Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications
- Title
- Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications
- Creator
- Bamagous G.A.; Ibrahim I.A.A.; Alzahrani A.R.; Shahid I.; Shahzad N.; Falemban A.H.; Alanazi I.M.M.; Hussein-Al-Ali S.H.; Arulselvan P.; Thangavelu I.
- Description
- Nanocomposite made up of inorganic and biocompatible polymer have gained significant attention for biomedical applications due to their enhanced multifunctional properties, offering solutions to serious issues like antimicrobial resistance and cancer treatment. Nanocomposite composed of SnO?, chitosan and D-carvone (SnO2-Cs-Dcar) was prepared to ascertain its efficacy in application for antimicrobial, anticancer activities, and antioxidant effects. The synthesized nanocomposite was characterized by XRD, UV-Vis, FTIR, PL, SEM, TEM, and XPS techniques, confirming successful integration. XRD results confirmed the tetragonal rutile phase of SnO2. The band gap energy was calculated as 4.32eV for SnO2 nanoparticles and 3.11eV for SnO2-Cs-Dcar nanocomposite as observed from UV-Visible spectra. PL emission results showed that SnO2-Cs-Dcar nanocomposite exhibited green emission at 507nm corresponds to number oxygen vacancy site. SEM and TEM results showed that the SnO2-Cs-Dcar nanocomposite entities appear more compact, and the single SnO2 particles are less differentiated, possibly because they have been covered by chitosan and D-carvone. Antimicrobial activity against the pathogens Klebsiella pneumoniae, Candida albicans, Shigella dysenteriae, Bacillus subtilis, and Staphylococcus aureus demonstrated that SnO2-Cs-Dcar exhibited enhanced bacteriostatic effect when compared to bare SnO2. MTT assay on MOLT-4 cancer cells revealed that SnO2-Cs-Dcar nanocomposite exhibited enhanced anticancer activity upon compared to SnO? nanoparticles. The IC50 values were calculated as 13.6 for SnO2 and 12.1 for SnO2-Cs-Dcar nanocomposite. SnO?-Cs-Dcar nanocomposites exhibits high antioxidant activity evidenced by improved free radical scavenging action in comparison with a bare SnO?. Experimental result indicates that the SnO?-Cs-Dcar nanocomposites can be used as biocidal agent for antimicrobial and anticancer therapies. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
- Source
- Journal of Inorganic and Organometallic Polymers and Materials
- Date
- 2024-01-01
- Publisher
- Springer
- Subject
- Anticancer Activity; Antimicrobial Activity; Antioxidant Activity; MOLT-4 Cells; SnO2; SnO2-Cs-Dcar Nanocomposites
- Coverage
- Bamagous G.A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Ibrahim I.A.A., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Alzahrani A.R., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Shahid I., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Shahzad N., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Falemban A.H., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Alanazi I.M.M., Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, P.O.Box 13578, Al-Abidiyah, Makkah, 21955, Saudi Arabia; Hussein-Al-Ali S.H., Department of Chemistry, Faculty of Sciences, Isra University, Amman, 11622, Jordan; Arulselvan P., Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, India; Thangavelu I., Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bangalore, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 15741443
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Bamagous G.A.; Ibrahim I.A.A.; Alzahrani A.R.; Shahid I.; Shahzad N.; Falemban A.H.; Alanazi I.M.M.; Hussein-Al-Ali S.H.; Arulselvan P.; Thangavelu I., “Multifunctional SnO?-Chitosan-D-carvone Nanocomposite: A Promising Antimicrobial, Anticancer, and Antioxidant Agent for Biomedical Applications,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/13461.