforts taken to create knowledge within these banks. Implications: The PIAs can facilitate effective Data Analysis and research in managing vast data eliminating the repeated tasks in portfolio reconciliation and offering personalized recommendations to manage portfolios. It enables in compliance, risk management, client relationship management, real-time monitoring and leveraged decision-making through predictive analysis. The Author(s) 2024. -
Religion, society and state in India: A legal perspective
[No abstract available] -
The shadow of truth: Ethical Concerns in the Writings of Alexander Solzhenitsyn
"One word of truth will outweigh the entire world." These were the words of Alexander Solzhenitsyn while accepting the Nobel Prize in 1974. The twentieth century was the bloodiest century in human history, thanks largely to two ideologies - Fascism and Marxism. While there have been numerous studies on Nazi Germany, there have been relatively few on what transpired in Soviet Russia. This paper examines the contributions of the Russian writer and philosopher Alexander Solzhenitsyn to the understanding of the workings of totalitarianism. Solzhenitsyn wrote numerous works like The First Circle, Cancer Ward and The Gulag Archipalego. This paper will be examining his major work called One Day in the Life of Ivan Denisovich. The main intention is to probe the ethical concerns that the writer raises in this work, along with his deep understanding of human nature. This paper also seeks to compare Solzhenitsyn's views with that of thinkers like Jean Paul Sartre and Vaclav Havel. The key query here will be the essence-existence debate that Sartre initiated in his seminal work 'Existentialism Is a Humanism' and an attempt will be made to show how Havel and Solzhenitsyn would differ from Sartre. Finally there will be an attempt to establish how Solzhenitsyn reaffirms Lev Tolstoy's theory of history, according to which history is a process where 'great individuals' play a minimal role. 2013 Journal of Dharma: Dharmaram Journal of Religions and Philosophies (Dharmaram Vidya Kshetram, Bangalore). -
Exploring the role of plant oils in aquaculture practices: an overview
As the global demand for seafood surges, the expanding aquaculture industry faces a pressing need for viable aquafeed ingredients. The raw material for fish oil is limited and expensive due to unpredictable fishery resources in the fishing zones and the overexploitation of wild fisheries, underscoring the urgency of finding alternatives. This review explores diverse plant oil sources, including soybean, rapeseed, linseed, and algal oils, emphasizing their crucial role in nutritionally balanced aquafeeds. These oils support aquatic animals growth, health, and development, influencing membrane structure, energy storage, and hormone production. Genetically modified oilseeds (GM), such as camelina and canola, offer a controlled nutrient content, enabling customized nutrient profiles. This comprehensive review provides an overview of different plant oil sources, elucidates their nutrient profiles, and assesses their potential applications in aquaculture. The discussion encompasses their impact on growth, feed efficiency, lipid profile, health, immunological status, disease resistance, and overall performance of both freshwater and marine fish. Furthermore, the review compiles relevant data on the current status of genetically modified plant oils and explores their potential integration into aquaculture practices. In summary, substituting plant oils for fish oil in aquafeed presents a promising solution to aquaculture industry challenges to meet nutritional requirements for fish. The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. -
Hermeneutic keys and pedagogic tips: Enrich case research
Pedagogy sharpens and complements hermeneutics to form the prolegomena statement for this chapter. The chapter undertakes two approaches: It deals with closer understanding of the text in depth and also explains the findings of the text for pedagogical applications. The science of interpretations will provide a proliferation of meanings and interpretations. The lessons from pedagogy will facilitate a lot of assistance for academic and teaching purposes. Radhakrishnan Nair's hermeneutic keys and Justin Joy's pedagogic tips form the crux of the matter in the research paper. Here, research in case studies culminate in some useful findings related to comprehension and conception of case as text. However, quite legitimately the research demands a specialist partner in complementary pedagogical research, which compels to find a research association from the management faculty, at once competent in pedagogy. Justin Joy shares and resolves the problems Nair has confronted with. 2023 by IGI Global. All rights reserved.