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Analgesic and Anti-Inflammatory Potential of Indole Derivatives
Some indole analogues show a good analgesic activity but on the other hand, it has some serious side effects like gastric ulcer. Therefore, there is still a need to develop derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) with fewer side effects. For this purpose, some indole derivatives were prepared with objectives to develop new derivatives with maximum efficacy and minimum side effects. 1-(1H-indol-1-yl)-2-(sstituephenoxy)-ethan-1-one derivatives (M1M4) were analyzed further by thin-layer chromatorgarphy (TLC), melting point, IR, and 1H-NMR. The synthesized compounds then underwent oral toxicity studies that include hematological, biochemical, and histopathological findings. The compound was then evaluated for invivo anti-inflammatory and analgesic activities on carrageenan-induced rat paw edema and acetic acid-induced writhing methods. As a result of the biological activities, promising results were obtained in the compound M2 (2-(2-aminophenoxy)-1-(1H-indol-1-yl)ethanone) and it was subjected to further studies. It was found that compound M2 was practically nontoxic, and no clinical abnormalities were found in hematology and biochemistry, correlated with histopathological observation. It also showed significant anti-inflammatory and analgesic activities at its oral high dose (400 mg/kg). The study suggested that compound M2 was found to have significant anti-inflammatory and analgesic activities. The possible mechanism of M2 might suggest being act as a central anti-nociceptive agent and peripheral inhibitor of painful inflammation. The possible mechanism of action of the compounds whose biological activity was evaluated was explained by molecular docking study against COX-1 and COX-2, and the most active compound M2 formed ?9.3 and ?8.3 binding energies against COX-1 and COX-2. In addition, molecular dynamics (MD) simulation of both M2s complexes with COX-1 and COX-2 was performed to examine the stability and behavior of the molecular docking pose, and the MM-PBSA binding free energies were measured as ?153.820 11.782 and ?172.604 9.591, respectively. Based on computational ADME studies, compounds comply with the limiting guidelines. 2022 Taylor & Francis Group, LLC. -
Analogy of Social Entrepreneurship and Community Empowerment: An Inclusive Tourism Approach with Technological Intervention
Destinations overall development is ascertained by its conscious measures toward inclusive engagement with responsible business practices. The social enterprises functioning in the tourism system engage the disadvantaged communities responsibly for economic prosperity and community empowerment. Tourism social entrepreneurship is an innovative mechanism toward social upliftment by enhancing the benefits and contemplating through the core issues of host communities. This chapter focuses on case lets on communities, particularly those located in less-developed regions of India, who encounter various social problems. A sustainable community development through tourism leads economic growth in developing marginalized communities and economically empowers the low-income localities. Technological intervention for community empowerment and better engagement is the need of the hour. It is instrumental to understand the ideology of social entrepreneurial opportunities for community empowerment. Tourism relies on multiple industries and it is challenging in delivering desired community development goals. Adaption of techno-enabled system toward community development can build the entrepreneurship capacity of marginalized communities. Technological interventions for empowering the community toward rural development is the thrust dealt in the proposed chapter. Springer Nature Singapore Pte Ltd 2024. -
Analyses of the Power Flow through Distributed Generator based on Unsynchronized Measurements
Based on measurements taken from the main substation and the connections between distributed generators and micro-grids that are not in sync, this study suggests a new way to look at the load flow of distributed generation. The conclusions are based on data from a distribution generatora's Load Flow Analysis that was not in sync. Distributed generation is what this approach is based on. Creating a strong communication system and using measurement data from the past are two ways to make this happen. This objective may be achieved with the use of previously gathered measurements. The time-tested backward-forward sweep method is the method of choice for analyzing power flow using unsynchronized data. This is the preferred approach. The angles of synchronization are likely to be unknowns that must be estimated. On a smart grid system with a large number of distributed generation and microgrids, a range of mathematical computations are conducted to verify the correctness of performance predictions produced by the suggested theory. The classic backward-forward sweep was shown to be the most effective method for analyzing power flow based on data that was not synchronized in many instances. This is the strategy that is presently being recommended. Because the angles of synchronization are presumed to be unknown, a mathematical equation must be devised to determine them. The Authors, published by EDP Sciences, 2024. -
Analysing Collaborative Contributions and Sentiments in the Quantum Computing Ecosystem
Quantum computing, a revolutionary paradigm leveraging the principles of quantum mechanics, has emerged as a transformative technology with the potential to solve complex problems at unparalleled speeds. Within the quantum computing ecosystem, companies and research institutes play pivotal roles in advancing hardware, algorithms, and applications. This research explores the transformative landscape of quantum computing, focusing on key contributors such as Google, IBM, D-Wave, Azure, Amazon, Intel, EeroQ, and IonQ. Through sentiment analysis, topic modelling, and thematic analysis, the study aims to comprehensively understand the current state and trends within the quantum computing ecosystem. The findings unveil an overall positive sentiment and identified topics ranging from cloud computing services to quantum computing advancements. Thematic analysis provides actionable insights, emphasizing collaboration within the ecosystem. Rooted in the analysis of secondary data from key companies' articles, the methodology establishes a robust framework for discerning contributions, collaborations, and strategic orientations in quantum computing. 2024 IEEE. -
Analysing Crypto Trends: Unveiling Ethereum and Bitcoin Price Forecasts Through Analytics-Driven Weighted Moving Averages
This research meticulously analyses the performance dynamics of two paramount cryptocurrencies, Bitcoin and Ethereum, over 2,682 observations. Preliminary findings indicate a near alignment in the mean returns of both assets, with Ethereum marginally outperforming Bitcoin. Interestingly, Ethereums superior returns are accompanied by heightened volatility, underlined by its more significant standard deviation. Both cryptocurrencies manifest negative skewness, hinting at a proclivity for negative returns, with Bitcoin showing a sharper skew. Their pronounced kurtosis values attest to the potential for extreme price swings. Regarding forecasting efficacy, the Weighted Moving Average (WMA) method emerges as superior for both assets, yielding the most accurate predictions. At the same time, the Exponential Moving Average (EMA) demonstrates the highest forecast errors. Further, the Relative Strength Index (RSI) evaluation suggests Ethereum may be oversold, alluding to potential investment opportunities. In contrast, Bitcoin, with its mid-range RSI, resides in a neutral zone devoid of clear market signals. The findings shed light on the nuanced performance and forecasting landscape of these leading cryptocurrencies, offering pivotal insights for potential investors. The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. -
Analysing Employee Management Using Machine Learning Techniques and Solutions in Human Resource Management
In the contemporary landscape of Human Resource Management (HRM), organizations are increasingly turning to advanced technologies to streamline employee management processes. This study explores the integration of machine learning (ML) techniques as a transformative solution for optimizing HRM practices, with a specific focus on employee management. By leveraging the power of ML algorithms, this research aims to enhance decision-making, efficiency, and overall effectiveness in HRM. The study encompasses a comprehensive analysis of existing HRM challenges, such as talent acquisition, performance evaluation, and employee retention, and proposes ML-based solutions to address these issues. By applying natural language processing, pattern identification, and predictive analytics, businesses may learn a great deal about employee behavior, performance patterns, and possible areas for development. HR professionals are more equipped to make well-informed choices, customize employee experiences, and put proactive talent development initiatives into action thanks to this data-driven approach. Additionally, the study examines the moral issues and difficulties surrounding the use of ML in HRM, stressing the significance of openness, justice, and privacy. By understanding and mitigating these concerns, organizations can successfully harness the transformative potential of ML in employee management, fostering a more dynamic and adaptive HRM framework. The study's conclusions add to the growing body of knowledge on the relationship between technology and HRM and offer useful advice to businesses looking to use cutting-edge approaches to improve labor management procedures. 2024 IEEE. -
Analysing grief on twitter: A study of digital expressions on Om Puri's death /
Funes Journal of Narratives And Social Sciences, Vol.2, pp. 136-152, ISSN No. 2532-6732. -
Analysing the Ascendant Trend of Veganism: A Comprehensive Study on the Shift towards Sustainable Dietary Choices
Background: Veganism has become a prominent social and culinary movement due to concerns about animal welfare, environmental sustainability, and ones own health. Vegans strive to consume only plant-based meals in order to lessen the suffering of animals, stop the environmental damage caused by the animal agriculture sector, and enhance their own health. Objective: This chapter aspires to understand various dynamics of consumer consciousness towards veganism through social media analysis (Twitter) and research opinions. Materials and Methods: This chapter used a qualitative approach and a three-part methodology. Firstly, a literature review examines the impact of veganism on human health, ethical needs and sustainable food choices. Secondly, the authors extracted tweets and analysed them using data visualisation software- NVivo with the essential parameters being themes, sentiment, world map, and word cloud. Results: Sentiment analysis explained consumer perception towards veganism as a storming blackball result of 36.1 present positive insights. Word map analysis describes veganism as a global phenomenon. The third part analysed the Scopus research data and identified food, diet and meat as major themes in veganism. The Scopus database sentimental analysis also re-emphasised the growing positive insights towards it. Conclusion: This study highlighted the significance of veganism as a sustainable dietary choice for addressing urgent global issues while promoting a thoughtful and compassionate approach to eating. It is also emerging as a powerful tool for positive change in preserving and promoting biodiversity. 2024 selection and editorial matter, Mourade Azrour, Jamal Mabrouki, Azidine Guezzaz, Sultan Ahmad, Shakir Khan and Said Benkirane; individual chapters, the contributors. -
Analysing the Impact of CSR Spending by Big 4 Firms on their Financial Profitability
This study delves into this ongoing debate whether socially responsible companies perform better which leads to financial profit or instead have no impact. This study focuses on leading accounting companies i.e., PricewaterhouseCoopers (PwC), Deloitte, Ernst & Young (EY), and KPMG and whether CSR Spending impacts their financial profitability or goes unnoticed. Grenze Scientific Society, 2024. -
Analysing the Impact of Perceived Risk, Trust and Past Purchase Satisfaction on Repurchase Intentions in Case of Online Grocery Shopping in India
The Indian online grocery market has been propelling since last few years. The size of online grocery market in 2020 was estimated as $2.9 billion and it is further anticipated to reach at the compound annual growth rate (CAGR) of 37.1% during 2021 to 2028. Companies such as Amazon, Flipkart grocery, BigBasket, Grofers and Jiomart have been coming up with new attractions for consumers such as providing timely no contact delivery, accepting various digital modes of payment and offering several discounts which have fascinated consumers towards buying their regular grocery from various online platforms. Corona virus has also fuelled up the safety concerns of people; due to which a large section of the citizens are working from home and are dependent on the online platform for various purposes including grocery shopping. This has provided several growth opportunities to the online grocery market. This research investigates about the purchase behaviour of customers towards online grocery shopping. The study aims to understand the purchase behaviour of e-grocery shoppers of India and to examine the association between satisfactions with online purchase, trust on online grocers, perceived risk and online repurchase intention of grocery items. The study uses primary data collected from 555 online grocery buyers. The findings of the study indicate that online customer satisfaction is a significant factor that influences repurchase intentions of online grocery shopping. Perceived risk negatively influence trust as well as repurchase intentions. Trust is found to be a mediating factor between shopping satisfaction and repurchase intentions. The study also builds and tests an online customer behavioural model with actual purchasing behaviour and identifies the continued presence of perceived risk, shopping satisfaction and trust in grocery e-retailing. 2023 IMI. -
Analysing the impact of the taxation law amendment of 2019 on corporate taxation in India
The Taxation Law (Amendment) Act, 2019 in India has brought major changes in the taxation revenue as well as in legal provisions. The actual ground reality of the Amendment on a microeconomic level is unknown, but a correlation analysis on macroeconomic indicators show that there is a high positive correlation between the corporate tax revenue and the GDP growth. The author also interlinks the effects of tax cuts on the economy with privatization and how it can mitigate the risks of tax evasion. There is a generalized misconception with privatization that it leads to a significant loss in taxation revenue. The study shows that in fact, privatization helps to expand the earnings of the Government by widening the taxation structure and slab, which the author has found through statistics. It is high time to have strong regulatory measures to prevent tax evasion by encouraging more corporate entities to become a part of the tax base. Indian Institute of Finance. -
Analysing the Influence of Activation Functions in CNN models for Effective Malware Classification
With the advancement of information technology, malware has become a persistent cyber security concern that targets computer systems, smart devices, and wide networks. Due to flaws in performance accuracy, analysis type, and malware classification methodologies that miss unsuspected malware attacks, malware classification has thus always been a significant concern and a challenging subject. Using the Malimg dataset, which has 9349 samples from 25 different families, this study classifies malware using a deep learning algorithm called a convolution neural network and evaluating the accuracy using a number of activation functions in this study. The proposed CNN model for malware classification achieves a high accuracy rate without the need for complex feature engineering. The model achieved the highest accuracy of 96.93% when using the Rectified Linear Unit (ReLU) activation functions whereas Leaky Relu gives accuracy of 96.76%, Pre relu gives 96.36%, ELU gives 95.72% and tanh gives accuracy of 95.58%. 2024 IEEE. -
Analysing the market for digital payments in India using the predator-prey model
Technology has revolutionized the way transactions are carried out in economies across the world. India too has witnessed the introduction of numerous modes of electronic payment in the past couple of decades, including e-banking services, National Electronic Fund Transfer (NEFT), Real Time Gross Settlement (RTGS) and most recently the Unified Payments Interface (UPI). While other payment mechanisms have witnessed a gradual and consistent increase in the volume of transactions, UPI has witnessed an exponential increase in usage and is almost on par with pre-existing technologies in the volume of transactions. This study aims to employ a modified Lotka-Volterra (LV) equations (also known as the Predator-Prey Model) to study the competition among different payment mechanisms. The market share of each platform is estimated using the LV equations and combined with the estimates of the total market size obtained using the Auto-Regressive Integrated Moving Average (ARIMA) technique. The result of the model predicts that UPI will eventually overtake the conventional digital payment mechanism in terms of market share as well as volume. Thus, the model indicates a scenario where both payment mechanisms would coexist with UPI being the dominant (or more preferred) mode of payment. 2023 Balikesir University. All rights reserved. -
ANALYSING THE SAFETY OF A CAMPUS USING SPATIAL SYNTAX
Everybody has been in campus environments and academic buildings at some point in their lives. The layout of these structures is crucial because it influences how a person behaves and presents themselves. The use of space syntax enables us to examine how individuals behave in relation to their surroundings and how places are used. The nature of the space and the way people move through it have improved because of the application of space syntax in campus planning.A primary concern is safety, this paper is devoted to comprehending how various user groups navigate across a university. Here, we'll be looking at how students move around and behave in relation to how safe they feel on campus. Each user group's paths, nodes and gathering places will be recorded and we'll confirm both the original puiposes and the current uses of the spaces. Additionally, several maps will be created to support the study that the campus is a safe place to be, including axial mapping and analysis mapping, convex mapping and grid analysis mapping. This with a combination of survey shall be used to understand safety with respect to space syntax. ZEMCH Network. -
Analysis and Actions Planned for Programme Outcomes in Outcome Based Education for a Particular Course
In India many of the technical institutions are NBA (National Board of Accreditation) accredited and the accreditation is a way to maintain quality of education. The outcome-based education (OBE) plays an important role in technical education across the world. So, in this research we will show how we can implement the attainment process related to OBE for a particular course. In this paper we will discuss how the course outcome and mapping of course outcome with program outcome can be defined. Then we will discuss the process to calculate the attainment. Finally, the program gaps were identified for that course and actions were suggested. 2024 IEEE. -
Analysis and dynamics of the Ivancevic option pricing model with a novel fractional calculus approach
The aim of the current study is to capture the complex behavior of the Ivancevic option pricing (IOP) model using the (Formula presented.) -homotopy analysis transform method ((Formula presented.) -HATM) with novel fractional operator. The generalization of the Black-Scholes model with the nonlinear Schringer equation plays a pivotal role in financial mathematics in studying the option-pricing wave function associated with two parameters. Based on adaptive market potential and volatility constant with distinct initial situations, we hired three distinct cases to exemplify the ability of (Formula presented.) -HATM. The considered method is elegant unification of the (Formula presented.) -homotopy analysis and Laplace transform algorithms. The derivative of fractional order is projected with the Atangana-Baleanu (AB) operator. The fixed-point theorem is used to present the existence and uniqueness of the attained result for the considered model, and we hire five distinct initial conditions. The hired scheme is highly methodical and exact to analyze the insights of the complex system with integer and fractional order exemplifying associated areas of science, which can be observed using plots and table. 2022 Informa UK Limited, trading as Taylor & Francis Group. -
Analysis and Forecasting of Area Under Cultivation of Rice in India: Univariate Time Series Approach
This study uses three distinct models to analyse a univariate time series of data: Holt's exponential smoothing model, the autoregressive integrated moving average (ARIMA) model, and the neural network autoregression (NNAR) model. The effectiveness of each model is assessed using in-sample forecasts and accuracy metrics, including mean absolute percentage error, mean absolute square error, and root mean square log error. The area under cultivation in India for the following 5years is predicted using the model whose fitted values are most like the observed values. This is determined by performing a residual analysis. The time series data used for the study was initially found to be non-stationary. It is then transformed into stationary data using differencing before the models can be used for analysis and prediction. 2023, The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. -
Analysis and Forecasting of Crude Oil Price Based on Univariate and Multivariate Time Series Approaches
This paper discusses the notion of multivariate and univariate analysis for the prediction of crude oil price in India. The study also looks at the long-term relationship between the crude oil prices and its petroleum products price such as diesel, gasoline, and natural gas in India. Both univariate and multivariate time series analyses are used to predict the relationship between crude oil price and other petroleum products. The Johansen cointegration test, EngleGranger test, vector error correction (VEC) model, and vector auto regressive (VAR) model are used in this study to assess the long- and short-run dynamics between crude oil prices and other petroleum products. Prediction of crude oil price has also been modeled with respect to the univariate time series models such as autoregressive integrated moving average (ARIMA) model, Holt exponential smoothing, and generalized autoregressive conditional heteroskedasticity (GARCH). The cointegration test indicated that diesel prices and crude oil prices have a long-run link. The Granger causality test revealed a bidirectional relationship between the price of diesel and the price of gasoline, as well as a unidirectional association between the price of diesel and the price of crude oil. Based on in-sample forecasts, accuracy metrics such as root mean square logarithmic error (RMSLE), mean absolute percentage error (MAPE), and mean absolute square error (MASE) were derived, and it was discovered that VECM and ARIMA models can efficiently predict crude oil prices. 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. -
Analysis and measurement of supply chain flexibility
Supply chain flexibility is a strategic and tactical necessity for sustenance and progress of business enterprises. Measurement of flexibility is therefore necessary for its monitoring, control and communication. The study proposes a framework and a methodology for flexibility performance measurement of supply chains. The framework identifies flexibility objectives and its contributing attributes at four levels of the supply chain and suggests taxonomy of flexibility performance measures. A methodology to prioritise the contribution of each performance attribute to achieve the desired flexibility objective using analytic hierarchy process (AHP) has also been proposed and demonstrated in this study. The research is based on detailed literature-based study and analysis of existing frameworks of flexibility performance measurement in supply chain and expert opinion. The proposed framework is suitable for measurement, monitoring and controlling flexibility in a supply chain in addition to prioritising contributing attributes of flexibility. The research does not test the model but suggests a platform for further development. Copyright 2015 Inderscience Enterprises Ltd. -
Analysis and optimization of uplink spectral efficiency in massive multiple-input and multiple-output
Fifth Generation (5G) specifications aims for data rate of 1 Gbps in high mobility and 10 Gbps in low mobility conditions, 15-30 bps/Hz of spectral efficiency with less than 1 milli second (ms) latency reduction. Massive multiple-input and multiple-output (Massive MIMO) is one of the promising technologies in 5G standard which offers a high spectral efficiency improvement. This work focus on the uplink scenario spectral efficiency in a Massive MIMO simulation network based on third generation partnership project (3GPP) and long term evolution (LTE) document of 5G. This work analyzes the spectral efficiency metric by simulating the 5G Massive MIMO network. Then, the research identified major constraint parameters; number of user antennas, K, number of base station antennas, M, transmission power, P, channel bandwidth, B, and coherence time, Tau_C and pilot time Tau_P which plays a significant role in varying this metric. The authors focus on improving the spectral efficiency by passing these constraint parameters through different meta-heurestic optimization algorithms, such as, convex optimization solver, White shark optimization (WSO) and Particle swarm optimization (PSO). The results show an overall, 1-10 percent of improvement of the parameter wnen compared with other research articles. The maximum value achieved is 49.84 bps/Hz, which is three times higher as per to the 3GPP and International Telecommunication Unioin (ITU) release document. 2022 Institute of Advanced Engineering and Science. All rights reserved.