TiO2-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application
- Title
- TiO2-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application
- Creator
- Menon S.V.; Sandhwar V.; Chaudhary S.; Bhanot D.; Arulselvan P.; Govindasamy C.; Khan M.I.; Suriyaprakash J.; Thangavelu I.; Boopathi T.S.
- Description
- Wounds that are not properly managed can cause complications. Prompt and proper care is essential, to prevent microbial infection. Growing interest in metal oxide nanoparticles (NPs) for innovative wound treatments targeting healing and microbial infections. In this research, sodium alginate-coated titanium dioxide (TiSA) NPs are synthesized through a green co-precipitation method, combining inorganic TiO2 (Titanium dioxide) and SA (sodium alginate). Analysis via XRD and TEM revealed that the resulting TiSA NPs possessed an anatase phase and polygonal structure, respectively. Biomedical investigations demonstrated that TiSA NPs exhibited enhanced antimicrobial activity compared to the positive control, as well as its counterparts, and showed higher wound healing capabilities compared to TiO2 NPs. The antimicrobial effectiveness of TiSA NPs relied on various physicochemical factors, including small particle size, an altered band gap, and the presence of oxygen vacancies, resulting in microbial cell death. Moreover, TiSA NPs treatment demonstrated higher wound healing activity (98 1.09 %) compared to its counterparts after 24 h of incubation. Assessment of cytotoxicity on healthy fibroblast cells (L929) revealed that TiSA NPs exhibited lower toxicity compared to TiO2 NPs. These findings support the potential of TiSA NPs as promising agents for antimicrobial activity and wound healing. 2025 Elsevier B.V.
- Source
- International Journal of Biological Macromolecules, Vol-300
- Date
- 2025-01-01
- Publisher
- Elsevier B.V.
- Subject
- Sodium alginate; Titanium dioxide; Wound healing
- Coverage
- Menon S.V., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, 560069, India; Sandhwar V., Department of Chemical Engineering, PIT, Parul University, Gujarat, Vadodara, 391760, India; Chaudhary S., Department of Sciences, Vivekananda Global University, Jaipur, 303012, India; Bhanot D., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, 140417, India; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India; Govindasamy C., Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia; Khan M.I., Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India
- Rights
- Restricted Access
- Relation
- ISSN: 1418130; PubMed ID: 39824397; CODEN: IJBMD
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Menon S.V.; Sandhwar V.; Chaudhary S.; Bhanot D.; Arulselvan P.; Govindasamy C.; Khan M.I.; Suriyaprakash J.; Thangavelu I.; Boopathi T.S., “TiO2-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/12532.