ItemArticle

A facile and economic electrochemical sensor for methylmalonic acid: A potential biomarker for vitamin B12 deficiency

Title
A facile and economic electrochemical sensor for methylmalonic acid: A potential biomarker for vitamin B12 deficiency
Creator
Rajeev R.; Benny L.; Roy M.; Mathew A.T.; Akshaya K.B.; Varghese A.; Hegde G.
Description
A facile and cost-effective method based on a modified pencil graphite electrode (PGE) has been developed for the sensing of methylmalonic acid (MMA). The electrode (Ag-PEDOT/PGE) was designed by the electrodeposition of Ag nanoparticles (NPs) on carbon fibre paper (CFP) coated with poly(3,4-ethylenedioxythiophene) (PEDOT). Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), and other electroanalytical techniques were used to characterize the modified electrodes. The fabricated sensor showcased a wide linear dynamic range (0.50 pM-55 nM) and a low detection limit (0.16 pM). A sharp increase in anodic peak current shows the excellent rate of electron transfer arising from Ag-PEDOT and PGE. The developed electrode was effectively utilized towards electrochemical MMA determination in urine and human blood serum samples. The results obtained certainly indicate that the sensor has high selectivity, ensures rapid detection, is reproducible, and has high stability towards the quantification of MMA in real samples. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Source
New Journal of Chemistry, Vol-46, No. 9, pp. 4114-4125.
Date
2022-01-01
Publisher
Royal Society of Chemistry
Coverage
Rajeev R., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Benny L., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Roy M., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Mathew A.T., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Akshaya K.B., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Varghese A., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India; Hegde G., Department of Chemistry, CHRIST, Deemed to Be University, Bangalore, 560029, India, Centre for Advanced Research and Development (CARD), CHRIST, Deemed to Be University, Bangalore, 560029, India
Rights
Restricted Access
Relation
ISSN: 11440546; CODEN: NJCHE
Format
Online
Language
English
Type
Article

Collection

Articles

Citation

Rajeev R.; Benny L.; Roy M.; Mathew A.T.; Akshaya K.B.; Varghese A.; Hegde G., “A facile and economic electrochemical sensor for methylmalonic acid: A potential biomarker for vitamin B12 deficiency,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/15134.

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