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Pyrazole Derivative Containing Naphthalene Moiety: Cytotoxocity (Breast and Cervical Cancer), Antibacterial and Antifungal Studies Using Experimental and Theoretical Tools
In the present study, the title compound is named 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(6-methoxynaphthalen-1-yl)methyl)-5-methyl-2-phenyl-1,2-dihydropyrazol-3-one was synthesized, and its antibacterial, antifungal, cytotoxic activity was studied by both experimental and in silico methods. The molecular structure was optimized using DFT/B3LYP method with cc-pVDZ as a besis set, and frontier molecular orbital (FMO) studies was used to explain the physiochemical properties of that molecule by the energy of interacting orbitals. NBO describes the intra delocalization of electrons in the molecule, which support the stability of that molecule. Noncovalent interaction (NCI) explains the nonbond interactions present in the molecule. Drug-likeness property of 405 C have been checked by absorption, distribution, metabolism and excretion (ADME) assay, result shown all the drug-likeness properties in red color region, so we have confirmed this molecule as a drug. 405 C undergoes antibiotic activity against P. aeruginosa organism, antifungal activity against B. cinerea and cytotoxicity activity against MCF-7 and HeLa cell when compared to standard drugs. 2022 Taylor & Francis Group, LLC. -
An insight into the superior performance of ZnO@PEG nanocatalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles under ultrasound
The investigation presents a straightforward synthesis of fifteen 1,4-dihydropyrano[2,3-c]pyrazoles using ZnO@PEG nanocatalyst in ethanol via Multicomponent approach under the influence of ultrasound. The present methodology successively tolerates a variety of functional groups and offers several advantages such as excellent yields without chromatographic purification, milder reaction conditions, shorter reaction times, and the use of an environmentally benign reusable catalyst. Ecstatically, the reaction was successfully scaled to gram level ascertaining the wider applicability of ZnO@PEG nanoparticles in multicomponent reactions. 2019 Elsevier Ltd. All rights reserved. -
Synthesis of 1, 8-Naphthyridine-3-Carbonitriles under solvent-free conditions using ceric ammonium nitrate
1,8-naphthyridines are synthesized using a four-component, one-pot approach. This method includes the reaction of aromatic aldehyde, malononitrile, 1,6-dimethylpyridin-2(1H)-one, substituted aniline in a solvent-free condition catalyzed by Ceric Ammonium Nitrate (CAN). Contrary to the reported literature, this distinct method houses several promising factors to the same degree as solvent-free reaction conditions, shorter reaction duration, excellent yields, and a straightforward extraction process. 2023 Elsevier Ltd. All rights reserved. -
One-pot sustainable synthesis of novel pyrido[2,3-d]pyrimidinones and their evaluation for antitubercular and anticancer activity
A novel green protocol for the construction of diversified pyrido[2,3-d]pyrimidinones was accomplished by a single-pot reaction of aryl aldehydes, Meldrum's acid, thiobarbituric acid, and ammonium acetate/aniline in H2O using ?-proline as an expeditious reusable catalyst at room temperature (26 C). Our strategy provides an innovative synthetic avenue for the construction of pyrido[2,3-d]pyrimidinones, as well as several advantages over traditional methods, including a simple procedure, shorter reaction duration, excellent yields, safe handling, easy workup, catalyst recovery, and environmental compatibility. Furthermore, the synthesised compounds were tested for their impact on different cell lines and microorganisms. Compounds 5d and 5e were particularly effective against Mycobacterium tuberculosis (antitubercular), human breast cancer cells (MCF-7), lung cancer cells (A549 and NCI-H460), and both Gram-positive (S. pyogenes) and Gram-negative (E. coli) bacteria. The derivatives with hydroxyl and nitro substitutions [5e, 5f] showed the highest potency against MCF-7, A549, and NCI-H460 cell lines, with IC50 values of 3.684.36, 3.823.41, and 11.3412.28 g/mL, respectively. 2024 The Author(s) -
(Mes-Acr-Me)+ClO4 Catalyzed Visible Light-Supported, One-Pot Green Synthesis of 1,8-Naphthyridine-3-Carbonitriles
Abstract: A novel, four-component one-pot green synthesis of biologically active 1,8-naphthyridines by a reaction of diverse aromatic aldehyde, malononitrile, 4-hydroxy substituted 1,6-dimethylpyridin-2(1H)-one, corresponding aniline in EtOH catalyzed by 9-Mesityl-10-methylacridinium perchlorate [(Mes-Acr-Me)+ClO4] under visible light generated from a 24W Blue LED wavelength 450460nm at 26C is reported. In contrast with the reported procedure, our methodology is diverse, versatile and has several favourable factors such as metal-free, excellent yields, shorter reaction durations, chromatography free and straightforward extraction process. Graphical Abstract: [Figure not available: see fulltext.]. 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
White LED Light-Mediated Eosin Y-Photocatalyzed One-Pot Synthesis of Novel 1,2,4-Triazol-3-Amines By Sequential Addition
Abstract: A facile and proficient, eco-friendly multicomponent synthesis of 12 novel biologically essential 1,2,4-triazol-3-amines via the sequential addition of substituted phenacyl bromide, aromatic aldehyde, hydrazinecarbothioamide, and urea under white LED with eosin Y as a photocatalyst has been developed. The intrinsic advantages are methodology is cost-effective, non-toxic, generates a high yield of product, is column chromatography free and does not need the use of a specific instrument. Surprisingly, our methodology uses moderate conditions and can count the tolerance of a wide variety of electron-donating and electron-withdrawing groups. The analysis and early conclusions give more value and context for the future development of organic synthesis using photocatalysts. Graphical Abstract: [Figure not available: see fulltext.] 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. -
Yttrium(III) oxide catalyzed facile synthesis of novel hydrazinyl thiazoles by multicomponent approach
A facile and a one-pot procedure for the synthesis of novel hydrazinyl thiazoles by the cyclo condensation reaction between substituted phenacyl bromides, aromatic aldehydes, and semicarbazides using Yttrium(III) oxide as reusable catalyst under acetic acid as a solvent medium is described. The chromatography-free methodology has several benefits such as being facile, atom economic, higher functional group tolerance and provides excellent yield in shorter reaction time. All the synthesized compounds were characterized by 1H NMR, 13C NMR, and HRMS (ESI) analysis. 2021 -
Nano ZnO@PEG catalyzed one-pot green synthesis of pyrano[2,3-d] pyrimidines in ethanol via one-pot multicomponent approach
A facile one-pot multicomponent protocol for the synthesis of bio-active Pyrano[2,3-d]pyrimidine derivatives by a one- step condensation reaction of substituted aldehyde, malononitrile/methyl cyanoacetate, barbituric acid has been demonstrated using nano ZnO@PEG as a catalyst at room temperature. The present approach offers several advantages, such as shorter reaction time, higher yields, and environmental friendliness. Easy isolation of products, absence of column chromatographic purification, use of commercially available low-cost starting materials and reusability of the catalyst make the methodology viable in organic synthesis. 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the Second International Symposium ''Functional Nanomaterials in Industrial Applications: Academy - Industry Meet''. -
International multi conference on computing, communication, electrial & nanotechnology /
Materials Today Proceedings, Vol.11, Issue 3, pp.889-115, ISSN No:2214-7853. -
Study On Impact of Employee Retention Strategies on Employee Turnover in IT IndustryAn Exploratory Study in Bangalore
Employee Turnover is a major challenge faced by the companies globally. Employee Turnover is predominant not only in IT sector, but in other sectors as well. This study has focused in IT sector. Employees are the assets of any organization. Organizations are striving to retain their talents by implementing effective retention strategies. High Employee Turnover would subsequently have an impact on productivity and sustainability of the organization. There are two types of Employee Turnover ?? functional and dysfunctional. When productive employees leave the organization, it is said to be dysfunctional turnover and when the poor performers leave, it is called functional turnover. The focus of this study was dysfunctional turnover. Dysfunctional turnover is the concern of HR managers. When an employee leaves, it takes approximately eight weeks for this position to be replaced and in the meantime, productivity suffers. Causes and consequences of the Employee Turnover is mentioned in detail in Chapter 2. This study is an attempt to understand the impact of Retention Strategies on Employee Turnover in IT sector in India. Bangalore, being the IT hub of India, was chosen as the location of the study. Results of the study showed that Retention Strategies has an impact on Employee Turnover. Other variables such as Welfare Benefits, Personal Satisfaction and Organization Culture, which are said to be associated with the Employee Turnover were also investigated as a part of this study. -
Role of knowledge management strategies on employees performance in selected information technology companies In Bangalore /
International Journal of Management And Social Sciences, Vol.8, Issue 2.1, pp.54-58, ISSN No: 2349-9761. -
Emotional intelligence and work life balance of women IT professional in Bangalore /
Adarsh Journal of Management Research, Vol.7, Issue 2, pp.241-253, ISSN No: 0974-7028. -
Financial access indicators of financial inclusion: A comparative analysis of SAARC countries /
International Journal Intelligent Enterprise, Vol.7, Issue 1/2/3, pp.28-36 -
Small finance banks and financial inclusion in India /
Research Review Journals, Vol.4, Issue 3, pp.1586-1588, ISSN No: 2455-3085. -
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System and method for detecting lung cancer using intelligent image pattern recognition technique /
Patent Number: 202241028120, Applicant: Dr.S.Balamurugan.
One of the most dreadful diseases that reports high mortality rates in literature is cancer. Among the different types of cancer, lung cancer is considered to be the most dangerous disease leading to death. Lung Cancer is caused due to abnormal multiplying of cells which grows as a tumour. It has been reported in literature that every year nearly 15 million people die due to lung cancer around the globe. Lung cancer is difficult to treat as the symptoms of the disease is shown up during its final stages. -
IOT and deep learning based emotion and hate speech regodnition to examine the person mind state in home/health care /
Patent Number: 202221053302, Applicant: Raghvendra Omprakash Singh.
IoT and deep learning based Emotion and hate speech recognition to examine the person mind state in home/health care ABSTRACT There are several applications for AEE, which stands for automatic emotion recognition. Various industries, including advertising, technology, and human-robot interactions, use the emotional responses of individuals as a signal. This paper analyses all pertinent scientific literature to determine the application of sensors. In these publications, numerous strategies that have already been researched or implemented are discussed. -
The effects on the financialand economic status of the country in covid pandemic @ its damages on human health /
Patent Number: 202241013748, Applicant: Dr. Ravikumar T.
The enhanced chi-square goodness of fit for the COVID-19 pandemic scenario is developed, and the proposed method is used to assess the increased testing rates in India and significant improvement in the COVID-19 medical sector. India has a population of approximately 1.39 billion people and is extremely densely inhabited in contrast to other countries. The current male population of 51.6 percent and the male population of 48.4 percent in areas with an overall low economic status have all posed significant challenges to India's first campaign against the COVID-19 hotspot. -
Machine learning based bitcoin - cryptocurrency price predicator /
Patent Number: 202141055964, Applicant: B.Rebecca Jeyavadhanam.Machine learning based Bitcoin - cryptocurrency price predictor Abstract: Due to the escalation of geopolitical and economic issues over the last two years, global currency values have fallen, the stock markets have had a rough patch, and investor wealth has dwindled. There has been a surge in the use of virtual currencies. It's no surprise that cryptocurrency, a well-known digital currency, has recently become a hot topic, with investors vying for a piece of the action and businesses eager to accept it as payment.