Construction of multifunctional hyaluronic acid modified gold nanoparticles clocked with Irinotecan and indocyanine green: Investigation of chemotherapy and cancer cell imaging
- Title
- Construction of multifunctional hyaluronic acid modified gold nanoparticles clocked with Irinotecan and indocyanine green: Investigation of chemotherapy and cancer cell imaging
- Creator
- Menon S.V.; Juneja B.; Joshi U.; Faujdar M.; Chinnathambi A.; Alahmadi T.A.; Arulselvan P.; Thangavelu I.
- Description
- To overcome the inherent limits of conventional cancer therapy, there is an immediate need to establish multifunctional drugs that combine accurate diagnosis with treatment. The work describes a small nanocomposite's mild and easy fabrication, including Irinotecan, folic acid, hyaluronic acid, and indocyanine green-integrated gold nanoparticles. The gold nanoparticles with indocyanine green integrated (HA@ICG/Au) were developed in one step for photodynamic treatment and biological fluorescence imaging. Both the drug delivery of Irinotecan and the enhancement of cellular selectivity are achieved by the hyaluronic acid-altered ICG/Au (HA@ICG/Au). To regulate the release of Irinotecan during tumour chemotherapy, the dual-targeted and pH-responsive system known as HA@ICG/Au:FA@IRI was developed. The nanocomposite composed of HA@ICG/Au:FA@IRI had a tiny surface area and was highly efficient at encapsulation and loading drugs. In an acidic milieu, the nanocomposite showed excellent biocompatibility, colloidal stability, photostability, and a rapid cumulative release rate. The improved cellular uptake of HA@ICG/Au:FA@IRI for fluorescence imaging was validated by fluorescence microscopy in vitro. The nanocomposite showed impressive cancer cell death when exposed to laser irradiation using a combination of synergistic chemotherapy and photodynamic treatment (PDT). Taken as a whole, the results show that the nanocomposite was successfully developed to target tumors in two different ways, resulting in a potentially helpful theranostics agent. 2025 Elsevier B.V.
- Source
- Journal of Drug Delivery Science and Technology, Vol-105
- Date
- 2025-01-01
- Publisher
- Editions de Sante
- Subject
- Cancer; Gold nanoparticles; Hyaluronic acid; Imaging; Indocyanine green; Irinotecan
- Coverage
- Menon S.V., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Juneja B., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Joshi U., Department of Mechanical Engineering, PIET, Parul University, Gujarat, Vadodara, 391760, India; Faujdar M., Department of Sciences, Vivekananda Global University, Jaipur, 391760, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, PO Box-2925, Riyadh, 11461, Saudi Arabia; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 17732247; CODEN: JDDSA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Menon S.V.; Juneja B.; Joshi U.; Faujdar M.; Chinnathambi A.; Alahmadi T.A.; Arulselvan P.; Thangavelu I., “Construction of multifunctional hyaluronic acid modified gold nanoparticles clocked with Irinotecan and indocyanine green: Investigation of chemotherapy and cancer cell imaging,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12506.