Mn2(CO)10 catalyzed visible-light-promoted synthesis of 1H-pyrazole-4-carboxamides; A sustainable multi-component statergy with antibacterial and cytotoxic evaluations
- Title
- Mn2(CO)10 catalyzed visible-light-promoted synthesis of 1H-pyrazole-4-carboxamides; A sustainable multi-component statergy with antibacterial and cytotoxic evaluations
- Creator
- Govindaraju S.; Ramaraj S.G.; Servesh A.; Rajprasad J.; Kumar N.; Sadaiyandi V.; Tabassum S.
- Description
- Multicomponent reactions play a pivotal role in synthesizing 1H-pyrazole-4-carboxamides, underscoring its significance in sustainable organic synthesis. These compounds, valued for their diverse biological activities, have garnered substantial attention in pharmaceutical research. A facile, rapid one-pot strategy to access an extensive array of 1H-pyrazole-4-carboxamide derivatives, utilizing substituted aldehydes, cyanoacetamide, and hydrazine hydrate as substrates and a readily accessible Mn2(CO)10 as photocatalyst in EL: H2O (1:1). Among the synthesized series, products 4b, 4 g, 4k showed remarkable antibacterial activity against E coli, P aeruginosa, S. aureus in agar medium and excellent cytotoxicity with Human colorectal carcinoma (HCT-116), Liver cancer cells (Hep-G2) and breast adenocarcinoma (MCF-7) cell lines. The current method is characterized by its affordability, non-toxicity, easy access to starting materials, and notably with minimal waste generation. Additionally, remarkable aspects include its mild operating conditions, environmentally friendly nature, and the ability to accommodate a wide range of both electron-donating and electron-withdrawing groups. 2024 The Author(s)
- Source
- Journal of Organometallic Chemistry, Vol-1022
- Date
- 2024-01-01
- Publisher
- Elsevier B.V.
- Subject
- 1H-pyrazole-4-carboxamides; Antimicrobial activity; Cytotoxicity; E. coli; P. aeruginosa
- Coverage
- Govindaraju S., Department of Sciences and Humanities, Christ University, School of Engineering and Technology, Kumbalagodu, Mysore Road, Bengaluru, 560074, India; Ramaraj S.G., Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Japan, Department of Materials Physics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMTS), Thandalam, Tamilnadu, Chennai, 602105, India; Servesh A., Department of Chemistry, Christ University, Hosur Road, Bengaluru, 560029, India; Rajprasad J., Department of Civil Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Tamilnadu, Kattankulathur, 603203, India; Kumar N., Department of Electronics & Communication Engineering, Graphic Era Deemed to be University, Uttarakhand, Dehradun, 248002, India; Sadaiyandi V., Department of physics and nanotechnology, SRM Institute of Science and Technology kattankulathur, Tamilnadu, Chengalpattu, India; Tabassum S., Department of Chemistry, Surana College - Autonomous, South End Road, Basavanagudi, Bengaluru, 560004, India
- Rights
- All Open Access; Hybrid Gold Open Access
- Relation
- ISSN: 0022328X; CODEN: JORCA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Govindaraju S.; Ramaraj S.G.; Servesh A.; Rajprasad J.; Kumar N.; Sadaiyandi V.; Tabassum S., “Mn2(CO)10 catalyzed visible-light-promoted synthesis of 1H-pyrazole-4-carboxamides; A sustainable multi-component statergy with antibacterial and cytotoxic evaluations,” CHRIST (Deemed To Be University) Institutional Repository, accessed April 21, 2025, https://archives.christuniversity.in/items/show/12678.