Solvent free microwave assisted synthesis and evaluation of potent antimicrobial activity of 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido [4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles
- Title
- Solvent free microwave assisted synthesis and evaluation of potent antimicrobial activity of 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido [4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles
- Creator
- Velmurugan R.; Vijayasankar A.V.; Sekar M.
- Description
- Microwave assisted condensation of urea, thiourea and hydrazine hydrate with 1-chloro-2-formyl carbazoles in the presence of PTSA as catalyst yields 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido[4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles, respectively. The structures of the synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. All the synthesized compounds have been evaluated for their antibacterial and antifungal activities. Some of the synthesized compounds 2a-g and 3a-g exhibit significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compounds 2a-g and 3a-g exhibit good antifungal activity against Candida albicans, Aspergillus flavus. Pyrazolo[3,4-a]carbazoles 4a-g register good antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. The compound 4e indicate maximum activity of 20 and 24 mm at 500 and 1000?g/disc, respectively, against Lipomyces lopofera fungi.
- Source
- Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, Vol-52, No. 3, pp. 414-421.
- Date
- 2013-01-01
- Subject
- Antimicrobial activity; Microwave irradiation; Pyrazolo carbazoles; Pyrimido carbazoles
- Coverage
- Velmurugan R., Post Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, India; Vijayasankar A.V., Department of Engineering Chemistry, Christ University, Bangalore 560 029, Karnataka, India; Sekar M., Post Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, India
- Rights
- Restricted Access
- Relation
- ISSN: 3764699; CODEN: IJSBD
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Velmurugan R.; Vijayasankar A.V.; Sekar M., “Solvent free microwave assisted synthesis and evaluation of potent antimicrobial activity of 1,11H-pyrimido[4,5-a]carbazol-2-ones, 1,11H-pyrimido [4,5-a]carbazol-2-thiones and pyrazolo[3,4-a]carbazoles,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/17354.