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Romance and Hitchcock? Viewing master of suspense as master of romance
This essay through literature and textual analysis argues that romance or romantic love is a dominant theme in Alfred Hitchcocks films alongside suspense. Romance in Hitchcocks films is highlighted in limited studies in the past and the findings are not conclusive. This study analysed a selected sample of 19 prominent films of Hitchcock. It argues that romantic content in Hitchcocks films is similar to classic Hollywood romantic films. However, unique features of romance specific to Hitchcocks films such as working together to solve a mystery, and complicated love were also found as recurring themes. Hitchcock employs his auteur style in the portrayal of romantic love to an extent that the romantic content in his films can be characterised as having a distinct style lending itself to term it as Hitchcock romance. Hitchcock romance is the amalgamation of suspense and romance that support each other to drive the narrative forward. 2024 Informa UK Limited, trading as Taylor & Francis Group. -
A Novel Machine Learning-Based Prediction Method for Early Detection and Diagnosis of Congenital Heart Disease Using ECG Signal Processing
Congenital heart disease (CHD) represents a multifaceted medical condition that requires early detection and diagnosis for effective management, given its diverse presentations and subtle symptoms that manifest from birth. This research article introduces a groundbreaking healthcare application, the Machine Learning-based Congenital Heart Disease Prediction Method (ML-CHDPM), tailored to address these challenges and expedite the timely identification and classification of CHD in pregnant women. The ML-CHDPM model leverages state-of-the-art machine learning techniques to categorize CHD cases, taking into account pertinent clinical and demographic factors. Trained on a comprehensive dataset, the model captures intricate patterns and relationships, resulting in precise predictions and classifications. The evaluation of the models performance encompasses sensitivity, specificity, accuracy, and the area under the receiver operating characteristic curve. Remarkably, the findings underscore the ML-CHDPMs superiority across six pivotal metrics: accuracy, precision, recall, specificity, false positive rate (FPR), and false negative rate (FNR). The method achieves an average accuracy rate of 94.28%, precision of 87.54%, recall rate of 96.25%, specificity rate of 91.74%, FPR of 8.26%, and FNR of 3.75%. These outcomes distinctly demonstrate the ML-CHDPMs effectiveness in reliably predicting and classifying CHD cases. This research marks a significant stride toward early detection and diagnosis, harnessing advanced machine learning techniques within the realm of ECG signal processing, specifically tailored to pregnant women. 2024 by the authors. -
Enablers and Outcomes of Supply Chain Collaboration for Sustainable Growth
This study explores the intricate dynamics, challenges, and potential benefits of supply chain collaboration, emphasizing its pivotal role in achieving sustainability goals. Modern Supply Chain Collaboration (SCC) projects focus on sustainability-related activities, fostering interdependence between partners and driving sustained competitive advantage. The study introduces a comprehensive framework encompassing specific enablers (e.g., Joint Decision Making, Technology Integration) and outcomes (e.g., Social, Economic, and Environmental Sustainability) of supply chain collaboration. It contributes to practical guidelines for businesses seeking to enhance collaboration strategies and delves into theoretical paradigms such as the Cooperative Advantage concept, Triple Bottom Line Theory, Resource-Based View Theory, and Network Theory. The Triple Bottom Line Theory serves as an integrated theory of sustainability, emphasizing economic advantages, environmental impact minimization, and societal benefits. The Resource-Based View Theory underscores the role of internal resources in gaining competitive advantages, aligning with sustainability goals. Network Theory explores collaborative dynamics among competing entities, emphasizing resource sharing. The study's findings offer practical implications, enabling companies to assess and improve the sustainability of their supply chain management. It advocates for the integration of supply chain collaboration into organizational missions, emphasizing the importance of trust-building through standardized guidelines. The insights gained from this study are applicable across sectors, aiding legislators in developing flexible regulations and refining collaboration processes. Additionally, the study highlights the potential cultural variations in supply chain collaboration, paving the way for future research. 2024, Iquz Galaxy Publisher. All rights reserved. -
Acidified groundnut cake for enhanced bio adsorption of anionic textile dye Reactive Red 195
This study focuses on the improvement of bioremediation of textile dye Reactive Red 195 using agro-industrial waste, groundnut oil cake (GNOC) obtained after oil-pressing. The treatment of GNOC with 1 N H2SO4 had resulted in physiochemical changes on the insoluble porous adsorbent, which improved their adsorption efficiency. The dye removal efficiency increased from 55% to 94% on acidification of GNOC. The raw groundnut oil cake (RGNOC) and acid-treated groundnut oil cake (AGNOC) were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction, and zeta potential. The rate and efficiency of dye adsorption were examined using adsorption kinetics and isotherm models. The results confirm that acid-treated GNOC eliminates impurities, alter the surface functional groups, and significantly increase porous surface areas of RGNOC. The investigation of key factors such as contact time, initial concentration of dye, static/agitation impact, particle size, and adsorbent dose had significantly influenced adsorption capacity of GNOC. Adsorption of dye fits best into the Langmuir model and equilibrium data of dye on AGNOC was explained by psuedo-second-order reaction with maximum adsorption capacity of 12.65 mg/g. This emphasis AGNOC has a very excellent potential to remove the textile dye Reactive Red dye from industrial effluent. 2024 Taylor & Francis Group, LLC. -
Role of Experiential Learning Program on Business Writing Skills of Management Students
Purpose: Writing has been identified as an important skill. Business writing refers to the form of writing that is used to communicate in formal settings in various corporations and organizations. A number of research studies have identified writing as a crucial skill that needs to be developed by students. The purpose of the study is therefore to understand how an experiential learning module on business writing can improve the email-writing and report-writing skills of management postgraduates. Design/Methodology/Approach: The study uses an experimental research methodology based on experiential learning pedagogy to obtain the results of the intervention on the business writing skills of the management postgraduate students. The module was developed by the researcher and then was taught to the students through the online platform Zoom. Pretest, posttest, and delayed posttest analysis was conducted to find the impact of the intervention. The students were evaluated by an industry expert to avoid bias as they were trained by the researcher. Findings: The results of the study indicated that the intervention had a significant impact on the business writing skills of the participants. The results of the component analysis also indicated a large effect on the content, persuasive abilities, lateral thinking abilities, and the interpersonal skills of the participants in written communication. The analysis of the test scores revealed that an initial training based on the experiential learning methods can have a long-term impact on the improvement of the skills of the students, as the delayed posttest results were more than the posttest results. Originality/value: The study will be beneficial to educators, trainers, as well as students in understanding how experiential learning can impact the business writing skills of the students. 2024 by the Association for Business Communication. -
A comparative study on the moderating impact of renewable energy and innovation on environmental quality
This study explores the complex interactions between renewable energy production, innovation, economic growth, institutional quality, economic globalization, and CO2 emissions in OECD countries and emerging economies from 1996 to 2021. Results from DriscollKraay standard error and feasible generalized least square reveal distinct trends: renewable energy production leads to increased CO2 emissions in emerging economies but significantly reduces emissions in OECD countries. Besides, residential and non-residential innovation, along with total innovation, show similar effects. Notably, technology-moderated renewable energy production effectively lowers CO2 emissions in both country groups. Similarly, economic growth enhances environmental quality in both sets of countries. However, institutional quality needs improvement in emerging economies, while current levels suffice in OECD nations to maintain environmental quality. Moreover, the study emphasizes the importance of considering globalization's impact on CO2 emissions, advocating for international agreements to leverage globalization for environmental benefits. Overall, these findings provide valuable insights for shaping renewable energy policies, fostering innovation, promoting economic growth, enhancing institutional quality, and harnessing globalization efforts to reduce CO2 emissions and enhance environmental quality. 2024 United Nations. -
Deep Learning for Early Detection of Tomato Leaf Diseases: A ResNet-18 Approach for Sustainable Agriculture
The paper explores the application of Convolutional Neural Networks (CNNs), specifically ResNet-18, in revolutionizing the identification of diseases in tomato crops. Facing threats from pathogens like Phytophthora infestans, timely disease detection is crucial for mitigating economic losses and ensuring food security. Traditionally, manual inspection and labour-intensive tests posed limitations, prompting a shift to CNNs for more efficient solutions. The study uses a well-organized dataset, employing data preprocessing techniques and ResNet-18 architecture. The model achieves remarkable results, with a 91% F1 score, indicating its proficiency in distinguishing healthy and unhealthy tomato leaves. Metrics such as accuracy, sensitivity, specificity, and a high AUC score on the ROC curve underscore the model's exceptional performance. The significance of this work lies in its practical applications for early disease detection in agriculture. The ResNet-18 model, with its high precision and specificity, presents a powerful tool for crop management, contributing to sustainable agriculture and global food security. (2024), (Science and Information Organization). All Rights Reserved. -
Fluorescent Carbonized Polymer Dots Derived from o-phenylenediamine and its Photonic Application
Optimizing the optoelectronic characteristics of low-dimensional carbon dots (CDs) through surface modifications and doping has proven instrumental in tailoring them for diverse applications. This study explores a facile and economical hydrothermal synthesis method for generating Carbonized Polymer Dots using o-phenylenediamine at different temperatures. The resulting materials exhibit structural and morphological variations linked to the synthesis temperature. A transition from carbon dots (CDs) embedded in reduced graphene oxide (rGO)-like sheet structures at low temperatures to the core-shell structure at the highest temperature is observed in HR-TEM, implying the formation of CPDs. X-ray photoelectron spectroscopy (XPS) corroborates these findings, showing an augmented degree of graphitization in alignment with HR-TEM results. The photoluminescence spectra of CPDs synthesized at the lowest temperature exhibit multiple emission peaks, resulting in a yellowish-orange color. Utilizing these CPDs to fabricate light-emitting diodes (LEDs) produces a vivid bright-green emission with CIE coordinates (0.378, 0.522). Moreover, the CPDs demonstrate solvatochromism across diverse solvents of varying polarity, covering the entire visible spectrum. This intriguing solvatochromic effect positions the CPDs as promising materials for polarity probing applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
On thermal performance of spine fin in magnetized hybrid fluid rooted with Cu and MoS4 nanoparticles
This study examines the thermal performance of diverse profiles of spine fins with variable thermal conductivity. A hybrid nanofluid comprising Cu, and MoS4 with water as the base fluid, is modeled mathematically. Both the cylindrical and concave parabolic profiles are taken into account. The comparative outcomes are inferred from numerical and semi-analytical methods. The non-dimensional temperature profiles are analyzed graphically while considering the fin tip to be insulated, and the effects of various thermal parameters are also investigated. We have observed that the heat transfer rate shows an opposite trend toward convective-conduction and porosity parameter. The study also revealed that the concave parabolic profile emits more heat in comparison with the cylindrical profile. 2024 Author(s). -
Studies on phase transitions and dielectric properties of biowaste synthesized porous carbon nanoparticlesferroelectric liquid crystal mixture
Ferroelectric liquid crystals(FLCs), an exciting class of liquid crystals(LCs), found potential applications in the display as well as non-display regimes due to their fast response, low driving voltage and nonvolatile memory. The amalgamation of nanoparticles into FLCs has opened up new avenues in the LCs research field by alterations/modification of the existing properties of LCs. In this work, porous carbon nanoparticles (PCNPs) were dispersed into FLC mixture (W206E) and investigated their doping effect on FLCs textural, phase transition temperatures and dielectric studies in planar-aligned cells. Dielectric spectroscopy was carried out in the frequency range of 20 Hz to 10 MHz to explore the frequency as well as the temperature dependent of FLC in the entire SmC* region. The transition temperature of FLC mixture is increased by 4 C in PCNPs doped FLC sample then undoped FLC sample. Nearly 8.42% increase in permittivity is observed. A Gold stone relaxation mode at ?627 Hz was observed at lower frequency. 2024 Taylor & Francis Group, LLC. -
Labor unrest at Wistron Corporation India plant What went wrong?
Learning outcomes: After completion of this case study, students/managers will be able to analyze reasons for the labor unrest at Wistron Corporations Indian manufacturing plant; examine the implementation of labor regulations applicable to the employment of contract workers by Wistron Corporation; infer the problems associated with rapid expansion in the workforce; analyze the labor regulatory challenges faced by Wistron Corporation; and demonstrate problem-solving skills. Case overview/synopsis: The focus of this case study was the crisis faced by Apples contract manufacturer Wistron Corporation due to labor unrest, riots and violence in its production facility located near Bangalore in India. This case study discussed the CEOs dilemma in resolving the crisis and regaining the confidence of stakeholders, namely, the contract employees, Apple Inc. and the State Government of Karnataka. To give the readers an overview of the crisis this case discussed in detail the underlying reasons for the labor unrest such as a rapid increase in manpower, unilateral increase in working hours without extra pay, unjustified pay cuts, understaffed and underqualified human resources (HR) department, ill-equipped attendance and payroll system. It also gave an overview of mistakes in labor management that could be avoided by a manufacturing firm. The case also discussed the pressure faced by the Wistron CEO due to probation and a new business freeze by Apple Inc. This case study is suitable for understanding the complexities of labor laws and the legal complications that can arise when a corporation disregards local labor laws while operating in foreign countries. Complexity academic level: The case is best suited for postgraduate and executive MBA students studying labor law, industrial psychology and HR management in commerce and business management streams. The authors suggest that the instructor should inform students to read the case study before attending the 90-min session. It can be executed in the classroom after discussing the theoretical concepts. Supplementary materials: Teaching notes are available for educators only. Subject code: CSS 6: Human Resource Management. 2024, Emerald Publishing Limited. -
ENHANCING FOREST ECOSYSTEM RESILIENCE TO CLIMATE CHANGE WITH VANET AND INTEGRATED NATURAL RESOURCES MODELLING
Forest ecosystems are immediately threatened by rising global temperatures and changing climatic patterns. Periodic assessments also contribute to a reduction in the frequency of monitor-ing, which could cause environmental changes to go unnoticed. This work develops a novel real-time monitoring and early warning system to meet this difficulty. By integrating Vehicular Ad Hoc Networks (VANET) with sophisticated natural resources modelling, the proposed method aims to revolutionise the way forest ecosystems are managed. This study strives to design and implement a comprehensive system that harnesses the power of VANET to collect real-time data from sensors deployed on vehicles, and integrates advanced modelling to predict, assess, and mitigate risks to forest ecosystems. The proposed method involves deploying a network of vehicles equipped with environmental sensors within VANET. These sensors continuously collect data on crucial environmental parameters, such as temperature, humidity, air quality, and spatial information. The data are transmitted through a secure VANET communication protocol to a centralised processing unit, where it is integrated with climate models and ecosystem dynamics models. Resilience metrics and thresholds are defined to trigger a tiered early warning system. Preliminary testing of the system demonstrates promising accuracy and responsiveness. The integrated approach allows for dynamic risk assessment, enabling the identification of potential threats such as extreme weather events, invasive species, or disease outbreaks. Early warnings prompt adaptive management strategies, showcasing the systems potential to significantly enhance forest ecosystem resilience. This research presents a pioneering solution to the escalating challenges faced by forest ecosystems in the time of climate change. The real-time monitoring, early warning system, amalgamating VANET and integrated modelling, stand as a robust tool for forest managers, policymakers, and communities to proactively address environmental changes. The findings underscore the systems potential to transform forest management practices, marking a critical step toward sustainable and resilient ecosystems. 2024, Scibulcom Ltd. All rights reserved. -
Evaluating the Categorical Exclusion of Khasi Women from Inheritance and Property Rights : A Case of East Khasi Hills
Customary laws govern inheritance among many tribal communities that fall within the ambit of the fifth and sixth schedules of the Indian Constitution. Under this papers scope, we shall look at the Khasi community hailing from the state of Meghalaya which is a matrilineal community. Where the Khasis draw their lineage from their mothers, there is a misnomer that women inherit and own the entire property. In light of the abovementioned background, the paper makes an analytical study of the customary inheritance rights of Khasi women, the nature of resource ownership and attempts to understand the grounds behind the claims of gender preference in the existing matrilineal system practised by the Khasis of Meghalaya. We also look at the intersection of gender and matrilineal system of inheritance in the Khasi community, the dispute between customs and legislations and examine whether there exists a need for codification. The paper also discusses the findings of the survey and focus group discussions including 90 Khasi women from East Khasi Hills and their growing consensus on equal inheritance rights but resistance towards statutory laws to govern their lives. JYOTI SINGH AND KAJORI BHATNAGAR, 2024. -
Examining the impact of website layout and dark triad approach on real estate purchase decisions in India: a young adult socialization mediated model
Purpose: This study aims to determine website quality, young adult socialization and dark triad personality as the factors influencing the real estate purchase decision. In addition, this study also measures the mediating effects of young adult socialization on real estate purchase buying behavior. Design/methodology/approach: Related literature, quantifiable variables with a five-point Likert scale, hypothesis testing and mediators are used to study the model. A systematic questionnaire that was divided into four sections was used. A total of 336 valid responses were collected and analyzed through a structural equation model. Findings: The results suggest that dark triad personality and young adult socialization considerably affect real estate purchase decisions. The development proves website quality does not significantly impact real estate purchase behavior. Research limitations/implications: This study is limited to a few young consumers responses. Future studies could be more widespread globally and should include more variables and offline methods of purchasing behavior. Originality/value: As per the review of existing literature, this research is the first, to the best of the authors knowledge, to determine the factors affecting the real estate purchase decision with factors like website quality, dark triad personalities and young adult socialization involving it. 2024, Emerald Publishing Limited. -
Eco-conscious photocatalytic degradation of organic textile dyes using green synthesized silver nanoparticles: a safe and green approach toward sustainability
Green synthesized nanoparticles from Strobilanthes barbatus leaf extracts are environmentally safe and feasible for enduring wastewater treatment, especially for organic textile dye degradation. The synthesized Strobilanthes barbatusmediated silver/silver-oxide nanoparticles (SB-Ag/AgO NPs) showed maximum absorbance at 428nm. The SB-Ag/AgO NPs were generally spherical with an average diameter of 37.59nm (FESEM and TEM analysis). The importance of functional groups in the production of SB-Ag/AgO NPs was recorded by FTIR investigations. In the degradation and rate of degradation for textile dyes, after 320min, SB-Ag/AgO NPs displayed 96.60% (5.31 10?1 L mg?1min?1) and 87.50% (1.179 10?1 L mg?1min?1) degradation of Reactive Blue 220 (RB-220) and Reactive Blue 222A (RB-222A), respectively. When compared to dye effluents, SB-Ag/AgO NPs-treated dye solutions revealed a considerable decrease in inhibitory efficiency during phytotoxicity evaluation on test organisms, Vigna radiata and Artemia salina. The biosynthesized SB-Ag/AgO NPs could serve as a feasible photocatalyst for the treatment of organic textile dyes in organic substancepolluted water ecosystems. SB-Ag/AgO NPs can serve as efficient, cost-effective and environmentally friendly sources for dye degradation. The current research offers a safe and environmentally friendly strategy for sustaining the environment. 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. -
Crisis Faced by a B-School
This article discusses the marketing missteps made by a prestigious B-school, exploring key concepts such as improper positioning and the imperative for repositioning. It provides an in-depth analysis of the decline in admissions at this well-established institution, culminating in a crisis. Additionally, the article explores a range of strategies available to the B-schools founder and top management team to enhance the institutions visibility and bolster its brand. Furthermore, it sheds light on the challenges the B-school faces, including inadequate infrastructure and other weaknesses, such as subpar research output, moderate placement offers and a low ranking in national B-school surveys. The case meticulously examines the errors made by the B-schools leadership team, such as discontinuing advertising and the ill-advised decision to withdraw from B-school surveys. Ultimately, this article epitomizes the predicament faced by an institution that relied on its historical strengths and failed to adapt to the evolving demands of its environment. It concludes by presenting short-term and long-term strategies available to decision-makers for crisis mitigation. It highlights digital marketing as one of the short-term solutions earnestly considered by the B-schools management to enhance brand awareness among its target audience. 2024 Lahore University of Management Sciences. -
Ag Ions Versus Ag Nanoparticle-Embedded Glass for Antimicrobial Activity Under Light
Incorporating silver nanoparticles (NPs) into a host material has been recognized to limit the release of Ag+ ions, yet their efficacy in neutralizing nearby microorganisms remains uncertain. This study aims to compare the toxicity of Ag+ ions versus the plasmonic effect of Ag NPs within a glass matrix, assessing their respective killing efficiency and mechanisms against microorganisms. To achieve this objective, a simple ion exchange technique was employed to embed glass with silver ions, nanoclusters (NCs), or NPs, which was confirmed by UVVis-NIR spectrometer, photoluminescence (PL), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocidal action of these Ag species on model Escherichia coli (E. coli) bacteria was investigated in the absence and presence of visible light. The findings revealed that in the absence of light, plasmonic Ag NPs were less toxic to E. coli compared to Ag+ ions due to the predominant release of Ag+ ions dictating the antibacterial effect. However, exposure to visible light triggered the plasmonic effect in Ag NPs to disintegrate 100% E. coli in 1h compared to Ag+ ions (68%) owing to the localized heating around the Ag NPs, facilitated by surface plasmon resonance relaxation. The cell morphology investigated by Bio-AFM assisted in unraveling the mechanism leading to bacterial cell damage. Overall, this study demonstrates the sustained disinfection capability of Ag NPs embedded in glass without significant leaching, emphasizing their potential in prolonged antimicrobial applications. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Valorization of waste chilli stalks (Capsicum annuum) as a sustainable substrate for cellulose extraction: insights into its thermomechanical, film forming and biodegradation properties
Rising global population accelerates food waste generation, thereby creating a crisis in food waste management. A solution involves deriving value-added products like cellulose biopolymer from food waste. Chilli stalk wastes are one such food waste which are generated in large quantities and are unsuitable for field use or incineration due to health and environmental challenges. A greener alternative is extracting cellulose biopolymer from chilli stalk waste. The extraction of cellulose biopolymer from chilli stalk results in a renewable, biodegradable and economically efficient biomaterial with a broad range of applications. The extraction process involving alkali treatment (NaOH) and bleaching (alkaline H2O2), resulted in a yield of 29.85% cellulose biopolymer. The extracted cellulose was subjected to quantification and functional property analysis followed by characterization (FTIR, XRD, TGA, DSC and SEM) to analyse functional groups, crystallinity, thermal properties and surface morphology. Functional property analysis resulted in higher values when compared with commercial cellulose. The characterization techniques confirmed the effective removal of impurities such as lignin, hemicellulose and pectin by the chemical treatments. Cellulose sheets, fabricated using solvent casting, exhibited exceptional biodegradability (85.36%) within 20days, surpassing conventional food packaging materials, commercial food packaging paper (15.95 0.12% [%w/w]) and plastic sheets (7.89 0.33% [%w/w]) over the same time period. The novelty of this research lies in the innovative valorization of chilli stalk waste, which often remains unused in large quantities globally. This study introduces a cost-effective method to convert it into a value-added, highly biodegradable biopolymer. The resulting cellulose sheets provide an eco-friendly substitute for traditional food packaging materials. 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. -
Determinants of Financial Development in Top and Bottom Remittances and FDI Inflows Recipient Developing RegionsHow Does Institutional Quality Matter?
In this paper, we empirically examine the effects of remittances inflows, foreign direct investment (FDI) inflows, and institutional quality index on financial development index in the top (15 Europe and Central Asian countries) and bottom (29 Sub-Saharan African countries) remittances and FDI recipient developing regions using balanced panel data over the period 19842020. We used economic growth and government investment as control variables in the financial development function. The findings from the panel PMG-ARDL model indicate that inflows of remittances, FDI, and institutional quality stimulate (reduce) financial development in the top (bottom) region. This varying finding appears to be conditional on introducing institutional quality in financial development function as moderating factor. It finds that financial development is positively associated with remittance and FDI inflows in the presence of institutional quality as moderating channel for both the regions. Financial development is also significantly associated with economic growth in both regions. The mixed impact of domestic investment on financial development is found in both the regions. Our results are robust to the FGLS technique as an alternative econometric set-up. Interestingly, institutional quality reduces the weak effects of remittances and FDI inflows on financial development in the bottom region. Overall, our findings confirm the Mishkins (2009) economic globalization-led (i.e., remittances and FDI inflows) financial development hypothesis. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Metal organic frameworks in biomedicine: Innovations in drug delivery
Metal-organic frameworks (MOFs) have emerged as a class of versatile materials, finding extensive applications in drug delivery because of their unique properties and flexible design. This comprehensive review aims to give a broad perspective on the recent advancements in the area of drug delivery applications using MOFs. The fundamental characteristics of MOFs, highlighting their exceptional porosity, high surface area, and tuneable framework structures, enable MOFs to serve as ideal drug carriers, allowing efficient drug loading and controlled release. The review delves into the various ligands and metal ions employed for drug encapsulation. These include physical encapsulation, covalent bonding, and host-guest interactions, each offering distinct advantages for diverse types of drugs and therapeutic applications. The importance of tailoring MOF properties to optimize drug loading capacity, stability, and release kinetics has been emphasized. Additionally, the explorations involve delving into the mechanisms of drug release from MOFs, with factors such as pH, temperature, and external stimuli that can be harnessed to trigger controlled drug release. The utilization of MOFs in combination therapies, such as co-delivery of multiple drugs or integrating imaging agents, has also been examined. Numerous examples of MOFs used for drug delivery, encompassing both in-vitro and in-vivo studies, covering a wide range of therapeutic areas, including cancer treatment, antimicrobial therapy, and targeted drug delivery, are included. Additionally, the review addresses the challenges and future perspectives in the development of MOFs for drug delivery. Strategies to improve MOF stability, biocompatibility, and scalability are discussed, along with the understanding of MOF-drug interaction and potential toxicity concerns. With their tuneable properties, high loading capacities, and controlled release capabilities, MOFs hold exceptional capabilities that promise to enhance the efficacy of therapeutic interventions. Continued research and development in this area can pave way for the translation of MOFs into clinical applications in the near future. 2024 The Author(s)