ItemArticle

Effects of Euphorbia thymifolia and Euphorbia hirta leaf extracts on membrane-bound, mitochondrial enzymes and lipid profile of carbon tetrachloride-induced hepatotoxicity in rats

Title
Effects of Euphorbia thymifolia and Euphorbia hirta leaf extracts on membrane-bound, mitochondrial enzymes and lipid profile of carbon tetrachloride-induced hepatotoxicity in rats
Creator
Muthu Mani G.D.; Balamuralikrishnan B.; Manikandan R.; Sampathkumar P.; Arun M.; Lakshminarayanan R.R.; Liu W.-C.; Anand A.V.
Description
The present investigation was aimed to identify the potentiality of Euphorbia thymifolia Linn. and Euphorbia hirta Linn. leaf extract on the toxin-induced (carbon tetrachloride- CCl4) Albino Wistar rats. The animals were grouped into 7 categories including control (basal diet, G1), CCl4-induced (1.5 mL/kg, b.w., i.p.) (G2), G1 administrated with 300 mg/kg b.w., extract of E. thymifolia (G3) and E. hirta (G4), G2 administrated with 300 mg/kg b.w., extract of E. thymifolia (G5), E. hirta (G6), and standard drug (silymarin 25 mg/kg b.w.; G7) for 21- days trial period with each group contains 6 rats. The samples were collected and the following parameters including mitochondrial enzymes, different ATPase and lipid profiles were analyzed. The membrane-bound enzymes, the mitochondrial enzymes levels and the lipid profiles were reduced in the toxin-induced rats but the levels of enzymes were restored, significantly increased and lipid profiles are returned to the normal in the treatment of both extracts. 2022 Visagaa Publishing House.
Source
Natural Resources for Human Health, Vol-2, No. 4, pp. 443-449.
Date
2022-01-01
Publisher
Visagaa Publishing House
Subject
Hepatoprotective activity; lipid profifiles; membrane-bound; mitochondrial enzymes
Coverage
Muthu Mani G.D., Department of Biochemistry, SRM Arts and Science College, Tamil Nadu, Chennai, India; Balamuralikrishnan B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, South Korea; Manikandan R., Department of Biochemistry, Shrimati Indira Gandhi College, Tamil Nadu, Trichy, India; Sampathkumar P., Department of Chemistry and Biosciences, SASTRA University, Tamil Nadu, Kumbakonam, India; Arun M., Department of Life Science, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560076, India; Lakshminarayanan R.R., Department of Animal Sciences, Bharathiadasan University, Tamil Nadu, Tiruchirappalli, India; Liu W.-C., Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China; Anand A.V., Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India
Rights
All Open Access; Hybrid Gold Open Access
Relation
ISSN: 25831194
Format
Online
Language
English
Type
Article

Collection

Articles

Citation

Muthu Mani G.D.; Balamuralikrishnan B.; Manikandan R.; Sampathkumar P.; Arun M.; Lakshminarayanan R.R.; Liu W.-C.; Anand A.V., “Effects of Euphorbia thymifolia and Euphorbia hirta leaf extracts on membrane-bound, mitochondrial enzymes and lipid profile of carbon tetrachloride-induced hepatotoxicity in rats,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/14913.

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