Browse Items (11810 total)
Sort by:
-
Genetic and cytogenetic screening of autistic spectrum disorder: Genotype-phenotype profiles
Autism, a pervasive developmental disorder typically characterized by repetitive behaviour, social skills deficit (or a deficit in social communication), speech and language impairments. Our prime focus is to analyze the clinical features and phenotypical behavioural changes using the diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM IV-TR), and locating the biomarkers associated with specific autistic characters using karyotyping and fluorescence in situ hybridization (FISH) techniques. The prevalence rate of the neurexin 1 (NRXN1) gene polymorphism was also assessed in the current study. The study group involved 196 samples with 98 autistics, and equal age-matched (2) controls based on their birth order and carrier. The participants include 35.2% males (n = 69) and 14.8% females (n = 29). The autistic and control participants were categorized based on their ages as group I (<12 yrs) with n = 62; males n = 41 (20.9%); females n = 21 (10.7%) and group II (?12 yrs)-n = 36; males n = 28 (14.2%); females n = 08 (4.08%). Karyotyping was done for autism participants (n = 98) and the results showed that 90% of autistic participants were either the only child or the first child with a low perception and frequency in both the groups. Subsequently, we carried out the FISH assay on participants (n = 37) with higher DSM-IV TR score (?30). Only 30 FISH tests were negative for subtelomeric deletions with NRXN1 polymorphism genotypic frequency as 62.50%, 25% and 25% for A/A, A/G and G/G genotype respectively. Our study suggests the link between a haplotype with clinical signs of autism for the single nucleotide sequence (SNP rs9636391) and links autistic characters and gene among autistic children according to their birth order, age and gender in India. 2021 Elsevier B.V. -
A genome wide association study of fast beta EEG in families of European ancestry
Background Differences in fast beta (2028Hz) electroencephalogram (EEG) oscillatory activity distinguish some individuals with psychiatric and substance use disorders, suggesting that it may be a useful endophenotype for studying the genetics of disorders characterized by neural hyper-excitability. Despite the high heritability estimates provided by twin and family studies, there have been relatively few genetic studies of beta EEG, and to date only one genetic association finding has replicated (i.e., GABRA2). Method In a sample of 1564 individuals from 117 families of European Ancestry (EA) drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed a Genome-Wide Association Study (GWAS) on resting-state fronto-central fast beta EEG power, adjusting regression models for family relatedness, age, sex, and ancestry. To further characterize genetic findings, we examined the functional and behavioral significance of GWAS findings. Results Three intronic variants located within DSE (dermatan sulfate epimerase) on 6q22 were associated with fast beta EEG at a genome wide significant level (p<5נ10?8). The most significant SNP was rs2252790 (p<2.6נ10?8; MAF=0.36; ?=0.135). rs2252790 is an eQTL for ROS1 expressed most robustly in the temporal cortex (p=1.2נ10?6) and for DSE/TSPYL4 expressed most robustly in the hippocampus (p=7.3נ10?4; ?=0.29). Previous studies have indicated that DSE is involved in a network of genes integral to membrane organization; gene-based tests indicated that several variants within this network (i.e., DSE, ZEB2, RND3, MCTP1, and CTBP2) were also associated with beta EEG (empirical p<0.05), and of these genes, ZEB2 and CTBP2 were associated with DSM-V Alcohol Use Disorder (AUD; empirical p<0.05). Discussion In this sample of EA families enriched for AUDs, fast beta EEG is associated with variants within DSE on 6q22; the most significant SNP influences the mRNA expression of DSE and ROS1 in hippocampus and temporal cortex, brain regions important for beta EEG activity. Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG. Converging data from GWAS, gene expression, and gene-networks presented in this study provide support for the role of genetic variants within DSE and related genes in neural hyperexcitability, and has highlighted two potential candidate genes for AUD and/or related neurological conditions: ZEB2 and CTBP2. However, results must be replicated in large, independent samples. 2016 Elsevier B.V. -
RASK: Request authentication using shared keys for secured data aggregation in sensor network
Accomplishing a robust security features to resists lethal attacks is still an open research area in wireless sensor network. The present paper review existing security techniques to find that there is still a trade-off between cryptographic-based security incorporations and communication performance. Moreover, we have identified that majority of the existing system has not emphasized on first line of defense i.e. security the route discovery process that can act as a firewall for all forms of illegitimate nodes existing in the network. The proposed study introduced RASK i.e. Request Authentication using Shared Key, which is a novel concept developed using simple quadratic formulation of generating keys for encrypting the message during data aggregation. The study outcome has been significantly benchmarked with recent studies and existing cryptographic standards to find RASK outperform existing techniques. Springer International Publishing AG 2017. -
N-tier modelling of robust key management for secure data aggregation in wireless sensor network
Security problems in Wireless Sensor Network (WSN) have been researched from more than a decade. There are various security approaches being evolving towards resisting various forms of attack using different methodologies. After reviewing the existing security approaches, it can be concluded that such security approaches are highly attack-specific and doesnt address various associated issues in WSN. It is essential for security approach to be computationally lightweight. Therefore, this paper presents a novel analytical modelling that is based on n-tier approach with a target to generate an optimized secret key that could ensure higher degree of security during the process of data aggregation in WSN. The study outcome shows that proposed system is computationally lightweight with good performance on reduced delay and reduced energy consumption. It also exhibits enhanced response time and good data delivery performance to balance the need of security and data forwarding performance in WSN. 2019 Institute of Advanced Engineering and Science. -
FSDA: Framework for Secure Data Aggregation in wireless sensor network for enhancing key management
An effective key management plays a crucial role in imposing a resilient security technique in Wireless Sensor Network (WSN). After reviewing the existing approaches of key management, it is confirmed that existing approachs does not offer good coverage on all potential security breaches in WSN. With WSN being essential part of Internet-of-Things (IoT), the existing approaches of key management can definitely not address such security breaches. Therefore, this paper introduces a Framework for Secure Data Aggregation (FSDA) that hybridizes the public key encryption mechanism in order to obtain a novel key management system. The proposed system does not target any specific attacks but is widely applicable for both internal and external attacks in WSN owing to its design principle. The study outcome exhibits that proposed FSDA offers highly reduced computational burden, minimal delay, less energy consumption, and higher data transmission perforance in contrast to frequency used encryption schemes in WSN. Copyright 2018 Institute of Advanced Engineering and Science. All rights reserved. -
Discovery of inverse-Compton X-ray emission and estimate of the volume-averaged magnetic field in a galaxy group
Observed in a significant fraction of clusters and groups of galaxies, diffuse radio synchrotron emission reveals the presence of relativistic electrons and magnetic fields permeating large scale systems of galaxies. Although, these non-thermal electrons are expected to upscatter cosmic microwave background photons up to hard X-ray energies, such inverse-Compton (IC) X-ray emission has so far not been unambiguously detected on cluster/group scales. Using deep, new proprietary XMM-Newton observations (?200 ks of clean exposure), we report a 4.6 ? detection of extended IC X-ray emission in MRC 0116 +111, an extraordinary group of galaxies at z = 0.131. Assuming a spectral slope derived from low frequency radio data, the detection remains robust to systematic uncertainties. Together with low frequency radio data from the Giant Metrewave Radio Telescope (GMRT), this detection provides an estimate for the volume-averaged magnetic field of (1.9 0.3) ?G within the central part of the group. This value can serve as an anchor for studies of magnetic fields in the largest gravitationally bound systems in the Universe. 2023 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society. -
Harnessing transition metal oxide?carbon heterostructures: Pioneering electrocatalysts for energy systems and other applications
Exponential demand for energy resources and fossil fuel substitution with green alternatives are essential to bringing sustainable development and a solution to the energy crisis. Transition metal oxides (TMOs) and their composites (TMOCs) as promising electrocatalysts to develop potential energy conversion and storage devices contribute to the solution to this crisis. The productivity of green fuels such as hydrogen from water-splitting reactions, the efficiency of energy storage and harvesting devices including supercapacitors and batteries, and the performance of electrochemical sensors can be remarkably enhanced with TMOs and their composites. Excellent electrochemical attributes, stability, abundant reserves, low cost, environment-friendly, and low toxicity make TMOs and their composites an excellent choice. The tunability of the physical and chemical properties of TMOs makes them attractive for research in designing different energy storage devices. This review presents a concise overview of the unique physical and electrochemical aspects of various TMOs and TMOCs, such as spinels, perovskites, and TMO-integrated carbon-based compounds, and their relevance for specific applications, emphasizing energy-related fields. The recent research advancements of TMOs-based functional materials for emerging applications, such as water splitting, fuel cells, supercapacitors, batteries, and sensing, are discussed. This review also highlights the advantageous properties and pertinent fabrication methods of TMOs and TMOCs for electrocatalysis, along with the methods to enhance their electrocatalytic abilities, which improve the overall efficiency of the desired applications. 2024 -
A Study on defective colouring of graphs
If different technology represents distinct colours that are to be located on some geographical region which can be represented as vertices of a graph, then the proper colouring is obtained when no two technology of same type share a common edge between the vertices they are placed on. The minimum number of technology required for such a colouring of a graph is the chromatic number of the graph. However, if the available technology are less than that of the minimum required, then the question arises on how to place the technology on the vertices of a graph in such a way that there is a minimum adjacency between the technology of same type. The solution for this problem can be attained by defining certain rules for the properness of colouring in which a few thresholds are tolerated. We know that, in a proper colouring every colour class is an independent set. If the available colours to colour a graph is less than that of the chromatic number of graphs, then a threshold that can be tolerated is permitting few colour classes to be non-independent set. An edge uv is said to be a monochromatic edge or bad edge if the colours assigned to both u and v are the same. A near proper colouring of graphs is a colouring that minimises the number of monochromatic edges by permitting few colour classes to have adjacency between the elements in it. The minimum number of monochromatic edges obtained from near proper colouring is called near defect number, denoted by B_k (G). A and#948;^((k))-colouring of graph G is a near proper colouring of G consisting of k given colours, where 1and#8804;kand#8804;and#967;(G)-1, which minimises the number of monochromatic edges by permitting at most one colour class to have adjacency among the vertices in it. The and#948;^((k))-defect number is the minimum number of monochromatic edges obtained from a and#948;^((k))-colouring of graphs and it is denoted by b_k(G). The study concerned is the further work on a near proper colouring and a and#948;^((k))-colouring of graphs. -
Predictive analytics for cardiac arrhythmia using machine intelligence
Myocardial Infarction (MI) is the primary cause of death worldwide. MI occurs when a plaque buildup in the inner surface of the coronary artery suddenly ruptures and prevents the blood flow. A heart attack is medically termed as MI. It is the irreversible damage caused by the prolonged ischemia. Ischemia is nothing but the heart organ doesn t get enough blood and oxygen which is also termed as coronary artery disease or coronary heart disease. The heart gets damaged if it has not received enough blood or oxygen. In connection to the damage of the heart, arrhythmia would occur. Arrhythmia is the problem based on the heart rhythm or rate of the heartbeat. Tachycardia, when there is a fast beat in the heart. Bradycardia, when the heart beats too slow. The common type of arrhythmia is atrial fibrillation. The great concern is that the patient who has arrhythmia has to be treated immediately. They lose consciousness in a few minutes when the heart is not pumping enough blood mainly to the brain. Death occurs when the patient is not given emergency treatment. newline Treatment which is included in the emergency is defibrillation and Cardiopulmonary Resuscitation (CPR). CPR is an emergency procedure which is combined with the chest compressions. It is through artificial ventilation which gives manual effort, preserves the brain functions until further treatment for the restoration of spontaneous blood circulation. The common symptoms of sudden cardiac death are chest pain, shortness of breath, severe wheezing, irregular heartbeats, fainting etc. newlineHeart Scar tissue which is not like heart muscle. It doesn t contrast like the normal heart muscle. Heart muscles get damaged for the heart attack patient based on the time of the treatment. The damage of the heart is based on the blockage of the artery. Arrhythmia can be predicted based on the volume of the scar region in the heart. Arrhythmia patients are treated by fixing Implantable Cardioverter Defibrillator (ICD). -
Predictive analytics for cardiac arrhythmia using machine intelligence
Myocardial Infarction (MI) is the primary cause of death worldwide. MI occurs when a plaque buildup in the inner surface of the coronary artery suddenly ruptures and prevents the blood flow. A heart attack is medically termed as MI. It is the irreversible damage caused by the prolonged ischemia. Ischemia is nothing but the heart organ doesn’t get enough blood and oxygen which is also termed as coronary artery disease or coronary
heart disease. The heart gets damaged if it has not received enough blood or oxygen. In connection to the damage of the heart, arrhythmia would occur. Arrhythmia is the problem based on the heart rhythm or rate of the heartbeat. Tachycardia, when there is a fast beat in the heart. Bradycardia, when the heart beats too slow. The common type of arrhythmia is atrial fibrillation. The great concern is that the patient who has arrhythmia has to be treated immediately. They lose consciousness in a few minutes when the heart is not pumping enough blood mainly to the brain. Death occurs when the patient is not given emergency treatment. -
Segmentation technique for medical image processing: A survey
Segmentation is one of the popular and efficient technique in context to medical image analysis. The purpose of the segmentation is to clearly extract the Region of Interest from the medical images. The main focus of this paper is to review and summarize an efficient segmentation method. While doing the comparison study on segmentation methods using the Support Vector Machine, K-Nearest Neighbors, Random Forest and the Convolutional Neural Network for medical image analysis identifies that Convolutional Neural Network works efficiently for doing in-depth analysis. The Convolutional Neural Network can be used as segmentation technique for achieving the high accuracy on medical image analysis. 2017 IEEE. -
Medical image classification using MRI: An investigation
The main objective of the paper is to review the performance of various machine learning classification technique currently used for magnetic resonance imaging. The prerequisite for the best classification technique is the main drive for the paper. In magnetic resonance imaging, detection of various diseases might be simple but the physicians need quantification for further treatment. So, the machine learning along with digital image processing aids for the diagnosis of the diseases and synergizes between the computer and the radiologist. The review of machine learning classification based on the support vector machine, discrete wavelet transform, artificial neural network, and principal component analysis reveals that discrete wavelet transform combined with other highly used method like PCA, ANN, etc., will bring high accuracy rate of 100%. The hybrid technique provides the second opinion to the radiologist on taking the decision. Springer Nature Switzerland AG 2019. -
Classification of myocardial ischemia in delayed contrast enhancement using machine learning
This chapter addresses the classification of myocardial ischemia in delayed contrast enhancement using machine-learning techniques for magnetic resonance imaging which solves the social issue of a sudden cardiac death. To automate the classification of myocardial ischemia, the computer-aided design has a crucial path on the mixture ensemble of machine learning. The mixture ensemble of machine learning can partition a high-dimensional image in a simultaneous and competitive way. The detection and the segmentation processes are carried out through Fuzzy C-Means multispectral and single-channel algorithms along with a morphological filtering technique for feature extraction. Furthermore, the feed forward neural network (FFNN) technique is trained through the Levenberg-Marquardt Back Propagation algorithm for the classification of myocardial ischemia in delayed contrast enhancement. The proposed classification model performs well for the classification of myocardial ischemia. The rigorous process of the proposed result reveals that the FFNN classifier produces 99.9% accuracy on the classification of myocardial ischemia and also shows that the given classifier is considered one of the best methods in classifying medical myocardial ischemia. 2019 Elsevier Inc. All rights reserved. -
An Integrated Segmentation Techniques for Myocardial Ischemia
Abstract: Myocardial Ischemia segmentation is a challenging task for basic and translational research on cardiovascular, as it provides ultimately realistic in heart muscle model. The main objective of the research work is to find an efficient segmentation technique for the myocardial ischemia based on the myocardial infarcted MRI data set for the accurate classification of scar volume. The paper will give an insight about the segmentation technique based on myocardial ischemia and discusses essential cellular components. The paper provides an integrated approach which comprises of fuzzy c-means and morphological operations along with median filtering enhancement technique help in detecting the myocardial ischemia. The developed model is tested with 2D and 3D enhanced myocardial ischemia MRI and also with normal heart. The purpose of segmentation in myocardial ischemia is to identify the scar region in the heart. The integrated model is evaluated based on statistical measures and validated based on manual segmentation done by clinical expert. The scar classification is done based on the myocardial ischemia segmentation which leads to better prediction of arrhythmia in heart patient. The integrated model is considered as one of the best model for segmenting myocardial ischemia. 2020, Pleiades Publishing, Ltd. -
Experimental evaluation of image segmentation for heart images
The cardiac death is the principal reason of the death in the world.The research work focuses on finding an efficient image segmentation technique for the computer aided detection and also to decrease the noise in the image.The segmentation is implemented with the help of fuzzy C-means clustering along with dual inverse thresholding function and Otsu thresholding.Experimental proof is evaluated with the help of morphological functions and with Gaussian function.The result of the work provides an accurate segmentation for myocardial ischemia in the human heart photo image as well as magnetic resonance imaging. Copyright 2021 Inderscience Enterprises Ltd. -
Perceived organizational support, employee engagement and organizational commitment among millennials
Millennials (born between 1981-2000) are drastically different from any other generational cohorts, with their high education level, technological skills, social networking, self-confidence and always teeming with energy, which makes them excellent team players, unlike the previous generations who preferred to work on their own for long hours. Millennials, having grown to constitute a considerable proportion of the workforce and will continue to grow to represent more over the next 20 years, desire for immediate result and speedy advancement, which has led to perceiving them to be impatient and inconsistent. Hence, retaining them has become one of the top managerial priorities. Millennials are prone to frequent switching of jobs which is why they are attributed with the character of job-hopping. Of all the generations in the work force, Millennials are found to be less consistent in their workplace relationships which calls for the purposeful need for cultivating positive relationships with them at workplace. Organizational commitment is evidently one such gesture of an employee, towards positive and long-term relationship with the organization, as a committed employee stays with the organization and this can be brought about if the employees realize that they are being supported well by the organization. Hence, the perceived organizational support plays a pivotal role in work place relations. Another construct in the employeeorganization relationship is, which has a decisive role to play, is Employee engagement. Thus, this study intents to examine how perceived organizational support is related to organizational commitment where employee engagement mediates the relation between the two variables. An empirical study has been done, whereby carrying out a survey among 402 millennial employees across various companies in the information technology sector, as this sector experiences the rush of millennials more, compared to other traditional industries. And it was found that there is a vi significant relation that existed among perceived organization support and organizational commitment and employee engagement and organizational commitment as well. Employee engagement also turned out to be partially mediating the relationship between POS and OC. This study, done to find the relation between the three important constructs in organizational behavior and human resource management, and also to find out the difference in the variation of these three constructs based on the demographical factors, is the first of its kind to be done, among Millennials -
A study on the current status of Kathakali with special reference to participation of women /
The human evolution has witnessed a journey of joy and pain, might vary from region to region yet all community share a common thread and nostalgia. Art forms are such communication tools which preserved and promoted such cultural events. Kathakali is the indigenous art form of Kerala, the southern state of India. Katha means Story and Kali means Performance Kathakali, the world renowned Classical Dance-Drama of Kerala, originated in Kottarakkara during the first quarter of the 15th Century. -
Reportage of AFSPA incidents in mainstream media: Media shying away from criticising army /
The primary focus of the research work deals with the limited coverage of Armed Forces Special Powers Act by the National Media. Armed Forces Special Powers Act came into existence in the newly formed India in the year 1957. Media has been catering the interest of millions, but what about those sections of the Indian society which are suppressed by the imperialistic state apparatus? -
Social Media Dependency and Facebook Usage among the Older Adults of Kerala
Social media has become an integral part of modern society, with people of all ages using various platforms to connect, share information, and stay up-to-date on current events. However, there has been a recent trend of increased Facebook usage among older adults, which has raised concerns about social media dependency. The current study explores the trends in social media dependency and Facebook intensity among older adults of Kerala. The present study employed a quantitative research design and the sample consisted of 416 older adults, aged above 60 years. Two scales were used to collect data: the Social Media Dependency Scale (SMDS) and the Facebook Intensity Measure (FBI). Frequency and percentage analysis, Spearman's Rho, Kruskal-Wallis H test, and Mann-Whitney U test were carried out using SPSS (Version 23) for deriving results. Those individuals who are more dependent on social media are also more likely to engage in high levels of Facebook activity. A good majority of the participants were found to be using social media and Facebook for more than 3 hours in a day and having more than 400 friends. Social media dependency and Facebook intensity were reported to be high in urban localities, South Kerala having significantly higher rates of social media dependency when compared to North and Central regions. Social media dependency was found to be high among males, whereas no difference was in Facebook intensity among male and females. Implications: Given the importance of social connections for the well-being of older adults, it is critical to understand the impact of social media use on their lives and develop strategies to promote healthy social media behaviour. 2023 Redfame Publishing Inc.. All Rights Reserved. -
Idiosyncratic Deals: Understanding Effect of Intrinsic and Extrinsic Motivation I-Deals on Innovative Work Behaviour
I-deals or Idiosyncratic deals are specialised, adaptable work patterns by mutual agreement between employees and their managers to meet demands of a dynamic work place. Innovative work behaviour also known as IWB is referred to as the employee behaviour that intends to create and introduce novel and valuable products, processes, innovations and ways of working within a job-role or work-group of an organization. This research discovers the connection between various types of intrinsic and extrinsic motivational deals such as the work responsibility idiosyncratic deals, flexibility deals and financial ones and innovative behaviour, specially within the purview of the working women. It also provides an overview on the outcome of these deals on innovation at a workplace. Our study adopted descriptive research to assess the association of Idiosyncratic deals with IWB using a quantitative study across 352 female employees of Indian Corporate sector. It was found that there exists a direct and positive association amid intrinsically and extrinsically motivated Idiosyncratic deals and an innovative mind-set, in the context of Indian IT sector. This study establishes the influence of idiosyncratic deals and the motivational factors within them in driving an innovative mind set. Thus, the study helps to recognize the value that I-deals brings in establishing an effective innovative environment for employees playing a vital role in the growth of the organization. 2024, Iquz Galaxy Publisher. All rights reserved.