Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery
- Title
- Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery
- Creator
- Bhatta A.; Krishnamoorthy G.; Marimuthu N.; Dihingia A.; Manna P.; Biswal H.T.; Das M.; Krishnamoorthy G.
- Description
- In the study we have reported the physico-chemical, photophysical and morphological properties of chlorin e6 (Ce6) decorated doxorubicin (DOX) encapsulated chitosan (CS)-tripolyphosphate (TPP) nanoparticles which prepared by ionotropic gelation method. The Ce6 physically loaded onto the nanoparticles by self-assembly of CS with TPP-DOX under aqueous conditions. The results from DLS studies highlights the prepared nanoparticles that possess the size in the range of 80120 nm. with negatively charged of ?6 mV. The SEM and AFM images showed 80120 nm size while the average size of the Ce6 decorated nanoparticles was found to be around 100130 nm. The absorption spectra of Ce6 decorated nanoparticles are similar when compared to free Ce6 which suggest there is no change in the Ce6 chromophore upon decoration. This nanoparticle showed high photostability and singlet oxygen generation (SOG). The Ce6 decorated and DOX encapsulated nanoparticles sizes and charges are in the range of 90130 nm and ?30 mV respectively. The nanoparticles showed high encapsulation efficiency towards DOX as well as pH controlled release. This has significant anti-proliferative activity against MCF-7 breast cancer cells after irradiation at near infra-red (NIR) ranges were evaluated. This could have potential applications in photo-controlled smart DOX delivery system for cancer treatment. 2019 Elsevier B.V.
- Source
- International Journal of Biological Macromolecules, Vol-136, pp. 951-961.
- Date
- 2019-01-01
- Publisher
- Elsevier B.V.
- Subject
- Chitosan nanoparticles; Chlorin e6; Doxorubicin; Photosensitizer; Photostability
- Coverage
- Bhatta A., Natural Products Chemistry Groups, Chemical Science & Technology Division, CSIR-North East Institute of Science & Technology (NEIST), Jorhat, 785 006, Assam, India; Krishnamoorthy G., Natural Products Chemistry Groups, Chemical Science & Technology Division, CSIR-North East Institute of Science & Technology (NEIST), Jorhat, 785 006, Assam, India; Marimuthu N., Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, 560029, Karnataka, India; Dihingia A., Biotechnology Group, Biological Science & Technology Division, CSIR-North East Institute of Science & Technology (NEIST), Jorhat, 785 006, Assam, India; Manna P., Biotechnology Group, Biological Science & Technology Division, CSIR-North East Institute of Science & Technology (NEIST), Jorhat, 785 006, Assam, India; Biswal H.T., Department of Chemistry, Indian Institute of Technology Guwahati (IITG), Guwahati, 781 039, Assam, India; Das M., Department of Chemistry, Indian Institute of Technology Guwahati (IITG), Guwahati, 781 039, Assam, India; Krishnamoorthy G., Department of Chemistry, Indian Institute of Technology Guwahati (IITG), Guwahati, 781 039, Assam, India
- Rights
- Restricted Access
- Relation
- ISSN: 1418130; PubMed ID: 31226376; CODEN: IJBMD
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Bhatta A.; Krishnamoorthy G.; Marimuthu N.; Dihingia A.; Manna P.; Biswal H.T.; Das M.; Krishnamoorthy G., “Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 25, 2025, https://archives.christuniversity.in/items/show/16594.