Diazanorbornene: A Valuable Synthon towards Carbocycles and Heterocycles
- Title
- Diazanorbornene: A Valuable Synthon towards Carbocycles and Heterocycles
- Creator
- Preethalayam P.; Jijy E.; Prakash P.; Chand Sarngadharan S.; Vijayan A.; Radhakrishnan K.V.; John J.
- Description
- Desymmetrization of meso compounds is well recognized as a powerful method for delivering biologically relevant molecular skeletons in a few synthetic steps. Heterobicyclic olefins are a class of meso compounds which exhibit exceptional reactivity due to their high ring strain originating from the unfavorable bond angles and eclipsing interactions. Extensive research was carried out towards the synthetic transformations of oxa-, aza-, and diazanorbornenes/norbornadienes for the synthesis of a wide variety of carbocycles and heterocycles in a single step, most importantly in a stereo- and chemo-selective manner. This review summarizes the relevant aspects of diazanorbornene reactivity which will inspire the synthetic community for exploiting these highly strained bicyclic systems for the creation of extensive libraries of novel structurally and biologically interesting molecules. The review is divided into several sections based on the type of reactions that diazanorbornenes are subjected to. 2020 Wiley-VCH GmbH
- Source
- European Journal of Organic Chemistry, Vol-2020, No. 42, pp. 6588-6613.
- Date
- 2020-01-01
- Publisher
- Wiley-VCH Verlag
- Subject
- CH activation; Diazanorbornene; Metal catalysis; Substituted cyclopentanoid; Tandem reaction
- Coverage
- Preethalayam P., Department of Chemistry, Payyanur College, Payyanur, Kerala, India; Jijy E., Department of Chemistry, MES College, Chembalam PO, Nedumkandam, 685553, Kerala, Idukki, India; Prakash P., Department of Chemistry, Sree Narayana College, Kollam, 691001, Kerala, India; Chand Sarngadharan S., School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, 30332, GA, United States; Vijayan A., Department of Chemistry, CHRIST (Deemed to be University), Hosur road, Bengaluru, 560029, India; Radhakrishnan K.V., CSIR - National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India; John J., CSIR - National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India
- Rights
- Restricted Access
- Relation
- ISSN: 1434193X; CODEN: EJOCF
- Format
- Online
- Language
- English
- Type
- Review
Collection
Citation
Preethalayam P.; Jijy E.; Prakash P.; Chand Sarngadharan S.; Vijayan A.; Radhakrishnan K.V.; John J., “Diazanorbornene: A Valuable Synthon towards Carbocycles and Heterocycles,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/21627.