Dual drug co-encapsulation of bevacizumab and pemetrexed clocked polymeric nanoparticles improves antiproliferative activity and apoptosis induction in liver cancer cells
- Title
- Dual drug co-encapsulation of bevacizumab and pemetrexed clocked polymeric nanoparticles improves antiproliferative activity and apoptosis induction in liver cancer cells
- Creator
- Ganesan S.; Upadhye V.J.; Aulakh D.; Bishnoi S.; Chinnathambi A.; Alahmadi T.A.; Abudoleh S.M.; Arulselvan P.; Thangavelu I.
- Description
- Nanoparticle (NP) enabled approaches have been employed for chemotherapeutic administration due to their capacity to regulate drug release and reduce side effects. Additionally, these methods can use several drugs concurrently and impede the proliferation of cancer cells that have developed resistance. Bevacizumab (BVZ) and pemetrexed (PEM) have demonstrated encouraging outcomes in the treatment and management of cancer. This work investigates the combined antiproliferative efficacy of BVZ and PEM co-loaded PLGA-PEG NPs (BVZ/PEM@PLGA-PEG NPs) against HepG2 liver cancerous cells. The BVZ/PEM@PLGA-PEG exhibited a sphere-shaped and consistent nanosized distribution. In addition, we evaluated the potential mechanisms for inhibiting cell growth and inducing apoptosis using DAPI staining and cell cycle study. The beneficial combined antiproliferative activity and the apoptosis pathway were detected in the HepG2 cells exposed to BVZ/PEM@PLGA-PEG NPs. Our study determined that the combinational drug treatment of BVZ/PEM@PLGA-PEG NPs has a significant effect on promoting the effectiveness of liver cancer treatment. 2024 Wiley Periodicals LLC.
- Source
- Journal of Applied Polymer Science, Vol-141, No. 47
- Date
- 2024-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- biomedical applications; drug delivery systems; nanoparticles, nanowires and nanocrystals
- Coverage
- Ganesan S., Department of Chemistry and Biochemistry, JAIN (Deemed-to-be University), Karnataka, Bangalore, India; Upadhye V.J., Parul Institute of Applied Sciences, Parul University, Gujarat, Vadodara, India; Aulakh D., Centre of Research Impact and Outcome, Chitkara University, Punjab, Rajpura, India; Bishnoi S., Department of Sciences, Vivekananda Global University, Jaipur, India; Chinnathambi A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Alahmadi T.A., Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Medical City, Riyadh, Saudi Arabia; Abudoleh S.M., Faculty of Pharmacy, Middle East University, Amman, Jordan; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, India
- Rights
- Restricted Access
- Relation
- ISSN: 218995; CODEN: JAPNA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Ganesan S.; Upadhye V.J.; Aulakh D.; Bishnoi S.; Chinnathambi A.; Alahmadi T.A.; Abudoleh S.M.; Arulselvan P.; Thangavelu I., “Dual drug co-encapsulation of bevacizumab and pemetrexed clocked polymeric nanoparticles improves antiproliferative activity and apoptosis induction in liver cancer cells,” CHRIST (Deemed To Be University) Institutional Repository, accessed April 22, 2025, https://archives.christuniversity.in/items/show/12681.