Multi-component condensation mediated synthesis of bioactive heterocyclic compounds

Multi-component condensation mediated synthesis of bioactive heterocyclic compounds

Chemistry

Aromatic heterocycles constitute the most diverse family of organic compounds. Moreover, aromatic heterocycles are widely used for the synthesis of dyes and polymeric materials of high value. The development of selective reactions that utilize easily available and abundant precursors for the efficient synthesis of heterocyclic compounds is a long-standing goal of chemical research. Despite the centrality of its role in a number of important research areas, including medicinal chemistry, total synthesis,and materials science, a general, selective, step-economical, and stepefficient synthesis of heterocycles is still needed.Pyrano[2,3-c]pyrazole derivatives have been synthesised by a one-pot multicomponent condensation of different aldehydes, dialdehydes, and ketones with malononitrile, ethyl acetoacetate, hydrazine hydrate (or phenylhydrazine) in the presence of magnetic nano-[CoFe2O4] catalyst under ultrasonic irradiation. The catalyst can be retrieved using an external magnet and used repeatedly. A practical, scalable method for obtaining various pyranopyrazoles has been demonstrated.

Chemistry

CHRIST (Deemed to be University)

English

PhD