Genetic correlates of the development of theta event related oscillationsin adolescents and young adults
- Title
- Genetic correlates of the development of theta event related oscillationsin adolescents and young adults
- Creator
- Chorlian D.B.; Rangaswamy M.; Manz N.; Meyers J.L.; Kang S.J.; Kamarajan C.; Pandey A.K.; Wang J.-C.; Wetherill L.; Edenberg H.; Porjesz B.
- Description
- The developmental trajectories of theta band (47Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. Associations between the theta EROs and genotypic variants of 4 KCNJ6 single nucleotide polymorphisms (SNPs) were found to vary with age, sex, scalp location, and task modality. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta EROs in adults in a previous family genome wide association study. Since measures of the P3 response have been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of genetic effects on its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions. 2016 Elsevier B.V.
- Source
- International Journal of Psychophysiology, Vol-115, pp. 24-39.
- Date
- 2017-01-01
- Publisher
- Elsevier B.V.
- Subject
- Adolescent; Development; ERO; KCNJ6; P3; Theta
- Coverage
- Chorlian D.B., Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, United States; Rangaswamy M., Department of Psychology, Christ University, Bangalore, India; Manz N., Department of Physics, College of Wooster, Wooster, OH, United States; Meyers J.L., Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, United States; Kang S.J., Stratton VA Medical Center, Albany, NY, United States; Kamarajan C., Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, United States; Pandey A.K., Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, United States; Wang J.-C., Mount Sinai School of Medicine, New York, NY, United States; Wetherill L., Indiana University School of Medicine, Indianapolis, IN, United States; Edenberg H., Indiana University School of Medicine, Indianapolis, IN, United States; Porjesz B., Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Department of Psychiatry, Brooklyn, NY, United States
- Rights
- All Open Access; Green Open Access
- Relation
- ISSN: 1678760; PubMed ID: 27847216; CODEN: IJPSE
- Format
- Online
- Language
- English
- Type
- Article
Collection
Citation
Chorlian D.B.; Rangaswamy M.; Manz N.; Meyers J.L.; Kang S.J.; Kamarajan C.; Pandey A.K.; Wang J.-C.; Wetherill L.; Edenberg H.; Porjesz B., “Genetic correlates of the development of theta event related oscillationsin adolescents and young adults,” CHRIST (Deemed To Be University) Institutional Repository, accessed February 23, 2025, https://archives.christuniversity.in/items/show/17104.