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Exploring the mediating role of job and life satisfaction between workfamily conflict, familywork conflict and turnover intention
Purpose: This study investigates the influence of work-to-family and family-to-work conflict on turnover intention (career break), mediated through job and life satisfaction among Indian women in the service sector, using role conflict theory as the base. Design/methodology/approach: A total of 421 usable responses from women who had taken a career break were collected using a 36-item scale from six major metro cities in India through social and digital media platforms. A purposive-cum-snowballing sampling method was adopted. The hypotheses were tested using structural equation modeling (SEM) through AMOS. Findings: Findings suggest that job satisfaction (JS) is a significant predictor of turnover intention, both when work spills into the family domain, and family responsibilities spill into the work domain, thereby confirming the mediating influence of JS. Interestingly, life satisfaction (LS) only seems to mediate between inter-domain conflict and turnover intention partially. Research limitations/implications: This is a descriptive study, and is thereby limited in terms of its generalizability, specifically as it included respondents only from six major metro cities in India. Practical implications: The extended work-family conflict model could help managers structure organizational interventions that support women to deal with the challenges of managing the demands of both work and family domains, thereby reducing the negative influence on JS. Such initiatives could help reduce career breaks among women. Originality/value: We explored the cause of career breaks among Indian urban women employed in the service sector, using the extended model of inter-role conflict and their attitudes towards both life and job. 2024, Emerald Publishing Limited. -
Exploring the motivating factors for opportunity recognition among social entrepreneurs: aqualitative study
Purpose: This paper explores the motivating factors that lead to opportunity recognition among social entrepreneurs in India. Design/methodology/approach: The study followed an exploratory, qualitative design based on thematic analysis of the interview data collected from 13 Indian social entrepreneurs. Findings: The study identifies two aggregate factors that motivate social entrepreneurs: personal and contextual. Personal factors include life experiences, social awareness, social inclination since childhood, spiritual motives, the need for a meaningful career and entrepreneurial intention. Contextual factors included institutional voids, community development, the presence of a role model and volunteer experiences. Research limitations/implications: This study contributes to the social entrepreneurship literature by providing a model for motivating factors that lead to opportunity recognition. This study enables policymakers and social entrepreneurship educators to identify aspiring social entrepreneurs and provide target-specific support to them. Practical implications: This study enables policymakers and social entrepreneurship educators to identify aspiring social entrepreneurs and provide target-specific support to them. Originality/value: The study uniquely contributes to the social entrepreneurship field by offering deep qualitative insights into the motivational and opportunity recognition patterns of social entrepreneurship. 2024, Parvathy Viswanath and A. Sadananda Reddy. -
Exploring the motivating factors for opportunity recognition among social entrepreneurs: aqualitative study
Purpose This paper explores the motivating factors that lead to opportunity recognition among social entrepreneurs in India. Design/methodology/approach The study followed an exploratory, qualitative design based on thematic analysis of the interview data collected from 13 Indian social entrepreneurs. Findings The study identifies two aggregate factors that motivate social entrepreneurs: personal and contextual. Personal factors include life experiences, social awareness, social inclination since childhood, spiritual motives, the need for a meaningful career and entrepreneurial intention. Contextual factors included institutional voids, community development, the presence of a role model and volunteer experiences. Research limitations/implications This study contributes to the social entrepreneurship literature by providing a model for motivating factors that lead to opportunity recognition. This study enables policymakers and social entrepreneurship educators to identify aspiring social entrepreneurs and provide target-specific support to them. Practical implications This study enables policymakers and social entrepreneurship educators to identify aspiring social entrepreneurs and provide target-specific support to them. Originality/value The study uniquely contributes to the social entrepreneurship field by offering deep qualitative insights into the motivational and opportunity recognition patterns of social entrepreneurship. 2024 Parvathy Viswanath and A. Sadananda Reddy -
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Exploring The Multifaceted Benefits Of Strobilanthes Jomyi P. Biju, Josekutty, Rekha & J. R. I. Wood : A Comprehensive Pharmacognostic Investigation On Its Medicinal And Insecticidal Properties
Plant-based medication, is an established practice in Indian medicine, initially newlineinvolvedin the direct use of raw plant parts for treating various health conditions. Later, valuable components are identified, isolated, and utilized to treat diseases. The newlineStrobilanthes Blume genus has a rich therapeutic history around the globe, especially in countries such as India, China, Myanmar, and Thailand. Strobilanthes jomyi, a recently identified species found in Kerala, India is still in wide use by tribal communities in the Kasaragod district for wound healing. This study aimed to evaluate the microscopic, macroscopic, organoleptic, fluorescent, physicochemical, mineral composition, phytochemical, Gas Chromatography Mass Spectrometry, antioxidant, anthelmintic, insecticidal, antimicrobial, and cytotoxicity activities of S. jomyi leaves, stem, and root. The different vegetative parts were subjected to Soxhlet extraction using methanol as a newlinesolvent and analysed using standard Protocols. Macroscopic andmicroscopic examinations revealed non-glandular trichomes and paracytic stomata in the leaves, raphides in the stem and petiole, and tannin cells in the root. Cystoliths were observed only in the petiole. Powder analysis exhibited the presence of fibres, trichomes, palisade cells, spiral xylem vessels, bordered pit vessels, and raphides. The leaves contained higher phenolics, flavonoids, carbohydrate, protein, proline, and chlorophyll content compared to the root and stem. The methanolic extract of leaves showed higher antioxidant activities than the root and stem. GC-MS analysis identified bioactive compounds such as 2,4-di-tert-butyl phenol, phytol,squalene, phenol, neophytadiene, and lupeol in the root, stem, and leaves. All vegetative partsof S. jomyi exhibited excellent anthelmintic activity, with the highest newlineobserved in the leaves, followed by the root and stem. Insecticidal activity was only newlineobserved in the leaf extract. Anti-microbial and anti-cancerous activities were remarkable newlineacross all vegetative parts. -
Exploring the nexus of climate change and vector-borne disease transmission
Climate change is a critical global challenge that significantly impacts the redistribution of malaria endemicity worldwide. While efforts have been made to model malaria transmission using climatic factors, relying solely on these factors can lead to discrepancies and ineffective decision-making. To address this, we used the VECTRI modela dynamic framework developed by the International Center for Theoretical Physics (ICTP) that integrates both climatic and entomological factorsto map malaria risk for India and project its potential future under the SSP370 warming scenario. Our findings indicate that the length of malaria transmission is expected to increase across India by the end of this century. The shift of malaria endemicity to further north and also into highland areas could increase the at-risk population due to lower immunity in these regions. Therefore, integrated climate and entomological modeling is essential for effectively anticipating malaria transmission risks and enhancing public health responses. 2025 -
Exploring the Nexus of Deepfakes and VFX Technology: Unveiling Insights, Challenges, and Innovations
This research paper explores the intersection of Deepfakes and Visual Effects (VFX) technology, investigating their convergence, implications, and advancements. Deepfakes, driven by artificial intelligence algorithms, have revolutionized the creation of synthetic media, while VFX techniques have long been utilized in the film industry for various purposes. This paper delves into the technical underpinnings of both Deepfakes and traditional VFX, highlighting similarities, differences, and synergies. It examines the potential applications of Deep-fakes in VFX-driven storytelling, digital compositing, and character animation, while also addressing the ethical concerns and risks associated with their misuse. Furthermore, the paper discusses emerging trends and innovations that bridge the gap between Deepfakes and VFX technology, paving the way for new creative possibilities and challenges. Through a comprehensive analysis, this paper aims to provide valuable insights into the evolving landscape of synthetic media and its implications for the VFX industry. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025. -
Exploring the Nexus: An in-depth analysis of brand activism's influence on consumer behaviour
This study delves into the intricate relationship between brand activism and consumer behavior, aiming to unravel the nuanced dynamics that underlie contemporary market influences. Employing a comprehensive analysis, the authors investigate how brands' engagement with social and environmental causes resonates with consumers, shaping their attitudes, preferences, and ultimately, their purchasing decisions. The research employs a multi-faceted approach, combining qualitative and quantitative methodologies to capture the depth and breadth of brand activism's impact. By examining real-world examples and conducting surveys, the authors seek to discern patterns and correlations that illuminate the mechanisms through which brand activism leaves an indelible mark on the modern consumer landscape. The findings promise to provide valuable insights for marketers, businesses, and scholars alike, offering a deeper understanding of the evolving interplay between corporate values, social responsibility, and consumer choices in today's dynamic marketplace. 2024, IGI Global. All rights reserved. -
EXPLORING THE NEXUS: DESIGN CHARACTERISTICS OF URBAN LOCAL PUBLIC SPACES AND CHILDRENS PLAY BEHAVIOR IN BANGALORE, INDIA
Research in the field of childrens play highlights its diverse benefits on developmental requisites. Specifically, parks and playgrounds emerge as key public spaces in an urban environment, which facilitates a range of play experiences conducive to developmental processes. The main aim of the study is to examine the design characteristics of formal public spaces that influence play behavior of children and the supervision modalities in the Indian context. To achieve this objective the study investigated a park and playground in a rapidly developing neighborhood in Bangalore. Systematic observations were conducted to observe childrens play opportunities with respect to the physical environments including adult supervision modalities. The outcomes reveal that childrens play in the urban context is a supervised activity. The study demonstrates a strong correlation between the age demographics and utilization patterns of play spaces. Though affordances for functional play and rule based games were exhibited in these public spaces, the research found minimal occurrences of Constructive, Imaginative and Exploratory play. Implications for planning and design includes adopting an age-responsive approach to accommodate diverse developmental needs and preferences of children while integrating natural and manipulable materials to enhance play value of play spaces. 2024, Jomard Publishing. All rights reserved. -
Exploring the Opportunities of AI Integral with DL and ML Models in Financial and Accounting Systems
With the integration of artificial intelligence (AI), today's fast financial landscape increasingly promises the most efficient and accurate processes for decision-making in accounting practices. On the other hand, the opacity of models represents a truly difficult challenge, given that transparency and accountability are key for using AI in making financial decisions. This is a research paper that focuses on the explanation of an XAI model application as a way of improving transparency in financial decision-making within the accounting field. The paper begins by outlining how transparency is important and opens the room for trust and understanding in the process of financial decision-making. Traditional black-box AI models, although able to provide remarkable predictions, usually exhibit low interpretability; this entails that stakeholders may have a small degree of understanding regarding the rationale behind the decisions. This provides a cloudy appearance not to hamper trust and supports compliance with regulatory standards like GAAP (Generally Accepted Accounting Principles) and IFRS (International Financial Reporting Standards). The proposed work applies to the accounting domain and brings about some of the different XAI techniques that are designed under this domain. The following techniques aim at demystifying the AI algorithms for effective AI stakeholders' understanding of the model predictions and underlying decision-making processes. 2024 IEEE. -
Exploring the Optical Properties of Functional Carbon Dots Derived from Jackfruit Seeds and their Potential Applications
Carbon dots are nanomaterials that exhibit exceptional optical properties due to their fluorescence, photoluminescence tunability, broad absorption, and photostability. This study reports the synthesis of carbon dots (CDs) from agricultural remains, Jackfruit seeds (Artocarpus heterophyllus), through a facile synthesis technique of a one-step microwave-assisted solvothermal method. The synthesized CDs offer good optical properties, by absorbing UV radiation and giving a broad excitation wavelength-dependent emission (300 to 700nm). This evidences the synthesized material to act as a down-converter in various applications, like solar cells and LEDs. The tunability of the bandgap of these nanocarbons is also explored by employing solvatochromism in solvents of varying polarity, including DI water, DMF, and NMP, enhancing their optical properties. Further, they can also be used for UV protection applications like window panes, sunglasses, and sunscreen creams, owing to the 97.44% UV absorption for the CDs dispersed in NMP. Similarly, the down-conversion ability of this material is utilized to convert UV-LEDs to W-LEDs with CRI point, Ra = 77, and CCT = 6785 K, which resembles cool bright daylight. Thus, the synthesized CDs from jackfruit seeds exhibit exemplary optical properties, opening wide avenues into UV protection, lighting technologies, and other such potential applications. 2025 Wiley-VCH GmbH. -
Exploring the Patterns of Recreational Polysubstance Use and Executive Functions in Indian Young Adults: A Cross-Sectional Study
Background: Substance use is a serious public health concern and young adults in India often use multiple substances, often together. There is a dearth of research examining this and its neuropsychological consequences. Polysubstance use (PSU) usually indicates higher chances of dependence and negative outcomes. This study aims to describe the patterns of PSU and associated executive function profiles in a sample of young adults in India. Methods: Fifty-four participants aged 1825 years filled out a self-report questionnaire on PSU, for lifetime and current use of seven classes of substances. Thirty-four participants also performed four executive functions (Flexibility, Inhibition, Working Memory, and Planning). A descriptive analysis was used to identify patterns of PSU and one-way analysis of variance (ANOVA) was conducted to compare the executive functions between three groups of substance users with nonusers. Results: Three patterns of PSU were identified in our sample: simultaneous (16.3%), concurrent (37.2%), and mixed (46.5%) patterns of use. Simultaneous and concurrent users reported the most commonly used substance combinations (alcohol/nicotine/cannabis). Performance on executive function tasks was compared among the different groups of substance users and nonusers. Executive function assessments revealed deficits in simultaneous users for inhibition (most errors) and planning (most number of moves) compared to other groups. Concurrent users had the lowest accuracy for the two-back visual working memory. Conclusions: The findings of this small sample study suggest executive function deficits are more common in simultaneous users and underscore the need for more research to examine the synergistic effects of substances on cognition and executive functions. 2025 The Author(s). -
Exploring the pharmaceutical potential of discarded ink glands from Amphioctopus aegina
Ocean is called the Natural Medicine Chest of the New Millennium, as it encompasses diverse marine ecosystems that are rich in bioactive compounds. One of the fascinating organisms is cephalopods as they are known for their inking capabilities. The ink, composed mainly of melanin and mucous, has garnered attention for its diverse bioactive properties. In addition to melanin, components like Quinones, 8-hydroxy-4-quinolone, and various amino acids exhibit anti-oxidant and other therapeutic activities. Researches have shown that cephalopod ink can possess anti-inflammatory, anti-cancer, anti-microbial, anti-hypertensive, anti-ulcerogenic, and antiretroviral properties. However, these ink glands are discarded in the seafood industry. Amphioctopus aegina is one of the octopus species found in Indian waters and is less explored. This study was conducted to explore the chemical composition and pharmaceutical properties of the discarded ink glands of A. aegina. The study revealed the gland of this organism to be rich in bioactive compounds like alkaloids, phenols and flavonoids. Antioxidant studies revealed both aqueous and ethanol extracts showed good antioxidant capability, with remarkable radical scavenging activity, with IC50 values-65.76 g/mL and 51.7 g/mL respectively. The extracts also showed moderate inhibition of protein denaturation and were non-toxic to RAW264.7 cell lines. These findings highlight A. aegina ink as a promising source of therapeutic biomolecules and offer a sustainable approach for valorizing cephalopod waste. 2026, ScienceIn Publishing. All rights reserved. -
Exploring the Pharmaceutical Potential of Meretrix casta (Gmelin, 1791) (Mollusca: Bivalvia)
Meretrix casta, a marine mollusk, has been recognized traditionally for its nutritional and medicinal properties. This study aims to investigate the pharmacological potential of M. casta extracts, specifically focusing on the antioxidant, hemolytic, anti-inflammatory and antimicrobial activities. The antioxidant activity, assessed via hydrogen peroxide scavenging and phosphomolybdate assays, revealed concentration-dependent inhibition, with the methanol extract showing 61.04% inhibition at 100 g/mL compared to 61.19% for ethyl acetate, while the standard ascorbic acid exhibited 87.80%. Anti-inflammatory activity was evaluated using heat-induced hemolysis, hypotonicity-induced hemolysis and protein denaturation assays. Both extracts demonstrated significant anti-inflammatory effects, with the ethyl acetate extract achieving 85.40% inhibition of hemolysis, closely matching acetylsalicylic acids 90.50% and methanol extract showing 87.60% at 100 g/mL. Antibacterial and antifungal assays demonstrated significant inhibitory effects against pathogenic bacteria and fungi, with the methanolic extract frequently exhibiting higher efficacy. These findings highlight the therapeutic potential of M. casta extracts as natural bioactive agents. Future investigations should aim to isolate and characterize the specific bioactive compounds underlying these pharmacological effects and to explore their mechanisms of action in detail. Such studies could pave the way for new therapies derived from marine biodiversity, addressing various health challenges. 2025 Asian Publication Corporation. All rights reserved. -
Exploring the Photocatalytic and Cytotoxic Potential of Quassia indica-Derived Bimetallic Silver-Zinc Oxide Nanocomposites
In response to the escalating need for nanomaterials characterized by enhanced properties and reduced environmental impact, this study addresses critical challenges associated with conventional nanomaterial synthesis methods, particularly focusing on concerns related to environmental toxicity and economic feasibility. In this study, we report the eco-friendly synthesis of silver-zinc oxide nanocomposites using leaf extracts of Quassia indica (QI- Ag: ZnO NC). The synthesized QI- Ag: ZnO nanocomposites were characterized using various techniques including UV-visible spectroscopy, X-ray diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Field-Emission Scanning Electron Microscopy (FE-SEM) with Energy Dispersive X-ray Spectroscopy (EDX), High Resolution Transmission Electron Microscopy (HR-TEM), and Selected Area Electron Diffraction (SAED). The photocatalytic activity of the biosynthesized QI- Ag: ZnO NC was evaluated against several textile dyes. Reactive Blue-220 exhibited the highest percentage of degradation (99.97%), closely followed by Reactive Blue-222 (99.37%), while Reactive Red-120 displayed significant degradation (94.62%). Remarkably, these nanocomposites exhibited significant photocatalytic degradation of the tested dyes, suggesting their potential application in wastewater treatment for dye removal. Furthermore, phytotoxicity studies were conducted to assess the impact of the nanocomposites on plant growth and brine shrimp mortality. To evaluate their cytotoxicity, the nanocomposites synthesized were assessed using the MTT assay on MCF-7 and MDA-MB-231 cancer cells. These findings suggest that QI- Ag: ZnO NCs have promising applications in environmental remediation and cancer therapy, opening avenues for further advancements in the arena of nanomaterial synthesis and utilization. The Author(s), under exclusive licence to Springer Nature B.V. 2024. -
Exploring the Plausibility of Pre-Purchase Decision Process in User Acceptance of Smart Wearable Technology Devices
The market for smart wearable technology products is growing rapidly. Although wearable technology is still in its early stages, a longer-term outlook is required. This study inspected the existence of consumers pre-purchase stage for smart wearable technology devices. It further analyzed the factors that influenced customers decisions in the pre-purchase phase. The methodology adopted was quantitative, using which 240 users of smart wearables were given a structured questionnaire to fill up. The Smart PLS 3.0 software was used for structural equation modeling and path analysis. The results indicated that customers go through a pre-purchase decision journey. Their decisions are influenced by individual characteristics, product description, information source utility, data usefulness, trust, visibility of the product, and demonstrability. Together, these factors resulted in the customers successful transition from the pre-purchase stage to the purchase decision stage. 2022, Associated Management Consultants Pvt. Ltd.. All rights reserved. -
Exploring the potential application of Cr2AlC MAX phase as an emerging electrocatalyst for overall water splitting
A three-dimensional (3D) chromium carbide ceramic type, H-phase (211) categorized as Cr2AlC, MAX phase has garnered enormous attention in recent times due to its unique structure and bonding, surface area, thermal stability, and thermo-electrical conductivity, and hydrophilicity. A simple synthesis approach is proposed for obtaining layered Cr2AlC, MAX phase, with X-ray diffraction data and SEM morphology confirming the formation of the H-phase. The electrocatalyst Cr2AlC is being utilized for electrocatalytic water splitting application. The Cr2AlC is observed to exhibit an overpotential and Tafel slopes of 215 mV/88.3 mV dec? 1 for the hydrogen evolution reaction (HER) and 376 mV/96.5 mV dec? 1 for the oxygen evolution reaction (OER), respectively, demonstrating good stability for up to 7200s. This study establishes a straightforward method for producing emergent material, Cr2AlC MAX phase, and highlights its promising applications in water electrolysis, hydrogen evolution, and oxygen evolution reactions. Qatar University and Springer Nature Switzerland AG 2024. -
Exploring the potential application of Cr2AlC MAX phase as an emerging electrocatalyst for overall water splitting
A three-dimensional (3D) chromium carbide ceramic type, H-phase (211) categorized as Cr2AlC, MAX phase has garnered enormous attention in recent times due to its unique structure and bonding, surface area, thermal stability, and thermo-electrical conductivity, and hydrophilicity. A simple synthesis approach is proposed for obtaining layered Cr2AlC, MAX phase, with X-ray diffraction data and SEM morphology confirming the formation of the H-phase. The electrocatalyst Cr2AlC is being utilized for electrocatalytic water splitting application. The Cr2AlC is observed to exhibit an overpotential and Tafel slopes of 215 mV/88.3 mV dec? 1 for the hydrogen evolution reaction (HER) and 376 mV/96.5 mV dec? 1 for the oxygen evolution reaction (OER), respectively, demonstrating good stability for up to 7200s. This study establishes a straightforward method for producing emergent material, Cr2AlC MAX phase, and highlights its promising applications in water electrolysis, hydrogen evolution, and oxygen evolution reactions. Qatar University and Springer Nature Switzerland AG 2024. -
Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
Cancer is one of the dreaded diseases of the twentieth century, emerging the major global causes of human morbidity. Cancer research in the last 15 years has provided unprecedented information on the role of epigenetics in cancer initiation and progression. Histone deacetylases (HDACs) are recognized as important epigenetic markers in cancer, whose overexpression leads to increased metastasis and angiogenesis. In the current study, thirty-four (34) compounds from Andrographis paniculata were screened for the identification of potential candidate drugs, targeting three Class I HDACs (Histone deacetylases), namely HDAC1 (PDB id 5ICN), HDAC3 (PDB id 4A69) and HDAC8 (PDB id 5FCW) through computer-assisted drug discovery study. Results showed that some of the phytochemicals chosen for this study exhibited significant drug-like properties. In silico molecular docking study further revealed that out of 34 compounds, the flavonoid Andrographidine E had the highest binding affinities towards HDAC1 (?9.261 Kcal mol?1) and 3 (?9.554 Kcal mol?1) when compared with the control drug Givinostat (-8.789 and ?9.448 Kcal mol?1). The diterpenoid Andrographiside displayed the highest binding affinity (-9.588 Kcal mol?1) to HDAC8 compared to Givinostat (-8.947 Kcal mol?1). Statistical analysis using Principal Component Analysis tool revealed that all 34 phytocompounds could be clustered in four statistical groups. Most of them showed high or comparable inhibitory potentials towards HDAC target protein. Finally, the stability of top-ranked complexes (Andrographidine E-HDAC1 and HDAC3; Andrographiside-HDAC8) at the physiological condition was validated by Molecular Dynamic Simulation and MM-PBSA study. Communicated by Ramaswamy H. Sarma. 2023 Informa UK Limited, trading as Taylor & Francis Group. -
Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
Cancer is one of the dreaded diseases of the twentieth century, emerging the major global causes of human morbidity. Cancer research in the last 15 years has provided unprecedented information on the role of epigenetics in cancer initiation and progression. Histone deacetylases (HDACs) are recognized as important epigenetic markers in cancer, whose overexpression leads to increased metastasis and angiogenesis. In the current study, thirty-four (34) compounds from Andrographis paniculata were screened for the identification of potential candidate drugs, targeting three Class I HDACs (Histone deacetylases), namely HDAC1 (PDB id 5ICN), HDAC3 (PDB id 4A69) and HDAC8 (PDB id 5FCW) through computer-assisted drug discovery study. Results showed that some of the phytochemicals chosen for this study exhibited significant drug-like properties. In silico molecular docking study further revealed that out of 34 compounds, the flavonoid Andrographidine E had the highest binding affinities towards HDAC1 (?9.261 Kcal mol?1) and 3 (?9.554 Kcal mol?1) when compared with the control drug Givinostat (-8.789 and ?9.448 Kcal mol?1). The diterpenoid Andrographiside displayed the highest binding affinity (-9.588 Kcal mol?1) to HDAC8 compared to Givinostat (-8.947 Kcal mol?1). Statistical analysis using Principal Component Analysis tool revealed that all 34 phytocompounds could be clustered in four statistical groups. Most of them showed high or comparable inhibitory potentials towards HDAC target protein. Finally, the stability of top-ranked complexes (Andrographidine E-HDAC1 and HDAC3; Andrographiside-HDAC8) at the physiological condition was validated by Molecular Dynamic Simulation and MM-PBSA study. Communicated by Ramaswamy H. Sarma. 2023 Informa UK Limited, trading as Taylor & Francis Group.