Occupational Exposure to Cooking Oil Fumes : Biochemical, Cytogenetic and Molecular Signatures

Title

Occupational Exposure to Cooking Oil Fumes : Biochemical, Cytogenetic and Molecular Signatures

Creator

Chaudhary, Aditi

Contributor

P, Manikantan

Description

Occupational exposure to Cooking Oil Fumes (COFs) is a widespread concern in the newlineculinary industry, and it has raised significant health apprehensions due to its potential adverse effects on individuals working in kitchens. This current research presents a comprehensive analysis of the biochemical, cytogenetic, and molecular analysis observed in individuals exposed to COFs in their workplace. The study employed a cross-sectional approach, involving a cohort of kitchen personnel working in diverse culinary settings. Biochemical assessments focused on analyzing blood parameters, such as lipid profiles, liver enzymes, and markers of oxidative stress, to gauge the impact of COFs on the participants systemic health. Cytogenetic investigations encompassed the assessment of chromosomal aberrations and micronuclei frequency in peripheral blood lymphocytes, shedding light on potential genotoxicity associated with COF exposure. Moreover, molecular analyses involved the examination of ApoE and BMAL1 gene expression patterns related to inflammation, oxidative stress response, and detoxification pathways also this aspect aimed to uncover the newlineunderlying molecular mechanisms influenced by COFs. Preliminary results suggest a significant association between COF exposure and alterations in biochemical parameters, newlineparticularly an increase in oxidative stress markers and changes in lipid profiles, indicative of potential cardiovascular risks. Cytogenetic assessments revealed an elevated frequency of chromosomal aberrations and micronuclei formation, highlighting genotoxic effects linked to COF exposure. Molecular investigations demonstrated differential expression patterns of ApoE and BMAL1 genes involved in inflammation and oxidative stress responses, further corroborating the adverse effects of COFs on cellular processes. The findings of this research underscore the importance of addressing occupational exposure to COFs and implementing appropriate safety measures in cooking area.

Source

Author's Submission

Date

2024-01-01

Publisher

Christ(Deemed to be University)

Subject

Life Sciences

Rights

Open Access

Relation

61000318

Format

PDF

Language

English

Type

PhD

Identifier

http://hdl.handle.net/10603/563525