Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives
- Title
- Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives
- Creator
- Al-Hazmi G.H.; Marrakkur V.; Naik L.; Refat M.S.
- Description
- The in vitro antifungal, antibacterial, and antioxidant activities of a substituted pyrazole derivative (FHM) have been evaluated in the current work. The addition of 4-methylpiperidin-4-ol, which increases the molecules lipid solubility and speeds up absorption by increasing its rate of absorption, gives the molecule strong in vitro antifungal and antibacterial properties. Additionally, it is clear from the findings of structure-activity relationship (SAR) investigations. Additionally, the ab-intio technique was used to theoretically evaluate the photophysical characteristics of produced substances. Using the DFT-B3LYP-6-31G(d) basis set, the ground state optimization and HOMO-LUMO energy levels are computed. Global chemical reactivity and descriptive characteristics are evaluated using theoretically estimated HOMO-LUMO values, and the results demonstrate that the synthesized molecule possesses a high electrophilicity and electronegative index. Overall findings indicate that substituting a 4-methylpiperidin-4-ol substituted pyrazole derivative shows good photophysical and in vitro biological applications. 2024, HARD Publishing Company. All rights reserved.
- Source
- Polish Journal of Environmental Studies, Vol-33, No. 5, pp. 5557-5565.
- Date
- 2024-01-01
- Publisher
- HARD Publishing Company
- Subject
- GCRD parameters; HOMO-LUMO; in-vitro and in-silico biological activity; Pyrazoles
- Coverage
- Al-Hazmi G.H., Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia; Marrakkur V., Department of Chemistry, NMKRV College for Women, Bengaluru, 560006, India; Naik L., Department of Physics and Electronics, CHRIST (Deemed to be University), Bengaluru, 560029, India; Refat M.S., Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
- Rights
- All Open Access; Gold Open Access
- Relation
- ISSN: 12301485
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Al-Hazmi G.H.; Marrakkur V.; Naik L.; Refat M.S., “Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/13573.