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Synthesis of Thiazines, Thiazinones and N-Cycloalkyl Azoles Via Novel Synthetic Routes
Heterocyclic building blocks have gained the utmost importance in recent past on the newlineaccount of their significance in biological and pharmaceutical fields. Among these newlinenitrogen and sulphur containing heterocyclic building blocks such as thiazines, newlinethiazinones and N-cycloalkyl heterocyclic motifs hold an important role in medicinal newlinechemistry. Thiazine cores are used for the treatment of various life threating diseases newlinelike cancer, cardiovascular and fabry diseases. Drugs containing thiazinone cores were used to treat Parkinson, Alzheimer s and various neuro degenerative diseases. Ncycloalkyl azole motifs are used to treat various life threating cancers like neck, lung, prostate, breast etc. As per the literature review, synthesis of these motifs are done using multi steps and harsh conditions, which limited the substrate scope. In this thesis we describe our studies on development of one pot, mild condition for newlinesynthesis of thiazinone cores using P(NMe2)3 (HMPT). We had developed HMPT [P(NMe2)3] mediated reactions towards synthesis of Carbon-Nitrogen/Carbon-Sulphur bond. The developed methodology was extended for thiazine cores as well. This new synthetic methodology is useful to synthesize various N, S-heterocycles including the novel spiro molecules. HMPT reagent under the mild and aerobic reaction conditions provided the access for many manifold immense molecules. Molecular docking studies were conducted for the synthesized compounds considering MOA-B inhibitors as target. MOA-B inhibitor motifs were approved for the treatment of Parkinson illness. The synthesized thiazine and thiazinone molecules showed good binding affinity in molecular docking studies conducted. We had developed a new strategy using T3P (1-Propanephosphonic anhydride, ~ 50 % wt, in EA solution) mediated synthetic procedure for the synthesis of N-cycloalkyl newlineazoles. -
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P(III)-Mediated Cascade C-N/C-S Bond Formation: A Protocol towards the Synthesis of N,S-Heterocycles and Spiro Compounds
A P(III)-mediated entry towards construction of C?N/C?S bond has been devised. The developed heterocyclization method was exercised for the synthesis of a diverse range of N,S-heterocycles and related spiro molecules. P(NMe2)3 revealed the maximum efficacies under the aerobic reaction conditions and a spectrum of bis-nucleophiles, and isothiocyanates were tolerated well to serve the access of manifold immense molecules. (Figure presented.). 2020 Wiley-VCH GmbH -
Aza-Michael addition of 1,2-diazoles to structurally diverse enones: Efficient methods toward ?-amino ketones
An efficient and mild protocol was realized using 1,2-diazoles and related heterocycles with cyclic and acyclic enones in presence of T3P (2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide) toward the regioselective formation of N-cycloalkyl heterocycles at room temperature. The developed reaction conditions showcased good selectivity over a wide range of 1,2-diazoles and enones by delivering N-cycloalkyl heterocycles in excellent yields. 2020 Wiley Periodicals LLC. -
GASP XXIII: A Jellyfish Galaxy as an Astrophysical Laboratory of the Baryonic Cycle
With MUSE, Chandra, VLA, ALMA, and UVIT data from the GASP program, we study the multiphase baryonic components in a jellyfish galaxy (JW100) with a stellar mass 3.2 1011 M o hosting an active galactic nucleus (AGN). We present its spectacular extraplanar tails of ionized and molecular gas, UV stellar light, and X-ray and radio continuum emission. This galaxy represents an excellent laboratory to study the interplay between different gas phases and star formation and the influence of gas stripping, gas heating, and AGNs. We analyze the physical origin of the emission at different wavelengths in the tail, in particular in situ star formation (related to H?, CO, and UV emission), synchrotron emission from relativistic electrons (producing the radio continuum), and heating of the stripped interstellar medium (ISM; responsible for the X-ray emission). We show the similarities and differences of the spatial distributions of ionized gas, molecular gas, and UV light and argue that the mismatch on small scales (1 kpc) is due to different stages of the star formation process. We present the relation H?-X-ray surface brightness, which is steeper for star-forming regions than for diffuse ionized gas regions with a high [O i]/H? ratio. We propose that ISM heating due to interaction with the intracluster medium (either for mixing, thermal conduction, or shocks) is responsible for the X-ray tail, observed [O i] excess, and lack of star formation in the northern part of the tail. We also report the tentative discovery in the tail of the most distant (and among the brightest) currently known ULX, a pointlike ultraluminous X-ray source commonly originating in a binary stellar system powered by either an intermediate-mass black hole or a magnetized neutron star. 2019. The American Astronomical Society. All rights reserved. -
The future of business management with the power of distributed systems and computing
Distributed systems and computing have emerged as key technologies for businesses seeking to improve their operations, decision-making, and customer experience. In this chapter, we examine the potential of distributed systems and computing for the future of business management. We analyze the key characteristics and advantages of distributed systems and computing for business management, including improved scalability, flexibility, and availability, as well as increased efficiency and reduced costs. We also discuss the various applications of distributed systems and computing in business management, including inventory management, supply chain optimization, customer relationship management, financial management and accounting, data analytics, decision-making, and collaboration and communication. We also explore the emerging trends and technologies in distributed systems and computing, including edge computing, blockchain, and artificial intelligence, and their potential implications for the future of business management. Furthermore, we discuss the opportunities for research and innovation in the field of distributed systems and computing, including the development of new algorithms and protocols, the exploration of novel applications, and the investigation of the social and ethical implications of distributed systems and computing. In conclusion, distributed systems and computing offer a powerful set of tools for businesses seeking to enhance their performance and competitiveness in the digital age. However, the adoption of distributed systems and computing also entails a range of challenges and risks that must be addressed through careful planning and management. By embracing the potential of distributed systems and computing while also addressing its challenges, businesses can position themselves for success in the increasingly interconnected and digital world of the future. 2024 John Wiley & Sons Ltd. All rights reserved. -
Impact of blended education system on outcome-based learning and sector skills development
An effective education system transforms the teaching and learning process into innovative idea generation and independent working ability. A blended education system is the representation of effective education that connects the teachers, students, and educational institutions for content development, delivery of effective teaching methods, and choice-based learning. The motive for initiating the research work was to address the demand for outcome-based learning in society that can fulfill the sector-wise human resource requirements and sector skill development. A blended education system helps to design effective courses and degrees with the capacity of choosing subjects, lectures, and teachers either in online or offline mode of education. The system may also assist in preparing the learning pattern like classroom-based learning, internship-based learning, or learning through project works. The researchers identified the dependent and independent variables with the help of expert opinion. The questionnaire was designed with all relevant questions based on the variables and refined through a pilot study. The research outcomes are described by understanding the nature of quantitative data using statistical tools like frequency distribution, t-test, and ANOVA test with the connectivity of qualitative data and the reality of social issues. 2023 IEEE. -
Level of green computing based management practices for digital revolution and new india
The reality is staring us in the form of global warming, climate changes and air-quality degradation. This reality constitutes an increasing zone on the strategic front. These strategic changes need necessarily to be responded through employees of an organization. Against this backdrop, the Green Information Technology and Green HRM have emerged as a sequel to rapid degradation of our planet due to human activities. Therefore, incorporating the environmentally friendly practices through IT practices, recruitment, training and performance management functions constitute important components of Green IT and HRM. Green information technology is the revolutionary initiatives especially for human resources management practices that lead to digital life towards sustainable society. Keeping this practical and emergent context in view, the present study makes an attempt to develop a framework for assessing the level of green HRM practices actually prevailing in Indian organizations. The requisite data were collected from original sources and clarified with existing sources. The results of the study led to the inference that Information Technology and HRM practices of promoting individual performance needs fine-tuning because any green initiative has necessarily to be a collective exercise by all concerned. BEIESP. -
E-Development and Sustainable Management Education for Effective Leadership and Sustainable Society
Electronic development is the process of systematic evolution for mankind and society at large that ensures the overall progress of the electronic mode of learning, education, healthcare, society, and corporate governance. The main objective of the chapter was to address the impacts of e-development and sustainable management education for effective leadership that leads to constructing a sustainable society. The required data were collected both from primary and secondary sources. Primary data were collected from 120 respondents. The secondary data sources included official websites. The study is empirical and various statistical tools like mean, standard deviation, and t-test were executed for data analysis. The results of the research study were indicated the high degree and low degree of contribution from e-development and sustainable management education are not significant between effective leadership and sustainable society. E-development can be effective for creating a sustainable society with the goal setting of improving effective leadership skills. Copyright 2022, IGI Global. -
Research Initiative on Sustainable Education System: Model of Balancing Green Computing and ICT in Quality Education
Green Computing Practices (GCP) convey the revolutionary changes of the modern education system. The education system is transforming into a hybrid mode of operations in effective teaching and learning procedure. In the modern era, computer devices are playing a foremost role in performing ICT based teaching and learning (ICT-BTL). The GCP and ICT-BTL are the creative and innovative practices that can ensure the eco-friendly enactment and safeguard from various harmful environmental impacts. The motive of projecting the present research outcome is to address the impact of GCP on ICT-BTL activities. The creative and innovative practices of ICT-BTL support the implementation of GCP towards a sustainable education system. A sustainable education system interconnects the teachers, learners, institutions, and industrial experts through eco-friendly electronic and computer devices that ensure maximum efficiency in education with minimum environmental impacts. 2022 IEEE. -
Consumer ethnocentrism and buying intentions on OTT platforms
This research delves into how OTT platforms are transforming media consumption patterns and explores the role of consumer ethnocentrism in shaping buying behaviors within this context. Through a literature review and quantitative research methodology using a Likert-scale questionnaire, the study investigates the relationship between consumer ethnocentrism, buying intentions, and various influencing factors on OTT platforms. Contrary to expectations, the findings show that consumer ethnocentrism has minimal impact on buying behavior. Instead, factors such as price, content variety, personalized recommendations, cultural alignment, ease of platform usage, familiarity with foreign content, and language preferences are crucial in determining viewers' buying intentions. The chapter concludes by recommending that OTT platforms integrate cultural sensitivities into their strategies to better cater to diverse viewer preferences, thereby enhancing market competitiveness and audience engagement. 2024, IGI Global. -
Node Overlapping Detection for Draggable Node-Based Applications
Node-based interfaces are user interfaces that are based on the concept of nodes, which represent individual units of functionality, and edges, which represent the connections between nodes. In a node-based interface, nodes are connected by edges to form a graph, which represents the data flow and relationships between different parts of the system. The Node overlapping detection technique is only for react flow version 11 and higher. Users having previous versions are not able to use that functionality. To detect the overlapping, based on the output of this library, several user-defined functions can be used to resolve to overlap. It will see the single-pixel overlap. Using this library, users can avoid Node and edge overlapping by creating custom edges. It is a simple JavaScript function currently used for reactjs. In the future, if any other script develops a draggable node-based flowsheet-creating feature, the user can use this library accordingly. 2023 IEEE. -
An efficient ZnO and Ag/ZnO honeycomb nanosheets for catalytic green one-pot synthesis of coumarins through Knoevenagel condensation and antibacterial activity
This study pioneers the synthesis of porous Ag/ZnO nanosheets, focusing on their role as a catalyst in Knoevenagel condensation. Notably, these nanosheets display exceptional catalytic efficacy and captivating antibacterial properties. The research delves into the Ag/ZnO catalyst's recyclability and proposes a potential reaction mechanism, marking the first comprehensive exploration of Knoevenagel condensation on porous Ag/ZnO nanosheets. Key findings underscore the successful synthesis of coumarin derivatives using various o-hydroxy benzaldehyde and 1,3-dicarbonyl compounds, with nano-Ag/ZnO serving as a catalyst via a monomode microwave-assisted approach. X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM) and UV-Vis spectroscopy were used in conjunction with other physicochemical methods to characterize the synthesized catalytic samples. The method boasts advantages such as high product yields, brief reaction durations, and the ability to reuse the catalyst for multiple cycles. The Ag/ZnO nanosheets, functioning as an acid catalyst, activate carbonyl groups and facilitate their interaction with methylene-containing active molecules. In addition, antibacterial activity assessments demonstrate the superior effectiveness of Ag/ZnO nanocomposites compared to ZnO nanosheets against Staphylococcus aureus germs. This multifaceted study not only advances catalytic synthesis but also unveils promising biological applications of porous Ag/ZnO nanosheets. 2024 Walter de Gruyter GmbH, Berlin/Boston 2024. -
Mining and Interpretation of Critical Aspects of Infant Health Status Using Multi-Objective Evolutionary Feature Selection Approaches
The rate of infant mortality (IMR) in a population under one year of age is a marker for infant mortality. It is a major sensitive marker of a community's overall physical health. Protecting the lives of newborns has become a challenging issue in public health, development programs, and humanitarian initiatives. Almost 10.1% infants died in the United States of America (USA) in 2021. Therefore, this paper aims to extract and understand the various influential factors causing infant deaths in the USA. A crowding distance-based multi-objective ant lion optimization (MOALO-CD) is proposed here with statistical evidence for feature selection. The proposed technique is compared with competitive metaheuristic models such as multi-objective genetic algorithm based on crowding distance (MOGA-CD), multi-objective filter approaches, and recursive feature elimination. Various machine learning classifiers are applied to the selected feature subset obtained from MOALO-CD on the USA's infant dataset. Extensive experimental results indicate that the proposed model outperforms the existing metaheuristic approaches in terms of Generational Distance, Inverted Generational Distance, Spread, and Hyper volume. Also, the comparative analysis of various machine learning models reveals that random forest achieves significantly better performance on the feature subset obtained from MOALO-CD. 2013 IEEE. -
Sexual Function and Sexual Satisfaction among Non-Working Married Women in Bengaluru
Background: Sexual function and satisfaction are two important components of the sexual health of women. Both are influenced by various external and internal factors over their life cycle. This study aims to explore the factors of sexual function and newlinesatisfaction among non-working married women in Bengaluru using an exploratory newlinesequential research study and highlighting the implications for social work practices. newlineMaterials and Methods: The study has two phases. The first phase was a qualitative newlineexploratory research study that adopted an inductive thematic data analysis. In-depth newlinequalitative interviews were conducted with 11 non-working working married women. The interviews were audio recorded and the transcribed data were analyzed with ATLAS.ti software. The results were presented thematically. The second phase was a newlinecross-sectional survey of 180 non-working married women. The data were collected newlinethrough semi-structured interviews with the Female Sexual Function Index, the New newlineSexual Satisfaction scale, the Psychological Distress Scale, the Subjective Happiness newlinescale, and questions related to socio-demographic details, and health. Descriptive and inferential statistics were carried out and multiple regression analyses were conducted with jamovi v2.3. to find the predictors of both sexual function and satisfaction. Results: In the qualitative phase various factors of sexual function and satisfaction were explored and organized into three global themes. They are Somatic and personal factors, Factors related to the mind, and Situational and extrinsic factors. The quantitative study found that physical, psychological, couples characteristics-related, family, and socio-cultural factors together predict a 17.3% variance in sexual function and a 78.6% variance in sexual satisfaction of women. Conclusion: The study could find positive and negative factors of sexual function and satisfaction. -
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Hierarchically porous MN-MOFS composite with RGO as an efficient electrode material for supercapacitor application /
Patent Number: 202241046378, Applicant: Sruthi Rajasekaran.
The present invention shows the energy storage application of the manganese-reduced graphene oxide metal organic frameworks (Mn-rGO MOFs) using the ligand, pyridine 2,6 dicarboxylic acid (PDA), under mild conditions. The methodology followed was hydrothermai at 160°C with manganese sulfate as metal salt, rGO along with the PDA ligand in pyridine, and water as solvent. The development of efficient Mn-rGO MOFs is suitable for supercapacitance energy storage applications, which is the future need for various industrial applications. -
Bismuth ferrite nanoparticles decorated CR2C MXENE: A highly efficient electrocatalyst for hydrogen evolution /
Patent Number: 202241040877, Applicant: B Shalini Reghunath.
The current invention demonstrates the efficiency of bismuth ferrite/Cr2C MXene binary composite as a highly efficient electrocatalyst for hydrogen evolution reaction in alkaline media. The methodology for preparing O2C MXene is by etching the O2AIC MAX phase with hydrofluoric acid for 30 min at room temperature. Cr2C MXene and bismuth ferrite nanoparticles are mixed under solvothermal conditions to obtain the bismuth ferrite/Cr2C-MXene binary composite. -
Two-dimensional CR2C MXENE decorated with COFE204 nanoparticles for high-performance supercapacitor application /
Patent Number: 202241046374, Applicant: B Shalini Reghunath.
The current innovation shows the cobalt ferrite (CoFe204) decorated on O2C MXene binary composite. This is used as a high-efficiency electrocatalyst for supercapacitor applications in alkaline media. The O2C MXene/CoFe204 binary composite is prepared by etching the O2AIC MAX phase with hydrofluoric acid for 30 min at room temperature, followed by a solvothermal technique using cobalt ferrite nanoparticles. The interlayer spaces of O2C MXene/CoFe204 electrocatalyst improves on introducing CoFe204 nanoparticles between the O2C MXene layers, thereby boosting the capacitance of the composite. -
Synthesis of amine functionalized metal organic framework using H2FIPBB ligand for energy storage application /
Patent Number: 202241023295, Applicant: Sruthi Rajasekaran.
The present invention shows the energy storage application of the Mn-Ni@NH2-h2fipbb MOF using the ligand 4,4:hexafluoroisopropylidene bis- benzoic acid (h2fipbb) under mild conditions. The methodology followed was hydrothermal at 120°C with manganese and nickel metal salts along with the ligand in dimethylformamide (DMF). The development of efficient Mn-Ni@NH2-h2fipbb material is suitable for supercapacitance-energy storage applications, which is the future need for various industrial applications.