Exploring the Pharmaceutical Potential of Meretrix casta (Gmelin, 1791) (Mollusca: Bivalvia)

Title

Exploring the Pharmaceutical Potential of Meretrix casta (Gmelin, 1791) (Mollusca: Bivalvia)

Creator

Thippesh, Deepak; Velayudhannair, Krishnakumar

Description

Meretrix casta, a marine mollusk, has been recognized traditionally for its nutritional and medicinal properties. This study aims to investigate the pharmacological potential of M. casta extracts, specifically focusing on the antioxidant, hemolytic, anti-inflammatory and antimicrobial activities. The antioxidant activity, assessed via hydrogen peroxide scavenging and phosphomolybdate assays, revealed concentration-dependent inhibition, with the methanol extract showing 61.04% inhibition at 100 g/mL compared to 61.19% for ethyl acetate, while the standard ascorbic acid exhibited 87.80%. Anti-inflammatory activity was evaluated using heat-induced hemolysis, hypotonicity-induced hemolysis and protein denaturation assays. Both extracts demonstrated significant anti-inflammatory effects, with the ethyl acetate extract achieving 85.40% inhibition of hemolysis, closely matching acetylsalicylic acids 90.50% and methanol extract showing 87.60% at 100 g/mL. Antibacterial and antifungal assays demonstrated significant inhibitory effects against pathogenic bacteria and fungi, with the methanolic extract frequently exhibiting higher efficacy. These findings highlight the therapeutic potential of M. casta extracts as natural bioactive agents. Future investigations should aim to isolate and characterize the specific bioactive compounds underlying these pharmacological effects and to explore their mechanisms of action in detail. Such studies could pave the way for new therapies derived from marine biodiversity, addressing various health challenges. 2025 Asian Publication Corporation. All rights reserved.

Source

Asian Journal of Chemistry;Volume;37;Issue;6;pp.1469-1476

Date

01-01-2025

Publisher

Asian Publication Corporation

Subject

Medicinal marine mollusks; Meretrix casta; Natural antioxidants; Therapeutic marine resources

Coverage

Thippesh D., Department of Life Sciences, Christ University, Dharmaram College Post, Hosur Road,, Bengaluru, 560029, India; Velayudhannair K., Department of Life Sciences, Christ University, Dharmaram College Post, Hosur Road,, Bengaluru, 560029, India

Rights

All Open Access; Gold Open Access

Relation

ISSN: 9707077; CODEN: AJCHE

Format

online

Language

English

Type

Article

Identifier

https://doi.org/10.14233/ajchem.2025.33827

https://www.scopus.com/pages/publications/105012758639?origin=resultslist