CoFe2O4-APTES nanocomposite for the selective determination of tacrolimus in dosage forms: Perspectives from computational studies
- Title
- CoFe2O4-APTES nanocomposite for the selective determination of tacrolimus in dosage forms: Perspectives from computational studies
- Creator
- Agnihotri A.S.; Ann Maria C.G.; Varghese A.; Mane P.; Chakraborty B.; M N.
- Description
- An innovative and cost effective electrochemical sensor was fabricated to determine tacrolimus (TAC) in pharmaceutical samples. In the present study, cobalt ferrite nanoparticles (CFO) were synthesized hydrothermally using chitosan as the template and were further functionalized using (3-Aminopropyl) triethoxysilane (APTES). The synthesized CFO were characterized using various analytical techniques such as X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry and high- resolution transmission electron microscopy. The CFO and CFO-APTES were further drop-casted on to the glassy carbon electrode (CFO-NH2/GCE) for the electrochemical determination of TAC. Under the optimum conditions, the CFO-NH2/GCE showed a very low detection limit of 0.03 nM with a high sensitivity of 21,448 ?A?M?1cm?2 and a wide linear TAC concentration range of 0.14 nM 75.83 nM. The proposed sensor showed good sensitivity, selectivity, reproducibility and stability for the sensing of TAC and this has been demonstrated by analysing TAC in different dosage forms. This is the first study to report the interaction of CFO-TAC and CFO-NH2-TAC at the electrode/electrolyte interface. To support the experimental findings qualitatively, extensive density functional theory simulations were carried out to study the interaction at the interface. Hence the proposed sensor is very selective and sensitive towards the detection of TAC. 2022 Elsevier B.V.
- Source
- Surfaces and Interfaces, Vol-35
- Date
- 2022-01-01
- Publisher
- Elsevier B.V.
- Subject
- APTES; Cobalt ferrite nanoparticles; Dosage forms; Electrochemical determination; Tacrolimus
- Coverage
- Agnihotri A.S., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Ann Maria C.G., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Varghese A., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India; Mane P., Seismology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India; Chakraborty B., High pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India, Homi Bhabha National Institute, Mumbai, India; M N., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, India
- Rights
- Restricted Access
- Relation
- ISSN: 24680230
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Agnihotri A.S.; Ann Maria C.G.; Varghese A.; Mane P.; Chakraborty B.; M N., “CoFe2O4-APTES nanocomposite for the selective determination of tacrolimus in dosage forms: Perspectives from computational studies,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/14842.