Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)
- Title
- Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)
- Creator
- Attah E.I.; Ugwuagbo S.C.; Chinnam S.; Eze F.I.; Nnadi C.O.; Agbo M.O.; Obonga W.; Rudrapal M.; Walode S.G.; Nizam A.; Sahoo R.K.; Bendale A.R.; Khairnar S.J.; Jagtap M.R.
- Description
- Over the years, medicinal plants have been employed in the treatment of inflammation and related ailments. This study evaluated the anti-inflammatory potential of the aerial parts of S. brevipes. The extracts and fractions were further evaluated for anti-inflammatory activity in carrageenan-induced rat model at varying doses (200 and 400 mg/kg doses, orally) for 5 h of treatment. The result of the phytochemical screening showed the presence of alkaloids, terpenoids, glycosides, flavonoids and tannins in the aerial parts of the plant. The in vivo anti-inflammatory study exhibited inhibition of 42% and 44%, 47% and 36%, 33% and 31%, and 43% and 42% for methanol extract n-hexane fraction, ethyl acetate fraction, and methanol fraction, at 200 and 400 mg/kg doses, respectively. The positive control (diclofenac sodium) showed an inhibition value of 51% at 5 mg/kg dose. Finally, it is concluded that S. brevipes possesses anti-inflammatory potential which validates the enthnomedicinal claim of the plant. 2022. Attah EI et al. All Rights Reserved.
- Source
- Pharmacia, Vol-69, No. 2, pp. 311-317.
- Date
- 2022-01-01
- Publisher
- Pensoft Publishers
- Subject
- anti-inflammatory; carrageenan; paw edema; phytochemicals; Sabicea brevipes
- Coverage
- Attah E.I., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Ugwuagbo S.C., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Chinnam S., 2 Department of Chemistry, M. S. Ramaiah Institute of Technology, Affiliated to Visvesvaraya Technological University, Karnataka, Bengaluru, 560054, India; Eze F.I., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Nnadi C.O., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Agbo M.O., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Obonga W., 1 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Nigeria; Rudrapal M., 3 Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Maharashtra, Pune, 411019, India; Walode S.G., 3 Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Maharashtra, Pune, 411019, India; Nizam A., 4 Department of Chemistry, CHRIST (Deemed to be University), Karnataka, Bengaluru, 560029, India; Sahoo R.K., 5 School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, Bhubaneswar, 752050, India; Bendale A.R., 6 Sandip Institute of Pharmaceutical Sciences, Maharashtra, Nashik, 422213, India; Khairnar S.J., 7 MET Institute of Pharmacy, Bhujbal Knowledge City, Maharashtra, Nashik, 422003, India; Jagtap M.R., 8 JMCT Institute of Pharmacy, Maharashtra, Nashik, 422006, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 4280296; CODEN: FMTYA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Attah E.I.; Ugwuagbo S.C.; Chinnam S.; Eze F.I.; Nnadi C.O.; Agbo M.O.; Obonga W.; Rudrapal M.; Walode S.G.; Nizam A.; Sahoo R.K.; Bendale A.R.; Khairnar S.J.; Jagtap M.R., “Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae),” CHRIST (Deemed To Be University) Institutional Repository, accessed February 24, 2025, https://archives.christuniversity.in/items/show/15421.