Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process
- Title
- Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process
- Creator
- Ganapathy K.; Pandey S.P.; Bishnoi S.; Suriyaprakash J.; Alarfaj A.A.; Hirad A.H.; Thangavelu I.
- Description
- In recent years, the development of dual dopant-based nanoparticles (NPs) has gained significant attention as they possess exceptional physico-chemical and biomedical properties, making them potential candidates for antimicrobial and anticancer uses. In this research, we successfully synthesized nickel oxide (NiO) and copper, manganese-doped NiO (CuMn:NiO) NPs using a green synthesis method. The synthesis process involved Trigonella foenum-graecum (T.f.graecum) leaves extract as a nucleating agent. The synthesized nanoparticles were confirmed by various physico-chemical studies. Based on X-ray diffraction analysis, the median size was determined as 36 nm for NiO and 32 nm for CuMn:NiO NPs. The antibacterial study revealed that CuMn:NiO NPs exhibited a higher zone of inhibition in contrast to both Gram-positive (Streptococcus pneumoniae, Bacillus subtilis, Bacillus megaterium) and Gram-negative bacteria (Klebsiella pneumoniae, Escherichia coli, Vibrio cholerae) compared with NiO NPs and commercial amoxicillin. The antifungal studies conducted against Candida albicans demonstrated that CuMn:NiO NPs exhibited enhanced efficacy in comparison to NiO NPs. In vitro testing against human breast cancer cells (MCF-7) demonstrated the anticancer potential of NiO and CuMn:NiO NPs, supported by IC50 concentrations of 11 and 9?g/mL, respectively. The photoluminescence (PL) spectra of NiO and CuMn:NiO NPs exhibited a green emission at 508 and 518 nm, respectively, which indicated the generation of active free radicals by the NPs. These findings suggest that CuMn:NiO NPs hold promise in the healthcare industry. 2024 John Wiley & Sons Ltd.
- Source
- Applied Organometallic Chemistry, Vol-38, No. 4
- Date
- 2024-01-01
- Publisher
- John Wiley and Sons Ltd
- Subject
- antimicrobial and anticancer properties; copper and manganese; NiO; Trigonella foenum-graecum
- Coverage
- Ganapathy K., Department of Biotechnology, School of Sciences, Jain (Deemed-to-be University), Bangalore, India; Pandey S.P., Department of Physics, Teerthanker Mahaveer University, Uttar Pradesh, Moradabad, India; Bishnoi S., Department of Chemistry, Vivekananda Global University, Rajasthan, Jaipur, India; Suriyaprakash J., Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China; Alarfaj A.A., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Hirad A.H., Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Bangalore, India
- Rights
- Restricted Access
- Relation
- ISSN: 2682605; CODEN: AOCHE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Ganapathy K.; Pandey S.P.; Bishnoi S.; Suriyaprakash J.; Alarfaj A.A.; Hirad A.H.; Thangavelu I., “Biocidal activities of nickel oxide nanoparticles modified by copper and manganese, synthesized by green process,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/13187.