Bougainvillea glabra-mediated synthesis of Zr?O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility
- Title
- Bougainvillea glabra-mediated synthesis of Zr?O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility
- Creator
- Pradeep L.; Thangavelu I.; Suriyaprakash J.; Arulselvan P.; Salmen S.H.; Chinnathambi A.; Boopathi T.S.
- Description
- The effectiveness and safety of nanomaterials (NMs) are essential for their use in healthcare. This study focuses on creating NPs with multifunctional antibacterial and anticancer properties to combat bacterial infections and cancer disease more effectively than traditional antibiotics. This study investigates the synthesis of Zr3O and chitosan (ch) coated zirconium oxide nanoparticles (chZrO NPs) using Bougainvillea glabra (B. glabra) plant extract through a green, one-pot precipitation method. The synthesized NPs were analyzed using various techniques. Their antibacterial properties are attributed to the production of reactive oxygen species (ROS), influenced by their size, large surface area, oxygen vacancies, ion release, and diffusion capabilities. The chZrO NPs showed superior antibacterial activity compared to Zr3O and chitosan alone, with effective inhibition against both Gram-positive bacteria (S. aureus and B. subtilis) and Gram-negative bacteria (E. coli and P. aeruginosa). Additionally, anticancer studies of chZrO NPs demonstrated significant activity against colon cancer HCT116 cells with C50 values of 4.98 ?g/mL compared to chitosan and Zr3O with 9.62, 6.69 ?g/mL, while biocompatibility tests on L929 cells confirmed their safety showing 93 % cell viability compared to ch and Zr3O. These findings suggest that chZrO NPs are promising candidates for future use in clinical and healthcare applications. 2025 Elsevier B.V.
- Source
- International Journal of Biological Macromolecules, Vol-300
- Date
- 2025-01-01
- Publisher
- Elsevier B.V.
- Subject
- Chitosan coated zirconium oxide; colon cancer HCT116 cells; Zr3O
- Coverage
- Pradeep L., Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Tamil Nadu, Chennai, 602 105, India; Salmen S.H., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia; Boopathi T.S., Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India, Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India
- Rights
- Restricted Access
- Relation
- ISSN: 1418130; PubMed ID: 39809398; CODEN: IJBMD
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Pradeep L.; Thangavelu I.; Suriyaprakash J.; Arulselvan P.; Salmen S.H.; Chinnathambi A.; Boopathi T.S., “Bougainvillea glabra-mediated synthesis of Zr?O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/12550.