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Multifunctional characteristics of biosynthesized CoFe2O4@Ag nanocomposite by photocatalytic, antibacterial and cytotoxic applications
Carissa carandas, a traditional medicinal herb with a high concentration of antioxidant phytochemicals, has been used for thousands of years in the Ayurveda, Unani, and homoeopathic schools of medicine. By employing Carissa carandas bark extract as a reducing and capping agent in green biosynthesis, we extend this conventional application to produce CoFe2O4 and CoFe2O4@Ag nanocomposite. A variety of techniques have been used to characterize the synthesised nanocomposite, including UVVis, FTIR, XRD, FESEM, EDX, and BET. The CoFe2O4 and CoFe2O4@Ag nanocomposite demonstrated promising antibacterial action against human bacterial pathogens like B. subtilis and S. aureus as gram positive and P. aeruginosa and E. coli as gram negative with inhibition zones of 24.3 0.57, 17.4 0.75 and 20.5 0.5, 19.8 1.6 mm respectively, and the obtained results were superior to the nanocomposite without silver. Moreover, in-vitro cytotoxicity effects of biosynthesized CoFe2O4 and CoFe2O4@Ag were performed on the human breast cancer cell MCF-7. It was found that the MCF-7 cells' 50% inhibitory concentration (IC50) was 60 ?g/mL. Additionally, biosynthesized CoFe2O4 and CoFe2O4@Ag nanocomposite was used to demonstrate the photocatalytic eradication of Rhodamine Blue (RhB). Due to the addition of Ag, which increases surface area, conductivity, and increased charge carrier separation, the CoFe2O4@Ag nanocomposite exhibits a high percentage of photocatalytic degradation of ? 98% within 35 min under UV light irradiation. The photocatalytic performance of as-synthesised nanocomposite was evaluated using dye degradation-adsorption in both natural light and dark condition. Under dark conditions, it was found that 2 mg mL?1 CoFe2O4@Ag in RhB aqueous solution (5 ppm) causes dye adsorption in 30 min with an effectiveness of 72%. Consequently, it is anticipated that the CoFe2O4@Ag nanocomposite will be a promising photocatalyst and possibly a noble material for environmental remediation applications. 2023 Elsevier Ltd -
Multifunctional electrospun membranes incorporated with metal oxide nanoparticles, cellulose acetate, and polyvinylpyrrolidone for wastewater treatment: Oil/water separation, dye adsorption, and dye degradation
Multifunctional membranes have gained considerable attention as useful materials for the treatment of complex wastewater that contains dye and oil substances. Electrospun nanofiber membranes (ENM) have substantial advantages and potential for complex wastewater remediation, owing to their unique properties. In this study, an environmentally compatible ENM is fabricated by incorporating photocatalytic metal oxide nanoparticles of zinc oxide (ZnO) or silver-zinc Oxide (Ag-ZnO) into cellulose acetate (CA)/polyvinylpyrrolidone (PVP) nanofibers using electrospinning. Composite membranes ZnO/CA/PVP, Ag-ZnO/CA/PVP, ZnO/DCA/PVP (DCA: deacetylated cellulose acetate), and Ag-ZnO/DCA/PVP (deacetylated) were employed for oilwater emulsion separation, owing to their superhydrophilic and underwater superoleophobic nature, photocatalytic dye degradation due to the presence of ZnO or Ag-ZnO, and dye adsorption resulting from their high surface area. The composite membranes showed more than 95% efficiency for oil/water separation, malachite green adsorption, and photocatalytic methylene blue degradation. These membranes displayed simultaneous oilwater and dye separation efficiency, as well as antibacterial properties. The membrane we present here provides a simple and effective platform for wastewater remediation with a low energy consumption. 2024 Elsevier B.V. -
Multifunctional Evaluation of CaCO3Sodium Alginate Nanocomposite for Antibacterial, Antifungal, and Anticancer Applications
In this study, Calcium carbonate (CaCO?) nanoparticles and calcium carbonatesodium alginate (CaCO?SA) nanocomposite were successfully synthesized via a controlled precipitation method and evaluated for multifunctional biomedical applications. Structural and surface analyses confirmed the formation of a calcite phase with effective surface functionalization using SA. The nanocomposite exhibited reduced crystallite size (~ 29nm vs. ~38nm for CaCO?), improved dispersion, and enhanced defect density, as evidenced by XRD, DLS, PL, and TEM analyses. PL studies revealed multiple defect-related emission bands (370534nm), indicating the presence of active surface states. The CaCO?SA nanocomposite demonstrated significantly enhanced antimicrobial activity compared to CaCO?, with zone of inhibition values reaching ~ 20mm (S. aureus), ~ 21mm (S. pneumoniae), ~ 20mm (E. coli), and ~ 18mm (C. albicans), comparable to standard drugs. CFU analysis confirmed a concentration-dependent reduction in bacterial viability, while MIC and MBC values were reduced to 500g mL? and 750g mL?, respectively, indicating improved bacteriostatic and bactericidal efficiency. In anticancer studies, the nanocomposite exhibited enhanced cytotoxicity against MG-63 osteosarcoma cells, reducing cell viability to ~ 30% at higher concentrations, while maintaining high biocompatibility of > 80% viability toward L929 fibroblast cells. Overall, this work highlights the potential of surface engineered CaCO? based nanomaterials as promising candidates for combined antimicrobial and anticancer applications, providing a foundation for future in-depth biological investigations and translational studies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2026. -
Multifunctional Inorganic Nanomaterials: Synthesis, Properties, and Applications
Multifunctional Inorganic Nanomaterials: Synthesis, Properties, and Applications focuses on the latest discoveries and advances in the field of inorganic nanomaterials dealing with synthesis, functionalization, morphology, and physio-chemical properties of 1D, 2D, and 3D advanced materials and their interdisciplinary applications. This book reveals the significance of understanding the synthesis methodologies in tuning the nano-size properties of inorganic materials using various parameters to functionalize to specific applications in a variety of sectors covering energy, environment, and health. 2026 selection and editorial matter, H. C. Ananda Murthy, Velumani Subramaniam, Mika Sillanp, R. Balachandran, and Gurumurthy Hegde; individual chapters, the contributors. -
Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications
Nanocomposite made up of inorganic and biocompatible polymer have gained significant attention for biomedical applications due to their enhanced multifunctional properties, offering solutions to serious issues like antimicrobial resistance and cancer treatment. Nanocomposite composed of SnO?, chitosan and D-carvone (SnO2-Cs-Dcar) was prepared to ascertain its efficacy in application for antimicrobial, anticancer activities, and antioxidant effects. The synthesized nanocomposite was characterized by XRD, UV-Vis, FTIR, PL, SEM, TEM, and XPS techniques, confirming successful integration. XRD results confirmed the tetragonal rutile phase of SnO2. The band gap energy was calculated as 4.32eV for SnO2 nanoparticles and 3.11eV for SnO2-Cs-Dcar nanocomposite as observed from UV-Visible spectra. PL emission results showed that SnO2-Cs-Dcar nanocomposite exhibited green emission at 507nm corresponds to number oxygen vacancy site. SEM and TEM results showed that the SnO2-Cs-Dcar nanocomposite entities appear more compact, and the single SnO2 particles are less differentiated, possibly because they have been covered by chitosan and D-carvone. Antimicrobial activity against the pathogens Klebsiella pneumoniae, Candida albicans, Shigella dysenteriae, Bacillus subtilis, and Staphylococcus aureus demonstrated that SnO2-Cs-Dcar exhibited enhanced bacteriostatic effect when compared to bare SnO2. MTT assay on MOLT-4 cancer cells revealed that SnO2-Cs-Dcar nanocomposite exhibited enhanced anticancer activity upon compared to SnO? nanoparticles. The IC50 values were calculated as 13.6 for SnO2 and 12.1 for SnO2-Cs-Dcar nanocomposite. SnO?-Cs-Dcar nanocomposites exhibits high antioxidant activity evidenced by improved free radical scavenging action in comparison with a bare SnO?. Experimental result indicates that the SnO?-Cs-Dcar nanocomposites can be used as biocidal agent for antimicrobial and anticancer therapies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications
Nanocomposite made up of inorganic and biocompatible polymer have gained significant attention for biomedical applications due to their enhanced multifunctional properties, offering solutions to serious issues like antimicrobial resistance and cancer treatment. Nanocomposite composed of SnO?, chitosan and D-carvone (SnO2-Cs-Dcar) was prepared to ascertain its efficacy in application for antimicrobial, anticancer activities, and antioxidant effects. The synthesized nanocomposite was characterized by XRD, UV-Vis, FTIR, PL, SEM, TEM, and XPS techniques, confirming successful integration. XRD results confirmed the tetragonal rutile phase of SnO2. The band gap energy was calculated as 4.32eV for SnO2 nanoparticles and 3.11eV for SnO2-Cs-Dcar nanocomposite as observed from UV-Visible spectra. PL emission results showed that SnO2-Cs-Dcar nanocomposite exhibited green emission at 507nm corresponds to number oxygen vacancy site. SEM and TEM results showed that the SnO2-Cs-Dcar nanocomposite entities appear more compact, and the single SnO2 particles are less differentiated, possibly because they have been covered by chitosan and D-carvone. Antimicrobial activity against the pathogens Klebsiella pneumoniae, Candida albicans, Shigella dysenteriae, Bacillus subtilis, and Staphylococcus aureus demonstrated that SnO2-Cs-Dcar exhibited enhanced bacteriostatic effect when compared to bare SnO2. MTT assay on MOLT-4 cancer cells revealed that SnO2-Cs-Dcar nanocomposite exhibited enhanced anticancer activity upon compared to SnO? nanoparticles. The IC50 values were calculated as 13.6 for SnO2 and 12.1 for SnO2-Cs-Dcar nanocomposite. SnO?-Cs-Dcar nanocomposites exhibits high antioxidant activity evidenced by improved free radical scavenging action in comparison with a bare SnO?. Experimental result indicates that the SnO?-Cs-Dcar nanocomposites can be used as biocidal agent for antimicrobial and anticancer therapies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. -
Multifunctional SrO?Sodium AlginateL-Arginine Nanocomposite: A Green Approach against Colon Cancer and Pathogenic Microbes
Pathogenic microbes pose a significant threat to human health due to their increasing resistance to standard antibiotics. Colon cancer is among the deadliest forms of cancer worldwide and often exhibits resistance to conventional treatments, highlighting the urgent need for alternative therapeutic agents. In this study, a SrO2SALA nanocomposite was synthesized via a green chemical approach using Bougainvillea glabra extract and evaluated for its anticancer, antioxidant, and antimicrobial potential. In this work, SrO2-SA-LA nanocomposite was prepared via a green chemical approach using Bougainvillea glabra extract and evaluated for its potential anticancer, antioxidant, and antimicrobial properties. The nanocomposite was successfully synthesized and functionalized, as confirmed by characterization studies. XRD revealed a crystalline phase of tetragonal SrO2. The calculated optical bandgap energies were 4.11eV for pristine SrO2 and 4.35eV for SrO2-SA-LA nanocomposite. DLS analysis indicated median particle sizes of 128.40nm and 142.70nm for SrO? and SrO2SALA, respectively. PL studies showed that the SrO2SALA nanocomposite exhibited green emission in the range of 494534nm, suggesting an increase in oxygen-related defect states compared to pure SrO2. Disc diffusion assay revealed that SrO2-SA-LA nanocomposite exhibited enhanced antimicrobial activity against common disease-causing pathogens, while MTT assay showed enhanced cytotoxicity against HCT-116 colon cancer cells. Additionally, the SrO2-SA-LA nanocomposite exhibited superior free radical scavenging in DPPH assays, indicating high antioxidant potential. Furthermore, cytocompatibility studies using L929 fibroblast cells confirmed that both SrO? and SrO?SALA nanocomposite are non-toxic to normal cells, with cell viability exceeding 80%, indicating their biosafety. The results suggest that SrO2-SA-LA nanocomposite is a promising candidate for applications in anticancer, antioxidant, and antimicrobial therapies with good biocompatibility. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. -
Multigene Genetic Programming Based Prediction of Concrete Fracture Parameters of Unnotched Specimens
This study explores the fracture energy of notched and unnotched concrete specimens subjected to the classical three-point bend test, instantiating a gradational step in the continued development of concrete fracture mechanics. An experimental campaign involving 18 notched test specimens and nine unnotched specimens of three different grades of concrete, an examination of the existing literature models for unnotched specimens, and a novel Multigene Genetic programming (MGGP) based concrete fracture energy model for unnotched specimens are integral to this study. As a salient result, the multiple approaches to quasi-brittle materials adopted in the study, highlighted the criticality of the determination of fracture energy, tensile strength and characteristic length for the crack width study. The failure modes of notched and unnotched specimens were found to be similar. The reported literature has mainly focused on a limited number of fracture energy influencing parameters. Therefore, six impact parameters have been chosen and incorporated into the present study to provide a more acceptable explanation of concrete fracture behaviour. A sensitivity analysis of the parameters and an error analysis of the model undertaken have established the accuracy and robustness of the developed MGGP model. 2023 by the authors. Licensee C.E.J, Tehran, Iran. -
Multilayer classification based Alzheimer's disease detection
Hippocampus, a small brain region plays a role in the initiation of the neurodegenerative pathways that leadto Alzheimer's. Humans with MCI are probable to develop Alzheimer's disorder. Hippocampal volume has been proven to indicate which patients with MCI will later develop Alzheimer's. Brain degeneration in MCI progresses over time and varies from person - to - person, making early detection difficult. Magnetic resonance imaging is a tool in diagnosing clinically suspected Alzheimer's disease. Information about the historical development of structural changes as the disease progresses from preclinical to overt stages is shaping understanding of the disease, and also guides diagnosis and treatment decisions in the future. In this study, we developed a new multilayer classification method to identify Alzheimer's disease from brain MRI using contour model and multilayer classifier. This method is evaluated on 436 samples of OASIS dataset and achieved accuracy of method is 93.75 %. 2024 Author(s). -
Multilayer flow and heat transport of nanoliquids with nonlinear Boussinesq approximation and viscous heating using differential transform method
Multilayer fluid flow models are significant in various applications, namely, cooling electronic systems, solar thermal systems, and nuclear reactors. The density of a fluid fluctuates nonlinearly due to large temperature difference circumstances in thermal systems. Thus, the linear Boussinesq approximation is no longer relevant. Therefore, this article describes a multilayer flow of nanoliquids in the presence of nonlinear Boussinesq approximation. The hybrid nanoliquid layer is sandwiched between two nanoliquid layers. The single-phase khanafer-vafai-lightstone model is implemented to simulate the nanoliquids. The quadratic density temperature fluctuation and viscous heating are taken into account. The temperature and velocity across the interface are assumed to be continuous. The equations that govern the problem are solved analytically by using the differential transformation method. The results show that the presence of a hybrid nanoliquid layer affects the velocity and heat transfer properties of the nanofluid flow. Hybrid nanofluid can be used to achieve the desired multilayer flow properties of a nanofluid and its heat transfer properties. Further, the quadratic convection aspect increases the velocity distributions. 2021 Wiley Periodicals LLC -
Multilevel CNN Based Hybrid Framework for Adaptive Credit Card Fraud Detection
Credit card fraud presents a substantial problem to financial organizations, as fast changing fraudulent activities necessitate advanced detection techniques. Conventional machine learning methods frequently encounter challenges with adaptability and precision in imbalanced datasets. This study presents a multilevel CNN-based hybrid architecture that combines deep convolutional networks with traditional ensemble classifiers for adaptive credit card fraud detection. The platform includes an adaptive learning module that facilitates ongoing model upgrades, guaranteeing responsiveness to emerging fraud trends. The system, evaluated using a benchmark Kaggle dataset, attained an accuracy of 99.48%, precision of 98.76%, recall of 99.05%, F1-score of 98.90%, and AUC-ROC of 99.91%, outperforming established baseline models such as Logistic Regression, Random Forest, and XGBoost. The suggested system's capacity to integrate deep feature extraction with hybrid classifiers yields enhanced detection efficiency, reduced false positives, and improved generalization. This research enhances fraud detection by overcoming the constraints of static models, rendering it applicable for real-time financial applications and adaptable to emerging threats. 2025 IEEE. -
Multilevel Inverter-Fed Closed Loop Control and Analysis of Induction Motor Drive
Multilevel inverters have discovered more extensive extent of utilization in moderate and also in high-power adjustable-speed drives. This chapter introduces a vector control scheme of induction motor drive which includes pulse width modulations for reducing harmonics and total harmonic distortion (THD). For better control of induction motor, indirect vector control has been applied which offers advantages such as removal of flux sensor, more dynamic responses, and minimum torque pulses is applied. The inverter named neutral point clamped inverter is applied for observing dynamic control of the motor drive along with efficiency. The main attention of this chapter is to improve the performance of indirect vector controller. The THD analysis proves the better operation of induction motor as compared to conventional voltage source inverter-fed induction motor drive. By the help of MATLAB simulation, the dynamic performance as well as steady-state of multilevel inverter-based drive are analyzed. 2024 Scrivener Publishing LLC. -
Multilevel Quantum Inspired Fractional Order Ant Colony Optimization for Automatic Clustering of Hyperspectral Images
Hyperspectral images contain a wide variety of information, varying from relatively large regions to smaller manmade buildings, roads and others. Automatic clustering of various regions in such images is a tedious task. A multilevel quantum inspired fractional order ant colony optimization algorithm is proposed in this paper for automatic clustering of hyperspectral images. Application of fractional order pheromone updation technique in the proposed algorithm produces more accurate results. Moreover, the quantum inspired version of the algorithm produces results faster than its classical counterpart. A new band fusion technique, applying principal component analysis and adaptive subspace decomposition, is successfully proposed for the pre-processing of hyperspectral images. Score Function is used as the fitness function and K-Harmonic Means is used to determine the clusters. The proposed algorithm is implemented on the Xuzhou HYSPEX dataset and compared with classical Ant Colony Optimization and fractional order Ant Colony Optimization algorithms. Furthermore, the performance of each method is validated by peak signal-to-noise ratio which clearly indicates better segmentation in the proposed algorithm. The Kruskal-Wallis test is also conducted along with box plot, which establishes that the proposed algorithm performs better when compared with other algorithms. 2020 IEEE. -
Multilevel Security and Dual OTP System for Online Transaction Against Attacks
In the current internet technology, most of the transactions to banking system are effective through online transaction. Predominantly all these e-transactions are done through e-commerce web sites with the help of credit/debit cards, net banking and lot of other payable apps. So, every online transaction is prone to vulnerable attacks by the fraudulent websites and intruders in the network. As there are many security measures incorporated against security vulnerabilities, network thieves are smart enough to retrieve the passwords and break other security mechanisms. At present situation of digital world, we need to design a secured online transaction system for banking using multilevel encryption of blowfish and AES algorithms incorporated with dual OTP technique. The performance of the proposed methodology is analyzed with respect to number of bytes encrypted per unit time and we conclude that the multilevel encryption provides better security system with faster encryption standards than the ones that are currently in use. 2019 IEEE. -
Multilingual Sentiment Analysis of YouTube Live Stream using Machine Translation and Transformer in NLP
YouTube has become one of the all-inclusive video streaming sources on the internet. Today, the news is streamed on YouTube, marketing of a product is done live on YouTube and it has become a platform for one of the biggest PR producers for companies. Various companies have proposed an optimized way of understanding and getting the opinions of the viewers from YouTube live chat and find the best possible way to provide relevant and informative content to boost the business strategy. This study uses Natural Language Processing (NLP) based approach along with NLP transformers to classify and analyses the sentiment. 2022 IEEE. -
Multilingual Sentiment Analytics for India's NEP 2020
This study presents a multilingual sentiment analysis framework for evaluating public sentiments on India's National Education Policy (NEP) 2020. The authors developed a dataset related to NEP 2020 using web scraping from open sources. The curated dataset comprises 50,000 social media posts (English: 30,000, Hindi: 12,000, Tamil: 8,000) processed through a confidence-gated hybrid annotation pipeline. Sentiment labels were created using Transformer models (BERT, mBERT, XLMR) and validated by native-speaker with F1-scores of 87.6%, 81.2% and 78.0% for English, Hindi and Tamil respectively: outperforming baselines (SVM, Naive Bayes, BiLSTM) by 12-18% (p<0.001). We use computational efficiency measures to illustrate that training takes 3.2-5.3 hours and inference lasts between 118 and 187 posts per second. Topic modeling revealed sentiment divergences: positive for linguistic inclusivity and teacher training, negative for affordability and infrastructure. Cross-linguistic analysis showed English-Hindi convergence (similarity: 0.61) versus Tamil divergence (0.46), reflecting regional priorities. Tamil emphasized linguistic identity while English prioritized implementation critiques. Quantitative policy impact analysis shows very strong correlation (r=0.68, p<0.01) between regional sentiment scores and state adoption rates. This open-sourced contribution is filling the crucial gap of inclusive policy analytics in multilingual society informing evidence-based policy. 2025 IEEE. -
Multilingual Voice-Assisted for Traffic Sign Detection and Classification in Adverse Weather Conditions
In a world where millions of people are wounded in auto accidents each year due to negligence, a lack of understanding of traffic laws, and bad weather, there is an urgent need for greater road safety. This is particularly the case in India, where a disproportionately high number of traffic accidents lead to numerous fatalities. Ignoring traffic signs raises these risks and endangers not only vehicles but also passengers and pedestrians. This project addresses the significant issue of traffic sign recognition in bad weather and offers voice-based instruction in many languages to increase road safety. Using a mix of state-of-the-art technologies, including YOLOv8 for real-time sign detection and the Google Translate API, which supports NLP tasks, this research offers a full solution. The model's remarkable precision and efficacy underscore its capacity to revolutionize traffic safety and furnish a more secure and expedient driving encounter. With the world moving towards more autonomous mobility, this study is laying the groundwork for safer and more effective driving in the future. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025. -
Multimedia Enhanced Teaching and Learning with Special Reference to Developing Cognitive Skills
Indian Streams Research Journal, Vol-3 (7), pp. 25-28. ISSN-2230-7850 -
Multimodal artificial intelligence for early cancer detection via liquid biopsy, imaging, and clinical records
Tumours are diverse and multiscale, making it difficult for modern medicine to diagnose early cancer. Using structured clinical data, radiologic imaging features, and liquid samples, this research presents a multimodal AI framework for the early and reliable detection of cancer. The proposed approach surpasses single-modality approaches by integrating signals from various domains, including cancer genetic, anatomical, and physiological data. Using attention-based fusion, representation learning, and better preprocessing, we developed a prediction model that fine-tuned the weights of different modes. The results of the experiments demonstrated that it outperformed unimodal models on all datasets in terms of sensitivity, specificity, and generalisation. The framework has potential for screening purposes because of its ability to detect cancer at an early stage. Clinical confidence and interpretability were both boosted by the results of explainability tests, which revealed substantial feature contributions. The suggested multimodal framework outperformed unimodal baselines across all assessment cohorts with an AUC of 0.94, sensitivity of 0.91, and specificity of 0.88. Experimental results confirm multimodal fusion's clinically interpretable early cancer detection and precision oncology decision assistance. Copyright 2026. Published by Elsevier B.V. -
Multimodal Classification on PET/CT Image Fusion for Lung Cancer: A Comprehensive Survey
Medical image fusion has become essential for accurate diagnosis. For example, a lung cancer diagnosis is currently conducted with the help of multimodality image fusion to find anatomical and functional information about the tumor and metabolic measurements to identify the lung cancer stage and metastatic information of the disease. Generally, the success of multimodality imaging for lung cancer diagnosis is due to the combination of PET and CT imaging advantages while minimizing their respective limitations. However, medical image fusion involves the registration of two different modalities, which is time-consuming and technically challenging, and it is a cause of concern in a clinical setting. Therefore, the paper's main objective is to identify the most efficient medical image fusion techniques and the recent advances by conducting a collective survey. In addition, the study delves into the impact of deep learning techniques for image fusion and their effectiveness in automating the image fusion procedure with better image quality while preserving essential clinical information. The Electrochemical Society