Parental Psychological Distress of Missed Diagnosis of Down Syndrome at Antenatal Screening: A Rare, but Still Real Occurrence-A Case Report and Review of Literature
- Title
- Parental Psychological Distress of Missed Diagnosis of Down Syndrome at Antenatal Screening: A Rare, but Still Real Occurrence-A Case Report and Review of Literature
- Creator
- Giuseppe Macri P.; Tosto V.; Tsibizova V.; Meyyazhagan A.; Di Renzo G.C.
- Description
- Introduction: Prenatal screening programs are important components for pregnant women care and are often linked with grief and shock based on gestational age or the diagnosis. Lower/no sensitivity is also associated with these screening programs leading to providing false-negative outputs. Case Presentation: Present work shows a case of missed antenatal diagnosis of Down syndrome and its persistant medical and psychological impact on the family members. We have also discussed the relevant economic and medical-legal issues related to the context and aimed to maintain an adequate awareness among healthcare to discuss properly these investigations (difference between screening and diagnostic testing), their possible outcome (chances of false results) and enabled the pregnant women/couple to take informed decision on early pregnancy. Conclusion: These programs are considered as routine clinical practice in many countries from last few years and are necessary to assess the pros and cons of these programs. One of the prime cons involves the likeliness of obtaining a false-negative result due to lack of 100% sensitivity and specificity. 2023 S. Karger AG, Basel.
- Source
- Fetal Diagnosis and Therapy, Vol-50, No. 3, pp. 175-178.
- Date
- 2023-01-01
- Publisher
- S. Karger AG
- Subject
- False-negative results; Noninvasive prenatal test; Prenatal screening; Psychological effects; Trisomy 21
- Coverage
- Giuseppe Macri P., Department of Forensic Medicine of South Tuscany, Ospedali Riuniti di Arezzo, Arezzo, Italy; Tosto V., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy; Tsibizova V., International School PREIS, Firenze, Italy; Meyyazhagan A., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, International School PREIS, Firenze, Italy, Department of Life Science, Christ University, Bengaluru, India; Di Renzo G.C., Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy, International School PREIS, Firenze, Italy, IE Sechenov State University Medical School, Moscow, Russian Federation
- Rights
- Restricted Access
- Relation
- ISSN: 10153837; PubMed ID: 36966537; CODEN: FDTHE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Giuseppe Macri P.; Tosto V.; Tsibizova V.; Meyyazhagan A.; Di Renzo G.C., “Parental Psychological Distress of Missed Diagnosis of Down Syndrome at Antenatal Screening: A Rare, but Still Real Occurrence-A Case Report and Review of Literature,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/14108.