In-Vitro Investigation of the ?-Amylase Inhibition Activity of Bare Bis-Benzylidene-Cyclohexanone Synthesized by a Highly Selective Solvent-Free Route
- Title
- In-Vitro Investigation of the ?-Amylase Inhibition Activity of Bare Bis-Benzylidene-Cyclohexanone Synthesized by a Highly Selective Solvent-Free Route
- Creator
- Veigas L.M.; Ravi L.; Narasimhaiaha N.; Chundattu S.J.; Nagaraju K.; Krishna Mohan M.
- Description
- Current work reports the highly selective, solvent-free synthesis of an endorsed bioactive compound, Bis benzylidine cyclohexanone (BBC) through solid acid catalysed cross aldol condensation route and checks its in-vitro bio activity. The catalytic support (Multiwalled carbon nanotube) employed was synthesized through the highly sophisticated catalytic chemical vapor deposition (CVD) method and simple mechanical grinding strategy was adopted to decorate sulfonic acid on the support. The C1s X-ray photoelectron peak of at 290.3 eV confirms the effective interaction of sulfonic acid with MWCNT. The sharp and intense desorption peaks observed at approximately 528.7 C and 655.15 C in the TPD analysis unmistakably substantiate the strong acidity of the synthesized system. The alpha amylase inhibition activity of the synthesized compound was calculated to be around 88.5 %, which is in par with the commercial drug as it could inhibit only 96 %. Further, the in-silico (Docking and Molecular Dynamic Simulation) investigations unveiled a new target site for the compound and this can further be studied in detail to advance the applications in drug design. Detailed scrutiny of various parameters was conducted to validate the bioactivity and pharmaceutical potential of the synthesized compound. 2023 Wiley-VCH GmbH.
- Source
- ChemistrySelect, Vol-8, No. 47
- Date
- 2023-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- Enzyme Inhibition; Molecular Dynamic Simulation; MWCNT; Sulfonic acid; TPD
- Coverage
- Veigas L.M., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India; Ravi L., Department of Food Technology, Faculty of Life and Allied Health Sciences, MS Ramaiah University of Applied Sciences, Karnataka, Bengaluru, 560054, India; Narasimhaiaha N., St. Joseph's University, Lalbagh Road, Karnataka, Bengaluru, 560027, India; Chundattu S.J., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India; Nagaraju K., CIIRC, Jothy Institute of Technology, Tataguni, Off Kanakapura Road, Karnataka, Bengaluru, 560082, India; Krishna Mohan M., Department of Sciences and Humanities, Christ (Deemed to be University), School of Engineering and Technology, Mysore Road, Karnataka, Bengaluru, 560074, India
- Rights
- Restricted Access
- Relation
- ISSN: 23656549
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Veigas L.M.; Ravi L.; Narasimhaiaha N.; Chundattu S.J.; Nagaraju K.; Krishna Mohan M., “In-Vitro Investigation of the ?-Amylase Inhibition Activity of Bare Bis-Benzylidene-Cyclohexanone Synthesized by a Highly Selective Solvent-Free Route,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/13877.