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A synbiotic composition and application thereof /
Patent Number: 202041045417, Applicant: Alok Kumar Malaviya. -
Gut Microbiota and Cancer Correlates
The human microbiota is a concoction of bacteria, archaea, fungi, and other microorganisms. It is necessary to maintain a partnership between the host and the microbiota in order to maintain the different aspects of human physiology, such as nutrient absorption, immune function and metabolism. The microbiota can contribute to both progression and suppression of the disease, including cancer. A disturbance in this interspecies balance called microbiome dysbiosis becomes a reason for the host to be more prone to issues such as immunodeficiency and cancer. Gut microbiota could potentially influence the factors that govern cancer susceptibility and progression through mechanisms such as immunomodulation, by producing metabolites, such as, bacteriocins, antimicrobial peptides involved in tumor suppression, and short-chain fatty acids (SCFA), and through enzymatic degradation. It is now an established fact that the host physiology as well as risk of diseases such as cancer could be greatly modulated by these commensal microbes and the regulation of cancer development, progression as well as response to anticancer therapy is greatly dependent on the host microbiota. Therefore, it is being envisaged that by the involvement of microbiome in augmenting antitumor responses to therapeutic approaches, potentially a new era of research with potentially broad implication on cancer treatment could be established. Better cancer treatment responsiveness can be achieved by understanding the role of the tumor microbiome in shaping the tumor microenvironment. This will help us to develop personalized anticancer solution with the goal to discover a bacterial species or a combination of species that decreases systemic toxicity and helps in anticancer therapy. This chapter is written in same context, which focuses on the association of the gut microbiome with the suppression and progression of cancers, the role of the immune system in this interaction, the utilization of these organisms for the treatment of cancers, and future perspectives. Springer Nature Singapore Pte Ltd. 2021, corrected publication 2021. -
Saccharomyces - eukaryotic probiotic for human applications
Probiotics are viable microorganisms which are meant to confer health benefits to host after ingestion. Any probiotic strain has a special characteristic to survive in the extremely acidic and hostile conditions of stomach and intestine. Among all the commercially available probiotic strains, prokaryotes constitute the bulk of it, with quite a few belonging to eukaryotic yeasts. Eukaryotic probiotics are very limited and currently there are only two yeast strains (Saccharomyces boulardii and Kluyveromyces sp.), which are approved for human consumption and are available commercially in market. S. boulardii has been reported to have tremendous therapeutic potential. The main mechanism of action for S. boulardii includes strong antagonistic effect against a number of enteric pathogens, trophic effects on the intestinal mucosa, neutralisation of bacterial toxins as well as modification of host cell signaling pathways involved in inflammatory and non-inflammatory intestinal disease. Pertaining to these advantages, S. boulardii have been reported to be exceptionally effective against diarrheal diseases and intestinal inflammatory conditions including inflammatory bowel disease (IBD). Increasing scientific reports confirming the therapeutic potential of eukaryotic probiotics and their advantages over prokaryotic probiotic strains have dramatically increased the worldwide interest in these probiotics. 2019 Scrivener Publishing LLC. -
Artemisinin: A potent antimalarial drug
Artemisinin is known to be a potent antimalarial drug which is naturally obtained from the plant Artemisia annua L. Malaria is a global health problem with nearly 1.2 billion people at high risk. In 2001, WHO recognised artemisinin based combination therapies (ACTs), as the frontline drugs to fight against malaria and therefore, artemisinin is the most effective anti-malarial drug. It appears to be a safe drug with no adverse reactions or noticeable side effects, even for pregnant women. However, access to ACTs by malarial patients, especially in poor countries, is inadequate due to high volatility in price, unpredictable demand and low yield from A. annua. The huge gap in demand and supply has motivated researchers to explore artemisinin production in alternative systems like bacteria, yeast and tobacco. Scientists have been successful in producing this wonder molecule in heterologous hosts. Challenges associated with large-scale production and drug resistance against artemisinin has also been discussed to present a comprehensive picture of artemisnin production, application and limitations. 2019 Scrivener Publishing LLC. All rights reserved. -
Gut-Skin Axis: Role in Health and Disease
The human microbiome includes microorganisms and their cumulative genetic details that reside in the human body. Skin, the bodys most external organ and exposed to the external environment, is an ecosystem with 1.8 m2 area. It has a varying epidermal thickness, folds, and appendages in different areas including along with varying moisture and temperature level on the skin surface. Microbial colonization on the skin surface starts from the time of birth. The mode of delivery affects the colonization process to a considerable extent. The group of microbes colonizing the skin surface is determined by physical and chemical features of it, which applies to microbes inhabiting the gut and other ecological niches in the body as well. There is several common important characteristics shared commonly by gut and skin, where both are (1) heavily vascularized, (2) richly perfused, (3) densely innervated, (4) integrated to the immune system, (5) highly associated with the endocrine system, (6) extensively colonized with recognizable microbiota, and (7) both helps our body to communicate with its external environment. It has variously been reported that a close and bidirectional association within the gut and skin in maintaining the homeostasis and allostasis of skin and also gastrointestinal (GI) health. Therefore, numerous intestinal pathologies have been linked to skin comorbidities. It has been found that skin is directly impacted by the various circumstances that principally affect the intestine. Similarly, various gastrointestinal disorders could be linked to distinct dermatological entities. In the same context, a growing body of proof proposes an association of intestinal dysbiosis with many regular inflammatory skin pathologies including atopic dermatitis (AD), psoriasis, rosacea, and acne vulgaris. And the realization of this interconnected association between skin and gut has resulted in a new concept of the Gut-Skin Axis. An intimate bidirectional engagement between the gut and the skin has been well established by growing research evidence in this domain. Recent reports have indicated that the administration of specific Lactobacilli strains to mice can significantly alter the overall skin phenotype. Despite increasing research efforts in this domain, a systematic investigation of the Gut-Skin Axis remains ill explored by both gastroenterology as well as dermatology researchers. And in this context, here we are discussing various aspects of the Gut-Skin Axis and its role in the general well-being of individuals. The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2022. -
Improving Image Clarity with Artificial Intelligence-Powered Super-Resolution Methods
Super-resolution has advanced significantly in the last 20years, particularly with the application of deep learning methods. One of the most important image processing methods for boosting an image's resolution in computer vision is image super-resolution besides providing an extensive overview of the most recent developments in artificial intelligence and deep learning for single-image super-resolution. This study delves into the subject of image enhancement by investigating sophisticated AI-based super-resolution techniques. High-quality photographs have become more and more in demand in a variety of industries recently, including medical imaging, satellite imaging, entertainment, and surveillance. Pixilation reduction and detail preservation are two areas where traditional image enhancing techniques fall short. Artificial intelligence has demonstrated amazing promise in addressing these issues, especially with regard to Deep Learning models. The applications, benefits, and difficulties of modern super-resolution techniques are thoroughly examined in this work. We also suggest new approaches and push the limits of image enhancement by experimenting with state-of-the-art artificial intelligence algorithms. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
Revolutionising Tumour Diagnosis: How Clinical Application of Artificial Intelligence and Machine Learning Enhances Accuracy and Efficiency
This research paper examines the transformative influence of Artificial Intelligence (AI) and Machine Learning (ML) on tumour diagnosis within clinical settings. The advent of AI and ML technologies has revolutionised the field of oncology, offering the unprecedented potential for more accurate, timely, and personalised cancer detection. By leveraging vast datasets of medical images, genomic information, and patient records, these intelligent systems enable the early identification of tumours, classification of cancer types, and prediction of patient outcomes with remarkable precision. This paper delves into the mechanisms through which AI and ML algorithms analyse complex data, highlighting their ability to detect subtle patterns and anomalies that may escape human perception. Moreover, we examine the successful integration of these technologies into clinical workflows, their potential to reduce diagnostic errors, and the implications for patient care and outcomes. As AI and ML continue to emerge, the synergy between technology and clinical expertise promises to enhance tumour diagnosis, ultimately contributing to more effective and personalised cancer treatments. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024. -
Cardiovascular Disease Prediction Using Machine Learning-Random Forest Technique
Cardiovascular diseases (CVDs) pose a significant global health challenge. Early and accurate diagnosis is crucial for effective treatment. This research focuses on developing a robust classification system for CVDs using machine learning techniques. This study proposes an enhanced Random Forest (RF) model optimized for big data environments and explore the potential of CNN-based classification. By leveraging medical imaging data and employing these advanced algorithms, we aim to improve the accuracy and efficiency of CVD diagnosis. 2024 IEEE. -
A new computational technique for the analytic treatment of time-fractional EmdenFowler equations
This paper presents the study of fractional EmdenFowler (FEF) equations by utilizinga new adequate procedure, specifically the q-homotopy analysis transform method (q-HATM). The EF equation has got greater significance in both physical and mathematical investigation of capillary and nonlinear dispersive gravity waves. The projected technique is tested by considering four illustrations of the time-fractional EF equations. The q-HATM furnish ?, known as an auxiliary parameter, by the support of ? we can modulate the various stages of convergence of the series solution. Additionally, to certify the resolution and accurateness of the proposed method we fitted the suitable numerical simulations. The redeem results guarantee that the proposed process is more convincing and scrutinizes the extremely nonlinear issues emerging in the field of science and engineering. 2021 International Association for Mathematics and Computers in Simulation (IMACS) -
Novel approach for nonlinear time-fractional Sharma-Tasso-Olever equation using Elzaki transform
In this article, we demonstrated the study of the time-fractional nonlinear Sharma-Tasso-Olever (STO) equation with different initial conditions. The novel technique, which is the mixture of the q-homotopy analysis method and the new integral transform known as Elzaki transform called, q-homotopy analysis Elzaki transform method (q-HAETM) implemented to find the adequate approximated solution of the considered problems. The wave solutions of the STO equation play a vital role in the nonlinear wave model for coastal and harbor designs. The demonstration of the considered scheme is done by carrying out some examples of time-fractional STO equations with different initial approximations. q-HAETM offers us to modulate the range of convergence of the series solution using ?, called the auxiliary parameter or convergence control parameter. By performing appropriate numerical simulations, the effectiveness and reliability of the considered technique are validated. The implementation of the new integral transform called the Elzaki transform along with the reliable analytical technique called the q-homotopy analysis method to examine the time-fractional nonlinear STO equation displays the novelty of the presented work. The obtained findings show that the proposed method is very gratifying and examines the complex nonlinear challenges that arise in science and innovation. 2023 Balikesir University. All rights reserved. -
Fractional ReactionDiffusion Model: An Efficient Computational Technique for Nonlinear Time-Fractional Schnakenberg Model
In this article, the q-homotopy analysis transform method (q-HATM) is committed to finding the solutions and analyzing the gathered results for the nonlinear fractional-order reactiondiffusion systems such as the fractional Schnakenberg model. These models are well known for the modelling of morphogen in developmental biology. The efficiency and reliability of the q-HATM, which is the proper mixture of Laplace transform and q-HAM, always keep it in a better position in comparison with many other analytical techniques. By choosing a precise value for the auxiliary parameter ?, one can modify the region of convergence of the series solution. In the current framework, the investigation of the Schnakenberg models is implemented with exciting results. The acquired results guarantee that the considered method is very satisfying and scrutinizes the complex nonlinear issues that arise in the arena of science and technology. 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. -
IDS for Internet of things (IoT) and Industrial IoT Network
The Internet of Things (IoT) is a swiftly increasing domain of interconnected gadgets, technologies, and structures that may be achieved in a small, tightly associated environment or can travel across big geographic areas, including Smart Cities. IoT devices are increasingly deployed for numerous goals inclusive of records sensing, accumulating, and controlling. The IoT enhances user affairs by permitting a huge variety of smart gadgets to link and possible information. IoT gadgets are hastily evolving universally while IoT offerings have become pervasive. IoT devices include a big assortment of devices, along with small, embedded sensors, AI assistants, digital cameras, and so on, which can be found in various backgrounds, i.e., Smart Homes, Smart Communities, and Smart Cities. Smart Cities have developed into intriguing areas with technologies consisting of traffic-conscious streetlights which dynamically react to emergencies by editing site visitors styles. Moreover, with the adoption of 5G networks, technologies and techniques throughout towns have become blended. This persevered improvement of IoT advocated the expansion of sophisticated and complicated systems which appreciably adjust the community. However, these technologies have guided to a brand new threat to the security of grids. Many present-day malware assaults, targeted at classic computer systems linked to the Internet, will also be required for IoT gadgets. With those enhancements, malicious actors have found new methods to control their weaknesses. One of the biggest cyber-attacks in instances of terabits in step with 2d operated, infected IoT gadgets harmonized within a botnet provides a massive DDoS assault which disrupts the Internet range for large geographic regions. This attack underlines the increasing hazard posed via uncertain IoT devices. Moreover, attacks that include those are evolving as greater threats as a larger quantity of exposed gadgets is introduced to networks throughout the globe. Their actions are anomalous and higher are the numbers of hazards and assaults toward IoT devices. Cyber-attacks arent new to the IoT, however as the IoT may be deeply interwoven in our lives and societies, traditional protection resolutions are inadequate when managing these dangers. Oftentimes, safety answers are created to run locally on host appliances, i.e., antivirus software, or as standalone machines (i.e. community firewalls and intrusion detection structures (IDSs). However, the IoT has obtained a clean set of community protocols, together with Zigbee, Ant+, and 6LoWPAN, that traditional safety solutions, such as rule-primarily based firewalls and host-based total antivirus software programs, had been not equipped with or have no longer been revised to account for. Moreover, many IoT gadgets suffer from computational, storehouse, or network situations. Due to those constraints, IoT safety answers, especially an IoT IDS, must be lightweight enough, in phrases of the computational, garage, and networking resources, to be living on the devices but sturdy enough to accurately hit upon potential intrusions. Therefore, a holistic method needs to be regular while coming to IoT intrusion detection. IoT devices cant be considered in a vacuum as self-contained machines due to the fact a totally fledged, modern protection answer is just too aid-annoying for constructing on those gadgets. The normal safety of the network necessitates IoT gadgets to be included as associates within a security answer rather than as man or woman nodes. Therefore, green protection of IoT devices could keep millions of net customers away from malicious moves. However, present malware detection techniques are afflicted by excessive computational complexity. Hence, theres a real necessity to protect the IoT, which has therefore resulted in a requirement to completely recognize the threats and assaults in an IoT infrastructure. 2024 selection and editorial matter, Mayank Swarnkar and Shyam Singh Rajput; individual chapters, the contributors. -
Significance of buoyancy, velocity index and thickness of an upper horizontal surface of a paraboloid of revolution: The case of non-Newtonian carreau fluid
The problem of fluid flow on air-jet weaving machine (i.e. mechanical engineering and chemical engineering) is deliberated upon in this report using the case of non-Newtonian Carreau fluid flow. In this report, the boundary layer flow of the fluid over an upper horizontal surface of a paraboloid of revolution is presented. The dimensional governing equations were nondimensionalized, parameterized, solved numerically and discussed. Maximum horizontal velocity is ascertained at smaller values of thickness parameter, a larger value of buoyancy related parameter and the flow is characterized as shear-thickening. Local skin friction coefficient is an increasing and a decreasing property of Deborah number for Shear thinning and Shear-thickening cases of the flow respectively. The velocity of the flow parallel to the surface (uhspr) is a decreasing property of thickness parameter and increasing function of velocity index parameter. 2018 Trans Tech Publications, Switzerland. -
MHD nanofluid flow past a rotating disk with thermal radiation in the presence of aluminum and titanium alloy nanoparticles
The effects of thermal and exponential space dependent heat sources (THS and ESHS) on magneto-nanoliquid flow across a rotating disk with uniform stretching rate along radial direction are scrutinized in this communication. H2O based nanoliquids containing aluminium (AA 7075) and titanium (Ti6Al4V) alloy nanoparticles are considered. The AA7075 is made up of 90% Al, 5-6% Zn, 2-3% Mg, 1-2% Cu with additives such as Fe, Mn and Si etc. The flow is driven due to rotating disk with uniform stretching of the disk. Impacts of Joule and viscous heating are also deployed. The multidegree ordinary differential equations are formed via Von Karman transformations. The obtained non-linear BVP is solved by Runge-Kutta-Fehlberg based shooting approach (RKFS). Graphical illustrations depict the impacts of influential parameters on flow fields. The skin friction and Nusselt number are also calculated. Results pointed out that the thermal boundary layer growth stabilizes due to the influence of ESHS aspect. Velocities of AA7075 H2O nanofluid are superior than that of Ti6 Al4V H2O nanoliquid. Furthermore, the thermal performance of base liquid is outstanding when we added titanium alloy nanoparticles in comparison with aluminium alloy nanoparticles. 2018 Trans Tech Publications, Switzerland. -
Effect of nonlinear thermal radiation on MHD boundary layer flow and melting heat transfer of micro-polar fluid over a stretching surface with fluid particles suspension
A comprehensive numerical study is conducted to investigate effect of nonlinear thermal radiation on MHD boundary layer flow and melting heat transfer of micro-polar fluid over a stretching surface with fluid particles suspension. Using suitable transformations, the governing equations of the problem are transformed in to a set of coupled nonlinear ordinary differential equations and then they are solved numerically using the Runge-Kutta-Fehlberg method with the help of shooting technique. Authentication of the current method is proved by having compared with established results with limiting solution. The impact of the various stimulating parameters on the flow and heat transfer is analyzed and deliberated through plotted graphs in detail. We found that the velocity, angular velocity and temperature fields increase with an increase in the melting process of the stretching sheet. Also it is visualize that the shear stress factor is lower for micropolar fluids as compared to Newtonian fluids, which may be beneficial in flow and heat control of polymeric processing. 2017 Trans Tech Publications, Switzerland. -
Transforming Financial Sector Through Financial Literacy and Fintech Revolution
The current research focuses on the financial literacy among the women, youth and impact of fin-tech on the socioeconomic well-being of the economy. The researcher has incorporated extensive data mining on financial well-being and assesses the financial literacy along with attitude and behavior for financial knowledge mainly focusing on youth and usage of AI in financial services. It has been observed during research that the benefits of the technology are limited only to the urban areas, but the rural places are not much benefited and therefore more focus is needed for the financial technology to get amalgamated with rural lifestyle for convenience and transparency of financial transactions. This research paper contributes to the awareness of financial literacy and importance of financial reliance for the youth of today through knowledge sharing. The research also highlights the importance of government involvement in financial literacy and creating awareness at a global level for well-being of youth and women. Financial literacy can also improve the rate of entrepreneurs growth and financial decisions. Financial knowledge and fin-tech services can help in better financial decisions and saving culture for self-reliant youth. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021. -
Artificial intelligence its growing role in human resource management
In this competitive era, the impact of artificial intelligence in human resource management is increasing quickly. Collecting the relevant data and then analyzing it accurately can accelerate the efficient working process of the organization. Artificial intelligence has paved its way in the working of various departments like IT, finance, marketing, and HRM. In this research, the researcher focused on the emerging role of artificial intelligence in HR department and how it is acting as a stimulator in enhancing the efficiency and accuracy of various HR functions like recruitment, hiring, work- life balance, performance appraisal, etc. The chapter is based on descriptive research, in which the researcher has collected secondary data from various research papers, articles, blogs, and websites. The chapter focuses on the growing role of artificial intelligence in the human resource function of the organization. 2024, IGI Global. All rights reserved. -
Reliability analysis of cement manufacturing technique in computerized clinker processing method
Cement production will face severe resource constraints in the future, as they rely on natural resources. Therefore, the industry focuses on raising natural resource requirements at both the development and operational levels. One of the situations left unattended in cement production is modelling reliability on a clinker production device with a defect in its three main components. Bridging this gap, this paper provides a reliability model on the manufacturing method of clinkers. The manufacturing of clinkers is the first step in the cement production process. The clinker manufacturing process comprises three main components: crusher, roller mill, and rotary kiln. Three reliability models are developed in this paper, with failures in its three important components considering three situations. All three components are operative, the first two components are operative, and only the first component is operative. In this paper, the transition probabilities and mean sojourn times and also MTSF are measured. 2023 Author(s). -
Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro
Sundarbans Mangrove Ecosystem (SME) is a rich repository of bioactive natural compounds, with immense nutraceutical and therapeutic potential. Till date, the algal population of SME was not explored fully for their anticancer activities. Our aim is to explore the potential of these algal phytochemicals against the proliferation of cervical cancer cells (in vitro) and identify the mode of cell death induced in them. In the present work, the chloroform fraction of marine green alga, Chaetomorpha brachygona was used on SiHa cell line. The algal phytochemicals were identified by GCMS, LCMS and column chromatography and some of the identified compounds, known for significant anticancer activities, have shown strong Bcl-2 binding capacity, as analyzed through molecular docking study. The extract showed cytostatic and cytotoxic activity on SiHa cells. Absence of fragmented DNA, and presence of increased number of acidic vacuoles in the treated cells indicate nonapoptotic cell death. The mode of cell death was likely to be autophagic, as indicated by the enhanced expression of Beclin 1 and LC3BII (considered as autophagic markers) observed by Western blotting. The study indicates that, C. brachygona can successfully inhibit the proliferation of cervical cancer cells in vitro. 2020, The Author(s). -
Changing representation of women in recent bollywood cinema /
For almost a century, popular Hindi films rarely dealt with women issues and if it all it attempted to do so, the role of a women was restricted to be either that of nurturer or the epitome of sacrifice and forgiveness. Films like Mother India or Bandini glorified woman’s ability to give up her choices and even life for the sake of her family and dear ones. But post LPG (Liberalization, Privatization and Globalization) this scenario has gradually changed. Today, we come across films where a woman not only expresses her choice but she is also unapologetic about herself. Cinema very interesting deals with gender representation in a consensually problematic manner where the provider of the image as well as the receiver of the medium believes that the space is designed to give women her place only in a particular way.