Facile fabrication of dasatinib laden multifunctional polymeric micelles: Evaluation of anti-proliferative and apoptotic activities in human cancer cells
- Title
- Facile fabrication of dasatinib laden multifunctional polymeric micelles: Evaluation of anti-proliferative and apoptotic activities in human cancer cells
- Creator
- Menon S.V.; Thakore S.; Verma A.; Dhadda S.; Chinnathambi A.; Alharbi S.A.; Bharathi M.; Arulselvan P.; Thangavelu I.
- Description
- Dasatinib (DAS) has recently gained significant interest for its anticancer potential. Yet, the lipophilicity inherent in DAS limited its potential use as a chemotherapeutic drug. This study aimed to examine the effectiveness of polyethylene glycol-polycaprolactone (PEG-PCL) as a nanocarrier for DAS to increase its anticancer capabilities. The DAS-loaded PEG-PCL nanoparticles (termed as DAS@PEG-PCL NPs) were characterized using Fourier transform infrared (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Morphological staining and MTT tests were employed to investigate drug-loaded nanoparticles' apoptotic and anti-proliferative effects. The MTT assay demonstrated that incorporating DAS onto PEG-PCL NPs resulted in a dose-dependent increase in cytotoxicity in A549 (lung cancer) and HeLa (cervical cancer) cells. The A549 cancer cells were analyzed for their morphology using the acridine orange/ethidium bromide (AO/EB) and DAPI staining techniques. Overall, these findings demonstrate that the polymeric PEG-PCL nanoparticle systems hold great potential as a novel therapeutic strategy for cancer treatment. 2024 Wiley Periodicals LLC.
- Source
- Journal of Applied Polymer Science, Vol-142, No. 3
- Date
- 2025-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- biomedical applications; conducting polymers; drug delivery systems
- Coverage
- Menon S.V., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Bangalore, India; Thakore S., Department of Applied Science, PIT, Parul University, Vadodara, India; Verma A., Centre of Research Impact and Outcome, Chitkara University, Rajpura, India; Dhadda S., Department of Sciences, Vivekananda Global University, Jaipur, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Alharbi S.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Bharathi M., Centre for Bioinformatics, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, India; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India
- Rights
- Restricted Access
- Relation
- ISSN: 218995; CODEN: JAPNA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Menon S.V.; Thakore S.; Verma A.; Dhadda S.; Chinnathambi A.; Alharbi S.A.; Bharathi M.; Arulselvan P.; Thangavelu I., “Facile fabrication of dasatinib laden multifunctional polymeric micelles: Evaluation of anti-proliferative and apoptotic activities in human cancer cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/12515.