Base mediated spirocyclization of quinazoline: One-step synthesis of spiro-isoindolinone dihydroquinazolinones
- Title
- Base mediated spirocyclization of quinazoline: One-step synthesis of spiro-isoindolinone dihydroquinazolinones
- Creator
- Venkateshwarlu R.; Murthy V.N.; Tadiparthi K.; Nikumbh S.P.; Jinkala R.; Siddaiah V.; Madhu Babu M.V.; Rama Mohan H.; Raghunadh A.
- Description
- A novel approach for the spiro-isoindolinone dihydroquinazolinones has been demonstrated from 2-aminobenzamide and 2-cyanomethyl benzoate in the presence of KHMDS as a base to get moderate yields. The reaction has been screened in various bases followed by solvents and a gram scale reaction has also been executed under the given conditions. Based on the controlled experiments a plausible reaction mechanism has been proposed. Further the substrate scope of this reaction has also been studied. This journal is The Royal Society of Chemistry.
- Source
- RSC Advances, Vol-10, No. 16, pp. 9486-9491.
- Date
- 2020-01-01
- Publisher
- Royal Society of Chemistry
- Coverage
- Venkateshwarlu R., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India, Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, 530045, India; Murthy V.N., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Tadiparthi K., Department of Chemistry, CHRIST (Deemed to Be University) Hosur Road, Bengaluru, 560029, India; Nikumbh S.P., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Jinkala R., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Siddaiah V., Department of Organic Chemistry and FDW, Andhra University, Visakhapatnam, 530045, India; Madhu Babu M.V., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Rama Mohan H., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India; Raghunadh A., Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd., Hyderabad, 500049, India
- Rights
- All Open Access; Gold Open Access; Green Open Access
- Relation
- ISSN: 20462069; CODEN: RSCAC
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Venkateshwarlu R.; Murthy V.N.; Tadiparthi K.; Nikumbh S.P.; Jinkala R.; Siddaiah V.; Madhu Babu M.V.; Rama Mohan H.; Raghunadh A., “Base mediated spirocyclization of quinazoline: One-step synthesis of spiro-isoindolinone dihydroquinazolinones,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/16328.