Phytofabricated bimetallic synthesis of silver-copper nanoparticles using Aerva lanata extract to evaluate their potential cytotoxic and antimicrobial activities
- Title
- Phytofabricated bimetallic synthesis of silver-copper nanoparticles using Aerva lanata extract to evaluate their potential cytotoxic and antimicrobial activities
- Creator
- Thirumoorthy G.; Balasubramanian B.; George J.A.; Nizam A.; Nagella P.; Srinatha N.; Pappuswamy M.; Alanazi A.M.; Meyyazhagan A.; Rengasamy K.R.R.; Veerappa Lakshmaiah V.
- Description
- In this study, we demonstrate the green synthesis of bimetallic silver-copper nanoparticles (AgCu NPs) using Aerva lanata plant extract. These NPs possess diverse biological properties, including in vitro antioxidant, antibiofilm, and cytotoxic activities. The synthesis involves the reduction of silver nitrate and copper oxide salts mediated by the plant extract, resulting in the formation of crystalline AgCu NPs with a face-centered cubic structure. Characterization techniques confirm the presence of functional groups from the plant extract, acting as stabilizing and reducing agents. The synthesized NPs exhibit uniform-sized spherical morphology ranging from 7 to 12nm. They demonstrate significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, inhibiting extracellular polysaccharide secretion in a dose-dependent manner. The AgCu NPs also exhibit potent cytotoxic activity against cancerous HeLa cell lines, with an inhibitory concentration (IC50) of 17.63gmL?1. Additionally, they demonstrate strong antioxidant potential, including reducing capability and H2O2 radical scavenging activity, particularly at high concentrations (240gmL?1). Overall, these results emphasize the potential of A. lanata plant metabolite-driven NPs as effective agents against infectious diseases and cancer. 2024, The Author(s).
- Source
- Scientific Reports, Vol-14, No. 1
- Date
- 2024-01-01
- Publisher
- Nature Research
- Coverage
- Thirumoorthy G., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Sciences, Sejong University, Seoul, South Korea; George J.A., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Nizam A., Department of Chemistry, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Nagella P., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Srinatha N., Department of Physics, RV Institute of Technology and Management, Bengaluru, 560 076, India; Pappuswamy M., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Alanazi A.M., Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; Meyyazhagan A., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India; Rengasamy K.R.R., Laboratory of Natural Products and Medicinal Chemistry (LNPMC), Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai, 602105, India, Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa; Veerappa Lakshmaiah V., Department of Life Sciences, CHRIST (Deemed to be University), Hosur Rd, Karnataka, Bengaluru, 560029, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 20452322; PubMed ID: 38218918
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Thirumoorthy G.; Balasubramanian B.; George J.A.; Nizam A.; Nagella P.; Srinatha N.; Pappuswamy M.; Alanazi A.M.; Meyyazhagan A.; Rengasamy K.R.R.; Veerappa Lakshmaiah V., “Phytofabricated bimetallic synthesis of silver-copper nanoparticles using Aerva lanata extract to evaluate their potential cytotoxic and antimicrobial activities,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/12776.