Toxicological Profiling of Onion-Peel-Derived Mesoporous Carbon Nanospheres Using In Vivo Drosophila melanogaster Model
- Title
- Toxicological Profiling of Onion-Peel-Derived Mesoporous Carbon Nanospheres Using In Vivo Drosophila melanogaster Model
- Creator
- Bhat V.S.; Kudva A.K.; Naik H.V.; Reshmi G.; Raghu S.V.; De Padova P.; Hegde G.
- Description
- Toxicological profiling of the novel carbon materials has become imperative, owing to their wide applicability and potential health risks on exposure. In the current study, the toxicity of mesoporous carbon nanospheres synthesized from waste onion peel was investigated using the genetic animal model Drosophila melanogaster. The survival assays at different doses of carbon nanoparticles suggested their non-toxic effect for exposure for 25 days. Developmental and behavioral defects were not observed. The biochemical and metabolic parameters, such as total antioxidant capacity (TAC), protein level, triglyceride level, and glucose, were not significantly altered. The neurological toxicity as analyzed using acetylcholinesterase activity was also not altered significantly. Survival, behavior, and biochemical assays suggested that oral feeding of mesoporous carbon nanoparticles for 25 days did not elicit any significant toxicity effect in Drosophila melanogaster. Thus, mesoporous carbon nanoparticles synthesized from waste onion peel can be used as beneficial drug carriers in different disease models. 2022 by the authors. Licensee MDPI, Basel, Switzerland.
- Source
- Applied Sciences (Switzerland), Vol-12, No. 3
- Date
- 2022-01-01
- Publisher
- MDPI
- Subject
- Acetylcholine; Carbon nanospheres; Drosophila; Nanotoxicity; Total antioxidant capacity (TAC)
- Coverage
- Bhat V.S., Centre for Nano-Materials & Displays (CND), B.M.S. College of Engineering, Bull Temple Road, Karnataka, Bengaluru, 560019, India, Department of Materials Science, Mangalore University, Mangalagangothri, Karnataka, 574199, India; Kudva A.K., Department of Biochemistry, Mangalore University, Mangalagangothri, Karnataka, 574199, India; Naik H.V., Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri, Karnataka, 574199, India; Reshmi G., Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri, Karnataka, 574199, India; Raghu S.V., Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri, Karnataka, 574199, India; De Padova P., Consiglio Nazionale delle Ricerche-ISM, Via Fosso del Cavaliere 100, Roma, 00133, Italy, INFN-LNF, Via Enrico Fermi 54, Frascati, 00044, Italy; Hegde G., Centre for Advanced Research and Development (CARD), CHRIST (Deemed to be University), Hosur Rd, Bhavani Nagar, S.G. Palya, Karnataka, Bengaluru, 560029, India, Department of Chemistry, CHRIST (Deemed to be University), Hosur Rd, Bhavani Nagar, S.G. Palya, Karnataka, Bengaluru, 560029, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 20763417
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Bhat V.S.; Kudva A.K.; Naik H.V.; Reshmi G.; Raghu S.V.; De Padova P.; Hegde G., “Toxicological Profiling of Onion-Peel-Derived Mesoporous Carbon Nanospheres Using In Vivo Drosophila melanogaster Model,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 27, 2025, https://archives.christuniversity.in/items/show/15174.