ItemReview

COVID-19 and the world with co-morbidities of heart disease, hypertension and diabetes

Title
COVID-19 and the world with co-morbidities of heart disease, hypertension and diabetes
Creator
Arumugam V.A.; Thangavelu S.; Fathah Z.; Ravindran P.; Sanjeev A.M.A.; Babu S.; Meyyazhagan A.; Yatoo M.I.; Sharun K.; Tiwari R.; Pandey M.K.; Sah R.; Chandra R.; Dhama K.
Description
Newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) pandemic has now spread across the globe in past few months while affecting 26 million people and leading to more than 0.85 million deaths as on 2nd September, 2020. Severity of SARS-CoV-2 infection increases in COVID-19 patients due to pre-existing health co-morbidities. This mini-review has focused on the three significant co-morbidities viz., heart disease, hypertension, and diabetes, which are posing high health concerns and increased mortality during this ongoing pandemic. The observed co-morbidities have been found to be associated with the increasing risk factors for SARS-CoV-2 infection and COVID-19 critical illness as well as to be associated positively with the worsening of the health condition of COVID-19 suffering individuals resulting in the high risk for mortality. SARS-CoV-2 enters host cell via angiotensin-converting enzyme 2 receptors. Regulation of crucial cardiovascular functions and metabolisms like blood pressure and sugar levels are being carried out by ACE2. This might be one of the reasons that contribute to the higher mortality in COVID-19 patients having co-morbidities. Clinical investigations have identified higher levels of creatinine, cardiac troponin I, alanine aminotransferase, NT-proBNP, creatine kinase, D-dimer, aspartate aminotransferase and lactate dehydrogenase in patients who have succumbed to death from COVID-19 as compared to recovered individuals. More investigations are required to identify the modes behind increased mortality in COVID-19 patients having co-morbidities of heart disease, hypertension, and diabetes. This will enable us to design and develop suitable therapeutic strategies for reducing the mortality. More attention and critical care need to be paid to such high risk patients suffering from co-morbidities during COVID-19 pandemic. 2020 Journal of Pure and Applied Microbiology. All rights reserved.
Source
Journal of Pure and Applied Microbiology, Vol-14, No. 3, pp. 1623-1638.
Date
2020-01-01
Publisher
Journal of Pure and Applied Microbiology
Coverage
Arumugam V.A., Medical Genetics and Epigenetic Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, India; Thangavelu S., Medical Genetics and Epigenetic Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, India; Fathah Z., Kings College London, London, United Kingdom; Ravindran P., Medical Genetics and Epigenetic Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, India; Sanjeev A.M.A., Medical Genetics and Epigenetic Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, India; Babu S., Medical Genetics and Epigenetic Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, 641 046, India; Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560 029, India; Yatoo M.I., Division of Veterinary Clinical Complex, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Alusteng Srinagar, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, 190 006, India; Sharun K., Division of Surgery, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly- Uttar Pradesh, 243 122, India; Tiwari R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit DeenDayal Upadhayay Pashu Chikitsa Vigyan, Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, 281 001, India; Pandey M.K., Department of Veterinary Pathology, College of Veterinary Science, Durg - Chhattisgarh, 491 001, India; Sah R., Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Chandra R., Department of Microbiology, School of Environmental Sciences, Babasaheb Bhimrao Ambedkar University, (A Central University), Vidya Vihar, Raebareli Road, Lucknow - Uttar Pradesh, 226 025, India; Dhama K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly -, 243 122, India
Rights
All Open Access; Gold Open Access
Relation
ISSN: 9737510
Format
Online
Language
English
Type
Review

Collection

Reviews

Citation

Arumugam V.A.; Thangavelu S.; Fathah Z.; Ravindran P.; Sanjeev A.M.A.; Babu S.; Meyyazhagan A.; Yatoo M.I.; Sharun K.; Tiwari R.; Pandey M.K.; Sah R.; Chandra R.; Dhama K., “COVID-19 and the world with co-morbidities of heart disease, hypertension and diabetes,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/21628.

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