Assessing oral acute toxicity and histopathological effects of Strelitzia reginae Aiton leaf extracts in Zebrafish (Danio rerio Hamilton)
- Title
- Assessing oral acute toxicity and histopathological effects of Strelitzia reginae Aiton leaf extracts in Zebrafish (Danio rerio Hamilton)
- Creator
- Omnes D.S.; Xavier J.; Suresh A.
- Description
- Strelitzia reginae, commonly known as the Bird of Paradise, is a decorative shrub endemic to southern Africa. This study marks the first comprehensive investigation into the safety of S. reginae leaf extract through oral acute toxicity assessments and histopathological examinations in Zebrafish (Danio rerio). The interest in this research arises from the historical use of S. reginae components by various indigenous South African societies to treat conditions like swollen glands and sexual problems. GC-MS analysis was used along with traditional methods to look at the phytochemical parts of S. reginae. The results showed the presence of several substances, such as eicosane, hexacosane, 1-octadecene, and neophytadiene. Notably, the analysis also identified certain chemicals with potential cytotoxic properties, such as octacosane and bis (2-ethylhexyl) phthalate. Drawing upon the biological similarities between Zebrafish and humans, who share a majority of their genes, this study represents the first attempt to evaluate the toxicity and histopathology of S. reginae using D. rerio as the test model, aligning with the OECD recommendations outlined in Article 203. The oral acute toxicity tests were done using ethanolic leaf powdered extracts of S. reginae. Higher concentrations (1200 mg/L) were toxic, but lower doses were less harmful to D. rerio. As observed in the histopathology examination, exposure to higher concentrations of S. reginae extract induced severe histological abnormalities in the Zebrafish's gills, liver, kidneys, intestines, and brain. This work contributes greatly to our understanding of S. reginae's safety profile and its potential therapeutic applications for enhancing well-being. 2024 Horizon e-Publishing Group. All rights reserved.
- Source
- Plant Science Today, Vol-11, No. 2, pp. 262-270.
- Date
- 2024-01-01
- Publisher
- Horizon e-Publishing Group
- Subject
- Danio rerio; GC-MS; Histopathology; Mineral content; Strelitzia reginae; Toxicity
- Coverage
- Omnes D.S., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India; Xavier J., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India; Suresh A., Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, University, Karnataka, 560029, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 23481900
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Omnes D.S.; Xavier J.; Suresh A., “Assessing oral acute toxicity and histopathological effects of Strelitzia reginae Aiton leaf extracts in Zebrafish (Danio rerio Hamilton),” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/13657.