Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis
- Title
- Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis
- Creator
- Liu W.-C.; Pushparaj K.; Meyyazhagan A.; Arumugam V.A.; Pappuswamy M.; Bhotla H.K.; Baskaran R.; Issara U.; Balasubramanian B.; Mousavi Khaneghah A.
- Description
- Ochratoxin A (OTA) is a toxic metabolite produced by Aspergillus and Penicillium fungi commonly found in raw plant sources and other feeds. This review comprises an extensive evaluation of the origin and proprieties of OTA, toxicokinetics, biotransformation, and toxicodynamics of ochratoxins. In in vitro and in vivo studies, the compatibility of OTA with oxidative stress is observed through the production of free radicals, resulting in genotoxicity and carcinogenicity. The OTA leads to nephrotoxicity as the chief target organ is the kidney. Other OTA excretion and absorption rates are observed, and the routes of elimination include faeces, urine, and breast milk. The alternations in the Phe moiety of OTA are the precursor for the amino acid alternation, bringing about Phe-hydroxylase and Phe-tRNA synthase, resulting in the complete dysfunction of cellular metabolism. Biodetoxification using specific microorganisms decreased the DNA damage, lipid peroxidation, and cytotoxicity. This review addressed the ability of antioxidants and the dietary components as prophylactic measures to encounter toxicity and demonstrated their capability to counteract the chronic exposure through supplementation as feed additives. 2022 Elsevier Ltd
- Source
- Toxicon, Vol-213, pp. 59-75.
- Date
- 2022-01-01
- Publisher
- Elsevier Ltd
- Subject
- Biotransformation; Detoxification; Dietary prophylaxis; Ochratoxin; Toxicokinetics
- Coverage
- Liu W.-C., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Pushparaj K., Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil Nadu, Coimbatore, 641 043, India; Meyyazhagan A., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Arumugam V.A., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, 641 046, India; Pappuswamy M., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Bhotla H.K., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Baskaran R., Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Issara U., Division of Food Science and Technology Management, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12110, Thailand; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Mousavi Khaneghah A., Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), S Paulo, Campinas, Brazil
- Rights
- Restricted Access
- Relation
- ISSN: 410101; PubMed ID: 35452686; CODEN: TOXIA
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Liu W.-C.; Pushparaj K.; Meyyazhagan A.; Arumugam V.A.; Pappuswamy M.; Bhotla H.K.; Baskaran R.; Issara U.; Balasubramanian B.; Mousavi Khaneghah A., “Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/21519.