Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein
- Title
- Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein
- Creator
- Poochi S.P.; Easwaran M.; Balasubramanian B.; Anbuselvam M.; Meyyazhagan A.; Park S.; Bhotla H.K.; Anbuselvam J.; Arumugam V.A.; Keshavarao S.; Kanniyappan G.V.; Pappusamy M.; Kaul T.
- Description
- Angiotensin converting enzyme 2 (ACE2) and main protease (MPro) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome-coronaviruses or SARS-CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of Ipomoea obscura (L.) by using GC-MS analysis. These potential bioactive compounds were considered for molecular docking studies against ACE2 and MPro target proteins to determine the antiviral effects against SARS-COV. Results exhibits that among 11 compounds from I. obscura (L.), urso-deoxycholic acid, demeclocycline, tetracycline, chlorotetracycline, and ethyl iso-allocholate had potential viral inhibitory activity. Hence, the present findings suggested that chemical constitution present in I. obscura (L.) will address inhibition of corona viral replication in host cells. 2020 The Authors. Food Frontiers published by NCU, NWU, JSU, ZJU & FAFU and John Wiley & Sons Australia, Ltd.
- Source
- Food Frontiers, Vol-1, No. 2, pp. 168-179.
- Date
- 2020-01-01
- Publisher
- John Wiley and Sons Inc
- Subject
- ADME; GC-MS; Ipomoea Obscura (L.); Molecular docking; SARS-CoV-2
- Coverage
- Poochi S.P., Department of Biochemistry and Bioinformatics, Karpagam Academy of Higher Education, Coimbatore, 641021, India; Easwaran M., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India; Balasubramanian B., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Anbuselvam M., Department of Biotechnology, Selvamm College of Arts and Science, Namakkal, 637003, India; Meyyazhagan A., Euroespes Biomedical Research Centre, International Centre of Neuroscience and Genomic Medicine, Corunna, 15165, Spain, Department of Life Sciences, Christ (Deemed to be University), Bangalore, 560029, India; Park S., Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea; Bhotla H.K., Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; Anbuselvam J., Department of Animal Science, Bharathidasan University, Tiruchirappalli, 620024, India; Arumugam V.A., Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Tamil Nadu, Coimbatore, India; Keshavarao S., and Emeritus (Rtd.), Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Tamil Nadu, Coimbatore, 46, India; Kanniyappan G.V., Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Ethiopia; Pappusamy M., Department of Life Sciences, Christ (Deemed to be University), Bangalore, 560029, India; Kaul T., Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 26438429
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Poochi S.P.; Easwaran M.; Balasubramanian B.; Anbuselvam M.; Meyyazhagan A.; Park S.; Bhotla H.K.; Anbuselvam J.; Arumugam V.A.; Keshavarao S.; Kanniyappan G.V.; Pappusamy M.; Kaul T., “Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 26, 2025, https://archives.christuniversity.in/items/show/16294.