Structural investigation of discrete solvent protonated vanadium and other transition metal complexes of N-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]benzohydrazide, synthetic, spectroscopic and cytotoxicity studies
- Title
- Structural investigation of discrete solvent protonated vanadium and other transition metal complexes of N-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]benzohydrazide, synthetic, spectroscopic and cytotoxicity studies
- Creator
- Vineetha M.C.; Sithambaresan M.; Nair Y.S.; Prathapachandra Kurup M.R.
- Description
- A new ligand 3-ethoxysalicylaldehyde benzoic hydrazone (H2ESB) and its copper(II), nickel(II), cobalt(II), zinc(II), and dioxidovanadium(V) complexes have been synthesized and characterized by elemental analysis, IR, UVVis and EPR studies. Copper(II) complex (2) contains 2,2?-bipyridine as a coligand. Aroyl hydrazone and its copper and vanadium complexes were characterised by single crystal XRD. The vanadium compound crystallized in triclinic space group P1- and copper compound in orthorhombic space group P212121. The solvent molecule DMF protonates to form ammonium ion in vanadium complex which neutralises the charge on the vanadium ion. Both complexes copper and vanadium show distorted square pyramidal geometry. From EPR results, spin Hamiltonian and bonding parameters were calculated. The g values in copper complexes indicate the presence of the unpaired electron in the dx?y orbital. In vitro cytotoxicity studies of aroylhydrazone and its complexes showed that copper, cobalt and vanadium complexes are more cytotoxic than hydrazone and other complexes against Dalton's lymphoma ascites cells (DLA). 2019 Elsevier B.V.
- Source
- Inorganica Chimica Acta, Vol-491, pp. 93-104.
- Date
- 2019-01-01
- Publisher
- Elsevier S.A.
- Subject
- Aroylhydrazone; Azomethine; Copper(II) complex; EPR; Vanadium(V) complex; X-ray diffraction
- Coverage
- Vineetha M.C., Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, 682 022, Kerala, India, Department of Chemistry, Sree Kerala Varma College, Thrissur, 680 011, Kerala, India; Sithambaresan M., Department of Chemistry, Faculty of Science, Eastern University, Chenkalady, Sri Lanka; Nair Y.S., Department of Chemistry, Christ University, Bengaluru, 560 029, Karnataka, India; Prathapachandra Kurup M.R., Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, 682 022, Kerala, India, Department of Chemistry, School of Physical Sciences, Central University of Kerala, Tejaswini Hills, Periye, Kasaragod, 671 316, India
- Rights
- Restricted Access
- Relation
- ISSN: 201693; CODEN: ICHAA
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Vineetha M.C.; Sithambaresan M.; Nair Y.S.; Prathapachandra Kurup M.R., “Structural investigation of discrete solvent protonated vanadium and other transition metal complexes of N-[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]benzohydrazide, synthetic, spectroscopic and cytotoxicity studies,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/16714.