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Some case studies on importance of variables and scales of measurement in social sciences research /
International Advanced Research Journal In Science, Engineering And Technology, Vol.2, Issue 3, pp.34-37, ISSN No: 2393-8021 (Online) 2394-1588 (Print). -
Some case studies for non-parametric tests for ordinal data /
International Journal Of Advanced Research In Engineering Technology & Sciences, Vol.2, Issue 7, pp.309-313, ISSN No: 2394-2819. -
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Solvent-solute polarity, electrophilic, steric effects, reactive sites, themodynamic quantities discussion and biological evaluation of lung cancer antiproliferative activities of spirobrassinin derivatives
The current study of spirobrassinin and its related compounds, 1-methoxyspirobrassinol and the 5-bromo analogue of methoxyspirobrassinin is performed to reveal a comparison among these molecules to understand which is the most reactive and bioactive. DFT (Density Functional Theory) studies comprising geometry optimisation (energy minimisation), FMO (Frontier Molecular Orbital) Analysis, theoretical UV analysis, NLO (Non-Linear Optics), NBO (Natural Bond Orbital) and thermodynamics studies are performed using Gaussian 09W. IEFPCM model is employed to investigate the solvent effect on the reactivity and stability of the title compounds. ADME profiles are generated using SwissADME, PreADMET and ADMETLab 2.0. Interesting lung cancer target proteins are docked with the title compounds is finally performed to obtain insight into the molecules' anticancer potential. 2023 Elsevier B.V. -
Solvent-solute interaction, thermodynamic behaviour, structural, chemical and anti-cancer biological properties of 3(2H)-furanone derivatives
In this work, the structures, reactivities, and electronic and biological properties of the 3(2H)-furanone derivatives, 2-hydroxy-2,5-diphenyl-4-(phenylamino)furan-3(2H)-one (HDPF), 2-methoxy-2,4,5-triphenylfuran-3(2H)-one (MTPF), 3-oxo-2,4,5-triphenyl-2,3-dihydrofuran-2-yl acetate (OTDF), and 2-chloro-2,4,5-triphenylfuran-3(2H)-one (CTPF), are explored via theoretical investigations using DFT (Density Functional Theory) techniques as the main tools for the study. The DFT studies include geometry optimisation, FMO (Frontier Molecular Orbital) analysis, theoretical UV studies, molecular electrostatic potential (MEP) investigations, non-linear optical (NLO) analyses, and the evaluation of thermodynamic parameters. Multiwfn 3.8 software is utilised to conduct the topological analyses. The ADME (Absorption, Distribution, Metabolism, Excretion) profiles are produced with the SwissADME online tool. The target proteins, MCL-1 (Myeloid cell leukemia-1), BCL-2 (B-cell lymphoma-2), and myeloblastin, are docked with the title molecules using AutoDock 1.5.6. 2023 Elsevier B.V. -
Solvent polarity, structural and electronic properties with different solvents and biological studies of 3,3,5-triphenylfuran-2(3H)-one- cancers of the blood cells
The current work comprises synthesis, characterization and computational evaluation on 3,3,5-triphenylfuran-2(3H)-one with density functional theory (DFT) as the underlying principle. The theoretical optimized structure and corresponding geometrical parameters were obtained. Multiwfn 3. 8 was employed to conduct topological investigations such as R D G, E L F, L O L, and charge transfer analyses, which are used to identify the excited states, non-covalent interactions and important bonding regions in the molecule. Effect of solvents on the variation in molecular properties were studied with different polar solvents, with the IEFPCM model, as furanones interact with more polar solvents. The solvation studies were shown to impact on F M O, UV, M E P, and NLO analysis and thus between gas and solvent phases, a variation is observed in the properties under study. N B O studies were analysed to identify the natural bond orbitals within the molecule that contribute the maximum to the stabilization energy of the title compound. Pharmacological evaluation using readily available online tools that include SwissADME, Pre-ADMET, GUSAR, and ADMETLab 2.0 to determine the medicinal chemistry properties of the molecule was done. Furthermore, molecular docking onto chosen anticancer protein targets is performed utilising the softwares AutoDock Suite. PyMOL,and Discovery Studio Visualizer, is used to determine the best docked conformations that suggest potential capability of the compound to inhibit these proteins and protect the body from cancerous growths. 2022 Elsevier B.V. -
Solvent free microwave assisted synthesis and evaluation of potent antimicrobial activity of 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido [4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles
Microwave assisted condensation of urea, thiourea and hydrazine hydrate with 1-chloro-2-formyl carbazoles in the presence of PTSA as catalyst yields 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido[4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles, respectively. The structures of the synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. All the synthesized compounds have been evaluated for their antibacterial and antifungal activities. Some of the synthesized compounds 2a-g and 3a-g exhibit significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compounds 2a-g and 3a-g exhibit good antifungal activity against Candida albicans, Aspergillus flavus. Pyrazolo[3,4-a]carbazoles 4a-g register good antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compound 4e indicate maximum activity of 20 and 24 mm at 500 and 1000?g/disc, respectively, against Lipomyces lopofera fungi. -
Solutions for time-fractional coupled nonlinear Schringer equations arising in optical solitons
In this work, an efficient novel technique, namely, the q-homotopy analysis transform method (q-HATM) is applied to obtain analytical solutions for a system of time-fractional coupled nonlinear Schringer (TF-CNLS) equations with the time-fractional derivative taken in the Caputo sense. This system of equations incorporate nonlocality behaviors which cannot be modeled under the framework of classical calculus. With numerous important applications in nonlinear optics, it describes interactions between waves of different frequencies or the same frequency but belonging to different polarizations. We first establish existence and uniqueness of solutions for the considered time-fractional problem via a fixed point argument. To demonstrate the effectiveness and efficiency of the q?HATM, two cases each of two time-fractional problems are considered. One important feature of the q?HATM is that it provides reliable algorithms which can be used to generate easily computable solutions for the considered problems in the form of rapidly convergent series. Numerical simulation are provided to capture the behavior of the state variables for distinct values of the fractional order parameter. The results demonstrate that the general response expression obtained by the q?HATM contains the fractional order parameter which can be varied to obtain other responses. Particularly, as this parameter approaches unity, the responses obtained for the considered fractional equations approaches that of the corresponding classical equations. 2021 The Physical Society of the Republic of China (Taiwan) -
Solution structure of the tachykinin peptide eledoisin
Both the aqueous and the lipid-induced structure of eledoisin, an undecapeptide of mollusk origin, have been studied by two-dimensional proton nuclear magnetic resonance spectroscopy and distance geometry calculations. Unambiguous nuclear magnetic resonance assignments of protons have been made with the aid of correlation spectroscopy experiments and nuclear Overhauser effect spectroscopy experiments. The distance constraints obtained from the nuclear magnetic resonance data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water and dimethyl sulfoxide, eledoisin prefers to be in an extended chain conformation, whereas in the presence of perdeuterated dodecylphosphocholine micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M11) of the peptide. N terminus, though less defined, also displays some degree of order and a possible turn structure. The conformation adopted by eledoisin in the presence of dodecylphosphocholine micelles is similar to the structural motif typical of neurokinin-2 selective agonists and with that reported for kassinin in hydrophobic environment. -
Solution of boundary eigenvalue problems and IBVP involving a system of PDEs using the successive linearization method
The paper illustrates a numerical technique to solve a system of three partial differential equationsthat govern the problem of Rayleigh-Bard-Brinkman convection in a two-dimensional porous rectangular box. As a result of linear and weakly nonlinear stability analyses of the system a boundary eigenvalue problem (BEVP) and an initial boundary value problem (IBVP) arise. Spatial information on the periodicity of the convection cells is first used in the system of PDEs to make it possible for the successive linearization method (SLM) to be applied. The resulting much-simplified versions of BEVP and the IVP are then solved by direct and time multi-stepping versions of SLM, respectively. The SLM solution of the BEVP is compared with that obtained through MATLAB routine bvp4c and the multi-stepping-SLM solution of the IVP is validated with that of the Runge-Kutta-Fehlberg (RKF45) method (using MATLAB routine ode45). The present numerical technique is found to have quadratic convergence for any desiredaccuracy. 2023 Wiley-VCH GmbH. -
Solution of a dengue fever model via fractional natural decomposition and modified predictor-corrector methods
In this paper, we solved a model of a well-known infectious disease called dengue fever via fractional natural decomposition and modified Predictor-Corrector (PC) methods. A study of the dengue epidemic in the Cape Verde Islands off the coast of West Africa in 2009 has been resumed here for a better understanding of the results. The results are obtained using Liouville-Caputo and new generalized Caputo-type fractional derivatives. The numerical simulations are presented for various orders of given derivatives. Existence and uniqueness analysis of the given problem are also performed in the new generalized Caputo sense. The explored results are verified using figures. The main target of this paper is to explore the different dynamics of the given dengue fever model via two types of fractional numerical algorithms. 2024 World Scientific Publishing Company. -
Solution for fractional potential KdV and Benjamin equations using the novel technique
In this paper, we find the solutions for fractional potential Kortewegde Vries (p-KdV) and Benjamin equations using q-homotopy analysis transform method(q-HATM). The considered method is the mixture of q-homotopy analysis method and Laplace transform, and the Caputo fractional operator is considered in the present investigation. The projected solution procedure manipulates and controls the obtained results in a large admissible domain. Further, it offers a simple algorithm to adjust the convergence province of the obtained solution. To validate the q-HATM is accurate and reliable, the numerical simulations have been conducted for both equations and the outcomes are revealed through the plots and tables. Comparison between the obtained solutions with the exact solutions exhibits that, the considered method is efficient and effective in solving nonlinear problems associated with science and technology. 2021 -
Solution for Fractional KuramotoSivashinsky Equation Using Novel Computational Technique
In this paper, we analyse the nonlinear model describing the different physical and chemical phenomena, namely KuramotoSivashinsky equation. For the fractional KS (FKS) equation the approximated analytical solution is obtained with the help of the q-homotopy analysis transform method (q-HATM). The projected technique is a mixture of Laplace transform and homotopy analysis method. The considered technique offers ?-curves that show convergence range of the obtained series solution. To confirm the efficiency and applicability of the projected scheme, we consider four distinct examples. The numerical study is conducted to authorize the accuracy and reliability of the considered method. Further, natures of the achieved results have been presented for different order. The obtained solution illuminates that, the projected algorithm is very effective and easy to implement to examine the behaviour nonlinear models exist in science and technology. 2021, The Author(s), under exclusive licence to Springer Nature India Private Limited part of Springer Nature. -
Solution Focused vs Problem Focused Questions on Affect and Processing Speed among Individuals with Depression
The present study investigated the effect of solution-focused and problem-focused questions on affect and processing speed in a sample of 60 individuals diagnosed with depression. Participants were equally and randomly assigned to the solution focused question group, problem focused question group, and delayed experimental group. The Beck depression inventory-II was used to assess the severity of depressive symptoms of the participants. The positive and negative affect schedule was used to measure affect. Symbol search and coding were used to measure the processing speed. Solution-focused questions significantly reduced negative affect and improved coding compared to problem-focused questions. Even though there was no significant interaction between the groups in positive affect and symbol search test performance, solution-focused questions caused simple effects in both. Findings imply the scope of solution-focused questions as psychological first aid in intervening depression. Possible long-term effects of solution-focused questions on individuals with depression were discussed. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Solute-solvent interaction and DFT studies on bromonaphthofuran 1,3,4-oxadiazole fluorophores for optoelectronic applications
In the present work, computational and experimental studies were carried out to explore the photophysical properties of bromonaphthofuran substituted 1,3,4-oxadiazole derivatives for optoelectronic applications. Density functional theory (DFT) was used to demonstrate the electronic and optical properties of the synthesised molecules. The theoretical ground state dipole moments of the fluorophores in gas and solvent environments were also computed using Gaussian 09W software. Further, the HOMO-LUMO energies of the fluorophores determined using DFT agree well with the experimental values. Molecular electrostatic potential 3D plots were used to identify the sites which are electrophilic and nucleophilic in nature. Dipole moment of both the fluorophores in ground and excited states were determined experimentally. The excited state dipole moments being higher than that of the ground state shows the redistribution of electron densities in the excited state than in the ground state in both the fluorophores. The solute-solvent interactions, both specific and non-specific, were assessed using Catalan parameters. Further, the nature of chemical reactivity was determined based on global descriptors. The photophysical properties of the fluorophores studied suggest their potential use as promising candidates for organic light emitting diode (OLED), solar cell and chemosensor applications. 2022 Elsevier Inc. -
Solidarity, job satisfaction, and turnover intent in employees
Purpose: While the role of solidarity in the workplace has been examined in previous research, it is still an important component of the workplace for Japanese employees. The purpose of this paper is to integrate findings on solidarity at the workplace, job satisfaction and intent to turnover. A moderated mediation model is hypothesized where solidarity predicts intent to turnover via job satisfaction, but the strength of this whole mediation process is moderated by employees length of working overtime or working long hours. Design/methodology/approach: The data analyzed in this study were acquired from the Japanese General Social Survey 2010, which was administered to 527 men and 278 women. Findings: The results generally supported the assumptions; the proposed mediation model proved to be statistically significant, even when background covariates were introduced into the model to control for pre-existing differences. Also, the proposed moderated mediation model was supported; solidarity strongly increased job satisfaction when working overtime was low. Research limitations/implications: Because of measurement of solidarity, this study results may limit the generalizability. Researchers should explore the relationship between the dimension of solidarity and job satisfaction. Practical implications: The paper includes the implications for human resource management, the developing of solidarity at the workplace and for managing the strain of working overtime. Originality/value: This study was the first to examine the relationship between solidarity at the workplace and job satisfaction and the moderating effects of working overtime. 2019, Emerald Publishing Limited. -
Solid-State Organic Fluorophore for Latent Fingerprint Detection and Anti-Counterfeiting Applications
A highly fluorescent material exhibiting solid-state fluorescence is particularly important in detecting latent fingerprints (LFPs) and anti-counterfeiting applications. Herein, we have synthesized a coumarin-benzothiazole moiety 3-(benzo[d]thiazol-2-yl)-2H-chromen-2-one (3-BTC) to inspect its capability to visualize LFPs and work as an anti-counterfeiting ink. The compound showed yellow-greenish emission under UV excitation and good covertness under visible light conditions. With the help of the powder dusting method, the latent fingerprints were coated with 3-BTC powder and images of the LFPs developed over various substrates including plastic, steel, aluminium plate, rubber, etc. under UV 365 nm light displayed good resolution be able to discern the patterns of all the levels 13. Apart from fresh fingerprints (taken within 10 seconds), aged (over 60 days) and incomplete eccrine LFPs were successfully visualized using 3-BTC powder. Anti-counterfeiting ink prepared using 3-BTC also proved to be a promising candidate as an anti-counterfeiting ink. Various types of paper materials, including tissue paper, printing paper, newspaper, etc. were used for evaluating 3-BTC as a satisfactory anti-counterfeiting ink. 2024 Wiley-VCH GmbH. -
Solid-state fermentation of pigment producing endophytic fungus Fusarium solani from Madiwala lake and its toxicity studies
Several consumer products look enticing due to colors and there has been a demand for colors for various applications ever since human civilization started. Although in the primitive days, humans had used natural colors, the wake of the industrial revolution saw the excessive use of diverse types of synthetic colors. Although it looked very fancy initially, slowly scientists discovered the dangers of large-scale use of these colorants. The current demand is for natural colors, and hence, there is a scope for sources of natural colors from biosources. The present study involved the isolation of an endophytic fungus, Fusarium solani producing a red pigment from the polluted waters of Madiwala lake in Bangalore. The fungal extract showed good antimicrobial and moderate antioxidant properties. Cytotoxicity assays using brine shrimps proved negligible toxicity which is a positive trait for natural colorants for safer applications in industries. Media optimization and solid state fermentation were carried out to improve the yield of the fungal pigment and also to formulate a cheaper media for fungal multiplication and pigment production. Green synthesis of silver nanoparticles was also carried out with the fungal extract and the nanoparticles were characterized. Thus, the present study provides an option for the extraction of environment friendly natural colorant from the fungus F. solani for potential industrial applications. 2024 Bhoomika Prakash Poornamath, et al.